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Blockchain-enabled solutions for clinical trials

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Blockchain-enabled solutions for clinical trials TRIALL.IO © 2021 Triall (Clinblocks B.V.) | The content of these slides is privileged and confidential. Do not share or copy unless permitted.
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Page 1: Blockchain-enabled solutions for clinical trials

Blockchain-enabled solutions for clinical trials

TR IA L L . IO

© 2021 Triall (Clinblocks B.V.) | The content of these slides is privileged and confidential. Do not share or copy unless permitted.

Page 2: Blockchain-enabled solutions for clinical trials

What are clinical trials?C O N T E X T

Multi-stage research process. Typically takes 10 years or longer.

Increasingly data heavy. Result of digitalization and the adoption of mobile devices for data collection.

Complex interplay between many specialist parties.

Crucial part of the development of new medicines. Establish evidence of safety and efficacy.

Documentation and constant inspection-readinessdemanded by authorities.

Page 3: Blockchain-enabled solutions for clinical trials

What’s the problem?P R O B L E M

FragmentationData is scattered across sites and systems.1

234

Lack of oversightReported by virtually all clinical trial professionals.

Recordkeeping failureCausing significant delays, costs, and safety risks.

Data integrity issuesA growing concern according to authorities such as FDA, EMA, WHO.

Development of vaccines and drugs is destined to become unreliable and unaffordable , due to:

Page 4: Blockchain-enabled solutions for clinical trials

Verial eTMF Our MVP: Blockchain-secured verifiable proofs of clinical trial documents.

World’s first implementation of blockchain in a live and running clinical trial (July 2019).

Awarded Seal of Excellence by European Commission for underlying concept.

Commercial version being onboarded by growing number of clinical trials.

Verial eTMFBlockchain-secured document management

F I R STECOSYSTEM

APPL I CAT IONS

Triall CTMSIntegrated trial managementdashboard

Atena PRMMulti-sidedpartneringplatform

An ecosystem of industry-validated, blockchain-integrated products to streamline clinical trials

MVP HIGHLIGHTS

APIs and moreIntegrating in-house and third-party solutions

S O L U T I O N

Page 5: Blockchain-enabled solutions for clinical trials

What are the unique benefits of the Triall ecosystem?

We bring Web 3.0 to medical research,by realizing a digital ecosystem for clinical trials

System Integration & Interoperability Blockchain-agnostic, decentralized identityand access management. Secure connections and exchanges between isolated clinical trial systems and their users.

Efficiency & ComplianceIntegrated clinical trial metrics.Automation and assertion of clinical trial workflows through AI and smart contracts.

Availability & Ease of UseEcosystem utilities available from anywhere. On any device. Through a secured cloud-based environment.

S O L U T I O N

Data integrity & AuditabilityBlockchain-secured, tamper-resistant audit trails of clinical documentsand data.

Accelerated introduction of safe and affordable vaccines and drugs.

Page 6: Blockchain-enabled solutions for clinical trials

We serve a double-digit growth marketM A R K E T

$233 billion will be spend on pharmaceutical research in 2026, coming from $186B in 2019. Majority of this budget is allocated to clinical trials.

R&D BUDGET$233B

CAGR13,8%

Rapid digitalization spursdouble-digit market growth.High upside projected forthose who can underpinthis new digital playing field.Our solutions are designedto do so.

TRIALS / YEAR30K+

Over 30.000 new clinical trials are initiated each year. Roughly 70% take place in the US and Europe, where we have a strong footprint.

Our market is highly fragmented, with many small vendors of function-specific solutions. Vacuum for mid-sized players. Need for interoperability.

R&D spending on the rise. Nature Reviews Drug Discovery 13, 566 (2014).

Total global pharmaceutical R&D spending from 2012 to 2026. Statista (2019).

eClinical solutions market size, share, & trends analysis report. Grand View Research (2018).

Trends, Charts, and Maps. U.S. National Library of Medicine (retrieved April 2021, from: clinicaltrials.gov).

Sources :

Page 7: Blockchain-enabled solutions for clinical trials

Token Economics: two-token system

Access to ecosystem utilities

Direct P2P compensation

Community engagement

Ecosystem governance

Memberships & rewards

To fuel the micro-economy of the Triall ecosystem, we introduce our main network tokenTRL and its internal counterpart T-CRED.

T O K E N S A L E

Page 8: Blockchain-enabled solutions for clinical trials

Token Economics: two-token system

T-CRED gives the right to enter and use the services in the Triall ecosystemand can only be created by converting TRL (at a fixed conversion rate).

Fixed conversion rate1 T-CRED always equals $100.

Token burn policy2,5% of T-CRED burned on conversion to TRL.

Deflationary trendBurn policy stimulates a downtrend in the total TRL token supply.

Predictable & stable costsNo volatility.

T O K E N S A L E

Page 9: Blockchain-enabled solutions for clinical trials

Pre-sale & token allocationT O K E N S A L E

Private round price | hard cap$ 0,125 | $ 1.093.750,-

Retail round price | hard cap$ 0,20 | $ 875.000,-

Late bird round price | hard cap$ 0,20 | $ 1.025.000,-

Listing price$ 0,25

KEY FIGURES PRE-SALE ROUND

Private round vesting schedule3% at TGE, fully vested after 6 months

Market Cap at TGE$935.312,50 (2,1% of total supply)

8%

18%Liquidity, long-term operations & development

Pre-sale

24%Treasury

10%Triall Community Fund

12,5%Existing investors

8%Advisors

10%Founding team

9,5%Growth, acquisition & marketing

5,0% Private2,5% Retail2,9% Late Bird 4,6% Staking 3,0% Airdrop

Page 10: Blockchain-enabled solutions for clinical trials

Building out our digital ecosystem for clinical trialsF U T U R E V I S I O N & R O A D M A P

Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4

2020 2021 2022 2023

Verial eTMF

Triall CTMS

R E L E A S EAPI library

Trialwiki

Atena PRM

Ecosystem growth and support

Patient apps

Future steps

Trial l Community Fund, DAO, strategic partnering,third-party integrations, expansion into adjacent markets.

T O K E N P R E - S A L E

Page 11: Blockchain-enabled solutions for clinical trials

Meet our Management TeamT E A M & P A R T N E R S

Combined, our team has managed 100+ clinical trials across 30+ countries, and managed clinical and software companies through all stages of growth.

PRODUCT INNOVATION MANAGEMENTFINANCE & ADMINISTRATION LEGAL & COMPLIANCE

TEAMS: CLINOPSDEVELOPMENT MARKETING / BDUX / UI

Hadil Es-Sbai

Dr. Linda van de BurgwalCFO

CEO

CTO Head of Clinical Affairs Head of Product Design Head of Marketing General Counsel

Experienced CEO; Extensive experience in managing clinical trials

Academic entrepreneur; Project manager; Founder of two

successful Life Science consultancies

Experienced blockchain and SaaS developer;

Director of the Factomblockchain

Clinical researcher; Medical writer; Project

manager

Graphic designer; PhD candidate and consultant in

medical innovation management

Researcher; Consultant and copywriter focusing

on complex tech and R&D

Corporate lawyer; Extensive experience as legal counsel in healthcare and pharma

Niels Klomp Dr. Joost Flach Mark van der Waal Raymond van der Waal Rob Posthumus

Page 12: Blockchain-enabled solutions for clinical trials

Meet our Advisory BoardT E A M & P A R T N E R S

Triall brings together an international network of industry experts and thought leaders on a joint mission for smarter, safer, and more-efficient clinical trials.

Yassin MobarakDizer Capital US

Technology

Prof. Eric Claassen, PhDVU Amsterdam EU

Strategy

Prof. Niels Chavannes, MD, PhDLUMC & NeLL EU

Product Design

Prof. Sjaak Bloem, PhDNyenrode & Janssen (JnJ) EU

Product Design

Danielle BradburyGalera Therapeutics US

Quality & Compliance

Sina DjaliJanssen (JnJ) US

Product Design

Dr. Po Chi WuHKUST & UC Berkeley US

Strategy

Nick van den BulkCR2O EU

Product Design

Allan BukuyaTrialDocs AU

Product Design

Cari Jacobs-BlomCR2O EU

Quality & Compliance

Moses MaFutureLab Consulting US

Business Development

Maarten BoenderSphereon EU

Technology

Page 13: Blockchain-enabled solutions for clinical trials

Meet our Partner NetworkT E A M & P A R T N E R S

Triall unites in-depth, in-house understanding of industry needs and opportunities with the function-specific expertise of its strategic partners.

Tech Venture Capital Blockchain Innovation Agency

Deep Tech Strategy Consulting

Life Sciences Strategy ConsultingBlockchain APIs & Microservices

Enterprise Software DeveloperClinical Operations Partner

Life Sciences Recruitment & Staffing

National eHealth Institute

Industry Collaboration Platform Healthcare Research Institute Patient Recruitment & Retention

Page 14: Blockchain-enabled solutions for clinical trials

Follow the Triall project

triallcommunity @triallofficialinsights.triall.io triallofficial


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