Date post: | 22-Dec-2015 |
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CHiP-Seq
DNADNA-binding proteins
(histones, e.g)
crosslink
Immuno-precipitate and fragment DNA
Immuno-precipitateand fragment DNA
Reverse cross-links and sequence
ChIP-Seq and ChIP-chip comparison of two histone marks
Lower background & tighter peaks in ChIP-Seq (better contrast)
trxG(activation)
PcG(repression)
Promoter classeshigh CpG
gene
gene
genelow CpG
intermediate CpG
CpG
Highly expressed, housekeeping genes; other genesN=11,410
Genes with high tissue-specificityN=3,014
Mixture of genesN=3,338