MINUTES OF THE MEETING OF THE BOARD OF DIRECTORS OF SUNNYBROOK HEAL TH SCIENCES

CENTRE (SHSC) HELD ON WEDNESDAY, MARCH 8, 2017 AT 8:00 A.M. IN THE ELIZABETH TORY

BOARD ROOM, M6-120, SUNNYBROOK CAMPUS.

Chair: Mr. Blake Goldring

Directors:

Mr. S. Beatty Mr. S. Diamond Mr. D. Lang Ms. M. Ng Mr. W. Squibb Mr. S. Tile

Dr. J. Bodley Mr. T. Flynn Ms. E. Martin Sr. Anne Norman Dr. S. Symons Ms. M. Tory

Mr. R.Davloor Ms. H. Hayward Dr. B. McLellan Ms. H. Short Ms. R. Taggar Dr. T. Young

Regrets:

Dr. S. Belo

By Invitation: (in addition to members of the public)

Dr. J. Dellandrea Dr. M. Julius Ms. C.Rosebrugh Mr. M. Young

Dr. C. DuHamel Mr. S. Marafioti Dr. A. Smith

Ms. T. Hueper Mr. M. Moffat Ms. A. Welch

1.0 CALL TO ORDER - OPEN SESSION

Mr. Goldring, Chair, noting a quorum present, called the meeting of the Sunnybrook Board of Directors to order at 8:00 a.m.

1.1 APPROVAL OF AGENDA

The Chair requested approval of the agenda as pre-circulated. So moved by Mr. Tile and seconded by Mr. Beatty.

The Agenda was approved as circulated.

1.2 APPROVAL OF MINUTES

Minutes of Meeting of SHSC Board - February 81 2017

Mr. Goldring requested approval of the minutes of the meeting of the Sunnybrook Board of Directors held on Wednesday, February 8, 2017. A copy of the minutes was pre-circulated and appended to the agenda portfolio.

MOTION: Upon MOTION duly made by Mr. Beatty and SECONDED by Ms. Martin, IT WAS RESOLVED THAT the Minutes of the meeting of the Board of Directors of Sunnybrook Health Sciences Centre held on Wednesday, February 8, 2017 be hereby approved as pre-circulated.

CARRIED.

2.0 REPORT OF THE CHAIR

The Chair's report will be presented during the in-camera session.

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3.0 REPORT OF THE CEO

3.1 MARCH REPORT

A copy of the March CEO Report was pre-circulated and appended to the agenda portfolio for information.

Dr. McLellan referenced the report from the Sunnybrook Research Institute on the Cancer Ablation Therapy Program: A Canadian Health Care Success Story . Five years ago, SRI and the Odette Cancer Centre (OCC) began to plan establishing a platform for cancer management aimed at tackling early­stage cancers by destroying or ablating tumours, all without traditional surgery. Scientists at SRI and radiation oncologists at OCC dreamed up a trio of new radiation delivery technologies. These technologies formed the nexus of the Cancer Ablation Therapy (CAT) program. The strategy was to integrate MRI and advanced computed tomography imaging modalities capable of high-level tumour visualization to enable ablation.

Dr. McLellan commented that in 2016, the CAT program realized the first goal, to install a 1.ST MRI into a lead-lined and anesthesia-capable brachytherapy suite, the world's first. As a result of this achievement, clinicians will be able to implant radiation-delivering catheters and can target, treat and observe tumour destruction. The first integrated treatment will take place in 2017.

The CAT program realized the second goal with the installation of the Gamma Knife and in 2017, the Icon-imaging component will be installed. Once complete, it will allow patients to have precise brain radiation therapy without a surgical frame fixed to their head. The third component of the CAT program is the MR-Linac. Sunnybrook will be the first site in Canada and one of only seven other collaborators in the world with this technology.

Dr. McLellan reported that the CAT program is a coordinated effort made possible by many sources of funding, including the Sunnybrook Foundation, the government of Ontario, peer-reviewed grants as well as investment from SRI, the OCC and Sunnybrook.

In closing, Dr. McLellan commented that he would be pleased to answer questions on any matters arising out of his written report.

The Chair thanked Dr. McLellan for his report and opened the floor for discussion.

BOARD BUSINESS

4.0 EDUCATIONALPRESENTATION

The Chair called on Dr. Julius, VP Research to introduce the guest speakers, Dr. Isabelle Aubert and Dr. Nir Lipsman.

Dr. Aubert is a Senior Scientist, Biological Sciences, Hurvitz Brain Sciences Research Program at the Sunnybrook Research Institute and Professor, Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto. A copy of her slide presentation "Ultrasound Treatment for Alzheimer's Disease" was pre-circulated and appended to the agenda portfolio for information.

Dr. Nir Lipsman is a Neurosurgeon at Sunnybrook Health Sciences Centre and Assistant Professor, Department of Surgery, University of Toronto. He is also a Scientist in the Physical Sciences Platform, Hurvitz Brain Sciences Research Program at the Sunnybrook Research Institute. A copy of his slide presentation entitled "Focused Ultrasound: The Future of Non-Invasive Brain Therapy and Repair" was pre-circulated and appended to the agenda portfolio for information.

Dr. Aubert, referencing her slide deck, commented that Alzheimer's is a complex disease and there is no cure. Treatments are being tested to deliver therapeutic molecules across the blood-brain barrier.

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Dr. Aubert commented that she and her team are currently in phase 4 of a clinical trial to deliver antibodies through focused ultrasound to relevant brain regions where they are needed. Focused ultrasound increases the amount of therapeutics delivered by approximately 5 times. It reduces pathology from 20 to 60% with just 1 low dose of antibodies and repeated treatments are possible and efficient. In closing, Dr. Aubert commented that ultrasound significantly increases treatment efficacy.

Dr. Lipsman commented that brain diseases are a major cause of human disability and death. They are expected to increase dramatically in the next two decades and the global cost of Alzheimer's will reach approximately $1 Trillion by 2018. There is an urgent need to develop safe and effective treatments. Dr. Lipsman presented an overview of the current challenges for brain therapies. He also commented that the blood brain barrier is an obstacle for treatments reaching their targets. The Sunnybrook Centre of Excellence in MRI Focused Ultrasound is a globally unique centre at Sunnybrook with its technical and clinical expertise, scientific track record and hospital, industry and public support.

Dr. Lipsman reported that non-invasive brain surgery for tremors can now be done and is a global first in human patients. Opening the Blood Brain Barrier is also a global first in human patients. Dr. Lipsman provided an overview of various diseases where the Blood Brain Barrier is a major obstacle and highlighted global firsts at Sunnybrook.

In closing, Dr. Lipsman commented that the future of Focused Ultrasound (FUS) at Sunnybrook leads to the following:

• Inventing the Future of Non-invasive Brain Therapy and Repair; • 'Moving the dial' on humanity's most urgent and challenging diseases; • Phase I (First-in-human) to Phase III (Standard-of-care) studies; and • A versatile, scalable, disruptive and powerful technology.

The Chair thanked Drs. Aubert and Lipsman for their presentation and opened the floor for questions.

5.0 DECISION & INFORMATION ITEMS:

5.1 MEDICAL ADVISORY COMMITTEE

Dr. McLellan presented the report on behalf of the Medical Advisory Committee. The Committee met on February 14, 2017 . A copy of the report was pre-circulated and appended to the agenda portfolio for information.

5.1.1 Credentials - February 2017

A copy of the February 2017 appointment list was pre-circulated and appended to the agenda portfolio.

On behalf of the Medical Advisory Committee, Dr. McLellan requested a motion for the approval and/or affirmation of the appointments as recommended by the Credentials Committee at their meeting held on February 1, 2017.

So moved by Mr. Squibb and seconded by Mr. Beatty.

The Chair opened the floor for discussion, following which he called the question on the motion to accept and approve the following appointments as brought forward by the Medical Advisory Committee.

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ACTIVE/ACTIVE PROVISIONAL STAFF APPLICATIONS

PSYCHIATRY

Dr. Justin Delwo Active Provisional Staff Division: Adult Psychiatry With admitting privileges Effective: January 16, 2017

Preamble: Dr. Delwo is replacing Dr. H. Flett. Dr. Delwo will be a full time inpatient psychiatrist on F2 carrying 5-8 beds both on the regular ward and in the PIC. He will be the primary supervisor for a PGY2 psychiaty resident and for a clinical clerk. Dr. Delwo has an academic appointment as Lecturer with the role profile of clinician teacher. Dr. Delwo holds RCPSC certification in psychiatry. He holds an independent practice license with the CPSO.

OTHER APPLICATIONS None

TEMPORARY PRIVILEGES With the approval of the EVP & Chief Medical Executive, the following individuals were granted temporary privileges

FAMILY AND COMMUNITY MEDICINE

Dr. Hedieh M. Ghanbari Division: St. John's Rehab With admitting privileges Effective: January 6, 2017 to April 7, 2017

Preamble: Application for Courtesy Staff is in process. Temporary privileges were granted to allow Dr. Ghanbari to practice until the Courtesy Staff application is approved.

Dr. Amanda Y. Li Division: Long Term Care With admitting privileges Effective: January 9, 2017 to April 10, 2017

Preamble: Application for Clinical Associate Staff is in process. Temporary privileges were granted to allow Dr. Li to practice until the Clinical Associate Staff application is approved.

NEWBORN AN,J> DEVELOPMENTALPEDIATRICS

Dr. Asaph Rolnitsky With admitting privileges Effective: February 2, 2017 to May 1, 2017

Preamble: Application for Active Provisional Staff is in process. Temporary privileges were granted to allow Dr. Rolnitsky to practice until application for full time staff is approved.

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Dr. Holden Sheffield

PSYCHIATRY

Dr. Justin Delwo

SURGERY

Dr. Luke Marshall

Dr. Manveen Puri

Dr. Philippe Stewart

Dr. Isabelle Vallee

Dr. Kelly Riedel

With admitting privileges Effective: January 16, 2017 to April 15, 2017 Preamble: Temporary privileges were granted to allow Dr. Sheffield to get additional experience in caring for newborns.

With admitting privileges Effective: January 16 2017 to April 16, 2017 Preamble: Application for Active Provisional Staff is in process. Temporary privileges were granted to allow Dr. Delwo to practice until application for full time staff is approved.

Division: General Surgery Without admitting privileges Effective: January 29, 2017 to April 13, 2017 Preamble: Dr. Marshall is a physician with the Department of National Defence. Temporary privileges were granted to allow him to gain additional experience in Trauma and Critical Care.

Division: General Surgery Without admitting privileges Effective: February 5, 2017 to May 5, 2017 Preamble: Dr. Puri is a physician with the Department of National Defence. Temporary privileges were granted to allow him to gain additional experience in Trauma and Critical Care.

Division: General Surgery Without admitting privileges Effective: January 15, 2017 to April 15, 2017

Preamble: Dr. Stewart is a physician with the Department of National Defence. Temporary privileges were granted to allow him to gain additional experience in Trauma and Critical Care.

Division: General Surgery Without admitting privileges Effective: January 29, 2017 to April 13, 2017 Preamble: Dr. Vallee is a physician with the Department of National Defence. Temporary privileges were granted to allow her to gain additional experience in Trauma and Critical Care.

Division: Orthopedic Surgery Without admitting privileges Effective: January 1, 2017 to March 31, 2017 Preamble: Application for renewal of Clinical Associate Staff is in process. Temporary privileges were granted to allow Dr. Riedel to practice until the Clinical Associate Staff application is approved.

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ONE DAY TEMPORARY PRIVILEGES

Dr. Guido Hockmann Division: Orthopaedic Surgery Effective: January 12, 2017 only

Preamble: One day temporary privileges were granted to permit Dr. Hackmann to assist Dr. T. Axelrod in an orthopaedic surgery case.

MOTION: Upon MOTION duly made by Mr. Squibb and SECONDED by Mr. Beatty, IT WAS RESOLVED THAT the Board of Directors of Sunnybrook Health Sciences Centre hereby accept and approve the above noted appointments as recommended by the Medical Advisory Committee.

CARRIED.

CONSENT AGENDA

6.0 REPORT OF COMMITTEES

6.1 BUSINESS & HUMAN RESOURCESCOMMITTEE

6.1.1 Financial Report

The Board received and reviewed the Financial Reports for the 10 months ending January 31, 2017. A copy of the financial statements was pre-circulated and appended to the agenda portfolio for information.

7.0 INFORMATION ITEMS

The following information items were received and appended to the Agenda portfolio.

7.1 Media Reports 7.2 Speaker Series on Aging Well - March 27, 2017 7.3 Your Health Matters - January/February Issue

8.0 NEXT MEETING

The next meeting of the Board of Directors of Sunnybrook Health Sciences Centre is scheduled to take place on Wednesday, April 12, 2017 at 8:00 a.m. in the Elizabeth Tory Board Room, M6-120.

9.0 TERMINATION OF MEETING

There being no further business, the Chair called for a motion to terminate the open session of the Sunnybrook Board of Directors at 8:45 a.m. So moved by Mr. Tile and seconded by Ms. Tory

MEETING TERMINATED.

~-Trudy Hue

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