“Deeper understanding of how the brain operates

 will enable us to better understand ourselves.”

His Excellency Shimon Peres, President of the State of Israel

Peres Prize for Breakthroughs in NeuroscienceSeptember 12, 2012:$1 Million Global

B.R.A.I.N. Prize Announced by Israel Brain Technologies

Inspired by Israeli President Shimon Peres, Prize Will Recognize a Breakthrough Achievement in Brain Technology That Will Change Lives

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Obama Brain Mapping InitiativeApril 2, 2013. President Obama on Tuesday

announced a broad new research initiative, starting with $100 million in 2014, to invent and refine new technologies to understand the human brain

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What are neurological conditions?• Neurological diseases and disorders are those

which affect the brain, spinal cord and nerves throughout the body. They refer to a malfunction in a portion or several areas of the nervous system, which cause a number of difficulties to occur immediately or progressively over time.  Some of these challenges include problems with mobility, mental tasks (such as learning and memory), basic functions (such as swallowing and breathing), or emotional changes in mood. In the worst cases, a neurological deficit can lead to a shortened life expectancy.

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The USA Business Conference Board give us a positive reason for interestCognitive neuroscience, by showing us how we

look at the world, can teach us new ways to improve performance.

Knowing how the brain works — how people think and why they act and react as they do — can be an advantage in the workplace, where leading change and convincing people to follow are cornerstones of effective leadership.

Decision making, it turns out, is not all logical; it is emotional, too.

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Huge and unsustainable costs as a reason for concern, research & action.The cost of caring for Americans with

Alzheimer's and other forms of dementia may now be as high as $215 billion a year -- more than the cost of caring for heart disease or cancer, a new study finds.

And that number is expected to escalate as the elderly population grows.

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There are, correct, emotional, human reasons for brain disease focusAmericans fear developing Alzheimer’s

disease more than cancer, stroke, heart disease and any other life-threatening illness, according to a Marist Institute poll released this week on behalf of Home-Instead Senior Care.

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There is a visual ecomap of the large extent of Israeli brain researchhttp://www.israelbrain.org/wp-content/

uploads/2012/08/DA_Israel_brain_Eco_w_links.pdf

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BioNessBioNess is the world leader developing and

marketing Neuro-Stimulation devices for the leg and arm to give victims of stroke and other neuro-conditions, such as MS and CP, effective motion. The devices know the relevant nerves and how to stimulate them to enable patients to walk and grasp, for example.

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BioNess enables young woman with MS to resume full lifehttp://www.bioness.com/L300_for_Foot_Drop/

In_the_News.php

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Alpha Omega EngineeringAlpha Omega is a leader in developing and

marketing sophisticated and pioneering systems and micro-electrodes that enable online neural stimulation and recording for Neurosurgery & Neuroscience

Customer base: About 500 hospitals and research labs throughout the world

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Alpha Omega systems for neuro-surgeryThe MicroGuide Pro™ by Alpha Omega is the world’s most

advanced intra-operative MER (Micro Electrode Recording) system for functional neurosurgery - a comprehensive guidance unit available for target localization in the surgical treatment of movement disorders.

NeuroNav Si™ is a state-of-the-art MER system used clinically in the localization of surgical targets for the implantation of Deep Brain Stimulators (DBS) or ablation of target structures, in the treatment of neurological and psychiatric diseases. The NeuroNav Si ™ allows for the safe an accurate introduction of electrodes into the brain, while recording neural activity, stimulating neural tissue, and guiding the user to the optimal target.  

   

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InsightecInSightec® is the pioneer and global leader in MRI guided

focused ultrasound technology for image guided acoustic surgery.

InSightec’s ExAblate® Neuro integrates high intensity Focused Ultrasound Surgery with continuous Magnetic Resonance imaging (MRI) to provide a non invasive, acoustic surgery platform for treating neurological disorders without ionizing radiation through an intact skull.

ExAblate® is the first system to use the MRI guided focused ultrasound technology. In November 2012, ExAblate received the CE Mark for the treatment of three neurological disorders, Essential  Tremors, Parkinson's and Neuropathic Pain.

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TMS—TransCranial Magnetic StimulationThe next two companies use TMS technology Transcranial magnetic stimulation (TMS) is a

noninvasive technique used to apply brief magnetic pulses to the brain. The pulses are administered by passing high currents through an electromagnetic coil placed adjacent to a patient's scalp. The pulses induce an electric field in the underlying brain tissue. When the induced field is above a certain threshold, and is directed in an appropriate orientation relative the brain's neuronal pathways, localized axonal depolarizations are produced, thus activating the neurons in the relevant brain structure.

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Neuronix Neuronix is the only company in the world that has developed a system

that is clinically proven to increase cognitive levels in early and mid-stage Alzheimer’s patients every day, and, based on the CE mark, is selling systems and treating patients every day.

Neuronix systems utilize surface TMS in six cognitive areas of the brain, the left and right parietals, the left and right frontal lobes and Broca’s area (that integrates speech) and Wernicke’s area (that integrates hearing) with an innovation that combines the TMS with a relevant “cognitive event”.

For example, when TMS is applied to Broca’s area for 20 second, the patient reads for 20 seconds, and repeat; TMS is applied to Wernicke’s area for 20 seconds and a recording is played for 20 seconds;

In a small but compelling trial at Harvard-Beth Israel, the Alzheimer's patients increased their cognitive ability by about 1/3, from 20 on the standard ADAS-COGS scale, they realized an improvement by 5.83 points.

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16

1. Pre-Treatment:a) Perform an MRI scan on patient’s brainb) Locate and mark brain regions of

interest

BrocaWernicke

Dorsolateral Prefrontal cortex

Somatosensory Association Cortex

2. Focused Magnetic Stimulation:a) Position coil to stimulate specific region

3.Cognitive Training:a) “Tailor made” exercises, set to fit with

patient’s specific abilities

Con

curr

en

t

TMS coil

Patient CognitiveTraining screen

Neuronix Treatment Procedure How is it actually performed?

• Treatment phase – 30 sessions:

5 days a week, 6 weeks, 45-60 mins

– Each session: 3 regions per day

CONFIDENTIALProven effective Alzheimer Treatment

BRAINSWAY

Brainsway has patented deep TMS, penetrating 4-5 mm into the brain compared to the 1.5-3mm penetration of standard TMS. Deep TMS is the non-invasive analog to the very invasive deep brain electrode implant.

Brainsway has CE approval for the following indications Major Depressive Disorder (FDA indication)Bipolar DepressionPost-Traumatic Stress DisorderSchizophrenia (negative symptoms)Parkinson's DiseaseChronic PainBrainsway has FDA approval for depression.Brainsway has been doing clinical trials for indications such as

PSTD, bi-polar disorder, autism, Tourette’s, MS, MCI & Alzheimer’s and ADHD.

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Mazor RoboticsMazor Robotics’ Renaissance™ , FDA approved, is transforming spine surgery from

freehand procedures to highly-accurate, state-of-the-art robotic procedures, with less radiation—even for minimally invasive surgery (MIS), scoliosis, and other complex spinal deformity cases.

Powered by Clinically Validated Technology -- Highly Accurate and Safe Based on surgeons’ experience with thousands of SpineAssist® surgeries worldwide tens of thousands of implants placed No cases of permanent nerve damage 1.5 mm accuracyWide Range of Clinical Applications Hardware and software tools enable a variety of spine procedures Open, MIS, and percutaneous posterior thoracolumbar approaches Scoliosis and other complex spinal deformities Pedicle screws – short and long fusions Transfacet screws and translaminar-facet screws Osteotomies Biopsies

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CNS Companies in Clinical TrialsBrainsgate is developing a medical device to increase blood flow

to the brain to treat ischemic stroke and vascular.Brainsway is using mesenchymal stem cells converted to secrete

neurotrophic factors to treat ALS, Lou Gehrig’s disease. ElMindA’s Brain Network Activation Pattern technology is in

trials to give an objective measurement of concussion and other neuro-indications by sophisticated processing of high-channel EEG information.

Neurim has successful phase 2 clinical trials using its Circadin to show attenuation of cognitive deficits is early stage Alzheimer’s patients.

Nervomatrix is using automatic probes to diagnose and treat lower back pain.

Novocure is doing a Phase 3 clinical trial for glioblastoma in the brain using external, non-invasive AC generator to disrupt the tumor cells.

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SummaryNeuro-cognitive and degenerative (CNS) diseases, with

Alzheimer’s leading, are among the most intractable and costly and distressing diseases. Without effective therapies with minimal side effects, these diseases will break the healthcare systems, patients and caregivers.

Current therapies are inadequate and so many standard pharmaceutical responses have failed in late stage trials.

Only the most innovative solutions will yield effective therapies.

Israel, with its history & culture of scientific innovative innovation, Government support & early recognition of the challenges of CNS, is poised to be a leader in effective CNS therapies.

How can we make Israel’s leadership known to the world?

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