BREAKTHROUGH TECHNOLOGY FOR THE TREATMENT OF OSTEOARTHRITIS
Single injection
No reported side-effects
Cost-effective
Long-lasting relief
Delays need for surgery
Pure hyaluronic acid
Non-animal origins
OPTIMALLY USED IN THE EARLY STAGES OF OSTEO- ARTHRITIS
I first began using Crespine Gel when I started at NIMI in November 2010. I do a lot of injections with the use of x-ray, including hips. In a short period of time, I treated about 20 hips with Crespine Gel and I am impressed by the immediate effect it has on the patients I have treated. Most of them have experienced significant improvement immediately! I look forward with excitement to the long-term follow-up of these patients. Dr Göran Skog, NIMI (Norwegian Institute for Sports Medicine)
Throughout 2010 I treated many patients with Crespine Gel, giving injections in ankles, knees, hips and shoulders. I find it to be a very exciting product. Crespine Gel seems to have a longer-lasting effect than other types of hyaluronic acid products and cortisone. This means less-frequent injections for the patient and less expense. Dr. Rafn Lindal Björnsson, NIMI (Norwegian Institute for Sports Medicine)
Crespine Gel is indicated for use in the treatment of patients suf-fering from osteoarthritis pain in the knee who do not respond to other treatments for mild to moderate osteoarthritis. • Recommended for patients with mild to moderate osteoarthritis • To be used as an alternative to NSAIDs and other pain relief
medications • Ideal for patients who experience allergic reactions or other side-
effects from the use of NSAIDs and other pain relief medications • Suitable for patients who require a quick return to normal activity
An in-office treatment, Crespine Gel comes ready-to-use and takes10-20 minutes to administer in a single injection.
Crespine Gel © is a registered product under the essential requirements of Annex I of the Council Directive 93/42/EEC. Certificate Registration no. 368777 MRA, CE 0297.
As a consulting orthopedic surgeon, I have used Crespine Gel for one year on over 100 selected patients. There have been no com-plications in tolerance of the implant ( gel ) . Most of my patients have osteoarthritis of the knee joint. Even for grade III osteoarthri-tis, Crespine Gel can be used to delay knee replacement. Good indications for use of Crespine Gel are also rotator cuff tears ( old ) or older patients with secondary osteoarthritis of the shoulder joint. Even the single shot application is something very convenient for the patient because they only have to come for treatment once, get only one injection with one risk of joint infection. In serious arthritis cases we had to repeat the injection after 4 months, but the average effectiveness was 6 to 12 months. Dr Wolfgang Schmitt, OTS Clinic, Marbella
SINGLE INJECTIONCrespine Gel is a single injection treatment that takes only 10-20 minutes to administer and lasts for 6-8 months. This reduces the risk of infection and in-creases patient compliance and joint fluid.
NO SIDE-EFFECTSTo date, several thousand patients have been treated with Crespine Gel and there have been no reported side-effects associated with its use.
A NATURALLY-OCCURRING SUBSTANCECrespine Gel is 100% hyaluronic acid, a naturally-occurring substance in the body that is an important component of articular cartilage. COST EFFECTIVECrespine Gel costs half the price of other intraarticular injectables for osteoarthritis treatment and requires only a single injection to achieve effectiveness for 6-8 months. This makes it more afordable for patients and more cost-effective for healthcare providers.
NON-ANIMAL ORIGINCrespine Gel is a hyaluronan-based intraarticular injectable that is not derived from animal sources. This removes ethical concerns and eliminates the danger of allergic reactions. DELAYS NEED FOR SURGERYRegular treatment with Crespine Gel makes cartilage more flexible and delays the further deterioration of cartilage, slowing progress of decline in the patient’s condition.
Using Crespine Gel is simple. Remove
the syringe from the package and
it is ready for use –there is no
measuring or prep work of any
kind. Administer-ing Crespine Gel
takes only 10-20 minutes.
THE CRESPINE ADVANTAGE
TECHNOLOGY THAT SETS A NEW STANDARD
STEP 1Hyaluronic acid is synthesized from non-animal sources
STEP 2The first cross-linking of the hyaluronic acid solution is completed
STEP 3Washing and stabilization of the hyaluronic acid gel takes place
STEP 4The second cross-linking is completed, with the addition of hyaluronic acid coil-linked solution. This is followed by terminal purification.
CRM technology is a 4-step process developed by German scientists. Crespine Gel is cross-linked and stabilized due to unique CRM technology. This ensures that the body breaks down Crespine Gel slowly, resulting in a longer-lasting effect.
SINGLE INJECTION TREATMENT VS
MULTIPLE INJECTION TREATMENT
SINGLE INJECTIONLess frequent follow-up
Reduced risk of infection Cost effective
Increased patient satisfaction
MULTIPLE INJECTIONMore follow-up visits Greater infection potential Higher costsInconvenience to patients
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