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Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al...

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Page 1: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 2: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 3: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 4: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 5: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 6: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 7: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 8: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 9: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 10: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 11: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 12: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 13: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 14: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 15: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 16: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 17: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 18: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 19: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 20: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 21: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 22: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 23: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 24: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 25: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 26: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 27: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 28: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

ControlHDL

Nitrated ApoA-I

8.0

4.0

p<0.005

Cho

lest

erol

Effl

ux (%

con

trol

)

ClorinatedApoA-I

Myeloperoxidase Catalyzed Nitration and Chlorination Of ApoA-I Decreases ABCA1

Mediated Efflux

p<0.01

Nicholls SJ. et al. Trends in Cardiovascular Medicine 2005;15:212-219

Page 29: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 30: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 31: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 32: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 33: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Santos RD, et al. J Lipid Res 2008;49:349-357.

Homozygous Familial ApoA-I Deficiency

Page 34: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 35: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 36: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 37: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 38: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 39: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 40: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 41: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 42: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

ABCA1 Transporter Deficiency – Tangier Disease

Page 43: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 44: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 45: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

Page 46: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

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Page 54: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

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Page 57: Brewer HDL Metabolism Genetic Defects Master Class NLA - Lipid · ME, Schaefer EJ, Dupuis J, et al 2000; J Lipid Res 41:433441. Genetic Defects in Lipoprotein Metabolism ApoA-l Deficiency

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