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PTSD and Substance Use Disorders
Brian E. Lozano, Ph.D.
Contributing Collaborator: Sudie E. Back, Ph.D.
Medical University of South Carolina
Ralph H. Johnson VA Medical Center
ColleaguesDr. Kathleen BradyDr. Therese KilleenDr. Edna FoaDr. Colleen HanlonDr. Stacia DeSantisDr. Karen HartwellDr. Liz Santa AnaDr. Brian LozanoDr. Matt YoderDr. Kristy CenterDr. Julianne FlanaganDr. Jenna McCauleyMs. Sharon BeckerDr. Megan Moran-Santa MariaDr. Peter KalivasDr. Jacqueline McGinty
Thank you
Staff/CoordinatorsMr. Frank BeylotteMs. Mary Ashley MercerMs. Emily Hartwell Dr. Elizabeth CoxMs. Wendy MuzzyMs. Alex JefferyMs. Virginia McAlisterMr. Scott HendersonMs. Amanda FederlineMs. Anjinetta JohnsonMr. Drew Teer
Funding SourcesNIDA F31 DA00607 (Back)NIDA K23 DA021228 (Back)NIDA R01 DA030143 (Back)J. William Fulbright (Back)NIDA K24 DA00435 (Brady)NIH UL1RR029882 (Brady)NIDA T32 DA07288 (McGinty)DoD 803235 (Kalivas & Back)DoD 804237 (McGinty & Back)
No conflicts of interest to disclose
Previous and current research funding from:◦ National Institute on Drug Abuse◦ Department of Defense ◦ J. William Fulbright Foreign Scholarship Board
Disclosure Statement
Sequential Model – SUD first, then PTSD
Singular Model – Treat the “primary” disorderoTreat only the SUD
oTreat only the PTSD
Parallel Model – SUD and PTSD, different clinicians
Integrated Model - SUD and PTSD, same clinician
Treatment Models
Rates of Relapse:-With PTSD: 85%-Without PTSD: 59%(p = .12)
Time to 1st Use :-With PTSD: 26.5 days-Without PTSD: 54.5 days (p = .03)
(Brown et al., 1996; Psychology of Addictive Behaviors)
N = 31 women with alcohol or drug dependence disorders
PTSD and Relapse
Untreated PTSD contributes to poorer treatment outcome for substance use, and vice versa.
Traditionally, the standard of care = sequential model: (1) SUD treatment first, demonstrate sustained abstinence (3 to 6 months) then… (2) PTSD treatment
Clinic #1 Clinic #2
The Need to Treat Both PTSD and SUD
• Both conditions concurrently, by the same clinician
Clinic #1
Integrated Model of PTSD/SUD Treatment
• Both conditions concurrently, by the same clinician
• Driven by: o -Hypothesis that substance abuse is result of, in
part, PTSD symptoms.o -Reductions in PTSD are more likely to lead to
reductions in substance abuse, than the reverse.o -Patient preferences.
Clinic #1
Integrated Model of PTSD/SUD Treatment
PTSD Improvement Results in Alcohol Use Improvement
Back, Brady, Sonne & Verduin, JNMD, 2006
(N=94)
Alcohol Improvement Less Likely to Result in PTSD Improvement
94%
6% Related Unrelated
Do you believe that your alcohol/drug use and PTSD
symptoms are related?(N = 35 Veterans)
Back, et al., 2014
85%
10%5%
Increase
Stay the Same
Decrease
If your PTSD symptoms get worse,what happens to your alcohol/drug use?
62%
27%
9%
Decrease
Stay the Same
They Don't Improve
If your PTSD symptoms improve,
what happens to your alcohol/drug use?
Overview of PTSD – Substance Use Connection
PTSD Symptoms
Substance Use
Short Term Relief
Self Medication Hypothesis (Khantzian, 1985)
+
Overview of PTSD – Substance Use
Integrated Treatment
Treat PTSD +
SUD
Manage PTSD sx without
substances
Recovery from PTSD and SUD
Long Term Relief
SUD-PTSD Integrated Psychotherapies
Najavits (2002) - Seeking Safety. Relapse prevention + education + social skills training. Mostly group. 25 sessions.
Back, Foa, Killeen, Brady et al. (in press) – COPE. Relapse prevention + in vivo exposure + imaginal exposure. Individual. 12 sessions.
Treatment Imaginal exposure
In vivo exposure
Concurrent Treatment of PTSD and SUD Using Prolonged Exposure (COPE) – in press
Seeking Safety (SS) - 2002 Seeking Safety + Exposure Therapy-Revised (N=5) - 2005
Substance Dependence PTSD Therapy (SDPT) - 1999
CBT for PTSD in addiction treatment programs - 2009
van Dam et al., 2012; Clinical Psych Review, 32: 202-214
Synthesis of 2 theory-based and empirically-validated treatments:
(1) Prolonged Exposure for PTSD (Foa, Hembree, & Rothbaum, 2007)
(2) Relapse Prevention for SUD (Carroll, 1998)
COPE (Concurrent Treatment of PTSD & SUD using Prolonged Exposure)
1. Educate patients about the functional relationship between substance use and PTSD.
2. Decrease SUD symptom severity, initiate and maintain abstinence.
3. Decrease PTSD symptom severity.
Primary Goals of COPE
Psychoeducation – education about common reactions, normalize symptoms, help understand avoidance & how it maintains PTSD symptoms.
Breathing Retraining technique to decrease anxiety.
Prolonged Exposure (PE):o In-Vivo Exposureo Imaginal Exposure
CBT Techniques Used To Treat PTSD
In Vivo Exercises
▶ In between therapy sessions▶ Repeated exposures ▶ Prolonged duration▶ Common examples:o Walmart (or other crowed store)o Sitting in middle of restaurant o Going to a sporting evento Going to movie theatreo Driving during rush houro Being stopped at a stop lighto Watching or reading the newso Group activities (going to AA, church,
exercise class)
How it works:1. Emotional processing, organizing the memory 2. Habituation – anxiety does not last forever3. Distinguishing between memory vs. actual event, then
vs. now4. Cognitive modifications – increase sense of
control, mastery, confidence
Anx
iety
Time
Prolonged Exposure Therapy: The Wave of Anxiety
Foa et al. (1991)Foa et al. (1999)Foa et al. (2005)Marks et al. (1998)Tarrier et al. (1999)Taylor et al. (2001)Cloitre et al. (2002)Resick et al. (2003)Bryant et al. (2003)Schnurr et al. (2007)Rauch et al. (2009)Resick et al. (2012)
*18% with PTSD 5-10 yrs later
Empirical Support for PE
Psychoeducation regarding relationship between substance use and PTSD sx.
Effectively manage cravings and thoughts about substance use.
Identify triggers for substance use - both PTSD and substance-related triggers.
Learn coping skills to help prevent relapse/escalation to substances (e.g., managing anger, drug refusal skills).
CBT to decrease SUD Symptoms
Integrated treatments address both the PTSD and the SUD concurrently.
COPE uses Prolonged Exposure (in vivo and imaginal) to treat PTSD, and CBT (Relapse Prevention) to treat SUD.
Main Goals: ◦Psychoeducation◦Reduce PTSD symptoms ◦Reduce SUD symptoms
Summary
COPE Session Content
1 Introduction: Psychoeducation, Set Goals, Therapy Contract, Breathing Retraining
2 PTSD: Common Reactions to Trauma SUD: Awareness of Cravings
3 PTSD: In Vivo Hierarchy SUD: Managing Cravings
4 PTSD: First Imaginal ExposureSUD: Review coping skills
Session # Session Topic
General Session Overview
5 PTSD: Imaginal Exposure continuedSUD: Planning for Emergencies
6 PTSD: Imaginal Exposure continuedSUD: Awareness of High-Risk Thoughts
7 PTSD: Imaginal Exposure continuedSUD: Managing High-Risk Thoughts
8 PTSD: Imaginal Exposure continuedSUD: Refusal Skills
Session # Session Topic
General Session Overview continued
9 PTSD: Imaginal Exposure continuedSUD: Seemingly Irrelevant Decisions
10 PTSD: Imaginal Exposure continuedSUD: Awareness of Anger
11 PTSD: Final Imaginal ExposureSUD: Managing Anger
12 Review and Termination
Session # Session Topic
General Session Overview continued
Do integrated treatments
for PTSD/SUD work?
COPE Studies to Date
Brady et al. (2001) and Back et al. (2001): PTSD and cocaine; N=39
Mills et al. (2012): PTSD and mostly heroin; N=103; COPE + TAU vs TAU
Back et al. (ongoing): military PTSD and mostly alcohol; COPE vs RP
Hien et al. (ongoing): PTSD and mostly alcohol; COPE vs RP
Norman et al. (ongoing): military PTSD; COPE vs Seeking Safety
Preliminary, uncontrolled study N=39 PTSD and cocaine dependence 16 individual 90-minute sessions Assessment at weeks 4, 8, 12, and 16, and
at 6 months follow up.
Initial COPE Study
Positive Urine Drug Screen (UDS) Tests At treatment entry = 12.8% First half of treatment = 12.2% Second half of treatment = 9.7%
Timing of AttritionThe majority (75%) dropped out before PE initiated (e.g., transportation or employment problems, relocation, scheduling conflicts, unstable living conditions)
Brady, Dansky, Back, Foa & Carroll, 2001
(N=39) Cocaine Dependent + PTSD
Initial COPE Findings
Post-Treatment Outcomes
Base-line
4 8 12 16 Follow Up
0
5
10
15
20
25
30
35
40
45
50
Intrusion
Avoidance
Total
Sco
res
Weeks
Impact of Events Scale (IES)
Uncontrolled study Small sample sizeFocused on cocaine dependenceHigh drop-out rate
Considerations
Randomized controlled trial COPE + TAU vs TAU N=103 SUD (mostly heroin) + PTSD Majority (75%) had childhood trauma 62.1% women 78.6% unemployed 54.2% lifetime history of suicide attempt
Mills et al., 2012
Study Aims and Design
Baseline 6 Weeks 12 Weeks 3 month F/U
25
35
45
55
65
75
85
95
Treatment
Control*
Clinician Administered PTSD Scale (CAPS)
Baseline 6 Weeks 12 Weeks 3 month F/U
0
1
2
3
4
5
TreatmentControl
Using at 3 mth F/U:Treatment:
72.9%Control: 81.9%
Number of SUD Dependence Criteria Met
COPE among Military Veterans
Total N=90
3 Mth Follow-UpCOPE
RP
Study TimelineScreening, Consent, Assessed, and Randomized
COPE and RP Treatment Phase: 12, 90-min sessions
3 Mth Follow-Up
6 Mth Follow-Up
6 Mth Follow-Up
3 Mth Follow-Up 6 Mth Follow-Up
COPE pts: Sessions 4 and 11 fMRI scan to cues Back et al., ongoing
Study Design
◦ Single, caucasian, 25 yr old male◦ United States Marine (gunner)◦ Served 3 deployments in Iraq (24 months total) ◦ No history of mental health treatment
COPE Military Pt 001
Back, Killeen, Foa et al. Am J Psychiatry 2012; 169: 688-691
Index trauma: Combat related.
PTSD symptoms: Frequent nightmares, intrusive thoughts, isolation/distancing, aggression, extreme difficultly driving, hyperarousal in crowded places (e.g., Walmart, movies), avoidance of thoughts and memories through alcohol.
Substance use symptoms: Consuming 12.5 beers per day, 83.3% of the time (50/60 days pre study).
Tx motivation: Initially did not want treatment (“military pride”) but his friend drove him to clinic.
Case Details
Time-Line Follow Back Number of Standard Drinks
In Vivo Start
Imaginal Start
Reliable Change Index, p<.05
PTSD Checklist-Military Version (PCL-M)
Reliable Change Index, p<.05
CAPS:71 (Baseline)42 (Session 6)17 (Session 12) 4 (6 Mth F/U)
Reliable Change Index, p<.05
Beck Depression Inventory (BDI)
Studies among men and women, civilian and combat-related PTSD, multiple SUD and multiple traumas show:◦Feasible◦Safe – substance use did not increase with
trauma-work◦Effective
Summary