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(insight in to the IT Companies)K.P.Mishra (Director, URC Allahabad )
Brijesh Singh Yadav(Senior Research Associate &HeadBioinformatics Research)United Research Center, UIT Campus Allahabad,
E-mail: [email protected]
Ca reer inBio in formatic s
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What i sBioinformatics?
Bioinformatics is the application of
computer technology and statistics to
the management of biologicalinformation.
In the past decade bioinformatics has
become an integral component of
research and development in biologicalsciences.
The need for bioinformatics stems from
a fundamental change that is taking
place in biology.
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Bioin for matic s Is aMerg ing of D isc ipli nes
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Co re o fBio in form atic sTDQAAFDTNIVTLTRFVMEQGR
KARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLV
sequence 3D structure protein functions
Properties and evolution of genes, genomes, proteins, metabolicpathways in cells
Use of this knowledge for prediction, modelling, and design
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Need o fbioinformatics
Data growth is exponential
Difficult to understand life without BI Detection of new diseases
BI tools allow to save expr. Expend.
Rational Drug design
Computer-aided vaccine design
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Ne ed o fbioinformatics
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Need of bi oin format ic scont Handle the
growth of
information.
Knowledgediscovery.
Globalizing
theresearch.
Data
visualization
.
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Need ofbioinf orma tic s co nt
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BIOINFORMATI CSDE VELO PMENTS ININDIA Department of Biotechnology created in 1986
Bioinformatics programme started ever since
Biotechnology Information System Network
(BTISnet) in 1987. BTISnet today has 65 institutions and
universities.
Emphasis on infrastructure creation and human
resource development. Biotechnology in India has greatly benefited
from the capacity building in Bioinformatics
Dedicated virtual private network connecting
the major centres sharing of data as well ascom utin resources.
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Bioinf ormat icsFac iliti es in Ind ia
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Two forms of initiatives are in operationalTwo forms of initiatives are in operationalTwo forms of initiatives are in operational
Two forms of initiatives are in operational
Short-Term Training
Nationwide trainingsand workshops
Presently around 100organised per year inseven defined areas
More than 10000trainedso far
Long-Term Training
Advanced DiplomaCoursesin five universities
M.Sc., M.Tech., Ph.D.courses
in Bioinformatics
uca ona c v es oIndia i n Bi oin format ics
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Integrat ion o fBioinformatics &Biotechnology Collaborative effort
RFP (Request for Proposals) in
following areas: Parasitic diseases
Agro-biotech
Herbal medicine
BioPhara Development
Clinical Data management
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In -hous e sof twar edev elopm ent1. GeneScan, GenEvolve, PROCOR
2. PLHOST
3. APSSP (Protein structureprediction), MHCBN
4. PCR: s/w for setting PCR reactions5. LOOPSEARCH, CONFPLOT
6. VirGen, CE, AVIS
7. Micro array analysis (Avadis),Genome annotation (Acuris),Oligonucleotide probe design(Sarani)
8. BioSuite
JNU, DelhiIGIB, DelhiIMTECH, ChandigarhDevi Ahilya
UniversityBose Institute,
KolkattaUniversity of Pune,
Pune
Strand Genomics,BangaloreTCS, Hyderabad
These efforts needs to be strengthened withHuman resource development
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Bioinformatics Market
Global Bio-Informatics Market 1.2bn In 2004Overall Market Size Projected to reach USD 1.7 bnby 2006Indian Bioinformatics Market has touched USD22Million in 2004Indian Bioinformatics is growing at the rate of40% per annum
(Source: CII)
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Market sha re of dif ferentSegments o fBioinformatics Genomic 50%
Proteomics 20%
Chemoinformatics 19% Pharmacogenomics 15%
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Advanta ges fo r Ind ia Strong IT capabilities
R & D strength in Modern biology
Highly trained manpower inbiotechnology and Bioinformatics
Rich Biodiversity
Diverse ethnic population
Strong Biotechnology Infrastructure Wide Networking of Institutions and
Scientists.
Industrial enterprise.
HHBIO
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The Role of IT inBioinformatics
1. Electronic Data Capture2. Data Mining3. Data Warehousing
4. Data Visualization5. Customized Software
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Indian IT Companies Indian IT companies such as Tata Consultancy
Services (TCS), Cognizant Technologies,Infosys, Wipro, and Satyam have already set up
their bioinformatics divisions.
TCS, for instance, is entering the bio-informaticsmarket with its indigenously developedcomputing platforms and applications within this
year. The company is nurturing a 40-memberteam that is working on developing bio-informatics software solutions.
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Ind ian IT C omp ani es Cont.. A database application, specially created for the
bioinformatics segment is in the pipeline. TCS is alsolooking at developing bio-informatics softwareapplications in collaboration with biotech and pharma
companies.
Satyam's Center of Excellence has identified Data
warehousing and Datamining as a key initiative area inthe field of bio-informatics since the field is an emergingdomain where data warehousing and dataminingtechniques and concepts are used extensively fordeciphering complex patterns and to correlate and
analyze the vast volumes of data generated.
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Ind ian Ph ar maCompanies Pharmaceutical companies too, are making
moves into the bioinformatics arena. GVKBiosciences, Dr. Reddy's Laboratories, Biocon,
Astra Zeneca, Ranbaxy, Biological E, andNicholas Piramal are some of the names thathave either opted for the joint venture route orhave tied up with start-up companies.
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people requ ir ed by aIndust ri es Computer Programmer, who develop
software tool and application for
biotechnology and life science
companies.A good Programmerhaving knowledge ofHTML, XMLSAS-CGICGI between web and
databaseBuild HTML page tointerfaceKnow DNA analysisprograms
Understand:Basic MolecularBiologyHow a networkworksHow databasesare structured
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Peo ple req uired byaInd ustrie s c ont..
People with a background in life scienceswho are the end user of such programs andpackages and they use these tools to
translate the information into tangibleproducts such as new molecules, drugs,enzymes etc.
They can conduct their R&D program moreeffectively if they are cross-trained in
computing skills. They can also be business analysts for life
science companies.
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Skills needed for the Desing of Experiments Using Bioinformatics
Systems
Administration/Networking
2%
General Computer Sciences
7%
Artificial Inte lligence
3%Advanced algorithms
Data Structures
8%
Biochemistry
10%
Biophysics
6%
Structural Biology
7%
Genetics
11%
Molecular Biology
12%
Evolution
7%
Statistics
12%
Mathematics
6%
Computational Chemistr y
6%
Software Engineering3%
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What Is a Bioinformatics
Company L ike? Consists of Biologists, Computer Scientists,
Mathematicians and Marketing people.
Bioinformatics companies should expect
revenues in a few million dollars only. Only those companies who are able to adapt
and innovate will survive.
A great deal of competition exists in the field.
For any new company offering bioinformaticsservices or products, proof of concept, will beessential. This means that a nascent companywill need to demonstrate its ability before
getting business.
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Ar eas of opport un ity inIndia Bioinformatics
Vaccines, dignostics and therapeutics
Biomedical devices, instruments andsensors
Bioartificial organs using tissueengineering and stem cells
Clinical trial and contract research
Agriculuture disease and pest resistant,drought and salinity tolerant seeds andplants
Biofertilisers and Biopesticides
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Carrie r oppo rtun it y ava ilablein bioinformatics Life Science: Scientific Curator, Gene Analyst,
Phylogenitist, Protein Analyst,Research Scientist/Associates
Compu ter Sc ience: Database Programmer,Bio-informatics
Software Developer,Nerwork
Administrator/Analyst
Pha rama cu iti ca l Sc ience :Chemoinformatician,Pharmacogenetician,
Pharmacogenomics, Research
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Job opportuni ti es inBioi nfo rmati cs Postgraduatesand,Do ctorates
Bachelordegrees / 3ye ar dip lomaholders 3) Degreewith oneye ar courseincomputers
Qualification Experience Job Title
Formal Training andunderstanding marketrequirement ofBioinformatics
Sound knowledge inMolecular Biology andprogramming
Good typing speed,Knowledge in molecularBiology and computerapplication
Group leaders /Sr. Executives /Scientists/Faculties
System AnalystTechnical Asst./Programmer /
COs / DEOs
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Majo r Re search Areas i nBioinformaticsResearch Activities [%]
Gene Analysis
Prot. Struc. Pred.
Prot Design & Folding
Macr. Modelling
Evol. Biol.
Struc-Func Studies
Mech. of Dis.
Data Mining Stud
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Business Opportunitiesin BI Software development
Web servers development
Train manpower in Field of BI Database management
Rational Drug design
Develop Diagnostic kits
Assist user in Vaccine development Consultant to Biotech Companies
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u so urc n g o einTechno log yBusine ssesOutsourcing has developed as an
important concept in today'sbusiness.
1) Focus on core strength - theopportunity cost of adding a newsegment of services to an existing
business is high. Companies prefer tonot diverge from their focus on theircore competencies, and staycompetitive.
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Outso urcin g con t. 3) Leverage top talents from the bioinformatics
companies companies can make use of thebest resources engaged in IT services withouthaving to worry about recruiting, training andretaining professionals
4) Minimize on total cost of ownership the rateof obsolescence is very high in the IT sector.Companies who outsource do not have to bearthe replacement costs that accompany
obsolescence.
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Outso urcing con t. 5) Improve service delivery to
customers the company can dictateto the outsourcing partner the
timelines it is required to meet. 6) Reduce cost and time the time
spent otherwise on planning anddevelopment is saved and better
utilized to managing the existingresources.
7) Expand service portfolio companies can extend their serviceswithout having to invest on building inhouse capabilities
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Ou tso urcin g Inspite of a tremendous increase in
demand, the US educational stream hasnot significantly increased the
production of scientific workforce. As a result cost of research has gone
higher.
Many companies are realizing that they
can get their research done abroad, atcheaper cost, without any compromisein quality.
In clinical trials for example, GSK
(Glaxo smith Kline)has announced thatit will shift 30% of its clinical trials to
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The Ultimate Goals of Bioinformatics is
to:Implement LaboratoryInformation Manageme nt
Systems
14%
Design experiments using
bioinformatics
9%
Provide training and
assistance in the use of
bioinformatics software
tools
10%
Use existing software for
bioinformatics analyses
10%
Discover new insights or
hypotheses in molecular
genetics or evolutionary
processes
10%Rese arch new
technologies (algorithms,
principles, models,
databases) to ascertain
their potential for
bioinformatic analysis
11%
Develop software for
bioinformatics applications
12%
Implement web-interfaces
for bioinformatics
applications/data bases
12%
Create & maintain
laboratory research
databases
12%
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Bioinformatics Jobssea rch engines Medzilla(Biotech,Medical,etc job listings)
BioSpace (job listings)
BioView (job listings)
Bio online Carrier Center Symbios Career Service
(Biotech,MedDevice,Pharm )
Genomics ,Bioinformatics and
Biocomputing Jumping pills Biotech jobs
NEE-HOW Bioresource Finder jobs
JobsScience
http://www.bhrc.ca/
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