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JANUARY 1993 VOL 77 NO 1 BRITISH JOURNAL OF OPHTHALMOLOGY Editorial 1 Diabetes, glaucoma, sex, and cataract D W~lanagan Original articles Clinical science Laboratory science Perspective Case reports 2 Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studies JohnJ Harding, Muriel Egerton, Ruth van Heyningen, Ruth S Harding 7 Loss of contrast sensitivity in diabetic patients with LOCS II classified cataracts Leo T Chylack Jr, Nita Padhye, Patricia M Khu, Caroline Wehner, John Wolfe, Daniel McCarthy, Bernard Rosner, Judith Friend 12 Relationship of regression pattern to recurrence in retinoblastoma A D Singh, D Garway-Heath, S Love, P N Plowman, J E Kingston, J L Hungerford 17 Prevalence of glaucoma in the west of Ireland Michele Coffey, Angela Reidy, Richard Wormald, Wu XingXian, Lesley Wright, Parul Courtney 22 Reproducibility of transcranial Doppler ultrasound examinations of the ophthalmic artery flow velocity Prin Rojanapongpun, Brenda Morrison, Stephen M Drance 25 Ophthalmic artery flow velocity in glaucomatous and normal subjects Prin Rojanapongpun, Stephen M Drance, BrendaJ Morrison 30 Visual loss in an onchocerciasis endemic community in Sierra LeoneJ A G Whitworth, C E Gilbert, D M Mabey, D Morgan, A Foster 33 Choroidal rupture and optic atrophy Lou C Glazer, Dennis P Han, Mark S Gottlieb 36 Cataract development and outcome of surgery in bone marrow transplanted children B M Calissendorff, P Bolme 39 Increased D-arabinitol/creatinine ratio in sera of patients with Behqet's disease during an active phase Seiji Hayasaka, Sachiko Noda, Tomoichi Setogawa 41 Microbial contamination of contact lens cases in the west of Scotland P Devonshire, FA Munro, C Abernethy, BJ Clark 46 Pinealitis accompanying equine recurrent uveitis CarolynM Kalsow, Ann E Dvyer, Andrew WSmith, Thomas P Nifong 49 Disease and risks associated with contact lensesJohn K G Dart 54 Monostotic fibrous dysplasia of the orbit: an unusual lacrimal fossa mass Peter McCluskey, Richard Wingate, Ross Benger, Stanley McCarthy 57 Early treatment of juvenile xanthogranuloma of the iris with subconjunctival steroids I Casteels, J Olver, M Malone, D Taylor 61 Sporothrix schenckii endophthalmitis presenting as granulomatous uveitis MontJ Cartright, Mark Promersberger, Garth A Stevens 63 Letters to the editor Notices 64 Instructions for authors BMJ PUBLISHING GROUP on 1 August 2018 by guest. Protected by copyright. http://bjo.bmj.com/ Br J Ophthalmol: first published as on 1 January 1993. Downloaded from
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JANUARY 1993 VOL 77 NO 1

BRITISH JOURNAL OFOPHTHALMOLOGY

Editorial 1 Diabetes, glaucoma, sex, and cataract D W~lanagan

Original articlesClinical science

Laboratoryscience

Perspective

Case reports

2 Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studiesJohnJ Harding, Muriel Egerton, Ruth van Heyningen, Ruth S Harding

7 Loss of contrast sensitivity in diabetic patients with LOCS II classified cataracts Leo T ChylackJr,Nita Padhye, PatriciaM Khu, Caroline Wehner, John Wolfe, Daniel McCarthy, Bernard Rosner,Judith Friend

12 Relationship of regression pattern to recurrence in retinoblastomaA D Singh, D Garway-Heath,S Love, PN Plowman,JE Kingston, J L Hungerford

17 Prevalence of glaucoma in the west of Ireland Michele Coffey, Angela Reidy, Richard Wormald,Wu XingXian, Lesley Wright, Parul Courtney

22 Reproducibility of transcranial Doppler ultrasound examinations of the ophthalmic artery flowvelocity Prin Rojanapongpun, Brenda Morrison, StephenM Drance

25 Ophthalmic artery flow velocity in glaucomatous and normal subjects Prin Rojanapongpun,StephenM Drance, BrendaJ Morrison

30 Visual loss in an onchocerciasis endemic community in Sierra LeoneJA G Whitworth, CE Gilbert,DM Mabey, D Morgan, A Foster

33 Choroidal rupture and optic atrophy Lou C Glazer, Dennis P Han, Mark S Gottlieb36 Cataract development and outcome of surgery in bone marrow transplanted children

BM Calissendorff, P Bolme

39 Increased D-arabinitol/creatinine ratio in sera of patients with Behqet's disease during an active phaseSeiji Hayasaka, Sachiko Noda, Tomoichi Setogawa

41 Microbial contamination of contact lens cases in the west of ScotlandP Devonshire, FA Munro,C Abernethy, BJ Clark

46 Pinealitis accompanying equine recurrent uveitis CarolynM Kalsow, AnnE Dvyer, Andrew WSmith,ThomasP Nifong

49 Disease and risks associated with contact lensesJohnKG Dart

54 Monostotic fibrous dysplasia of the orbit: an unusual lacrimal fossa mass Peter McCluskey,Richard Wingate, Ross Benger, Stanley McCarthy

57 Early treatment of juvenile xanthogranuloma of the iris with subconjunctival steroids I Casteels,J Olver,M Malone, D Taylor

61 Sporothrix schenckii endophthalmitis presenting as granulomatous uveitisMontJ Cartright,Mark Promersberger, GarthA Stevens

63 Letters to the editor Notices

64 Instructions for authors

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VOLUME 77 * CONTENTS

No 1 JANUARY 1993 Page Editorial1 Diabetes, glaucoma, sex, and cataract D WFlanagan

Original articles - Clinical science2 Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studiesJohnJ Harding,

MurielEgerton, Ruth van Heyningen, Ruth S Harding7 Loss of contrast sensitivity in diabetic patients with LOCS II classified cataracts Leo TChylackJr, Nita Padhye,

PatriciaM Khu, Caroline Wehner, John Wolfe, Daniel McCarthy, Bemard Rosner,JIudith Friend12 Relationship of regression pattern to recurrence in retinoblastoma A D Singh, D Garway-Heath, S Love, PN Plowman,

IE Kingston,J L Hungerford17 Prevalence of glaucoma in the west of Ireland Michele Coffey, Angela Reidy, Richard Wornald, Wu XingXian,

Lesley Wright, Parul Courtney22 Reproducibility of transcranial Doppler ultrasound examinations of the ophthalmic artery flow velocity

Prin Rofanapongpun, Brenda Morrison, StephenM Drance25 Ophthalmic artery flow velocity in glaucomatous and normal subjects Prin Roanapongpun, StephenM Drance,

Brenda JMorrison30 Visual loss in an onchocerciasis endemic community in Sierra LeoneJA G Whitworth, CE Gilbert, D M Mabey,

D Morgan, A Foster33 Choroidal rupture and optic atrophy Lou C Glazer, Dennis P Han, Mark S Gottlieb36 Cataract development and outcome of surgery in bone marrow transplanted children BM Calissendorff, P Bolme

Laboratory science39 Increased D-arabinitol/creatinine ratio in sera of patients with Beheet's disease during an active phase Seiji Hayasaka,

SachikoNoda, Tomoichi Setogawa41 Microbial contamination of contact lens cases in the west of Scodand P Devonshire, FA Munro, CAbernethy, BJI Clark46 Pinealitis accompanying equine recurrent uveitis CarolynM Kalsow, Ann E Duyer, Andrew WSmith, Thomas P Nifong

Perspective49 Disease and risks associated with contact lenses John KG Dart

Case reports54 Monostotic fibrous dysplasia ofthe orbit: an unusual lacrimal fossa mass PeterMcCluskey, Richard Wingate, Ross Benger,

Stanley McCarthy57 Early treatment of juvenile xanthogranuloma of the iris with subconjunctival steroids I Casteels, J Olver, M Malone,

D Taylor61 Sporothrix schenckii endophthalmitis presenting as granulomatous uveitis Mont]7 Cartwright, Mark Promersberger,

Garth A Stevens

63 Letters to the editor Notices

64 Instructions for authors

No 2 FEBRUARY 1993 Editorials65 The Farnsworth-Munsell 100 hue test and optic neuritis Creig S Hoyt66 Trachoma - the future for a disease of the past Hugh R Taylor

Original articles - Clinical science68 The Farnsworth-Munsell 100 hue test in the first episode of demyelinating optic neuritis MJ Menage,

D Papakostopoulos,I C Dean Hart, S Papakostopoulos, Yu Gogolitsyn75 Clinical and infrared pupillometry in central retinal vein occlusion PA Bloom, D Papakostopoulos, YGogolitsyn,

JA Leenderz, S Papakostopoulos, R HB Grey81 Results of community-based eyelid surgery for trichiasis due to trachoma Heidrun Bog, David Yorston, Allen Foster84 Retinitis pigmentosa, ataxia, and mental retardation associated with mitochondrial DNA mutation in an Italian family

PieroPuddu, PieroBarboni, Vilma Mantovani, PasqualeMontagna, Angelina Cerullo, MichelaBragliani, Carla Molinotti,Roberto Caramazza

89 Influence of a thalassaemia on the retinopathy of homozygous sickle cell disease Peter D Fox, Douglas R Higgs,Graham R Serjeant

91 Follow-up study on premature infants with and without retinopathy of prematurity Rosemary Robinson, Michael O'Keefe95 Choroidoretinal neovascularisation following radon seed treatment of retinoblastoma in two patients D B Archer,

WMKAmoaku, GKelly100 Orbital volume measurement in the management of pure blowout fractures of the orbital floor D G .Charteris, C-H Chan,

R W Whitehouse, JL Noble

Laboratory science103 Direct clinico-histological correlation of parapapillary chorioretinal atrophy Toshiaki Kubota, JostB Jonas,

Gottfried 0HNaumann107 Detection of Toxoplasma gondii in aqueous humour by the polymerase chain reaction F Aouizerate, J Cazenave,

L Poirier, Ph V'erin, A Cheyrou,IBegueret, FLagoutte110 The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle Toshihiko Matsuo, Max S Cynader

Perspective115 The X2 test for data collected on eyesJ7ohn R Thompson

Case reports118 Churg-Strauss vasculitis presenting with severe visual loss due to bilateral sequential optic neuropathyl F Acheson,

0 C Cockerell, CR Bentley, MD Sanders120 Secondary retinitis pigmentosa and cerebral demyelination in Lyme borreliosis Anni Karma, Tuula A Pirttila,

MattiK Viljanen, YrjoE Lahde, ChristinaM Raitta122 Two cases ofcoloboma associated with unbalanced translocations Michael Goggin, Michael O'Keefe, Helen Hughes124 Spontaneous development of retinal ischaemia and rubeosis in eyes with retinal racemose angioma Philip A Bloom,

AlistairLaidlaw, DavidL Easy126 Ocular involvement in mycosis fungoides RJ'ane Leitch, Ian G Rennie, M Andrew Parsons

128 Letters to the editor Book reviews Notices

131 Instructions for authors

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No 3 MARCH 1993 Editorials133 Intraocular metastasis Alison McCartney134 Molecular genetics as a 'probe' in ophthalmology Neva Haites

Original articles - Clinical science136 Prophylactic use of acetazolamide to prevent intraocular pressure elevation following Nd-YAG laser posterior

capsulotomyIoannis D Ladas, George P Pavlopoulos, Stefanos N Kokolakis, George P Theodossiadis139 Internal sclerostomy using laser ablation of dyed sciera in glaucoma patients: a pilot study Shlomo Melamed,

Arieh Solomon, Doron Neumann, Ami Hirsh, Michael Blumenthal, Michael Belkin145 Transient hyperopia with lens swelling at initial therapy in diabetes YSaito, G Ohmi, S Kinoshita, YNakamura,

KOgawa, S Harino, M Okada149 Analysis of the incidence of intraocular metastasis Leonard Weiss152 Continuous curvilinear (circular) capsulorhexis and planned extracapsular cataract extraction - are they compatible?

MiltndPande158 Permeability of the blood-ocular barrier in adolescent and adult diabetic patients Akitoshi Yoshida, Satoshi Ishiko,

Mitsuru Kojima, Hironobu Ogasawara162 Ophthalmic findings in classical galactosaemia - prospective study Bijan Beigi, Michael O'Keefe, RogerBowell,

Eileen Naughten, Nadia Badawi, Bernadette Lanigan

Laboratory science165 Conjunctival biopsy in adult form galactosialidosis Tomoaki Usui, Shoichi Sawaguchi, HarukiAbe, Kazuo Iwata,

Kiyomitsu Oyanagi168 X linked exudative vitreoretinopathy: clinical features and genetic linkage analysis P Fullwood, J Jones, S Bundey,

JDudgeon, AR Fielder, M WKilpatrick171 Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis: a

preliminary report of intranasal induction of tolerance with retinal antigens AD Dick, YF Cheng, A McKinnon,J Liversidge,I VForrester

Perspective176 The rate of visual field loss in untreated primary open angle glaucomaJeffrey L Jay,John R Murdoch

Case reports179 Proptosis as a presenting sign of extradural haematoma CR Stewart, J F Salmon, Z Domingo, A D N Murray181 Iris crystals in chronic iridocycitis Sheridan Lam, Howard H Tessler, Karen Winchester, Holly van Hecke, Byron L Lam182 Coxsackievirus B3-associated panuveitis Werner Forster, AlexanderA Bialasiewicz, HolgerBusse184 Anterior visual system involvement in non-Hodgkin's lymphomaA G Zaman, EM Graham, MD Sanders187 Necrotic orbital melanoma arising de novoJerryA Shields, CarolL Shields, Ralph C Eaglejr, Patrick De Potter,

Glen L Oliver189 Late onset esotropia in monozygous twins SAhmed, J D H Young191 Presumed corneal intraepithelial neoplasia associated with contact lens wear and intense ultraviolet light exposure

Yan Guex-Crosier, CarlP Herbort193 Intracranial hypertension and papilloedema in chronic inflammatory demyelinating polyneuropathyAldo Fantin,

RichardM Feist, Chittaranjan VReddy

194 Letters to the editor Book review Notices

196 Instructions for authors

No 4 APRIL 1993 Editorials197 Expanding the role of vitrectomy in retinal reattachment surgery Peter Leaver198 Ocular complications of diabetes after cataract extraction Tom Barrie

Original articles - Clinical science199 Pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment uncomplicated by advanced proliferative

vitreoretinopathy D S Gartry, A H Chignell, WA Franks, D Wong204 Removal of silicone oil following diabetic vitrectomyR VPearson, D McLeod, ZJ Gregor208 Cystoid macular oedema after extracapsular cataract extraction and intraocular lens implantation in diabetic patients

without retinopathy Ugo Menchini, Francesco Bandello, Rosario Brancato, Fabrixio I Camesasca, Marcello Galdini212 Retinal detachment following anterior chamber lens implantation for the correction of ultra-high myopia in phakic eyes

AJE Foss, PH Rosen, RJ Cooling214 Is the season of birth a risk factor in glaucoma? Robert Weale218 Photocoagulation of choroidal neovascular membranes with a diode laser Michael W Ulbig, DominicA McHugh,

AM Peter Hamilton222 Clinical features of affected males with X linked ocular albinism SI Charles, JS Green, J WGrant, JR W Yates,

A TMoore228 Ocular and vision defects in preschool children Maureen Stayte, Barnaby Reeves, Catherine Wortham

Laboratory science233 Occlusion of retinal vessels using targeted delivery of a platelet aggregating agent Yuichiro Ogura, Theresa Guran,

Kanji Takahashi, Ran Zeimer238 Origin of fibronectin in epiretinal membranes of proliferative vitreoretinopathy and proliferative diabetic retinopathy

Salvatore Grisanti, Klaus Heimann, Peter Wiedemann

Perspective243 Photorefractive keratectomy: implications of corneal wound healing StephenJ Tuft, DavidS Gartry, IanM Rawe,

KeithM Meek

Case reports248 Primary tipid keratopathy: a morphological and biochemical assessment Antonio Silva-Araujo Maria Amdlia Tavares,

Maria Manuela Lemos, Maria Isabel Soares,JoseCastro-Correia,JoseSalgado-Borges250 Serious corneal complications of 5-fluorouracil Marie Hickey-Dwyer, PK Wishart251 Bilateral streptococcal corneoscleritis complicating iirradiation induced scleral necrosis AnthonyP Moriarty,

GeoffreyJ Crawford, Ian L McAllister, IanJ'Constable253 Ocular toxocariasis in a patient with repeatedly negative ELISA titre to Toxocara canisJ7amesA Sharkey, PeterS McKay254 The trap of the displaced blind spot in automated perimetryAvinoamB Safran, Gordana Sunaric, Albert Burger255 IgG-x extramedullary plasmacytoma of the conjunctiva and orbit Kazuaki Tetsumoto, Hiroshi Iwaki, Masanori Inoue258 Letter to the editor Book reviews Notices

260 Instructions for authors

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No 5 MAY 1993

No 6 JUNE 1993

Editorials261 Treatment of age-related subfoveal neovascular membranes by teletherapy I H Chisholm262 New entities in uveitis Susan Lightman263 Measurement of flare DJ Spalton

Original articles - Clinical science265 Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study Usha Chakravarthy,

RussellF Houston, DesmondB Archer274 Clinical features ofHTLV-I associated uveitis Kumiko Nakao, Norio Ohba280 Aqueous flare and cells in eyes with retinal vein occlusion - correlation with retinal fluorescein angiographic findings

NXNguyen, M Kuchke284 Manchineel keratoconjunctivitisJohn F Pitts, NigelH Barker, D Clive Gibbons, Jeffrey LJay289 Distichiasis: management with cryotherapy to the posterior lamella B A O'Donnell,I Richard 0 Collin293 'Correctable undetected visual acuity deficit' in patients aged 65 and over attending an accident and emergency

departmentD Z Reinstein, NL Dorvard, R P L Wormald, A Graham, I O'Connor, RM Charlton, M Yeatman,R Dodenhoff, R Touquet, TChallonerLaboratory science

297 Quantification ofmelanin and iron content in uveal malignant melanomas and correlation with magnetic resonanceimageJD Ferris, PA Bloom, PR Goddard, C Collins

302 Primary open angle glaucomas in the rhesus monkey William WDawson, Dennis E Brooks, GeorgeM Hope,DonaldA Samuelson, Mark B Shenwood, HaryM Engel, MathewJ Kessler

311 Finger prick blood testing in Leber hereditary optic neuropathy David Mackey, Steve Nasioulas, Susan ForrestPerspective

313 Orbital meningiomas: surgery, radiotherapy, or hormones? GeoffreyE RoseCase reports

315 Impairment of tritan colour vision after initiation of treatment with zidovudine in patients with HIV disease or AIDSStephanA Geier, Manfred Held, JohannesR Bogner, Ursula Kronawitter, Thomas Berninger, Volker Klauss,Frank D Goebel

316 Bilateral retinal haemorrhages following epidural injection C Ling, PL Atkinson, C G FMunton318 Panuveitis and multifocal retinitis in a patient with leucocytoclastic vasculitisJames C Tsai, DavidJ Forster,

RichardR Ober, NarsingA Rao321 Successful treatment of anisometropic amblyopia and strabismus following intravitreal silicone oil R R Goble,

WA Franks, D Avery, A H Chignell323324

NoticesInstructions for authors

Editorials325 An alternative approach to corneoscleral repairDJ Coster326 Glaucoma screening R A Hitchings

Original articles - Clinical science327 Use of split-thickness dermal grafts to repair corneal and scleral defects - a study of 10 patients

Joseph A MaurelloJr, Kathryn Pokorny332 Clinical evaluation of a multi-fixation campimeter for the detection ofglaucomatous visual field loss Erkan Mutlukan,

BertilE Damato, JeffreyLJay339 Investigation of limbal touch sensitivity using a Cochet-Bonnet aesthesiometerJ G Lawrenson,

G L Ruskell344 Effect of topical ketanserin administration on intraocular pressure C Costagliola, G Iuliano,

M Rinaldi, VRusso, G Scibelli, L Mastropasqua349 Subretinal exudative deposits in central serous chorioretinopathy Darmakusuma Ie,

LawrenceA Yannuzzi, Richard FSpaide, Maurice FRabb, Norman P Blair, MarkJ Daily354 Lens opacities in neurofibromatosis 2: further significant correlations EvrydikiA Bouzas,

Valeria Freidlin, DilysM Parry, RoswellEldridge, MurielIKaiser-Kupfer358 Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders

Kerry TGivens, DavidA Lee, Thomas Jones, DuaneM Ilstrup364 Reduction in mydriatic drop size in premature infants S Wheatcroft, A Sharma, J McAllister

Laboratory science366 Pathogenesis of acanthamoebic keratitis: hypothesis based on a histological analysis of 30 cases

Alec GarnerPerspective

371 Ocular involvement in toxoplasmosis Aniki RothovaCase reports

378 Dominantly inherited unilateral retinal dysplasia I C Lloyd, A Colley, A B Tullo, R Bonshek381 Anomalous Cloquet's canal in a case of optic nervehead coloboma associated with extensive retinal detachment

Jun Akiba, Akitoshi Yoshida, Isao Ohta, Hiromasa Igarashi, Akihiro Kakehashi382 Neurocytoma of the retina CecilyMetcalf, EdwardM Mele, Ian McAllister385 Optic nerve pit with serous macular detachment resulting in rhegmatogenous retinal detachment

G P Theodossiadis, Ch Koutsandrea, PG Theodossiadis386 Aspergillus terreus postoperative endophthalmitis Taraprasad Das, Prateep Vyas, Savitri Sharma388 Scytalidium dimidiatum fungal endophthalmitis AliA Al-Rajhi, AbdulazizHAwad,

Saleh SA Al-Hedaithy, Richard KForster, Kay C Caldwell390 Displaced intraocular lens repositioning using a reversed 10-0 straight polypropylene needle lasso technique

J D Stevens, AM P Hamilton3653923943%

No 7 JULY 1993

History ofophthalmologyRefereesLetters to the editor Book review NoticesInstructions for authors

Editorials397 The evolving role of visual electrodiagnosticsJohn R Heckenlively398 Blindness in the developing world Allen Foster, GordonJohnson

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Original articles - Clinical science400 Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment Bertrand Piguet,

John A Wells, IngeB Palmvang, Richard Wormald,Iain H Chisholm, Alan C Bird404 Cone dystrophies with negative photopic electroretinogram Ulrich Kellner, MichaelHFoerster410 Blindness in Africa: Zimbabwe schools for the blind survey Larry Schwab, Kenneth Kagame413 Congenital glaucoma in the West Bank and Gaza StripMarkjElder417 A population based, prospective study of the development of ROP in prematurely born children in the Stockholm area

of Sweden G Holmstrom, M elAzazi, L Jacobson, G Lennerstrand424 Monocular temporal hemianopia SeymourA Hershenfeld, JamesA Sharpe428 Suture needle drainage of subretinal fluid G L Raymond, M Lavin, CL Dodd, D McLeod430 Decreased choroidal thickness in eyes with secondary angle closure glaucoma Toshiaki Kubota, Jost BJonas,

GottfriedO HNaumann433 Role of mitomycinC in pterygium surgery PSMahar, GE Nwokora

Laboratory science436 Does autoimmunity to S-antigen play a role in Fuchs' heterochromic cyclitis? E La Hey, L Broersma, R van derGaag,

G S Baarsma, A Rothova, A Kijlstra440 Antigen presentation of herpes simplex virus by corneal epithelium -an in vitro andin vivo studyG TFahy, D CHooper,

DL EastyPerspective

445 Primary surgery for primary open angle glaucoma - justified or not? R A HitchingsCase reports

449 Adult nasolacrimal duct bypass tubes: where do they go? Hubertus vBelow, Geoffrey E Rose450 Simultaneous retinal and optic nerve lesions in toxoplasmosis: the advantages of magnetic resonance imaging

F-XBorruat, R Kapoor, MD Sanders452 Focal electroretinogram and visual field defect in multiple evanescent white dot syndrome MasayukiHoriguchi,

YozoMiyake, MakotoNakamura, Yukari Fujii455 Contralateral active ocular toxoplasmosis in Fuchs' heterochromic cycitisE La Hey, G S Baarsma457 Resolution of an external layer macular hole associated with an optic nerve pit after laser photocoagulation

Philip M Fakone, PeterL Lou459 A case of presumed congenital herpes zoster ophthalmicusJSingh, JM Gibson461 Orbital multiple myeloma mimicking acquired angio-oedema Rebecca L Snider, Bruce H Thiers, Gene R Howard409 History of ophthalmology464 Letters to the editor Obituary Notices468 Instructions for authors

No 8 AUGUST 1993 Editorials469 Hereditary retinopathies: insights into a complex genetic aetiology Peter Humphries471 Psychophysical testing in glaucoma Roger Hitchings

Original articles - Clinical science473 Autosomal dominant retinitis pigmentosa with apparentincomplete penetrance: a clinical, electrophysiological,

psychophysical, and molecular genetic study A TMoore, F Fitzke, MJay, G BArden, C FInglehearn, TJ Keen,SS Bhattacharya, A C Bird

480 Uveitis and Lyme borreliosisJBreeveld, H Kuiper, L Spanjaard, L Luyendijk, A Rothova482 Quantification of lacrimal function after D-shaped field irradiation for retinoblastomaS M Imhof, P Hofman,

KEWPTan485 Treatment of vitreous floaters with neodymium YAG laser Wu-Fu Tsai, Yen-Chih Chen, Chorng-YiSu489 Glare sensitivity in early cataracts Maria SusanM Lasa, MarvinJ Podgor, Manuel B Datiles III, Rafael C Caruso,

Benjamin VMagno492 Monocular visual outcome in untreated early onset esotropia William V Good, Luis C Fda Sa, ChristopherJ Lyons,

CreigS HoytLaboratory science

495 Ocularfindingsinafamily with autosomal dominant retinitis pigmentosa andaframeshift mutation altering the carboxylterminal sequence of rhodopsin EckartApfelstedt-Sylla, Markus Kunisch, Monika Horn, Klaus Ruther, Heinrich Gerding,Andreas Gal, EberhartZrenner

502 Chronic ocular hypertension alters local retinal responsiveness Ron Ofri, William WDawson, Kimberly Foli,Kirk N Gelatt

509 Activated T cells in an animal model of allergic conjunctivitis I Carreras, B Carreras, Lindsay McGrath, Ann Rice,DL E EastyPerspective

515 Collagens in ocular tissues GE Marshall, AG PKonstas, WR LeeCase reports

525 Penetrating keratoplasty in severe ocular graft versus host diseasejD Heath, J FAcheson, WE Schulenburg527 Orbital plexiform neurofibroma VeronicaM G Ferguson, PeterM Kyle528 Thelaziasis: a report of two cases TShantikwuarSingh, KNareshkumarSingh529 Sedation with nasal ketamine and midazolam for cryotherapy in retinopathy of prematurity Andre Louon,

Joan Lithander, Venu Gopal Reddy, Anil Gupta530 Congenital third nerve palsy associated with mid-trimester amniocentesis CKPatel, D SI Taylor, IM Russell-Eggitt,

A Kriss, PDemaerel534 Evaluation of idiopathic epiretinal membranes by a scanning laser ophthalmoscope Yuichiro Ogura, Yoshihito Honda514 History of ophthalmology536 Letters to the editor Book reviews Notices540 Instructions for authors

No 9 SEPTEMBER 1993 Editorials541 Factors influencing metastasis in retinoblastomaJohn Hungerford542 Anaesthesia for ophthalmic surgery Emanuel Rosen

Original articles - Clinical science544 Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors CarolL Shields,JenyA Shields,

Karin A Baez,Jacqueline Cater, Patrick VDe Potter

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549 Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane changeRobertL Steinmetz, Robert Haimovici, Chris3Jubb, Frederick WFitzke, Alan C Bird

555 Stage III macular hole surgeryJuan Orellana, RonniM Liebernan559 Diode laser for retinopathy of prematurity - early outcome Michael Goggin, Michael O'Keefe563 Dissociated eye movements in craniosynostosis: a hypothesis revived H Cheng, M A Burdon, GA Shun-Shin,

S Czypionka569 Limbal and corneal calcification in patients with chronic renal failure N Klaassen-Broekema, OP van Bijsterveld572 Prevention of intraocular pressure rise following intravitreal injection Nigel Morlet, StephanieH Young

Laboratory science574 Ultrastructure of retinal vessels in diabetic patients Tatsuro Ishibashi, Hajime Inomata579 Cataract and myotonic dystrophy: the role of molecular diagnosis WReardon,J3CMacMillan, Myring, HG Harley,

S A Rundle, L Beck, P S Harper, DJ Shaw584 Cellular autoimmunity to retinal specific antigens in patients with Behcet's diseaseJH Yamamoto, M Minami, G Inaba,

KMasuda, M MochizukiPerspective

590 Adverse effects of topical antiglaucomatous medications on the conjunctiva David Broadway, Ian Grierson,Roger HitchingsCase reports

597 Ocular melanomas in xeroderma pigmentosumA J Vivian, D WEllison, J I McGill599 Intracavernous chondrosarcoma associated with Ollier's diseaseDJ Brazier, J Roberts-Harry, A Crockard600 A rare cause of visual loss in AIDS patients: central retinal vein occlusion Yahya Ismail, PatrickM Nemechek,

EdwardL Arsura601 Persistent visual changes following hashish consumption Gian Luca Laffi, Avinoam B Safran602 Dirofilariasis: an uncommon parasitosis of the eye Merih Soylu, Kadri Ozcan, Mu'slime Yalaz, Seyhan Varinli,

Gulhan Slen604 Retrobulbar oedema after ophthalmic plaque radiotherapy Paul T Finger, Sandra Frazier Byrne, DariusM Moshfeghi,

HenryD Perry606 Retinal arterial macroaneurysm in a patient with congenital heart disease AhmedM Abu El-Asrar, Abdulaziz Awad,

KhalidF Tabbara607 Visual loss from central serous retinopathy in systemic lupus erythematosusM B Eckstein, DJ' Spalton, G Holder568 History of ophthalmology610 Letters to the editor Notices612 Instructions for authors

No 10 OCTOBER 1993

No 11 NOVEMBER 1993

Editorials613 Local resection of choroidal melanoma Ian Rennie614 Choroidal neovascularisation in age-related macular disease Alan C Bird

Original articles - Clinical science616 Predictive factors of visual outcome after local resection of choroidal melanoma Bertil E Damato, J'ames Paul,

Wallace S Foulds624 Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases

Patrick De Potter, CarolL Shields, J7erryA Shields, Hyman Menduke631 Post-traumatic angle recession glaucoma: a risk factor for bleb failure after trabeculectomy AndrdeMermoud,

John F Salmon, Clive Straker, AnthonyD N Murray635 Spontaneous hyphaema associated with anterior uveitis Donald S Fong, MichaelB Raizman639 The fixed dilated pupil after cataract surgery - is it related to intraocular use of hypromellose? Andrew KK Tan,

Roger C Humphry642 Ophthalmic features and visual prognosis in the Treacher-Collins syndrome Richard WHertle, SuleZiylan,

JamesA Katowitz646 Ocular fundus in neurofibromatosis type 2 Klara Landau, GaziM Yasargil650 Corneal transplantation in the United Kingdom and Republic of Ireland A Vail, SM Gore, B A Bradley, D L Easty,

C A Rogers on behalfofcollaborating surgeonsLaboratory science

657 Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy studyTheo L van derSchaft, CorneliaM Mooy, Wim C de Bruijn, Paul TVM dej'ongPerspective

662 Clinical and genetic patterns of neurofibromatosis 1 and 2 Nicola K RaggeCase reports

673 Bilateral optic neuropathy and white dot syndrome following a mycoplasmal infection M Cordonnier, L E Caspers-Velu,CJacquemin, C Van Nechel, M Tombroff

676 Orbital masquerade: hyperthyroidism and cavernous haemangioma of the orbit Martin L Leib678 Slow accommodation release with a cerebellar lesion Tsutomu Kawasaki, Motohiro Kiyosawa, Tadashi Fujino,

Takashi Tokoro679 Neurotrophic keratitis presenting in infancy with involvement of the motor component of the trigeminal nerve

J D Heath, G Long656 History of ophthalmology681 Letters to the editor Book review Notices Correction684 Instructions for authors

Editorials685 Melanomas, metastases, and survival Ian Rennie686 Macrophages in the pathobiology of epiretinal membranes: multifunctional cells for a multistage process Paul Hiscott

Original articles - Clinical science688 Prognostic factors following enucleation of 111 uveal melanomas Kate Coleman, Jan P A Baak, Paul Van Diest,

Joan Mullaney, Michael Farrell, Maurice Fenton693 Effects of topical mitomycin C on primary trabeculectomies and combined procedures VitalP Costa, Marlene R Moster,

RichardP Wilson, CourtlandM Schmidt, Sai Gandham, Maura Smith698 Pterygium excision with conjunctival autografting: an effective and safe technique BruceD S Allan, Perry Short,

GeoffreyJ Crawford, Graham D Barrett, IanJ Constable

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Contents

702 Treatment of band keratopathy by excimer laser phototherapeutic keratectomy: surgical techniques and long termfollow up DP S O'Brart, DS Gartry, CP Lohmann, A L Patmore, MG KerrMuir, J Marshall

709 Contrast sensitivity function in Graves' ophthalmopathy and dysthyroid optic neuropathy Maria S A Suttorp-Schulten,Rob Tijssen, Maarten Ph Mourits, Patricia Apkarian

713 A comparison of the efficacy and duration of action of topically applied proxymetacaine using a novel ophthalmicdelivery system versus eye drops in healthy young volunteersJ G Lawrenson, D F Edgar, A C Gudgeon, J M Burns,M Geraint, NA S Barnard

716 Impairment of colour contrast sensitivity and neuroretinal dysfunction in patients with symptomatic HIV infection orAIDS Stephan A Geier, Ursula Kronawitter, JohannesR Bogner, Gertrud Hammel, Thomas Berninger, Volker Klauss,Frank D Goebel

721 The effect of pilocarpine on the glaucomatous visual field Andrew R Webster, AndrewJ Luff, ChristopherR Canning,Andrew R Elkington

726 Visual field loss with capillary non-perfusion in preproliferative and early proliferative diabetic retinopathyCarolineKL Chee, Declan WFlanaganLaboratory science

731 Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy: differentiation of subpopulationsPeter Esser, Klaus Heimann, Peter WiedemannPerspective

734 Pterygium as an early indicator of ultraviolet insolation: a hypothesisM TCoroneoCase reports

740 Contact allergic dermatitis and contact urticaria due to topical ophthalmic preparations B F O'Donnell, I S Foulds741 Iris cyst after traumatic implantation ofan eyelash into the anterior chamberHB Hoh, MJ Menage, C Dean-Hart743 Recurrent episcleritis associated with adult T cell leukaemia Kaori Goto, Miyuki Sugita, Kazushiro Okada,

Hiroshi Hatano, Nobuhisa Ishiguro, Takashi Yoshiki, Shigeaki Ohno744 Development of retinal vascular leakage and cystoid macular oedema secondary to central serous chorioretinopathy

Howard Schatz, Mark D Osterloh, H Richard McDonald, Robert NJohnson747 Familial clustering ofhuman T lymphotropic virus type 1 uveitis ShinjiAraki, Manabu Mochizuki, Kazunari Yamaguchi,

Toshiki Watanabe, Ayako Ono, Koichi Yoshimura, Makoto Shirao, Norio Miyata748 An atypical Leber's hereditary optic neuropathy with the 11778 mutation Yoshihiro Hotta, Mutsuko Hayakawa,

Keiko Fujiki, Koutaro Shinohara, Kazushige Sado, Atsushi Kanai, Kenji Yanashima750 A cranial nerve palsy associated with Mycoplasma pneumoniae infection C G Fink, L Butler751 Topical chemotherapy for conjunctival melanoma Paul T Finger, Mark S Milner, Steven A McCormick

730 History of ophthalmology754 Letters to the editor Notices

756 Instructions for authors

No 12 DECEMBER 1993 Editorials757 The prospects of new treatment in age-related macular degeneration IH Chisholm758 Choice in local anaesthesia Christopher Liu, Richard Redmond

Original articles - Clinical science759 Treatment of choroidal neovascularisation in age-related macular degeneration with interferon alfa-2a and alfa-2b

Mark C Gillies, John P Sarks, PaulE Beaumont, Alex B Hunyor, David McKay, Margaret Kearns, Peterl McClusky,ShirleyH Sarks

766 Clinical experience with interferon alfa-2a for exudative age-related macular degeneration jNP Kirkpatrick, A D Dick,J V Forrester

771 Regional anaesthesia for cataract surgery: comparison of three techniques Timo Ali-Melkkila, Markku Virkkild,Kani Leino, Heikki Palve

774 Optociliary veins and central retinal vein occlusion Giuseppe Giuffre, Carlo Palumbo, Gaetano Randazzo-Papa778 Electrophysiology of type II mesangiocapillary glomerulonephritis with associated fundus abnormalities C O'Brien,

J' Duvall-Young, M Brown, C Short, M Bone781 Prognostic value of carotid ultrasound lesion morphology in retinal ischaemia: result of a long term follow up

CM O'Farrell, D E FitzGerald785 Ophthalmic results in patients with macroprolactinomas treated with a new prolactin inhibitor CV 205-502

Michele Grochowicki, Yad Khalfallah, Alain Vighetto, Serge Berquet, Genevieve Sassolas789 The frequency and clinical significance of bone involvement in outer canthus dermoid cystsN Sathananthan,

I F Moseley, GE Rose,J E WrightLaboratory science

795 Cancer-associated retinopathy with retinal phlebitis Yoshitaka Ohnishi, Susumu Ohara, Taiji Sakamoto,Toshihiko Kohno, Fuminori Nakao

799 Immunohistochemical analysis of lattice corneal dystrophies types I and II Tero Kiveld, Ahti Tarkkanen, Ian McLean,Jorge Ghiso, Blas Frangione, Matti HaltiaPerspective

805 Applications of monoclonal antibodies in the investigation, diagnosis, and treatment of retinoblastomaJohn F Tarlton,D L EastyCase reports

813 Manifesting heterozygosity in Norrie's disease? G Woodruff, R Newbury-Ecob, D S Plaha, I D Young815 Pasteurella multocida conjunctivitis K Tharmaseelan, M S Morgan815 Phthiruspubis infestation of the eyelids PaulA Rundle, DavidS Hughes817 Subcutaneous neuroglial choristoma: an immunohistopathological case study Selwa A F Al-Hazzaa, Charles S Specht,

Ian WMcLean, Laurence A Somers819 Multicentric sebaceous gland carcinoma of the lid? Hubertus von Below, Geoffrey E Rose, Alison C E McCartney,

John E Wright820 Therapeutic ptosis with botulinum toxin in epikeratoplasty Tim Freegard, Ian Mackie, Chad Rostron822 Exotropia as a sign of myasthenia gravis in dysthyroid ophthalmology MarinoE Vargas, FloydA Warren,

MarkJ Kupersmith824 A rare case of orbital mucormycosis with gas gangrene panophthalmitis VinodK Gupta, Waleed AI-Tuwarqui777 History of ophthalmology827 Letters to the editor Book reviews Notices832 Author Index839 Subject Index

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