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Beauty Potions
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Beauty P

otio

ns

Skin permeation

enhancerW

ell-balanced com

bination of botanical extracts

POTIO

N C

ON

CEPT

The$delivery$of$conventional$nutrients$should'not'interfere'with'skin'physiology.$

Research$shows$that$regulating$the'com

position'of'intracellular'lipids'in$the$skin$can$increase$or$decrease$the$bioavailability$of$nutrients.$

Skin$delivery$could$also$be$addressed$with$ingredients$w

hich$decrease'the'diffusional'(electrostatic)'resistance'of'the'lipid'bi:layer$to$the$passing$m

olecule.$

IMPR

OV

ING

SKIN PER

MEA

TION

•Tetrahydropiperine$(THP) $1$is$a$stabilized'derivative'of'the'alkaloid'piperine$extracted$from

$the$fruits$of$black'pepper.$

•It$is$able$to$enhance'skin'natural'ability'to'absorb'nutrients.$

•All'the'ingredients$in$Beauty$Potions$range$provide'TH

P'inside.

Piperine

THP

1.$US$Patent$5744161$(1998),$M

ajeed$M.,$Badm

aev$V.$and$Rajendran$R.$(to$Sabinsa$Corporation)$

THP – SKIN

PERM

EATIO

N EN

HA

NC

ER

Reproduced$from$Brian$W

$Barry,$Breaching$the$skin's$barrier$to$drugs,$Nature'Biotechnology'2004,$22,$165$–$167.

Experiments$done$both$in$vitro$and$in$vivo$w

ith$the$parent$com

pound$piperine$indicate$that$Cosm

operine'may'operate'by'increasing'either'

of'two'events:$$

1.mem

brane'fluidity'2.

affinity'of'nutrient$to$the$cell$mem

brane1.

1Majeed$M

,$Badmaev$V,$Prakash$S,$Bioperine$N

ature’s$own$therm

onutrient$and$Natural$bioavailability$enhancer.$N

utriScience$Publishers,$Inc.$1999.$pp.$82.$

THP – SKIN

PERM

EATIO

N EN

HA

NC

ER

Effect$of$THP$on'penetration'of'green'tea'polyphenols'across$egg$mem

brane$in$Franz$Diffusion$System*$$

THE PER

MEA

TION

ENH

AN

CIN

G A

CTIV

ITY

*(V.$Badmaev,$M

.$Majeed,$«Skin$and$its$rle$in$providing$

nourishement$to$the$body$–$Pungent$principles$of$black$pepper,$

alkaloid$piperine,$and$tetrahydropiperine$(THP)$as$Enhancers$of$nutrients$and$drug$bioavailability$^$Cosm

etic$Science$Technology$2004)

•M

C2

^CLA

IM:''

The$skin$bio$revitalizer$^

ACTIV

ITY:$$Counterbalance$daily$energy$drops$by$waking$up$and$em

powering$

$$

cellular$metabolism

$

•X

TEND

^

CLAIM

:''The'skin$rescuer$

^ACTIV

ITY:''Skin$cells$and$cutaneous$architecture$protection$and$recovery'

FIRST LA

UN

CH

ES – IN C

OSM

ETICS 2015

Beauty P

otio

ns

Based$upon$the$combination$of:$

•Ginseng$saponins$$

•Açai$polyphenols$

already$known$in$literature$for$their$tonic 1$and$antioxidant$properties 2.$

APPLICATIO

NS:'

Skin$revitalizing,$«urban$proof»$products$

MC

2 FEATU

RES

1Tan$SJ,$Li$N,$Zhou$F,$Dong$Q

T,$Zhang$XD,$Chen$BC,$Yu$Z,$Ginsenoside$Rb1$improves$energy$m

etabolism$in$the$skeletal$m

uscle$of$an$animal$m

odel$of$postoperative$fatigue$syndrom

e,$J$Surg$Res.$2014$Oct;191(2):344^9.$

2$Bonomo$Lde$F,$Silva$DN

,$Boasquivis$PF,$Paiva$FA,$Guerra$JF,$Martins$TA,$de$Jesus$Torres$ÁG,$de$Paula$IT,$Caneschi$W

L,$Jacolot$P,$Grossin$N,$Tessier$FJ,$

Boulanger$E,$Silva$ME,$Pedrosa$M

L,$Oliveira$Rde$P,$Açaí$(Euterpe$oleracea$M

art.)$modulates$oxidative$stress$resistance$in$Caenorhabditis$elegans$by$direct$and$

indirect$mechanism

s,$PLoS$One.$2014$M

ar$3;9(3):e89933.

GIN

SENG

RO

OTS•

Country'of'Origin:$native$to$northern'hem

isphere'regions'of'A

sia'$(mostly$Korea,$N

orth$China$and$eastern$Siberia)$and$N

orth$America:$$typically$grow

s$in$colder$climates.$The$

species$Vietnamese$Panax$is$the$m

ost$commonly$used.$

•Tradition:$over$five$thousand$years$ago,$in$the$m

ountains$of$M

anchuria,$China,$Panax'ginseng$was$com

monly$used$

for$its$rejuvenating$powers.$The'traditional'Chinese'

medicine'considers'the'plant'an'elixir'of'youth,$w

hich$has$all$the$im

aginable$therapeutic,$preventive,$curative$and$energy$activities;$ginseng$appears$in$the$earliest$treatises$on$m

edicine,$at$the$beginning$of$the$Christian$era.$

•Main'properties:$tonic,$anti$fatigue

•Country'of'O

rigin:$Amazon,$Brasil$

•The'Plant:$palm

$tree,$produces$dark$purple$berries$

•Tradition:$Brazilian$natives$discovered$the$healing'properties$of$the$acai$berry$thousands$of$years$ago,$as$they$found$it$boosted$their$energy$w

hen$consumed$regularly.$$

•Main'properties:$thanks$to$its$com

bination'of'antioxidants,'am

ino*acids*and'omega'fatty*acids'all$help$slow

'the'aging'process'by$boosting'im

mune'and$m

etabolic'function'and$rem

oving'destructive'

free'radicals'

from'our'

bodies.$Nicknam

ed$this$superfruit$the$“Beauty$Berry”.$

AI BER

RIES

In vitro

TESTS

•Cellular'm

etabolism'increase'24h

•Cellular'm

etabolism'increase'4h'

MC

2 TESTS

In V

ivo TEST

•Skin'Hydration''

•Skin'Extensibility'

•Skin'Gross'Elasticity'

•Skin'Brightness

Measurem

ent$of$ATP$is$considered$the$most$sensitive$

method$for$m

easuring$the$cellular$viability,$integrity$and$analyze$w

hether$a$substance$is$able$to$stimulate$the$

production$of$intermediates$of$cellular$energy$m

etabolism.$

Cells:$human$keratinocyte$cell$line$(HaCat).$

Timepoint:$24$h$

Measurem

ent:$bioluminescent$signal$derived$from

$the$transform

ation$of$luciferin$in$oxyluciferin$by$the$enzyme$

luciferase$in$the$presence$of$Mg2+$ions.$

Ce

llula

r me

tab

olism

inc

rea

se 24h

In V

itro

Ce

llula

r me

tab

olism

inc

rea

se 24h

In V

itro

Measurem

ent$of$ATP$is$considered$the$most$sensitive$

method$for$m

easuring$the$cellular$viability,$integrity$and$analyze$w

hether$a$substance$is$able$to$stimulate$the$

production$of$intermediates$of$cellular$energy$m

etabolism.$

Cells:$human$keratinocyte$cell$line$(HaCat).$

Timepoint:$4$h$

Measurem

ent:$bioluminescent$signal$derived$from

$the$transform

ation$of$luciferin$in$oxyluciferin$by$the$enzyme$

luciferase$in$the$presence$of$Mg2+$ions.$

Ce

llula

r me

tab

olism

inc

rea

se 4h

In V

itro

Ce

llula

r me

tab

olism

inc

rea

se 4h

In V

itro

20$wom

en,$between$35$^$65$years$old

T0,$T2weeks,$T4w

eeks

Twice$a$day$for$4$w

eeks

Half$Face$(each$subject$is$his$own$control)

5%$M

C2$cream

$Vs$placebo

Skin$elasticity,$hydration,$brightness,$self$assessment

ISPE$Institute$of$Skin$and$Product$Evaluation,$Milan,$Italy

MC

2 EFFICA

CY PR

OTO

CO

LIn

Vivo

MC2'is$able$to$perform

$a$statistically'significant'increase'in'skin'hydration'after'2'and'4'w

eeks'of'treatment.$M

C2'activity$leads$up'to'a'+'28%

'im

provement$in$hydration$in$com

parison$to$placebo.

Skin H

ydra

tion

In V

ivo

A'statistically'significant'decrease$in$skin$extensibility$(R0$param

eter)$was$evidenced$after$2$and$4$w

eeks$of$treatment.$$

Skin Exte

nsib

ility (R0) H

ydra

tion

In V

ivo

A'statistically'significant'increase'in$skin$elasticity$(R2$$param

eter)$was$

evidenced$after$2$and$4$weeks$of$treatm

ent.$At'4'w

eeks,$the'im

provement'w

as'almost'doubled.

Skin G

ross Ela

sticity (R

2)In

Vivo

After'4'w

eeks'of$treatment,$the$lum

inance$parameter$of$5%

'MC2'cream

$is$3'tim

es'higher'than'placebo.

Skin R

ad

ian

ce

4 we

eks

In V

ivo

After'4'w

eeks'of$treatment,$80%

'of'the'volunteers'have'declared'to'be'willing'to'use'again'the'product.

Co

nsu

me

r pe

rce

ptio

nIn

Vivo

TECH

NIC

AL D

ATA

MC

2

GLYCER

IN,'A

LCOHOL'D

ENAT.,'

TETRAHYD

ROPIPER

INE,'PA

NAX'G

INSEN

G'RO

OT'

EXTRACT,'A

QUA,'EU

TERPE'O

LERACEA

'FRUIT'

EXTRACT

Liquid$

Light$yellow$to$am

ber

2$^$5%

INC

I Nam

e

Aspect:

Colour:

Recom

mended use

PRIM

AR

Y SKIN

IRR

ITATION

TEST (in vivo): (patch test 0.5%

sol.)N

OT IR

RITA

NT

PRIM

AR

Y SKIN

IRR

ITATION

TEST: (hum

an reconstituted epidermidis)

NO

T IRR

ITAN

T

SKIN

SENSITISATIO

N (in vitro):

NO

T SENSITIN

G

MC

2 TOX

ICO

LOG

ICA

L PRO

FILE

Cla

ims

Skin'elasticity''enhancem

ent'

MC

2

Skin'firmness'

defender'Skin'R

adiance'im

provement

Skin'Eveness'source

Skin En

erg

y Boo

stCellular'm

etabolism'

awakening

Beauty P

otio

ns

Based$upon$the$combination$of:$

•Kuzu'isoflavonoids'(e.g.$puerarin)$$

•Cat’s'claw

'oxindole'alkaloids'and'quinic'acids$

already$known$in$literature$for$their$anti:glycation'potential'and$collagen'

renewal' 1$,anti:inflam

matory'and'protective'properties' 2. '

APPLICATIO

NS:'

Recovery,$soothing$and$protective$products,$night/weekend$form

ulations.$

1Kim$JM

,$Lee$YM,$Lee$GY,$Jang$DS,$Bae$KH,$Kim

$JS,$Constituents$of$the$roots$of$Pueraria$lobata$inhibit$form

ation$of$advanced$glycation$end$products$(AGEs),$Arch$Pharm$Res.$2006$O

ct;29(10):821^5.$2$Zhang$L,$Zhang$J,$Zhao$B,$W

ilson$XZ,$Quinic$Acid$Could$Be$a$Potential$Rejuvenating$N

atural$Com

pound$by$Improving$Survival$of$Caenorhabditis$elegans$under$Deleterious$Conditions,$

Rejuvenation$Res.$Dec$2012;$15(6):$573–583.

XTEN

D FEA

TUR

ES

•Country'of'O

rigin:$Kudzu$root$is$a$fast'growing'evergreen'vine'

originated'from'China'and$brought$to$the$U

nited$States$from$

Japan$in$the$late$1800s.$$

•Plant:$Pueraria'lobata''

•Tradition:$Kudzu’s$root,$flow

er,$and$leaf$have$been$used$in$Chinese$m

edicine$since$at$least$200$BC.$Actually$its$high'medicinal'

and'nutritional'value$have$earned$kudzu$herb$a$reputation$as$the$“Asian$ginseng”$and$“longevity$pow

der”$in$Japan,$where$it$is$

honored$as$the$“Royal$Special$food.”$$

•Main'benefits:$it$is$enjoying$great$popularity$in$the$w

est$and$Japan$for$a$variety$of$purposes,$e.g.$w

eight$loss,$breast$enlargem

ent,$hair$loss$treatment,$alcoholism

$prevention,$liver$tonic,$etc.$$

KUD

ZU R

OO

TS

•Country'of'O

rigin:$woody'vine'that$grow

s$in$the$tropical$jungles$of$South'and'Central'A

merica.'

•Plant:'Uncaria'tom

entosa$(popularly$known$in$English$as$cat's'claw

;$in$Spanish$as$uña'de'gato$)$w

hich$derives$its$name$from

$its$claw^shaped$

thorns.$

•Tradition:$traditionally$used$in$Peruvian$m

edicine$for$the$treatment'of'

a'wide'range'of'health'problem

s,$particularly$digestive$complaints$

and$arthritis$and$to$treat$wounds,$stom

ach$problems,$cancer,$and$

more.$It$has$only$recently$caught$the$attention$of$w

estern$herbalists$and$researchers.$Today,$m

ainly$by$word$of$m

outh,$it$has$become$one$

of$the$best$selling$herbs$in$the$USA.$

•Main'properties:$Antibacterial,$anti^inflam

matory,$antim

utagenic,$antioxidant,$antitum

orous,$antiviral,$cytostatic,$depurative,$diuretic,$hypotensive,$im

munostim

ulant,$vermifuge.

CA

T’S CLA

W R

OO

TS

In V

ivo TEST

Skin'Hydration*Skin'Density*Skin'Roughness

XTEN

D TESTS

In vitro

TEST

Citoprotective'activity*

In V

itro

Oxidative$stress$is$one$of$the$m

ain$causes$of$cellular$aging,$and$skin$ageing$from

$chronic$sun$exposure$is$a$clear$demonstration$of$this$

and$it$is$responsible$over$the$years,$of$wrinkles,$dryness$and$skin$

atrophy$(Gordon$J.R.$et$al.,$2012).$$

Cells:$human$keratinocyte$cell$line$(HaCat).$

Procedure:$incubation$with$the$ingredient$(24h)$and$

subsequent$exposure$to$UVA$(1J).$

Timepoint:$24$h.$

Measurem

ent:$transformation$of$the$dihydro^2'^7’^

dichlorofluorescein$diacetate$(H2DCF^DA)$into$a$fluorescent$molecule$(DCF)$in$the$presence$of$RO

S.$

Cito

pro

tec

tive a

ctivity

In V

itroC

itop

rote

ctive

ac

tivity: RESU

LTS

20$wom

en,$between$35$^$65$years$old

T0,$T2weeks,$T4w

eeks

Twice$a$day$for$4$w

eeks

Half$Face$(each$subject$is$his$own$control)

5%$XTEN

D$serum$Vs$placebo

Skin$hydration,$density,$roughness,$self$assessment

Skin$roughness,$skin$density

ISPE$Institute$of$Skin$and$Product$Evaluation,$Milan,$Italy

XTEN

D EFFIC

AC

Y PRO

TOC

OL

In V

ivo

XTEND'is$able$to$perform

$a$statistically'significant'increase'in'skin'hydration'after'2'and'4'w

eeks'of'treatment.$XTEN

D'activity$leads$up'to'a'+'25%

'improvem

ent$in$com

parison$to$placebo.

Skin H

ydra

tion

In V

ivo

A'statistically'significant'increase'in$skin$density$w

as$evidenced$after$2$and$4$weeks$of$treatm

ent$in$comparison$to$placebo.$A

t'4'weeks,$the'im

provement'w

as'doubled.

Skin D

en

sityIn

Vivo

A'statistically'significant'decrease$in$skin$roughness$(Sa$param

eter)$was$

evidenced$after$4$weeks$of$treatm

ent$in$comparison$to$placebo.$$

Skin R

ou

gh

ne

ssIn

Vivo

In V

ivo

After$4$weeks,$XTEN

D$is$able$to$visibly'im

prove'wrinkles'

appearance.$$Green/blue$areas$representing$skin$depressions$are$considerably$dim

inished$at$the$end$of$the$study.

T04'w

eeks

Primo

s Pico

Op

tica

l 3D Skin

M

ea

surin

g D

evic

e G

MS

Skin$treated$with$5%

$XTEND$show

ed$an$improvem

ent$of$the$sub$epidermal$low

^echogenic$band$related$to$skin're:densification.$$

''''''''Skin Ec

ho

ge

nic

ity

Digital$images$of$skin$

echogenicity$obtained$$by$U

ltrasound$$Scanner$$Derm

ascan$C$â$Ver.$3$(Cortex$Technology),$referred$to$the$area$treated$with$GEL$at$5%

$XTEN

D.

In V

ivo

After'4'w

eeks'of$treatment,$63%

'of'the'volunteers'have'declared'to'be'willing'to'use'again'the'product.

Co

nsu

me

r pe

rce

ptio

nIn

Vivo

INC

I Nam

e

Aspect:

Colour:

Recom

mended use

TECH

NIC

AL D

ATA

XTEN

D

GLYCER

IN,'PU

ERARIA'LO

BATA'RO

OT'EXTR

ACT,'

ALCO

HOL'D

ENAT.,'TETR

AHYD

ROPIPER

INE,'

UNCA

RIA'TO

MEN

TOSA

'EXTRACT

Liquid

Light$yellow$to$am

ber$

2$^$5%

PRIM

AR

Y SKIN

IRR

ITATION

TEST (in vivo): (patch test 0.5%

sol.)N

OT IR

RITA

NT

PRIM

AR

Y SKIN

IRR

ITATION

TEST: (hum

an reconstituted epidermidis)

NO

T IRR

ITAN

T

SKIN

SENSITISATIO

N (in vitro):

NO

T SENSITIZIN

G

TOX

ICO

LOG

ICA

L PRO

FILE

Smoothness$supporter

Skin$defender

Extracellular$matrix$fixer

Skin$firmness$booster

Youth$preserver

Skin$relief$promoter

XTEN

D C

laim

s

On

de

ma

nd

info

Clinical$tests

Formulations

Technical$Sheets

www.sinerga.it


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