bsd-ortho.prod.uchicago.edu Orth… · Lee, MD, a spine surgeon specializing in injuries,...

The Department of Orthopaedic Surgery + Rehabilitation Medicine

2013–2014 ANNUAL REPORT

Cobb Lecture Hall/Henry Ives Cobb

In this year’s annual report, we feature a few of the more notable buildings on campus that capture an astonishing range of architectural styles.

From gothic to contemporary, the architecture of the University of Chicago has been created by some of the world’s most innovative and

well-known designers and firms. On the cover (front and back): The Frederick C. Robie House is one of Frank Lloyd Wright’s master works. It is

often cited as the greatest example of the Prairie School style, and is listed on the National Register of Historic Places.

There is but one word to describe the work that has gone on in our department in the past year— AWESOME! The past twenty months have been a whirlwind of activity in moving forward with our new Depart-ment of Orthopaedic Surgery and Rehabilitation Medicine.

Our paramount focus has remained patient service and access. We are committed to meeting or exceeding the patient experience offered by any community orthopaedic practice, with new standards for efficient, friendly and convenient operations. We are building an atmosphere where the answer to just about every patient request will be “yes,” and that atmosphere is already driving significant improvements in patient satisfaction and volumes. Out-patient visits increased 38% from FY13

to FY14. Surgical cases jumped from 2,700 to over 3,400 during the same period—higher than they have ever been in the history of orthopaedic surgery at the University of Chicago.

New recruitments have helped us advance on this goal. In the past 18 months, five outstanding faculty have joined our department. James Mok, MD, resurrected the orthopaedic spine program and, in less than a year, was so effective in outreach and patient service that he was seeing three times as many patients as all other spine providers at UCM combined. Richard Kang, MD, a sports medicine specialist skilled in minimally invasive and arthroscopic procedures for the hip, came on board to spearhead our hip preservation program. Ryan Hudson, MD, who provides ultra-sound guided minimally invasive procedures for sports injuries, has added immensely to our nonsurgical sports capabilities. Muyibat Adelani, MD, who focuses primarily on patients who need joint replacement surgery, has provided excellent quality and capacity to our joint replacement program. Michael Lee, MD, a spine surgeon specializing in injuries, degenerative conditions and spinal deformity, will work with James to make us leaders in mini-mally invasive spinal surgery in the Chicago marketplace.

Common among all of these new faculty—as well as our established faculty—is a deep interest in using research to improve clinical outcomes. My own sights for the department are

closely trained on developing metrics for value-based care—careful evalu-ation of medical quality versus cost over time. We aim to integrate data collection on these factors much more directly into our EPIC electronic medical records system. For instance, we want to push out brief quality-of-life surveys to our patients over time and then use that data to help assess cost versus outcomes, informing best practice, producing scholarly works and leading national discussions on healthcare policy. To assist us in this endeavor, we are also building collaborations with the Booth Graduate School of Business, the Harris School of Public Policy, the Department of Economics, and the Center for Health and the Social Sciences. I think the University of Chicago is ideally positioned to become a national leader in demon-strating the value of quality, thoughtful musculoskeletal care. My dream is that our new Department of Ortho-paedic Surgery and Rehabilitation Medicine becomes known as a leader in this area, leadership that we can extend through our educational programs.

I am excited about the outstanding progress we have already made, as well as the opportunities ahead to advance orthopaedics at the University of Chicago and on a national level.

Douglas R. Dirschl, MDLowell T. Coggeshall Professor

of Orthopaedic SurgeryChairman, Department of

Orthopaedic Surgery and Rehabilitation Medicine

Overview

2013–2014 Annual Report

The Department of Orthopaedic Surgery and Rehabilitation Medicine

2013 14 20

1 Clinical Services

2 Highlights

6 Honors and Awards

10 Welcome

11 Faculty

12 Housestaff

14 Education

16 Rehabilitation Medicine

17 Weekly Conference Schedule

18 2013 Northshore Orthopaedic Program

18 2014 Wavering Lecture

19 Gerald S. Laros Memorial Visiting Professor

20 Research ActivitIes

26 Publications

32 ABC Fellowship

33 Alumni

34 Presentations

38 2014–2015 Orthopaedic Residency Program

39 In Memoriam: William Fisher Enneking, MD

DESIGN: WORDS&PICTURES, INC.

PHOTOS: ©THE UNIVERSITY OF CHICAGO/TOM ROSSITER

Contents

ADULT JOINT RECONSTRUCTION

Muyibat Adelani, MDHenry A. Finn, MDHue Luu, MD

FOOT AND ANKLE

Brian C. Toolan, MD

GENERAL ORTHOPAEDICS

Roderick Birnie, MD

HAND AND UPPER EXTREMITY

Jovito Angeles, MDDaniel P. Mass, MD

HIP PRESERVATION

Richard Kang, MD

ORTHOPAEDIC BIOLOGY

Tong Chuan He, MD, PhD

ORTHOPAEDIC ONCOLOGY

Rex C. Haydon, MD, PhDHue Luu, MD

ORTHOPAEDIC RESEARCH

John M. Martell, MD

OSTEOPOROSIS & BONE HEALTH

Svetlana Bielecki, BSN, MSN, CNP, ANPLauren Creighton MSN, CNPKimberly DeVine, DNP, CNP, ANP

PEDIATRIC ORTHOPAEDICS &

SCOLIOSIS

Robert Bielski, MDChristopher M. Sullivan, MD, MPH

PRIMARY CARE SPORTS MEDICINE

Ryan Hudson, MD

REHABILITATION MEDICINE

Cheryl Benjamin, DOMichelle Gittler, MDMary Lawler, MDEd Park, MDKarl Sandin, MDLisa Thornton, MD

SHOULDER

Lewis Shi, MD

SPINE

Michael Lee, MDJames Mok, MD

SPORTS MEDICINE

Sherwin S.W. Ho, MDJ. Martin Leland III, MDBruce Reider, MD

TRAUMA

Douglas R. Dirschl, MD

SECONDARY APPOINTMENTS

Anthony Montag, MDHolly J. Benjamin, MDAnn Zmuda, DPM

Orthopaedic SurgeryClinical Services

Reva and David Logan Center for the Arts/Tod Williams and Billie Tisen Architects

Rockefeller Memorial Chapel/Bertram Grosvenor Goodhue

Orthopaedic Surgery + Rehabilitation Medicine2

Myuibat Adelani, MD Dr. Muyibat Adelani joined the faculty this year upon completing a Fellowship at Stanford University. Dr. Adelani is an active researcher. She has investigated complications following hip and knee replacements, readmission rates after total knee arthroplasty and the impact of hip arthroplasty in patients 30 years or younger.

Jovito Angeles, MD Dr. Jovito Angeles specializes in hand and upper extremity surgery with a special interest in biomechanics of the hand,

bone stabilization devices and nerve regeneration. Dr. Angeles works with colleagues in the department providing microsurgical expertise for recon-structive procedures. Dr. Angeles works with Dr. Daniel Mass, program director for the hand fellowship, in training the hand fellows. He is a fellow, American Academy for Cerebral Palsy and Developmental Medicine. He is also a member of the International Society for Brachial Plexus and Peripheral Nerve Injury.

Robert Bielski, MD Dr. Robert Bielski continues as an examiner for the American Board of Orthopaedic Surgery. Dr. Bielski continues to serve as a reviewer for the Journal of Bone & Joint Surgery, Journal of Pediatric Orthopaedics, Journal of the American Medical Association and the Journal of Foot & Ankle Surgery. Dr. Bielski oversees the third and fourth year medical student rotation for the department.

Roderick Birnie, MD Dr. Roderick Birnie continues his busy clinical practice in hand, upper extremity, and general orthopaedic care (non-surgical) at the University of Chicago. Dr. Birnie also teaches the motor skills course for the Orthopae-dic Surgery Residency Program.

Douglas R. Dirschl, MD Dr. Douglas Dirschl is the Lowell T. Coggeshall Professor of Orthopaedic Surgery and Chairman of the Department of Orthopaedic Surgery and Rehabilitation Medicine. Dr. Dirschl sits on editorial and review boards for several notable scientific journals, including the Journal of Orthopaedic Research, Journal of Orthopaedic Trauma and Journal of Bone & Joint Surgery. Under Dr. Dirschl’s leadership, the new Department of Orthopaedic Surgery and Rehabilitation Medicine continues to expand and build upon an already outstanding faculty and training program.

HighlightsThe Department of Orthopaedic Surgery and Rehabilitation Medicine will continue to distinguish itself in patient care, research and education. Our faculty provides expert and compassionate care in a range of subspecialties including: foot and ankle, hand and upper extremity, joint/reconstruction, orthopaedic oncology, pediatric orthopaedic surgery, spine, sports medicine and rehabilitation medicine. Complementing the clinical practice are the expanded resident and fellowship programs as well as the active clinical and basic science efforts. The department is committed to growing the body of medical knowledge and creating a lasting contribution to the field of orthopaedic surgery.

The Department of Orthopaedic Surgery and Rehabilitation Medicine

2013–2014 Annual Report 3

Henry Finn, MD Dr. Henry Finn con-tinues in his role as medical director of the University of Chicago Bone and Joint Replacement Center at Weiss. He is also professor of surgery at the University of Chicago Medical Center’s Department of Orthopaedic Surgery and Rehabilitation Medicine, as well as chief, Section of Orthopaedic Surgery at Louis A. Weiss Memorial Hospital.

Rex Haydon, MD, PhD Dr. Rex Haydon continues as co-instructor for the annual Musculoskeletal Clinicopatho-logic Seminar for residents held at the Gleacher Center, Chicago. He is also the course director for the Ortho-paedic Basic Science Curriculum. Dr. Haydon is the program director for the Orthopaedic Oncology Fellowship Program at the University of Chicago. Dr. Haydon was recently named Dele-gate-at-Large to the 2014–2015 Executive Committee of the American Orthopaedic Association.

Tong-Chuan He, MD, PhD Dr. T-C He’s molecular oncology lab contin-ues research on cancer, stem cells and bone biology. He continues with collaborative efforts with other faculty in the areas of tendon and ligament repair research, articular cartilage regeneration research, and implant wear-induced osteolysis and spine research. Dr. He is a member of the

Committee on Molecular Medicine, the Committee on Cancer Biology, the Committee on Genetics and the Committee on Cell Physiology at the University of Chicago. He is also adjunct professor, School of Bioengi-neering, Chonqing University, China. Dr. He is also a member of the Inter-national Chinese Hard Tissue Society.

Sherwin Ho, MD Dr. Sherwin Ho con-tinues in his role as program director for the Sports Medicine Fellowship at the University of Chicago.

Ryan Hudson, MD Dr. Ryan Hudson specializes in sports medicine. In addition to performing general con-sultations, he diagnoses and treats a wide range of sports-related injuries. Dr. Hudson is experienced in muscu-loskeletal radiology and ultra-sound guided minimally invasive procedures.

Richard Kang, MD Dr. Richard Kang is an orthopaedic sports medicine surgeon skilled in a variety of mini-mally invasive and arthroscopic pro-cedures. He specializes in the diag-nosis and management of adolescent and adult hip conditions, including labral tears and femoroacetabular impingement. He also has expertise in the treatment of cartilage lesions of the hip, knee and shoulder. Dr. Kang has published extensively on various

topics within orthopaedic surgery. His research experience spans from developing novel basic science models to clinical outcomes studies, and has received a number of awards and grants. Notable research support includes that of the National Insti-tutes of Health (NIH) as well as the Orthopaedic Research and Education Foundation (OREF).

Michael Lee, MD Dr. Michael Lee treats spinal injuries, degenerative conditions and spinal deformity as well as complex tumors of the spinal cord. As the principal investigator for several research studies, Dr. Lee has worked to identify risk factors for post-operative lumbar spondylolis-thesis and to enhance lumbar spine surgical techniques. In addition to his research, Dr. Lee teaches medical students, residents and fellows about spine surgery. Past courses have focused on the surgical treatment of complex spinal tumors and minimally invasive surgery.

J. Martin Leland, MD Dr. Martin Leland is a board certified orthopaedic surgeon and specialist in sports medicine. He continues to be very busy with his clinical and academic endeavors.

Hue Luu, MD Dr. Hue Luu continues his busy clinical practice in total joint replacement and orthopae-dic oncology. Dr. Luu continues his teaching role of the oncology fellows, residents and students, one of the many aspects of his job that he truly enjoys. Dr. Luu was awarded an ABC Traveling Fellowship by the American Orthopaedic Association.

Highlights


John Martell, MD Dr. John Martell is the director of the Orthopaedic Research Institute at the University of Chicago. Dr. Martell continues the development for measuring the wear performance of polyethylene in total knee arthroplasty (TKA). Accurate measurement of TKA polyethylene wear is unprecedented, and suc-cess with this project will result in an entirely new research direction for the Institute. The ORS abstract “A Com-puter-assisted Radiographic Method to Measure Polyethylene Wear in To-tal Knee Arthroplasty (TKA)” demon-strated the performance of this novel approach based on digital phantoms. In addition, software has been devel-oped that allows the user to perform a knee evaluation for prosthetic interfaces and radiographic implant position. This is very useful to improve agreement between observers.

Daniel Mass, MD Dr. Daniel Mass is the program director for the hand fellow-ship, which has two hand fellows per year. Dr. Mass was awarded the Laros Teaching Award for 2014 by the resi-dents for his outstanding teaching skills.

James Mok, MD Dr. James Mok is an orthopaedic surgeon who specializ-es in the diagnosis and treatment of spine conditions. After completing his fellowship, Dr. Mok served as a major in the United States Army, where his duties included caring for members of elite special operations units. He also deployed as the orthopaedic surgeon for a combat support hospital in Iraq. He received notable military awards for his service, including the Meritorious Service Medal. In 2010, he

received the Norman T. Kirk Award for best scientific paper from the Society of Military Orthopaedic Surgeons.

Bruce Reider, MD Dr. Bruce Reider continues to serve as the editor- in-chief of the American Journal of Sports Medicine (AJSM). Dr. Reider is the leader of the University of Chicago Residency Program’s month-ly Orthopaedic Journal Club. Dr. Reider was inducted into the AOSSM Hall of Fame this past July.

Lewis Shi, MD Dr. Lewis Shi continues to have a busy academic shoulder practice with a mixture of arthrosco-py, arthroplasty and trauma cases. He has set up a research program that includes translational shoulder re-search, prospective and retrospective clinical research.

Michael Simon, MD Dr. Michael Simon continues in his role as associate dean of Graduate Medical Education and DIO. The conference room in the new Department of Orthopaedic Surgery and Rehabilitation Medicine suite was named the Michael A. Simon Confer-ence Room to acknowledge all Dr. Simon has accomplished in his years at the University of Chicago.

Christopher Sullivan, MD Dr. Christopher Sullivan continues his busy pediatric practice at the University of Chicago and many off-site clinics. Dr. Sullivan is a reviewer for Clinical Orthopaedics and Related Research.

Brian Toolan, MD Dr. Brian Toolan also continues in his role as program director for the Orthopaedic Surgery

Residency Program. Dr. Toolan is an American Board of Orthopaedic Surgery Examiner for the Part II (oral boards) and Maintenance of Certifi-cation. Dr. Toolan is a member of the AAOS-ABOS Orthopaedic Surgical Skills Curriculum Task Force and the ACGME-ABOS Orthopaedic Surgery Resident Milestone Project. Dr. Toolan is an assistant editor for Foot & Ankle International. In addition, Dr. Toolan is co-chair for the OMeGA Medical Grants Association, a Foot & Ankle Fellowship Grant Review Committee Member, and on the OMeGA Medical Grants Association, Residency/General Education Grant Review Committee. He is a member of the University of Chicago Dean’s Advisory Committee on Appointments and Promotions (COAP). Dr. Toolan also chairs the ACGME-ABOS Orthopaedic Surgery Foot & Ankle Fellowship Milestones. In 2013, he helped create the eight milestones for foot and ankle fellowship programs to use in the assessment of a fellow’s progress towards competency on the ACGME website.


School of Social Service Administration/Ludwig Mies van der Rohe


Honors & AwardsJovito Angeles, MD Reviewer for The Bone & Joint JournalMember, Reader Advisory Board of the Journal of Bone

& Joint Surgery

Robert Bielski, MD Board Examiner for the American Board of Orthopaedic

SurgeryReviewer for the Journal of Bone & Joint SurgeryReviewer for the Journal of Foot & Ankle SurgeryReviewer for the Journal of the American Medical

AssociationReviewer for the Journal of Pediatric OrthopaedicsBook Reviewer for the Journal of the American Medical

AssociationPromoted to Associate Professor

Roderick Birnie, MD Doctors Demystify finger deformities for OTs and PTs Boutonniere and Swan neck deformities

Douglas R. Dirschl, MDMember, Own the Bone Steering Committee, American

Orthopaedic AssociationMember, Budget and Finance Committee, Orthopaedic

Trauma AssociationMember, Classification Committee, Orthopaedic Trauma

AssociationImmediate Past President, American Orthopaedic

Association, June 2012–June 2013Lowell T. Coggeshall Professor of Orthopaedic Surgery,

University of Chicago, July 1, 2013

Henry Finn, MD Editorial Board, Journal of ArthroplastyOral Examiner, American Board of Orthopaedic Surgery

Rex Haydon, MD, PhD Associate Editor for Current Orthopaedic PracticeReviewer, Journal of Bone & Joint SurgeryReviewer, Clinical Orthopaedics and Related ResearchReviewer, Journal of Orthopaedic ResearchReviewer, Journal of Gene MedicineReviewer, American Journal of Sports MedicineReviewer, LifeScienceReviewer, Cancer ResearchGrant Reviewer for the Musculoskeletal Transplant

FoundationGrant Reviewer for the Orthopaedic Research and

Education FoundationGrant Reviewer for the Italian Association for Cancer

Research (AIRC)Delegate-At-Large, Executive Committee, The American

Orthopaedic Association

Tong-Chuan He, MD, PhD Reviewer, American Journal of Sports MedicineReviewer, American Journal of Human GeneticsReviewer, Cancer ResearchReviewer, Clinical Cancer ResearchReviewer, Critical Reviews in Oncology/HematologyReviewer, EMBOReviewer, EMBO ReportReviewer, GastroenterologyReviewer, Genomics


Honors & AwardsTong-Chuan He, MD, PhD (continued)Reviewer, Genes and DevelopmentReviewer, Journal of Clinical InvestigationReviewer, Journal of Orthopaedic ResearchReviewer, Laboratory InvestigationReviewer, Molecular and Cellular BiologyReviewer, Nature BiotechnologyReviewer, Nucleic Acids ResearchReviewer, OncogeneReviewer, PLoS Series JournalsReviewer, Proceedings National Academy of Science, USAReviewer, ScienceReviewer, Stem CellsReviewer, Stem Cells and DevelopmentReviewer, Special Emphasis Panel/NIH ZRG1 ONC-K (03)M,

June 2010Reviewer, Biomedical Research Council of Agency for

Science, Technology and Research of Singapore (A*STAR), July 2010

Reviewer, the Wellcome Trust Senior Fellowships, UK, February 2011

Charter member, the Drug Discovery and Molecular Pharmacology (DMP) Study Section, NIH/NCI, Bethesda, MD

Editorial Board, Recent Patent Reviews on Anti-Cancer Drug Discovery

Editorial Board, Laboratory InvestigationEditorial Board, The Open Cancer JournalEditorial Board, The Open Tissue Engineering and

Regenerative Medicine JournalGuest Editor, Current Gene TherapyEditorial Board, World Journal of Stem CellsEditorial Board, World Journal of Biological ChemistryEditorial Board, World Journal of OrthopaedicsEditorial Board, American Journal of Stem Cells

Sherwin SW Ho, MD Team Physician for Concordia University

Richard Kang, MDTeam physician for Kennedy King College

J. Martin Leland, MD Illinois Delegate, American Orthopaedic Society for

Sports Medicine (AOSSM) Council of DelegatesAssociate Editor of Technology, Arthroscopy JournalChairman of Social Media Task Force, Arthroscopy

Association of North America (AANA)Education Committee, American Orthopaedic Society

for Sports Medicine (AOSSM)Self-Assessment Committee, American Orthopaedic

Society for Sports Medicine (AOSSM)

Hue H. Luu, MD Grant Reviewer for the American Cancer Society Cell

Structure and Metastasis (CSM) Study Section (Ad Hoc) (Atlanta, GA)

Grant Reviewer for the Orthopaedic Research and Education Foundation

Grant Reviewer for the University of Chicago Internal Scientific Advisory Panel

Grant Reviewer for Liddy Schriver Sarcoma Initiative (Ossining, NY) (Ad Hoc)

Awarded the ABC Fellowship by the American Orthopaedic Association

Was an invited speaker at an international conference and demonstration of TKA surgeries in Chongqing, China in October 2014

John Martell, MD Abstract Reviewer for Orthopaedic Research Society,

Section of ArthroplastyReviewer, Journal of Wear


Reviewer, Journal of Bone and Joint SurgeryManuscript Reviewer, Clinical Orthopaedics and

Related ResearchGrant Submission Reviewer, National Institutes of HealthManuscript Reviewer, Journal of BiomechanicsManuscript Reviewer, Computer Methods in

Biomechanics and Biomedical EngineeringManuscript Reviewer, Journal of BiomaterialsManuscript Reviewer, Journal of American Academy of

Orthopaedic Surgeons

Daniel Mass, MDRecipient of the Gerald R. Laros, MD Teaching Award

for 2013

Bruce Reider, MD Continues in his role as editor of the American Journal

of Sports Medicine. Dr. Reider is also on the Board of Directors of the American Orthopaedic Society for Sports Medicine.

Reviewer, The Physician and Sports MedicineReviewer, World Book EncyclopediaReviewer, Journal of Orthopaedic ResearchConsultant Editor, Post-Grad Advances in Sports

Medicine, Publisher Forum Medicus, Inc.Reviewer, American Journal of Sports MedicineReviewer, Clinical Journal of Sports Medicine (Canada)Reviewer, AAOS Sports Medicine EvaluationEditorial Board, Operative Techniques in Sports MedicineReviewer, Orthopaedics TodayReviewer, ArthroscopyReviewer, Clinical Orthopaedics and Related Research

Lewis Shi, MDAppointed as a member of the AAOS Video Theater

Committee, March 2014 through March 2016

Michael Simon, MD The conference room in the new Department of Ortho-

paedic Surgery and Rehabilitation Medicine suite was named in honor of Dr. Simon to acknowledge his leadership to the Section of Orthopaedic Surgery at the University of Chicago Medicine

Christopher Sullivan, MD Reviewer, Clinical Orthopaedics and Related ResearchPromoted to Associate Professor

Brian Toolan, MD Oral examiner for Part II Oral Boards and Oral Recertifi-

cation for the American Board of Orthopaedic Surgery. Manuscript Reviewer, American Journal of Sports

MedicineCurrent Concepts and Topical Reviews Committee,

assistant editor for Foot & Ankle International


WelcomeDr. Ryan Hudson—Assistant Professor of Orthopaedic Surgery Ryan Hudson, MD, specializes in sports medicine. In addition to per-forming general consultations, he diagnoses and treats a wide range of sports-related injuries. Dr. Hudson is experienced in musculoskeletal radiology and ultra-sound guided minimally invasive procedures. Whenever possible, he offers patients non-operative solutions. Dr. Hudson has been the team physician for many professional, college and high school sports, including football, lacrosse, basketball and more.

Dr. Muyibat Adelani—Assistant Professor of Orthopaedic Surgery Muyibat Adelani, MD, specializes in the surgical treatment of orthopaedic conditions, with a primary focus on osteoarthritis and joint replacement surgery, including hip and knee replacements and revision surgeries. Along with her clinical work, Dr.

Adelani is also an active researcher. She has investigated complications following hip and knee replacements, readmission rates after total knee arthroplasty and the impact of hip arthroplasty in patients 30 years or younger.

Dr. Michael Lee—Associate Professor of Orthopaedic SurgeryAn expert spine surgeon, Michael Lee, MD, treats spinal injuries, de-generative conditions and spinal deformity as well as complex tumors of the spinal cord. He is dedicated to improving safety and quality measures for spine surgery. As the principal investigator for several research studies, Dr. Lee has worked to identify risk factors for post- operative lumbar spondylolisthesis and to enhance lumbar spine surgical techniques. He recently has focused efforts on creating models to predict the likelihood of complications after spine surgery. In addition to his

research, Dr. Lee teaches medical students, residents and fellows about spine surgery. Past courses have focused on the surgical treatment of complex spinal tumors and minimally invasive surgery.

Dr. Lee has published more than 100 journal articles, book chapters and abstracts on spinal conditions and surgical treatments. He has chaired several spinal surgery teaching courses and has edited two text-books. He also serves as a reviewer for numerous scientific journals. Dr. Lee has been invited to present his work at national and international conferences. In 2013, Dr. Lee was named to the list of Best Doctors in America by Best Doctors, Inc.

Muyibat Adelani, MDRyan Hudson, MD Michael Lee, MD


FacultyUniversity of Chicago

Professors of Orthopaedic SurgeryDouglas R. Dirschl, MDHenry Finn, MD John Martell, MD Daniel P. Mass, MD Anthony Montag, MD* Michael Simon, MD Brian Toolan, MD

Professor Emeritus of Orthopaedic Surgery Bruce Reider, MD

Associate Professors of Orthopaedic Surgery Robert Bielski, MDRex Haydon, MD, PhD Tong-Chuan He, MD, PhD Sherwin Ho, MD Hue Luu, MDChristopher Sullivan, MD

Assistant Professors of Orthopaedic Surgery Jovito Angeles, MD Holly Benjamin, MD*

Roderick Birnie, MD Ryan Hudson, MDRichard Kang, MDJ. Martin Leland, MD James Mok, MDLewis Shi, MDAnn Zmuda, DPM*

Clinical Associate Professor of Orthopaedic Surgery Michelle Gittler, MD

Clinical Assistant Professors of Surgery Mary Lawler, MD Lisa Thornton, MD

Clinical AssociatesCheryl Benjamin, DORaymond Lee, MDEdward Park, MD Karl Sandin, MD

Postdoctoral Fellows Xian Chen, MDFang Deng, MD, PhDJinhua Wang, MDSheng Wen, MDQiang Zhang, MD, MsC

Visiting Research Associates (Assistant Professors)Youlin Deng, MD, MScZhan Liao, MD, PhDHongmei Zhang, MD, PhD

Visiting ScholarsYunfeng He, MD, PhDWei Liu, MD, PhDGuoxin Nan, MD, PhDMin Qiao, MD, PhDZhongliang Wang, MD, PhDLiangjun Yin, MD, PhDJunhui Zhang, MDZhengjian Yan, MD, MsC

PhD/MD Student Mary Rose Rogers

NorthShore

Clinical ProfessorLeon Benson, MD

Clinical Associate ProfessorsJason Koh, MDJames Kudrna, MDWilliam Robb III, MDAnand Srinivasan. MD Howard Sweeney, MD

Clinical Assistant ProfessorsJoepsh Alleva, MDRavi Bashyal, MDDavid Beigler, MDEric Chehab, MDBradley Dunlap, MDMiledones Eliades, MDThomas Hudgins, MDEldin Karaikovic, MDSteven Levin, MDSeth Levitz, MDRobert McMillan, MDCraig S. Phillips, MDGary Shapiro, MD

Pritzker School of Medicine Clinician EducatorsPatrick Birmingham, MDRachel Kermen, MDMark Mikhael, MDMark Neault, MDHoward Robinson, MDDanielle Schiff, MDNaila Shaikh, MDRachel Sherman, MD

Senior Clinician EducatorJospeh Feldman, MDJames Fox, MDMichael O’Rourke, MDGregory Palutsis, MDGregory Portland, MDAmy Ptaszek, MDDavid Shapiro, MDVan Stamos, MDCraig Williams, MD

*Secondary appointment


HousestaffORTHOPAEDIC SURGERY RESIDENTS

PGY-1

Kenneth Chakour, MDUndergraduate/GraduateUniversity of Illinois at Urbana-Champaign/University of Illinois College of Medicine

Srikanth Divi, MDUndergraduate/GraduateJohns Hopkins University/University of Pittsburgh School of Medicine

Patrick Leung, MDUndergraduate/GraduateRutgers University/UMDNJ— Robert Wood Johnson Medical School

Jonathan Twu, MDUndergraduate/GraduateUniversity of Illinois at Urbana-Champaign/University of Illinois College of Medicine

Noelle White, MDUndergraduate/GraduateThe University of Western Ontario/Pennsylvania State University College of Medicine

PGY-2

Harpreet Bawa, MDUndergraduate/GraduateUniversity of California, Los Angeles/Case Western Reserve University School of Medicine

Kyle Borque, MDUndergraduate/GraduateTexas A&M University/Baylor College of Medicine

Pranay Patel, MDUndergraduate/GraduateWashington University in St. Louis/Southern Illinois University School of Medicine

Anna Rosenblum, MDUndergraduate/GraduateHarvard College/Albany Medical College

Robert Stewart, MDUndergraduate/GraduateUniversity of Washington/Jefferson Medical College of Thomas Jefferson University

PGY-3

Joseph Cohen, MDUndergraduate/GraduateUniversity of San Diego/Tufts University School of Medicine

Ananth Eleswarapu, MDUndergraduate/GraduateColumbia University/The University of Pittsburgh School of Medicine

Oliver Schipper, MDUndergraduate/GraduateBucknell University/Georgetown University School of Medicine

Jason Somogyi, MDUndergraduate/GraduateIllinois Wesleyan University/Loyola University Stritch School of Medicine

Cory Stewart, MDUndergraduate/GraduateCalvin College/Wayne State University School of Medicine

Orthopaedic Surgery and

Rehabilitation Medicine


PGY-4

Erwin Bennett, MDUndergraduate/GraduateSanta Clara University/University of Chicago Pritzker School of Medicine

Jimmy Jiang, MDUndergraduate/GraduateGeorgia Tech/University of Alabama School of Medicine

Min Lu, MDUndergraduate/GraduateUniversity of Chicago/University of Chicago Pritzker School of Medicine

Gautam Malhotra, MDUndergraduate/GraduateUCLA/University of Chicago Pritzker School of Medicine

Zachary Sisko, MDUndergraduate/GraduateUniversity of Notre Dame/St. Louis University School of Medicine

Aneet Toor, MDUndergraduate/GraduateUCLA/Ohio State University College of Medicine

PGY-5

Kevin Hardt, MDUndergraduate/GraduateUniversity of Notre Dame/Indiana University School of Medicine

Tyler Krummenacher, MDUndergraduate/GraduateUniversity of Notre Dame/St. Louis University School of Medicine

Deepak Reddy, MDUndergraduate/GraduateUniversity of Michigan/University of Chicago Pritzker School of Medicine

Christian Skjong, MDUndergraduate/GraduateCarleton College/University of Chicago Pritzker School of Medicine

ORTHOPAEDIC SURGERY FELLOWS

2014 GRADUATES

Amrish Patel, MDHand and Upper ExtremityCarrollton Orthopaedic Clinic— Carrollton, GA

Drew Moore, MDMusculoskeletal Oncology Beaumont Hospital—Royal Oak, MI

Alex Betech, MDAdult ReconstructionLouisiana State University— Baton Rouge, LA David Knesek, DOAdult ReconstructionThe CORE Institute (affiliated with Detroit Medical Center)— Southfield, MI

Neil Dunleavy, MDSports MedicineKSF Orthopaedic Center— Houston, TX

Matthew Marcus, MDSports MedicineUniversity of Illinois at Chicago— Chicago, IL

Byung Joo Lee, MDHand and Upper ExtremityIrving Orthopaedics and Sports Medicine—Irving, TX


MIDWAY LIGHTS Sin et volupta nimusci enisim denducia voles in necea aut harchit que laboribeatis aut et ut fugita intur, se dolupta ist esequiatquo moluptae sum re non plique rerem esciis et periatiat facipist que omnimus ad.

Education

Working toward fulfilling the Department of Orthopaedic Surgery and Rehabilitation Medicine’s mission to communicate knowledge through medical education, our faculty continue to be active in all levels of medical education.

William Rainey Harper Memorial Library/Shepley, Rutan & Coolidge

During the M3 year, we provide a core course for three hours, which includes instruction in casting and splinting, and a series of interactive lectures on orthopaedic topics. During their surgery clerkship, third year medical students are given the option of selecting orthopaedic surgery as their subspecialty rotation for 2.5 weeks. During this 2.5 week rotation, the junior medical students are introduced to the field of ortho-paedics and given the opportunity to experience first-hand the rewarding yet challenging work we do.

During the M4 year, we offer a four-week elective inpatient rotation. Students are exposed to the various orthopaedic subspecialties during this rotation. In addition to our own students from Pritzker, this rotation is very popular with visiting students from other institutions as well. We also offer an outpatient elective, which is aimed towards students entering into primary care fields. Year after year, we continue to see many of our own students choose ortho-paedics as a career.

Our residency program continued to flourish over the past year and has been greatly strengthened by the academic affiliation with the North-Shore University Health System (NSUHS). Through our affiliation with NorthShore, our residents rotate at Evanston Hospital, a designated Level I trauma center, and Glenbrook Hospital, a community hospital in Glenview, Ill. All members are of the NSUHS faculty are fellowship-trained subspecialty

surgeons in well-established commu-nity practices. The individual practices of the faculty collectively provide an extensive, subspecialty-driven ambulatory experience in the evalu-ation and management of outpatient orthopaedic conditions. We have six residents training at NSUHS at a time on the total joint arthroplasty, foot and ankle, trauma, hand, sports medicine and spine services.

The majority of the resident educational program in orthopaedic surgery continues to occur at the University of Chicago Medical Center. The clinical education is centered around inpatient units, on-site and off-site outpatient clinics, and the operating room. The management of patients is divided into clinical services that include joint reconstruc-tion including hip preservation, spine, oncology, pediatrics, foot and ankle, hand and upper extremity, and sports medicine. Our curriculum is organized through these subspecialties and teams of residents are assigned to each service.

The didactic portion of the residents’ education occurs mainly through the morning clinical conferences. Our 6:15 am conference is a monthly rotating conference on pediatric orthopaedics, trauma, basic science, morbidity and mortality, quality assurance, sports medicine, adult reconstruction, spine, hand and upper extremity, and surgical indications for musculoskeletal diseases. All of our conferences are attended and led by attendings. Following the 6:15 am

conferences, every weekday morning from 7:00 to 7:30 am, the junior resi-dent on-call presents the emergency room cases from the evening before. This serves as quality control and an educational experience for residents. After the emergency room review, all faculty are required to present their operative cases for the day and explain their operative indications. Following the faculty presentation, residents show radiographs of pa-tients who were operated on the day before, so that all individuals can see some of the technical results from the previous day’s surgery. In addition to our daily morning conferences, we also have a weekly Grand Rounds on Wednesdays and a monthly Journal Club. We are fortunate to have a large number of outside guest speakers present at our Grand Rounds.

Our four fellowship programs, Hand & Upper Extremity, under the direction of Dr. Daniel Mass; Sports Medicine, under the direction of Dr. Sherwin Ho; Musculoskeletal Oncol-ogy, under the direction of Dr. Rex Haydon; and Adult Reconstruction, based at Weiss Memorial Hospital, under the direction of Dr. Henry Finn, continue to train some of the nation’s brightest emerging ortho-paedic subspecialists. Staying at the forefront of orthopaedic medical education is a goal the Department of Orthopaedic Surgery and Rehabilita-tion Medicine strives toward at every level of education.


Mary Lawler, MD Cheryl Benjamin, DO

Rehabilitation Medicine

That is why Physical Medicine & Rehabilitation (PM&R) is often thought of as the “quality of life” specialty, adding both life to years and years to life. Our physiatrists lead interdisciplinary teams that include nurses, physical therapists, occupational therapists, speech-language pathologists, case managers and others. These teams develop individualized treatment plans to address each patient’s rehab needs. Treatment plans also focus on the patient’s longer term functional goals once they’re home in the community.

These doctors provide patient care on an inpatient and outpatient basis. They also participate in various teaching activities for Schwab’s fully accredited residency training program in PM&R with the University of Chicago Pritzker School of Medicine.

At the University of Chicago, our PM&R specialists are involved in many educational and clinical pursuits. Mary Lawler, MD, serves as advisor to Pritzker students who are interested in PM&R as a specialty. Dr. Lawler also works with Cheryl Benjamin, DO, covering inpatient physiatry consultations at the University of Chicago. Michelle Gittler, MD, is the resident program director at Schwab Rehabilitation Hospital and clinical associate professor at the University of Chicago. Together with the resident physicians, Dr. Gittler has had two projects go through the Institutional Review Board; Participation in a multi-institutional program to establish an amputee registry, and initiation of a project which looks at the use of topical ketamine for residual limb pain. She also teaches annually at the Primary Care Orthopaedics Course.

Rehabilitation Medicine physicians work with other rehab professionals to restore or maximize each patient’s functional skills, self-sufficiency and mobility.


Weekly Conference Schedule

DAY PLACE DESCRIPTION TIME

MONDAY CCD 7750 OITE Review/Anatomy 6:30 – 7:00 AM

CCD 7750 AM Intake Conference 7:00 – 7:15 AM

TUESDAY CCD 7750 Clinical Conference 6:15 – 7:00 AM


WEDNESDAY E 302 Basic Science 6:15 – 7:00 AM

E 302 Chairman/PD/Resident Meeting 7:00 – 7:20 AM

E 302 Grand Rounds 7:30 – 8:15 AM

E 302 AM Intake Conference 8:15 – 8:30 AM

THURSDAY CCD 7750 Indications 6:15 – 7:00 AM


FRIDAY CCD 7750 Clinical Conference 6:15 – 7:00 AM


University of Chicago Orthopaedic Residency Program

AM Intake ConferencePre-op & Post-op DiscussionX-ray Review from Previous DayER X-ray Review

TUESDAY & FRIDAY (Topics are covered on a rotating basis) TraumaMorbidity & MortalityAdult Reconstruction PediatricsHandSportsFoot & AnkleSpine

WEDNESDAY Basic Science Conference:July–Sept AnatomyOct–Dec PathologyJan–June Basic Science Curriculum

THURSDAY Indications Conference: (Topics are covered on a rotating basis)Trauma Adult ReconstructionSportsHandPediatricsFoot & Ankle

MONTHLY CONFERENCEJournal ClubLast Wednesday of each month7:00 AM—E 302 TH

ETHICS One Wednesday quarterly— 7:00 AM Vignettes in Ethics and Professionalism Compliance Education Annually Liability Education Annually Prosthetic Education Annually Cultural Competence Vingettes

Conference Details


NorthShore Orthopaedic Program The orthopaedic program at North-Shore University HealthSystem is a valuable and robust component of the orthopaedic surgery graduate medical education program at the University of Chicago. Five resi-dents rotate continually through the NorthShore orthopaedic department with subspecialty rotations in total joint, foot and ankle, hand, trauma and spine. Currently, the University of Chicago and NorthShore orthopaedic departments facilitate two combined fellowship programs; Sports Medi-cine, and Hand and Upper Extremity. Live daily interactive video provides linkage and continuity to the Univer-sity of Chicago campus. Daily con-ferences on the NorthShore campus compliment the University of Chicago programs with hand, trauma, surgical outcomes, arthroscopic correlation, journal club and spine conferences. Residents have the opportunity to interact with numerous clinical faculty

and gain experience and exposure through the NorthShore Orthopaedic outpatient clinic, operating rooms, Evanston Hospital (level 1 trauma) ER, Ravine Way surgicenter and clini-cal offices of the faculty. They also participate in sub-specialty specific motor skills education programs in the NorthShore Orthopaedic Psychomotor Skills & Virtual Reality Laboratory featuring state-of-the-art skills education in trauma and arthroscopic surgery. Another integral component of the residency and fellowship programs is the real-world experience gained through managing the NorthShore Community Health Center (CHC) clinics. Residents man-age two clinics per week while hand and sports fellows each manage one clinic per month. The orthopaedic faculty and CHC co-directors provide overall supervision for the clinics. The CHC clinic provides residents and fellows the opportunity to assess and treat varying orthopaedic conditions from a wide patient population in preparation for their future practices.

2014 Wavering LectureThe annual lecture series hosted by the orthopaedic department at NorthShore was pleased to feature Dr. Tania Ferguson as the Wavering Lecture 2014 guest speaker. Dr. Ferguson had the distinct honor of being the first female visiting profes-sor for Wavering. Dr. Ferguson is an associate professor and hip and pelvis surgeon at the University of Washing-ton, Department of Orthopaedics and Sports Medicine. She presented, “The Anterior Approach for Hip Fractures—ORIF and Arthroplasty” and “Fragility Fractures of the Acetabulum—Leave it, Fix it or Replace it?” Dr. Ferguson’s cadaveric session demonstrated the “Ilioinguinal Exposure for Acetabular Fractures” and “Acute ORIF+THA via Levine Approach for Osteoporotic Acetabular Fractures.”

2014 Northshore Orthopaedic Program

Jason Koh, MD

2014 Wavering Lecture—Tania Ferguson, MD (center)


Gerald S. Laros Memorial Visiting ProfessorScott Wolfe, MD

Dr. Scott Wolfe is acknowledged to be one of the most experienced, innovative and authoritative experts in orthopaedic upper extremity care. He maintains an active practice and teaches students daily as a Cornell Medical School Professor of Orthopedic Surgery. He is recognized for his expertise in the wrist and complex nerve injuries, fracture care, and for his leadership in improving the surgical education, skill level and techniques practiced by the most up-to-date hand surgeons.

As lead author, he has published well over 100 major papers throughout his 25-year career in the most respected, peer-reviewed, American medical journals. His career goal is to help achieve consistently superior patient outcomes in hand and nerve surgery.

Dr. Wolfe is frequently called upon to operate on highly complex and problematic conditions. He treats upper extremity problems that are incapacitating to the fingers, hands, wrists, elbows and the plexus in patients of all ages. World-class musicians and professional athletes have had their mobility restored through the care of Dr. Wolfe, who has consistently been rated as one of New York’s best doctors for over twenty years.


Center for Care and Discovery/Rafael Viñoly

Basic, clinical and translational research in orthopaedic science is an integrated part of our graduate medical education. Thus, in addition to the clinical and educational commitments, our faculty is actively involved in a broad range of research on bone and musculoskeletal diseases, which have been highlighted in the following areas.

The Orthopaedic Biomedical Imaging Institute As the director of The Orthopaedic Biomedical Imaging Institute, Dr. John Martell continues to develop collaborations with implant manufacturers and individual investigators. Dr. Martell’s research has been funded by grants from The Harris Foundation, NIH/NIAMS, Smith & Nephew, Stryker, Biomet and Zimmer. The Orthopaedic Biomedical Imaging Institute is known nationally

and internationally as a resource for the design and implementation of polyethylene wear studies and has been involved in the analysis of cross-linked polyethylene.

Dr. Martell accommodates requests from academic joint replacement programs to observe the techniques that are used in processing and analyzing films. The Orthopaedic Biomedical Imaging Institute has become a world-class resource for the analysis of polyethylene wear in total hip arthroplasty. The Institute has furthered its commitment to orthopaedic research by sponsoring the Geraldine Mary Maley Research Award, an annual research award for projects developed by faculty/residents in the Department of Orthopaedic Surgery and Rehabilitation Medicine at the University of Chicago.

Dr. Martell has recently developed several important and innovative biomedical imaging tools. First, mechanical analysis software allows investigators to estimate the joint reaction force and stress in normal and prosthetic hips. Using the joint stress as a predictor variable in combination with patient activity indicators (speed of walking, UCLA score or pedometer data), he has developed a multiple logistic regression model that can identify patients with total hips that are at risk for high wear and osteolysis in the long term. This model is now 87 percent accurate and has no false negatives in a series of 300 hips with minimum eight year follow-up.

Dr. Martell has partnered with Dr. Christian Heisel at Heidelberg University in Germany to investigate the biomechanical factors predisposing women to hip arthritis. Preliminary results show a significantly higher contact stress in the native hips of women patients compared to men. Factors that play a role in this finding are: a wider female pelvis, causing the body weight momentum to be larger, smaller femoral offset in women and smaller femoral heads, which increases contact stress. Dr. Martell is also working with Dr. William Walters from Australia to investigate the biomechanics of ceramic total hip arthroplasty to identify factors leading to squeaking in ceramic total hip arthroplasty.

Our mission is to inspire colleagues to create new knowledge, to communicate knowledge through medical education, and to provide superior and compassionate health care in a collegial atmosphere.

Research Activities


As an extension of the mechanical analysis software, Dr. Martell developed preoperative templating software which allows the surgeon to template pre-operatively using knowledge of the impact choices for stress and wear performance of the implanted prosthetic hip joint. This identifies reconstructive options that put the patient at risk for high wear, and assists the surgeon in choosing prosthetic position and designs to minimize this significant complication. Another modification of the mechanical analysis software allows the estimation of shear forces in the capital femoral epiphysis that predispose to slipped capital femoral epiphysis in children. These shear forces, in conjunction with the skeletal age of the pelvis, have a predictive value of 90 percent for the risk of SCFE.

Dr Martell has partnered with Argonne National Laboratories, and has received $20,000 through the BIASE initiative to fund a pilot project to develop a visual-tactile feedback system for use in minimally invasive robotic surgery. Preliminary testing of this video processing image analysis system has shown the capability to detect real-time suture strain rates that are 100 times lower than the strain to failure. Work now continues on perfecting the video processing, including and on measuring strains in sutures from archived clinical videos.Tendon and Ligament Injury RepairDrs. Daniel Mass, Sherwin Ho, Lewis L. Shi, and Jovito Angeles, in collaboration with Dr. T.-C. He, are investigating possible gene therapy approaches to enhancing tendon and ligament healing using recombinant adenoviral vectors expressing BMPs

and/or other biological factors. They have demonstrated that BMP-13 can significantly improve the biomechanical properties of lacerated flexor tendons in a rabbit model while BMP-14 is also shown to significantly improve the biomechanical properties of lacerated flexor tendons in a rabbit model. Based on time-course studies of gene expression after tendon injury, they identified several factors that may work alongside BMP-13 and BMP-14 at different stages of tendon healing. Dr. Shi is also investigating biological factors that may improve the healing of rotator cuff injuries.

Shoulder ResearchDr. Lewis L Shi is leading an active should research program, with multiple clinical and translational projects. In collaboration with Dr. T.-C. He, he is investigating biological factors that may improve the healing of rotator cuff injuries. He has an on-going IRB approved study examining patients undergoing shoulder arthroscopy, correlating the growth factors of the subacromial milieu to the condition and chronicity of cuff tears. The ultimate goal is to identify potential pharmacologic treatment to augment rotator cuff repairs in human patients.

Dr. Shi is leading several multi-centered shoulder clinical outcome studies. These are prospective randomized control trials studying the optimal methods of treatment for rotator cuff tears, biceps tendonitis, and labrum tears. He is also conducting several studies using the Marketscan, a national insurance claims database, to examine the patterns, complications, and the cost of shoulder surgery in the last decade.

Dr. Shi continues his collaborations with the several prestigious orthopaedic hospitals in China. In this past year he has co-authored several papers in PLoS One and Genetic Testing and Molecular Biomarkers on ankylosing spondylitis with investigators in 301 Military Hospital in Beijing. Additionally, his work on vascularized fibula graft with the Shanghai Sixth People’s Hospital has generated multiple podium presenta-tions at international conferences.

Foot and Ankle ResearchDr. Brian Toolan has focused on several clinical projects related to foot and ankle disorders. In the past, he studied the effects of acquired flatfoot deformity on tibiotalar contact pressures in a cadaveric model, and performed a follow-up study on the effects of UCBL orthotics and surgical techniques on joint contact characteristics in the same model. Both of these studies were published in Foot & Ankle International. He recently published a retrospective study in Foot & Ankle International comparing lateral column lengthening to a medial calcaneal osteotomy in the treatment of adult acquired flatfoot. He is currently conducted a similar comparison in a prospective clinical study that is currently ongoing. Lastly, he is retrospectively evaluating the results of a new procedure for salvaging malunited ankle fractures with chronic syndesmotic disruption using a distal fibular arthrodesis and soft tissue reconstructions.

In addition to his interests on flatfoot deformity, Dr. Toolan is interested developing a better understanding of ruptured Achilles


tendon healing process and potentially developing new means in treating patients with this injury. Achilles tendon ruptures are common injuries and both surgical and non-surgical treatments have frequent complications such as wound dehiscence and re-rupture. Therefore, Dr. Toolan, in collaboration with Dr. He, has used a rat model to investigate the effects of BMP-14 and other factors on Achilles tendon healing, finding a 70 percent increase in tensile strength at two weeks.

Articular Cartilage Regeneration and Anterior Cruciate Ligament RepairThe Sports Medicine Service, consisting of Drs. Sherwin Ho, Martin Leland, and Richard Kang, has been intensively investigating the biological processes in articular cartilage regeneration, anterior cruciate ligament repair, and rotator cuff tear repair. Articular cartilage has little intrinsic capacity to repair itself after injury, prompting many researchers to explore new methods to facilitate and augment cartilage regeneration. Currently, a variety of approaches have been developed, including chondroplasty, osteochondral transfer procedures (autologous and allograft procedure), microfracture and autologous cultured chondrocyte implant (ACCI). Each of these techniques is useful when utilized in appropriate conditions; however, a significant cohort of patients still fail to achieve good to excellent results even when surgical, pharmacologic and physical therapy are optimal by current standards. These clinical failures suggest that new biologic strategies, including gene therapy, may be a

useful adjunct to current treatments to further improve clinical outcome.

Drs. Ho, Leland and Kang are investigating the possible use of Sox9 and/or other biofactors to facilitate articular cartilage regeneration. Previously, Drs. T.-C. He and Rex Haydon successfully transduced intervertebral disc cells with Sox9, a transcription factor necessary for chondrogenesis and Type II collagen synthesis. They observed that human degenerative intervertebral disc cells transfected with Sox9 genes led to chondrocyte proliferation with increased production of Type II collagen (Spine 28: 755-763). Currently, Drs. Ho, Leland and Kang are investigating whether exogenous expression of Sox9 in articular cartilage cells or in mesenchymal stem cells will augment articular cartilage repair in a rabbit model. This research has included experiments comparing different man-made scaffolds that can be used to implant these genetically altered cartilage cells back into the host knee defects (J Biomed Mater Res A. 2013, 101(12): 3542–50). In addition, Drs. Ho, Leland, and Kang are investigating the potential use of BMP-13 and/or PRP (platelet-rich plasma) for rotator cuff tears using a rat model, as possible treatment options for patellar tendonitis, and a unique approach to rehabilitation following ACL reconstruction surgery.

The Sports Medicine Service has developed a surgical skills laboratory for medical students, residents and fellows to develop their arthroscopic and minimally-invasive surgical skills using a state-of-the-art virtual

reality arthroscopy simulator (MIST) developed by the Spanish aerospace company GMV (based in Madrid), as well as with cadavers. Such virtual and simulated surgery represents important new educational tools for training medical students, residents and fellows.

Dr. Reider is also engaged in an ongoing clinical prospective cohort study of possible links between knee proprioception in collegiate soccer and basketball players. Dr. Reider’s previous research has shown that athletes with ACL tears have abnormal proprioception of the knee that returns to normal after ACL reconstruction. The current project prospectively measures proprioception in a large number of healthy athletes to see if those who go on to tear their ACL’s have deficient proprioception prior to the injury. Dr. Reider has also completed a study of degenerative meniscal tears, which has been submitted for publication.


Osteosarcoma is a “Differentiation Disease”Under the direction of T.-C. He, M.D., Ph.D., Rex C. Haydon, M.D., Ph.D., and Hue H. Luu, M.D. the Molecular Oncology Laboratory has focused on the molecular aspects of bone and soft tissue tumors through collaborations with Drs. Michael A. Simon and Anthony Montag. They previously found that β-catenin signaling is activated in approximately 70 percent of human osteosarcoma samples, suggesting that deregulation of β-catenin may play a role in the development of human osteosarcoma. They examined the expression of the S100A6 in human osteosarcoma, and found that approximately 84 percent of the analyzed osteosarcoma specimens stained positive for S100A6. Thus, their findings suggest that S100A6 may be associated with the pathogenesis of osteosarcoma (International Journal of Cancer 102:338–342; Clin Orthop Relat Res 466: 2060–2070, and Cancer Letters 229: 135–148). More recently, Drs. Haydon, Luu and He found that, while in mesenchymal stem cells BMP-2 and BMP-9 induce osteogenic differentiation, osteosarcoma cells are refractory to BMP-induced bone formation with increased increased cell proliferation, suggesting that blocks to normal BMP-induced differentiation must exist. Downstream targets of the osteogenic BMPs include several key inhibitors of differentiation that are commonly expressed in human tumors. They hypothesize that that osteosarcoma may represent a

“disease of differentiation,” possibly caused by the defects in the terminal differentiation pathway of pre-osteoblast and/or osteoblasts (Laboratory Investigation 88: 1264–1277; Clinical Orthopaedics and Related Research 466: 2114–2130; Clinical Orthopaedics and Related Research 454: 237–246; Clinical Cancer Research 16; 2235–2245, Clinical Cancer Research 8: 1288–1294). They are attempting to reconstruct osteosarcoma-like cells from mesenchymal stem cells by disrupting the differentiation pathway and enhancing proliferation activity of the progenitors. Consistent with “disease of differentiation” model, generic differentiation agents, such as PPARg agonists and retinoic acids were shown to promote osteogenic differentiation and inhibit osteosarcoma tumor growth (Clinical Cancer Research 16; 2235–2245; PPAR Research 2010: 956427; PLoS ONE 5: e11917).

Drs. He, Haydon and Luu developed a novel orthotopic tumor model for osteosarcoma progression and pulmonary metastasis (Clin Exp Metastasis 22: 319–329). This model highlights different stages of primary bone tumor progression and the eventual development of pulmonary metastasis. They are currently using this model to investigate several genes for their role in controlling bone tumorigenesis and metastasis. Meanwhile, they have conducted gene profiling analysis of gene expression patterns between non-metastatic and highly metastatic osteosarcoma cells, and have identified several promising candidate

genes associated with pulmonary metastasis of osteosarcoma. Further functional characterization of these target genes is currently ongoing (Clinical & Experimental Metastasis 26:599–610). They have recently reported that insulin-like growth factor binding protein 5 (IGFBP5) suppresses tumor growth and metastasis of human osteosarcoma (Oncogene 30(37):3907-17).

Effects of natural products and herbal extracts on cancer cells and stem cell differentiation: As natural products and herbs represent a great deal of resources for drug discovery, we have collaborated with Dr. Chun-Su Yuan of the Tang Center for Herbal Medicine Research and investigated the effect of several herbal products, such as Berberine and ginseng extracts, on cancer growth and proliferation, as well as on stem cell differentiation. Dr. He was one of the PIs on a P01 grant from the NIH to study the role of herbal products in cancer (International Journal of Oncology 32: 975–983; Oncol Rep 22: 943–952; Biol Pharm Bull 32: 1552–1558; Cancer Lett 289: 62–70; Mol Pharmacol 79(2): 211–9).

Molecular Biology of Bone FormationIdentification of BMP-9 as the most osteogenic BMP in vitro and in vivo. Although several BMPs (mostly BMP-2 and BMP-7) have been shown to induce bone formation, it is unclear whether the ones currently used represent the most osteogenic BMPs. Through a comprehensive analysis of the 14 types of human BMPs, the He, Haydon, and Luu lab previously


demonstrated that BMP-2, BMP-6, and BMP-9 are the most potent osteogenic BMPs in osteoblastic progenitor cells in vitro, which was published in the Journal of Bone and Joint Surgery with over 500 citations so far. They have concluded several rounds of in vivo studies and found that BMP-2, BMP-6 and BMP-9 are the most potent osteogenic BMPs at inducing orthotopic bone formation in athymic mice (Gene Therapy 11: 1312–1320; J Orthop Res 25: 665–677; and Front Biosci 13: 2001–2021). Interestingly, they have also found that osteogenic BMPs can induce adipogenic differentiation of mesenchymal stem cells (Stem Cells and Development 18: 545–559). They have demonstrated that TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP-9-induced osteogenic signaling in mesenchymal stem cells (J Biol Chem. 285(38): 29588–98).

To identify potentially important mediators of BMP-induced osteo-genic signaling, Drs. He, Haydon and Luu determined the transcriptional differences between three osteogenic BMPs (i.e., BMP2, 6, and 9) and two inhibitory/non-osteogenic BMPs (i.e., BMP3 and 12). Through the microarray analysis in pre-osteoblast progenitor cells, they found that expression level of 203 genes (105 up-regulated and 98 down-regulated) was altered >2-fold upon osteogenic BMP stim-ulation. Gene ontology analysis revealed that osteogenic BMPs, but not inhibitory/non-osteogenic BMPs, activate genes involved in the prolif-eration of pre-osteoblast progenitor cells towards osteoblastic differen-

tiation, and simultaneously inhibit myoblast-specific gene expression. Their findings are consistent with the notion that osteogenesis and myo-genesis are two divergent processes (Journal of Cellular Biochemistry 90: 1149–1165). The Molecular Oncology Lab identified several potentially sig-naling mediators of BMP-induced os-teogenesis. Several such downstream targets are the Inhibitors of DNA bind-ing/Differentiation helix-loop-helix (a.k.a., Id proteins), Connective Tissue Growth Factor (a.k.a., CTGF), Hey1, and growth hormone. Their studies thus far have demonstrated that both Ids, CTGF, Hey1, and growth hormone play an important role in BMP-9 in-duced osteogenic signaling (Journal of Biological Chemistry 279: 32941–32949; Journal of Biological Chem-istry 279: 55958–55968; Journal of Biological Chemistry 284: 649–659; and J Bone Miner Res. 2012, 27(7): 1566–75).

Role of Wnt/β-catenin signaling in osteogenic differentiation of mesenchymal stem cells: The He, Haydon and Luu group previously demonstrated that Wnt/β-catenin signaling is de-regulated in over 70 percent of human osteosarcomas. He, Haydon, and Luu lab have demonstrated that normal Wnt/β-catenin signaling is required for BMP-9 signaling in MSCs (Journal of Cellular and Molecular Medicine 13: 2448–2464). They have completed a microarray analysis on the genes regulated by Wnt3A in mesenchymal stem cells, and found that CTGF is also highly regulated by Wnt. They have recently finished a study, in which they demonstrate that CTGF

is a mutual target of Wnt and BMP-9 and play an important role in regulating osteogenic differentiation (Journal of Biological Chemistry 279: 55958–55968; Molecular and Cellular Biology 26: 2955–2964. Furthermore, Drs. He, Haydon and Luu have recently investigated the potential synergistic effect of other factors on BMP-9-mediated osteogenic differentiation and bone formation. Such factors include retinoid receptors, IGFs, Wnts, growth hormone, HIF1a, and EGF (PLoS ONE 5: e11917, Journal of Bone and Mineral Research 25: 2447–59, Journal of Cellular and Molecular Medicine 13 (8B): 2448–2464; Journal of Bone and Mineral Research 27 (7): 1566–1575, Journal of Cell Science 126: 532–541; and Journal of Cellular and Molecular Medicine 17 (9): 1160–1172.


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Current Cancer Therapy Reviews 9:

55–77. (*co-corresponding authors)

Joseph D. Lamplot, Jiaqiang Qin,

Guoxin Nan, Jinhua Wang, Xing Liu,

Liangjun Yin, Justin Tomal, Ruidong Li,




Rose Rogers, Abdullah Pratt, Rex C

Haydon, Hue H. Luu, Jovito Angeles,


(2013) BMP9 Signaling in Stem Cell

Differentiation and Osteogenesis.

American Journal of Stem Cells 2 (1):

1–21 PMID: 23671813.

Maureen Beederman*, Joseph D.

Lamplot *, Guoxin Nan, Jinhua Wang,

Xing Liu, Liangjun Yin, Ruidong Li,




Rose Rogers, Abdullah Pratt, Rex C

Haydon, Hue H. Luu, Jovito Angeles,


(2013) BMP Signaling in Mesenchymal

Stem Cell Differentiation and Bone

Formation. Journal of Biomedical

Science and Engineering 6: 32–52.

(*These authors contributed equally

to the work)

Matthew R. Greives, Eric A. Odessey,

Darrel J. Waggoner, MD, Deana S.

Shenaq, Swaroop Aradhya, Allison

Mitchell, Neil Warshawsky,

Tong-Chuan He and Russell R. Reid

(2013) RUNX2 Quadruplication:

Additional Evidence Toward a New

Form of Syndromic Craniosynostosis.

Journal of Craniofacial Surgery 24(1):

126–129, PMID: 23348268.

Wang CZ, Li B, Wen XD, Zhang Z, Yu

C, Calway TD, He TC, Du W, Yuan

CS (2013) Paraptosis and NF-kap-

paB activation are associated with

protopanaxadiol-induced cancer

chemoprevention. BMC Complement

Altern Med. 13(1): 2. [Epub ahead of

print] PMID: 23281928.

Zhiyu Zhang, Guang-Jian Du,

Chong-Zhi Wang, Xiao-Dong Wen,

Tyler Calway, Zejuan Li, Tong-Chuan He, Wei Du, Marc Bissonnette, Mark

W. Musch, Eugene B. Chang, and

Chun-Su Yuan (2013) Compound K, a

ginsenoside metabolite, inhibits colon

cancer growth via multiple pathways

including ATM/p53-p21. International

Journal of Molecular Sciences 14(2):

2980–2995.

Ning Hu, Dianming Jiang, Enyi Huang,

Xing Liu, Ruidong Li, Xi Liang, Steph-

anie H Kim, Xiang Chen, Jian-Li Gao,

Hongyu Zhang, Wenwen Zhang, Yu-

Han Kong, Jiye Zhang, Jinhua Wang,

Wei Shui, Xiaoji Luo, Bo Liu, Jing Cui,

Mary Rose Rogers, Jikun Shen, Chen

Zhao, Ning Wang, Ningning Wu, Hue

H. Luu, Rex C. Haydon, Tong-Chuan He*

and Wei Huang* (2013): BMP9-reg-

ulated angiogenic signaling plays

an important role in the osteogenic

differentiation of mesenchymal stem

cells. Journal of Cell Science 126:

532–541, PMID: 23203800. (*co-cor-responding authors)

Wei Shui, Liangjun Yin, Jeffrey Luo,

Ruidong Li, Wenwen Zhang, Jiye

Zhang, Wei Huang, Ning Hu, Xi Liang,

Zhong-Liang Deng, Zhenming Hu,

Lewis Shi, Hue H. Luu, Rex C. Haydon,

Tong-Chuan He* and Sherwin Ho*

(2013): Characterization of Chondro-

cyte Scaffold Carriers for Cell-based

Gene Therapy in Articular Cartilage

Repair Journal of Biomedical Materials

Research: Part A 101(12): 3542-50;

PMID: 23629940. (*corresponding

authors)

Patrick J. Killela, Zachary J. Reit-

man,Yuchen Jiao, Chetan Bettegowd,

Nishant Agrawal, Luis A. Diaz Jr., Allan

H. Friedman, Henry Friedman, Gary

Gallia, Beppino C. Giovanella, Arthur P.

Grollman, Tong-Chuan He, Yiping He,

Ralph H. Hruban, George I. Jallo, Alan

K. Meeker, Fredrik Mertens, George

Netto, B. Ahmed Rasheed, Gregory

J. Riggins, Thomas Rosenquist, Mark

Schiffman, Ie-Ming Shih, Dan Theo-

dorescu, Michael S. Torbenson, Victor

E. Velculescu, Tian-Li Wang, Nicolas

Wentzensen, Laura D. Wood, Ming

Zhang, Roger E. McLendon, Darell

D. Bigner, Nicholas Papadopoulos,

Kenneth W. Kinzler, Bert Vogelstein,

and Hai Yan (2013) TERT promoter

mutations occur frequently in gliomas

and in a subset of tumors derived from

cells with low rates of self-renewal.

Proceedings of National Academy

of Sciences USA 2013 Mar 25. [Epub

ahead of print] PMID: 23530248.

Qi Wu, Qi Zhou, Que Zhu, Shunkang

Rong, Qi Wang, Rui Guoa, Chang-

ming Deng, Dichuan Liu, Gang Yang,

Yonghong Jiang, ZhiGang Wang, Han

Lei, Tong-Chuan He, ZhiBiao Wang

and Jing Huang (2013) Noninvasive

cardiac arrhythmia therapy using

High-Intensity Focused Ultrasound

(HIFU) ablation. International Journal

of Cardiology 2013 Feb 25. doi: pii:

S0167–5273 (13) 00295-7.10.1016/

j.ijcard.2013.01.235 [Epub ahead of


Qifeng Wang, Rui Guo, Shunkang

Rong, Gang Yang, Que Zhu, Yonghong

Jiang, Changming Deng, Dichuan Liu,

Qi Zhou, Qi Wu, Shunhe Wang, Jun

Qian, Qi Wang, Han Lei, Tong-Chuan He, Zhibiao Wang, and Jing Huang

(2013) Noninvasive renal sympa-

thetic denervation by extracorporeal

high-intensity focused ultrasound in

a preclinical canine model. Journal of

the American College of Cardiology

2013 Mar 26. doi:pii: S0735–1097(13)

01205–9. 10.1016/j.jacc.2013.02.050.

[Epub ahead of print] PMID: 23541964.

Yang Bi, Yun He, Jiayi Huang, Lei Xu,

Ni Tang, Tong-Chuan He, Tao Feng

(2013) Induced maturation of hepatic

progenitor cells in vitro. Brazilian

Journal of Medical and Biological

Research 46(7): 559–566.

Jian-Li Gao*, Gui-Yuan Lv, Bai-

Cheng He, Bing-Qiang Zhang,

Hongyu Zhang, Ning Wang, Chun-Zhi

Wang, Wei Du, Chong-Su Yuan, and

Tong-Chuan He* (2013) Ginseng

saponin metabolite 20(S)-protopa-

naxadiol inhibits tumor growth of by

targeting multiple cancer signaling

pathways. Oncology Reports 2013 Apr

30. doi: 10.3892/or.2013.2438. [Epub


Xiaojun Wang, Jing Cui, Bing-Qiang

Zhang, Hongyu Zhang, Yang Bi, Quan

Kang, Ning Wang, Ping Bie, Zhanyu

Yang, Huaizhi Wang, Xiangde Liu,

Rex C Haydon, Hue H Luu, Ni Tang,

Jiahong Dong* and Tong-Chuan He*

(2014) Decellularized liver scaffolds ef-

fectively support the proliferation and

differentiation of mouse fetal hepatic

progenitors. Journal of Biomedical

Materials Research: Part A 102(4):

1017–1025 PMID: 23625886.


Gaurav A. Luther, Joseph Lamplot,

Xiang Chen, Richard Rames, Eric R.

Wagner, Xing Liu, Akash Paresh, Enyi

Huang, Stephanie H. Kim, Jikun Shen, Rex C. Haydon, Tong-Chuan He and

Hue H. Luu (2013) IGFBP5 Domains

Exert Distinct Inhibitory Effects on

the Tumorigenicity and Metastasis of

Human Osteosarcoma. Cancer Letters

336(1): 222–230 PMID: 23665505.

Jian-Li Gao, Xing Ji, Tong-Chuan He,

Qi Zhang, Kai He, Yan Zhao, Su-Hong

Chen and Gui-Yuan Lv (2013) Tetran-

drine suppresses cancer angiogenesis

and metastasis in 4T1 tumor-bearing

mice. Evidence-Based Complemen-

tary and Alternative Medicine 2013:

265061 PMID: 23762115.

Zhiyu Zhang, Chong-Zhi Wang,

Guang-Jian Du, Lian-Wen Qi, Tyler

Calway, Tong-Chuan He, Wei Du

and Chun-Su Yuan (2013) Genistein

induces G2/M cell cycle arrest and

apoptosis via ATM/p53-dependent

pathway in human colon cancer cells. International Journal of Oncology

43(1): 289–296 PMID: 23686257.

Xing Liu, Jiaqiang Qin, Qing Luo, Yang

Bi, Gaohui Zhu, Wei Jiang, Stephanie

H Kim, Mi Li, Yuxi Su, Guoxin Nan, Jing

Cui, Wenwen Zhang, Ruidong Li, Xiang

Chen, Yuhan Kong, Jiye Zhang, Jinhua

Wang, Mary Rose Rogers, Hongyu

Zhang, Wei Shui, Chen Zhao, Ning

Wang, Xi Liang, Ningning Wu, Yunfeng

He, Hue H. Luu, Rex C. Haydon, Lewis

L. Shi, Tingyu Li, Tong-Chuan He* and

Ming Li* (2013) Crosstalk between EGF

and BMP9 signaling pathways regu-

lates the osteogenic differentiation of

mesenchymal stem cells. Journal of

Cellular and Molecular Medicine 2013

Jul 11. doi: 10.1111/jcmm.12097. [Epub


*corresponding authors


Yi Wang, Siqi Hong, Ming Li, Jiye

Zhang, Yang Bi, Yun He, Xing Liu,

Guoxin Nan, Yuxi Su, Gaohui Zhu,

Ruidong Li, Wenwen Zhang, Jinhua

Wang, Hongyu Zhang, Yuhan Kong,

Wei Shui, Ningning Wu, Yunfeng

He, Xian Chen, Hue H. Luu, Rex C.

Haydon, Lewis L. Shi, Tong-Chuan He* and Jiaqiang Qin* (2013) Noggin

Resistance Contributes to the Potent

Osteogenic Capability of BMP9 in

Mesenchymal Stem Cells. Journal of

Orthopaedic Research 2013 Jul 16.

doi: 10.1002/jor.22427. [Epub ahead of

print] PMID: 23861103. (*correspond-

ing authors)

Rui Wu, Liang Duan, Liwei Ye, Haiyang

Wang, Xia Yang, Yunyuan Zhang, Xian

Chen, Yan Zhang, Yaguang Weng,

Jingyong Luo, Min Tang, Qiong Shi,

Tong-Chuan He, Lan Zhou (2013)

S100A9 promotes the proliferation

and invasion of HepG2 hepatocellular

carcinoma cells via the activation of

the MAPK signaling pathway. Inter-

national Journal of Oncology 42(3):

1001–1010 PMID: 23354417.

Mi Li, Yuan Chen, Yang Bi, Wei Jiang,

Qing Luo, Yun He, Yuxi Su, Xing Liu,

Jing Cui, Wenwen Zhang, Ruidong Li,

Yuhan Kong, Jiye Zhang, Jinhua Wang,

Hongyu Zhang, Wei Shui, Ningning

Wu, Jing Zhu, Jie Tian, Qi-Jian Yi, Hue

H. Luu, Rex C. Haydon, Tong-Ch-uan He* and Gao-Hui Zhu* (2013)

Establishment and characterization

of the reversibly immortalized mouse

fetal heart progenitors. International

Journal of Medical Sciences 10(8):

1035–1046. (*corresponding authors)

He Y, Zhou JW, Xu L, Gong MJ, He TC,

Bi Y (2013) Comparison of prolifer-

ation and differentiation potential

between mouse primary hepatocytes

and embryonic hepatic progenitor

cells in vitro. Int J Mol Med. 2013

Jun 11. doi: 10.3892/ijmm.2013.1413.

[Epub ahead of print] PMID: 23756629.

Duan L, Wu R, Ye L, Wang H, Yang

X, Zhang Y, Chen X, Zuo G, Zhang Y,

Weng Y, Luo J, Tang M, Shi Q, He TC,

Zhou L (2013) S100A8 and S100A9 are

associated with colorectal carcino-

ma progression and contribute to

colorectal carcinoma cell survival

and migration via Wnt/b-catenin

pathway. PLoS One 8(4):e62092. doi:

10.1371/journal.pone.0062092 PMID:

23637971 PMCID: PMC3637369.

Shantaram Bharadwaj, Guihua Liu,

Yingai Shi, Rongpei Wu, Tong-Chuan He, Yuxin Fan, Xinyan Lu, Xiaobo

Zhou, Hong Liu, Jan Rohozinski,

Anthony Atala and Yuanyuan Zhang

(2013) Multi-potential Differentiation

of Human Urine-derived Stem Cells:

Potential Applications for Cell Based

Therapy. Stem Cells 31(9): 1840–1856,

PMID: 23666768.

Ning Hu, Changdong Wang, Xi Liang,

Liangjun Yin, Xiaoji Luo, Bo Liu,

Hongyu Zhang, Wei Shui, Guoxin Nan,

Ning Wang, Ningning Wu, Xian Chen,

Yunfeng He, Sheng Wen, Fang Deng,

Hongmei Zhang, Zhan Liao, Hue H.

Luu, Rex C. Haydon, Tong-Chuan He, and Wei Huang (2013) Inhibition

of Histone Deacetylases Potentiates

BMP9-Induced Osteogenic Signaling

in Mouse Mesenchymal Stem Cells.

Cellular Physiology and Biochemistry

32(2): 486–498.

Jiye Zhang, Yaguang Weng, Xing Liu,

Jinhua Wang, Wenwen Zhang, Steph-

anie H Kim, Hongyu Zhang, Ruidong

Li, Yuhan Kong, Xiang Chen, Wei Shui,

Ning Wang, Chen Zhao, Ningning Wu,

Yunfeng He, Guoxin Nan, Xian Chen,

Sheng Wen, Hongmei Zhang, Fang

Deng, Lihua Wan, Hue H. Luu, Rex C.

Haydon, Lewis L. Shi, Tong-Chuan He* and Qiong Shi* (2013) Endoplas-

mic reticulum (ER) stress inducible

factor cysteine-rich with EGF-like

domains 2 (Creld2) is an important

mediator of BMP9-regulated osteo-genic differentiation of mesenchymal

stem cells. PLoS ONE 8(9): e73086.

doi:10.1371/journal.pone.0073086. (*corresponding authors)

Yuhan Kong, Hongyu Zhang, Xian

Chen, Wenwen Zhang, Chen Zhao,

Ning Wang, Ningning Wu, Yunfeng

He, Guoxin Nan, Hongmei Zhang,

Sheng Wen, Fang Deng, Zhan Liao, Di

Wu, Junhui Zhang, Xinyue Qin, Rex

C. Haydon, Hue H. Luu, Tong-Chuan He*, and Lan Zhou (2013) Destabi-

lization of Heterologous Proteins

Mediated by the GSK3b Phosphoryla-

tion Domain of the b-Catenin Protein.

Cellular Physiology and Biochemistry

32(5): 1187–1199, PMID: 24335169.

(*corresponding author)

Xian Chen, Gaurav Luther, Wenwen

Zhang, Guoxin Nan, Eric R. Wagner,

Zhan Liao, Ningning Wu, Hongmei

Zhang, Ning Wang, Sheng Wen, Yun-

feng He, Fang Deng, Junhui Zhang, Di

Wu, Bosi Zhang, Rex C. Haydon, Lan

Zhou, Hue H. Luu, and Tong-Chuan He (2013) The E-F hand calcium-bind-

ing protein S100A4 regulates the

proliferation, survival and differenti-

ation potential of human osteosar-

coma cells. Cellular Physiology and

Biochemistry 32: 1083–1096, PMID:

24217649.




Xian Chen, Sheng Wen, Yunfeng He,

Fang Deng, Junhui Zhang, Hue H.

Luu, Lewis L Shi, Zhenming Hu, Rex C.

Haydon, James Mok, and Tong-Ch-uan He (2013) Characterization of




Materials Research: Part A [in press]

PMID: 24133046 [PubMed—as

supplied by publisher].

Wenwen Zhang, Hongyu Zhang, Ning

Wang, Chen Zhao, Hongmei Zhang,

Fang Deng, Ningning Wu, Yunfeng

He, Xian Chen, Junhui Zhang, Sheng

Wen, Zhan Liao, Qian Zhang, Zhonglin

Zhang, Wei Liu, Zhengjian Yan, Hue

H. Luu, Rex C. Haydon, Lan Zhou, and

Tong-Chuan He (2013) Modulation of

b-Catenin Signaling by the Inhibitors

of MAP Kinase, Tyrosine Kinase, and

PI3-Kinase Pathways. International

Journal of Medical Sciences 10(13):

1888–1898 PMID: 24324366.

Yanhong Gao*, Enyi Huang, Hongmei

Zhang, Jinhua Wang, Ningning Wu,

Xian Chen, Ning Wang, Sheng Wen,

Guoxin Nan, Fang Deng, Zhan Liao,

Di Wu, Bosi Zhang, Junhui Zhang, Rex

C. Haydon, Hue H. Luu, Lewis L Shi,

and Tong-Chuan He* (2013) Crosstalk

between Wnt/b-Catenin and Estrogen

Receptor Signaling Synergistically

Promotes Osteogenic Differentiation

of Mesenchymal Progenitor Cells.

PLoS ONE 8(12): e82436. doi:10.1371/

journal.pone.0082436. (*correspond-

ing authors)

Wen XD, Wang CZ, Yu C, Zhao L,

Zhang Z, Matin A, Wang Y, Li P, Xiao

SY, Du W, He TC, Yuan CS (2013)

Panax notoginseng Attenuates Exper-

imental Colitis in the Azoxymethane/

Dextran Sulfate Sodium Mouse Model.

Phytother Res. 2013 Oct 21. doi:

10.1002/ptr.5066. [Epub ahead of


Yueliang Liu, Wenjuan Wang, Jing Xu,

Li Li, Qian Dong, Qiong Shi, Guowei

Zuo, Lan Zhou, Yaguang Weng, Min

Tang, Tong-Chuan He, Jinyong Luo

(2013) Dihydroartemisinin inhibits tu-

mor growth of human osteosarcoma

cells by suppressing Wnt/b-catenin signaling. Oncology Reports 30(4):

1723–1730 PMID: 23917613.

Christine G. Joseph, Heejung Hwang,

Yuchen Jiao, Laura D. Wood, Isaac

Kinde, Jian Wu, Nils Mandahl, Jinyong

Luo, Ralph H. Hruban, Luis A. Diaz

Jr., Tong-Chuan He, Bert Vogelstein,

Kenneth W. Kinzler, Fredrik Mertens,

Nickolas Papadopoulos (2014) Exomic

analysis of myxoid liposarcomas, sy-

novial sarcomas, and osteosarcomas.

Genes Chromosomes & Cancer. 53(1):

15–24. PMID: 24190505.

Chen Zhao, Ningning Wu, Fang

Deng, Hongmei Zhang, Ning Wang,

Wenwen Zhang, Xian Chen, Sheng

Wen, Junhui Zhang, Liangjun Yin,

Zhan Liao, Zhonglin Zhang, Qian

Zhang, Zhengjian Yan, Wei Liu, Di Wu,

Jixing Ye, Youlin Deng, Guolin Zhou,

Hue H. Luu, Rex C. Haydon, Weike

Si*, and Tong-Chuan He* (2014)

Adenovirus-Mediated Gene Transfer

in Mesenchymal Stem Cells Can be

Significantly Enhanced by the Cationic

Polymer Polybrene. PLOS ONE 9(3):

e92908. PMID: 24658746. (*corre-

sponding authors)

Jinhua Wang, Hongmei Zhang, Wen-

wen Zhang, Enyi Huang, Ning Wang,

Ningning Wu, Sheng Wen, Xian Chen,

Zhan Liao, Fang Deng, Liangjun Yin,

Junhui Zhang, Qian Zhang, Zhengjian

Yan, Wei Liu, Zhonglin Zhang, Jixing

Ye Youlin Deng, Hue H. Luu, Rex C.

Publications

Orthopaedic Surgery & Rehabilitation Medicine28

Haydon, Tong-Chuan He* and Feng

Deng* (2014) BMP9 Effectively Induc-

es Osteo/Odontoblastic Differentia-

tion of the Reversibly Immortalized

Stem Cells of Dental Apical Papilla

(SCAPs). Stem Cells and Development

23(12): 1405–1416, PMID: 24517722.


Ning Wang, Hongyu Zhang, Bing-

Qiang Zhang, Wei Liu, Zhonglin

Zhang, Min Qiao, Hongmei Zhang,

Fang Deng, Ningning Wu, Xian Chen,

Sheng Wen, Junhui Zhang, Zhan Liao,

Qian Zhang, Zhengjian Yan, Liangjun

Yin, Jixing Ye, Youlin Deng, Hue H.

Luu, Rex C. Haydon, Houjie Liang*,

and Tong-Chuan He* (2014) Adeno-

virus-Mediated Efficient Gene Transfer

into Cultured Three-Dimensional

Organoids. PLOS ONE 9(4):e93608,

PMID: 24695466. (*corresponding

authors)

Ruidong Li, Wenwen Zhang, Jing Cui,

Wei Shui, Liangjun Yin, Yang Wang,

Hongyu Zhang, Ning Wang, Ningning

Wu, Guoxin Nan, Xian Chen, Sheng

Wen, Fang Deng, Hongmei Zhang,

Guolin Zhou, Zhan Liao, Junhui

Zhang, Qian Zhang, Zhengjian Yan,

Wei Liu, Zhonglin Zhang, Jixing

Ye, Youlin Den, Hue H. Luu, Rex

C. Haydon, Tong-Chuan He* and

Zhong-Liang Deng* (2014) Targeting

BMP9-Promoted Human Osteosarco-

ma Growth by Inactivation of Notch

Signaling. Current Cancer Drug Tar-

gets 14: 274–285, PMID: 24605944.

(*corresponding authors)

Sheng Wen, Hongmei Zhang, Yasha Li,

Ning Wang, Wenwen Zhang, Ke Yang,

Ningning Wu, Xian Chen, Fang Deng,

Zhan Liao, Junhui Zhang, Qian Zhang,

Zhengjian Yan, Wei Liu, Zhonglin

Zhang, Jixing Ye, Youlin Deng, Guolin

Zhou, Hue H. Luu, Rex C. Haydon,

Lewis L. Shi, Tong-Chuan He*, and

Guanghui Wei* (2014) Characteri-

zation of Constitutive Promoters for

piggyBac Transposon-mediated Stable

Transgene Expression in Mesenchymal

Stem Cells (MSCs). PLOS ONE 9(4):

e94397. PMID: 24714676; PMCID:

PMC3979777. (*corresponding authors)

Wei Ren, Xiaoxiao Sun, Ke Wang,

Honglei Feng, Yuehong Liu, Chang Fei,

Shaoheng Wan, Wei Wang, Jinyong

Luo, Qiong Shi, Min Tang, Guowei

Zuo, Yaguang Weng, Tong-Chuan He,

Yan Zhang (2014) BMP9 inhibits the

bone metastasis of breast cancer cells

by downregulating CCN2 (connective

tissue growth factor, CTGF) expres-

sion. Molecular Biology Reports 41(3):

1373–1383, PMID: 24413988.

Jing Wang, Qiong Shi, Tai-xian Yuan,

Qi-lin Song, Yan Zhang, Qiang Wei,

Lan Zhou, Jinyong Luo, Guowei Zuo,

Min Tang, Tong-Chuan He, Yaguang

Weng (2014) Matrix metalloproteinase

9 (MMP-9) in osteosarcoma: Review

and meta-analysis. Clinica Chimica

Acta 433: 225–231, PMID: 24704305.

Ningning Wu, Hongmei Zhang, Fang

Deng, Ruidong Li, Wenwen Zhang,

Xian Chen, Sheng Wen, Ning Wang,

Junhui Zhang, Liangjun Yin, Zhan

Liao, Zhonglin Zhang, Qian Zhang,

Zhengjian Yan, Wei Liu, Di Wu, Jixing

Ye, Youlin Deng, Ke Yang, Hue H. Luu,

Rex C. Haydon, and Tong-Chuan He

(2014) Overexpression of Ad5 Precur-

sor Terminal Protein (pTP) Accelerates

Recombinant Adenovirus Packaging

and Amplification in HEK-293 Packag-

ing Cells. Gene Therapy 21: 629–637,

PMID: 24784448.

Joseph D. Lamplot*, Bo Liu*, Liangjun

Yin, Wenwen Zhang, Zhongliang

Wang, Gaurav Luther, Eric Wagner,

Ruidong Li, Guoxin Nan, Wei Shui,

Zhengjian Yan, Richard Rames, Fang

Deng, Hongmei Zhang, Zhan Liao,

Wei Liu, Junhui Zhang, Zhonglin

Zhang, Qian Zhang, Jixing Ye, Youlin

Deng, Min Qiao, Rex C. Haydon, Hue

H Luu, Jovito Angeles, Lewis L. Shi,

Tong-Chuan He#, and Sherwin H.

Ho# (2014) Reversibly Immortalized

Mouse Articular Chondrocytes Acquire

Long-Term Proliferative Capability while

Retaining Chondrogenic Phenotype.

Cell Transplantation 2014 May 2. [Epub

ahead of print]PMID: 24800751. (*equal

contributions; #corresponding authors)

Ning Wang#, Wenwen Zhang#, Jing

Cui, Hongmei Zhang, Xiang Chen,

Ruidong Li, Ningning Wu, Xian Chen,

Sheng Wen, Junhui Zhang, Liangjun

Yin, Fang Deng, Zhan Liao, Zhonglin

Zhang, Qian Zhang, Zhengjian Yan,Wei

Liu, Jixing Ye, Youlin Deng, Zhongliang

Wang, Min Qiao, Hue H. Luu, Rex C.

Haydon, Lewis L. Shi, Houjie Liang*,

and Tong-Chuan He* (2014) The

piggyBac Transposon-Mediated Ex-

pression of SV40 T Antigen Efficiently

Immortalizes Mouse Embryonic Fibro-

blasts (MEFs). PLOS ONE 9(5):e97316.

PMID: 24845466. (#equal contribu-

tions; *corresponding authors)

Lei Qiang, Baozhong Zhao, Mei

Ming, Ning Wang, Tong-Chuan He,

Seungmin Hwang, Andrew Thorburn,

Yu-Ying He (2014) Regulation of

cell proliferation and migration by

p62 through stabilization of Twist1.

Proceedings of the National Academy

of Sciences USA 2014 Jun 9. pii:

201322913. [Epub ahead of print]

PMID: 24927592.

Sherwin S.W. Ho, MD

Joseph D. Lamplot*, Bo Liu*, Liangjun

Yin, Wenwen Zhang, Zhongliang

Wang, Gaurav Luther, Eric Wagner,

Ruidong Li, Guoxin Nan, Wei Shui,

Zhengjian Yan, Richard Rames, Fang

Deng, Hongmei Zhang, Zhan Liao,

Wei Liu, Junhui Zhang, Zhonglin

Zhang, Qian Zhang, Jixing Ye, Youlin

Deng, Min Qiao, Rex C. Haydon, Hue

H Luu, Jovito Angeles, Lewis L. Shi,

Tong-Chuan He#, and Sherwin H. Ho# (2014) Reversibly Immortalized

Mouse Articular Chondrocytes Acquire

Long-Term Proliferative Capability

while Retaining Chondrogenic Pheno-

type. Cell Transplantation 2014 May 2.

[Epub ahead of print]PMID: 24800751.

(*equal contributions; #corresponding

authors)

Richard Kang, MD

Van Thiel GS, Harris JD, Kang RW,

Chahal J, Della Valle CJ, Bush-Joseph

C, Nho SJ. Age-Related Differences in

Radiographic Parameters for Femo-

roacetabular Impingement in Hip Ar-

throplasty Patients. Arthroscopy: The

Journal of Arthroscopic and Related

Surgery. 2013 Jul; 29(7): 1182–7.

Kang RW, Mahony GT, Cordasco FA.

Pectoralis Major Repair With Cortical

Button Technique.Arthroscopy Tech-

niques. 2014: e1–5.

Moran CJ, Fabricant PD, Kang RW,

Cordasco FA. Arthroscopic Double

Row Anterior Stabilization and Bankart

Repair for the “High-Risk” Athlete.

Arthroscopy Techniques 2014: e1–7.

Lamplot JD, Angeline M, Angeles J,

Beederman M, Wagner E, Rastegar

F, Scott B, Skjong C, Mass D, Leland

M, Haydon RC, Luu HH, He TC, Kang RW, Ho S, Shi LL. Distinct Effects of

Platelet-Rich Plasma and BMP13 on

Rotator Cuff Tendon Injury Healing

in a Rat Model. American Journal of

Sports Medicine. 2014. (Accepted for

publication).

Fabricant PD, Taylor SA, McCarthy

MM, Gausden E, Moran CJ, Kang RW,

Cordasco FA. Open and Arthroscopic

Shoulder Stabilization. Journal of

Bone and Joint Surgery. 2014 (Ac-

cepted for publication.)

J. Martin Leland, MDLubowitz JH, Provencher MT, Rossi

MJ, Leland JM. The Growth and

Success of Arthroscopy Techniques. Arthroscopy. 2014 Jun; 30(6): 653.

Jiang JJ, Leland JM. Analysis of Pitch-

ing Velocity in Major League Baseball

Players Before and After Ulnar Collat-

eral Ligament Reconstruction. Am J

Sports Med. 2014 Apr; 42(4): 880–5.

Hue Luu, MDLuther GA, Lamplot J, Chen X, Rames

R, Wagner, ER, Liu X, Parekh A, Huang

E, Kim SH, Shen J, Haydon RC, He TC,

and Luu HH. (2013) IGFBP5 domains

exert distinct inhibitory effects on tu-

morigenicity and metastasis of human

osteosarcoma. Cancer Letters 336(1)

222–230 PMID 23665505.

Luther GA, Lamplot J, Chen X, Rames

R, Wagner, ER, Liu X, Parekh A, Huang

E, Kim SH, Shen J, Haydon RC, He TC,

and Luu HH. (2013) IGFBP5 domains

exert distinct inhibitory effects on tu-

morigenicity and metastasis of human

osteosarcoma. Cancer Letters 336(1)

222–230 PMID 23665505.

Shui W, Yin L, Luo J, Li R, Zhang W,

Zhang J, Huang W, Hu N, Liang X,

Deng Z, Hu Z, Shi L, Luu HH, Haydon

RC, He TC and Ho S (2013): Charac-

terization of Chondrocyte Scaffold

Carriers for Cell-based Gene Therapy

in Articular Cartilage Repair Journal of

Biomedical Materials Research: Part A.

Journal of Bone and Mineral Research

101(12): 3542–50. PMID 2362994.

Li M, Chen Y, Bi Y, Jiang W, Luo Q,

He Y, Su Y, Liu X, Cui J, Zhang W, Li

R, Kong Y, Zhang J, Wang J, Zhang

H, Shui W, Wu N, Zhu J, Tian J, Yi QJ,

Luu HH, Haydon RC, He TC, Zhu GH

(2013) Establishment and characteri-

zation of the reversibly immortalized

fetal heart progenitors. International

Journal of Medical Science 20: 10(8)

1035–0146.


Liu X, Qin J, Luo Q, Bi Y, Zhu G, Jiang

W, Kim SH, Li M, Su Y, Nan G, Cui J,

Zhang W, Li R, Chen X, Kong Y, Zhang

J, Wang J, Rogers MR, Zhang H, Shui

W, Zhao C, Wang N, Liang X, Wu N, He

Y, Luu HH, Haydon RC, Shi LL, Li T, He

TC, and Li M (2013) Crosstalk between

EGF and BMP9 signaling pathways

regulates the osteogenic differentia-

tion of mesenchymal stem cells. Jour-

nal of Cellular and Molecular Medicine

17(9): 1160–72. PMID 23844832.

Wang Y, Hong S, Li M, Zhang J, Bi Y,

He Y, Liu X, Nan G, Su Y, Zhu G, Li R,

Zhang W, Wang J, Zhang H, Kong Y,

Shu Wi, Wu N, He Y, Chen X, Luu HH,

Haydon RC, Shi LL, He TC and Qin J

(2013) Noggin Resistance Contributes

to the Potent Osteogenic Capability

of BMP9 in Mesenchymal Stem Cells.

Journal of Orthopaedic Research

31(11): 1796–803. PMID 23861103.

Hu N, Wang C, Liang X, Yin L, Luo X,

Liu B, Zhang H, Shui W, Nan G, Wang

N, Wu N, Chen X, He Y, Wen S, Deng F,

Zhang H, Liao Z, Luu HH, Haydon RC,

He TC, Huang W. Inhibition of histone

deacetylases potentiates BMP9-in-

duced osteogenic signaling in mouse

mesenchymal stem cells. Cell Physiol

Biochem. 2013; 32(2): 486–98. PMID

23988723.

Zhang J, Weng y, Liu X, Wang J,

Zhang W, Kim SH, Zhang H, Li R, Kong

Y, Chen X, Shui W, Wang N, Zhao C,

Wu N, He Y, Nan G, Chen X, Wen S,

Zhang H, Deng F, Wan L, Luu HH,

Haydon RC, Shi LL, He TC and Shi Q

(2013) Endoplasmic reticulum (ER)

stress inducible factor cysteine-rich

with EGF-like domains 2 (Creld2) is

an important mediator of BMP9-reg-

ulated osteogenic differentiation of

mesenchymal stem cells. PLOS One

8(9): e73086. PMID 24019898.

Shui W, Zhang W, Yin L, Nan G, Liao Z,

Zhang H, Wang N, Wu N, Chen X, Wen

S, He Y, Deng F, Zhang J, Luu HH, Shi

LL, Hu Z, Haydon RC, Mok J, He TC.

(2013) J Biomed Mater Res A. 2013

Oct 16. doi: 10.1002/jbma.35006.

[Epub ahead of print]. PMID 24133046.

Chen X, Luther G, Zhang W, Nan G,

Wagner ER, Liao Z, Wu N, Zhang H,

Wang N, Wen S, He Y, Deng F, Zhang

J, Wu D, Zhang B, Haydon RC, Zhou

L, Luu HH, He TC (2013) The E-F

hand calcium-binding protein S100A4

regulates the proliferation, survival

and differentiation potential of human

osteosarcoma cells. Cellular Physiolo-

gy and Biochemistry 32(4): 1083–96.

PMID 24217649.

Zhang W, Zhang H, Wang N, Zhao C,

Zhang H, Deng F, Wu N, He Y, Chen

X, Zhang J, Wen S, Liao Z, Zhang

Q, Zhang Z, Liu W, Yan Z, Luu HH,

Haydon RC, Zhou L, He TC. (2013)

Modulation of β-Catenin Signaling by

the Inhibitors of MAP Kinase, Tyrosine

Kinase, and PI3-Kinase Pathways.

Int J Med Sci. 2013 Nov 25; 10(13):

1888–98. PMID 24324366.

Kong Y, Zhang H, Chen X, Zhang W,

Zhao C, Wang N, Wu N, He Y, Nan G,

Zhang H, Wen S, Deng F, Liao Z, Wu

D, Zhang J, Qin X, Haydon RC, Luu HH, He TC, Zhou L. Destabilization of

Heterologous Proteins Mediated by

the GSK3β Phosphorylation Domain

of the β-Catenin Protein. Cell Physiol

Biochem. 2013; 32(5): 1187–99. PMID

24335169.

Gao Y, Huang E, Zhang H, Wang J, Wu

N, Chen X, Wang N, Wen S, Nan G,

Deng F, Liao Z, Wu D, Zhang B, Zhang

J, Haydon RC, Luu HH, Shi LL, He TC.

(2013) Crosstalk between Wnt/β-Cat-

enin and Estrogen Receptor Signaling

Synergistically Promotes Osteogenic

Differentiation of Mesenchymal Pro-

genitor Cells. PLoS One. 2013 Dec 5;

8(12): e82436. PMID 24340027.

Wang J, Zhang H, Zhang W, Huang E,

Wang N, Wu N, Wen S, Chen X, Liao Z,

Deng F, Yin L, Zhang J, Zhang Q, Yan

Z, Liu W, Zhang Z, Ye J, Deng Y, Luu HH, Haydon RC, He TC, Deng F. Bone

morphogenetic protein-9 effectively

induces osteo/odontoblastic differen-

tiation of the reversibly immortalized

stem cells of dental apical papilla.

Stem Cells Dev. 2014 Jun 15; 23(12):

1405–16. PMID 24517722.

Li R, Zhang W, Cui J, Shui W, Yin L,

Wang Y, Zhang H, Wang N, Wu N, Nan

G, Chen X, Wen S, Deng F, Zhang H,

Zhou G, Liao Z, Zhang J, Zhang Q,

Yan Z, Liu W, Zhang Z, Ye J, Deng Y,

Luu HH, Haydon RC, He TC, Deng ZL.

Targeting BMP9-promoted human os-

teosarcoma growth by inactivation of

notch signaling. Current Cancer Drug

Targets. 2014 Mar; 14(3): 274–85.

PMID 24605944.

Zhao C, Wu N, Deng F, Zhang H, Wang

N, Zhang W, Chen X, Wen S, Zhang J,

Yin L, Liao Z, Zhang Z, Zhang Q, Yan

Z, Liu W, Wu D, Ye J, Deng Y, Zhou

G, Luu HH, Haydon RC, Si W, He TC.

Adenovirus-mediated gene transfer

in mesenchymal stem cells can be

significantly enhanced by the cationic

polymer polybrene. PLoS One. 2014

Mar 21; 9(3): e92908. PMID 24658746.

Wang N, Zhang H, Zhang BQ, Liu W,

Zhang Z, Qiao M, Zhang H, Deng F,

Wu N, Chen X, Wen S, Zhang J, Liao

Z, Zhang Q, Yan Z, Yin L, Ye J, Deng Y,

Luu HH, Haydon RC, Liang H, He TC.

Adenovirus-mediated efficient gene

transfer into cultured three-dimen-

sional organoids. PLoS One. 2014 Apr

2; 9(4): e93608. PMID 24695466.

Wen S, Zhang H, Li Y, Wang N, Zhang

W, Yang K, Wu N, Chen X, Deng F, Liao

Z, Zhang J, Zhang Q, Yan Z, Liu W,

Zhang Z, Ye J, Deng Y, Zhou G, Luu HH, Haydon RC, Shi LL, He TC, Wei G.

Characterization of constitutive pro-

moters for piggyBac transposon-me-

diated stable transgene expression in

mesenchymal stem cells (MSCs). PLoS

One. 2014 Apr 8; 9(4): e94397. PMID

24714676.

Lamplot JD, Liu B, Yin L, Zhang W,

Wang Z, Luther G, Wagner E, Li R,

Nan G, Shui W, Yan Z, Rames R, Deng

F, Zhang H, Liao Z, Liu W, Zhang J,

Zhang Z, Zhang Q, Ye J, Deng Y, Qiao

M, Haydon RC, Luu HH, Angeles J, Shi

LL, He TC, Ho SH. Reversibly Immor-

talized Mouse Articular Chondrocytes

Acquire Long-Term Proliferative Ca-

pability while Retaining Chondrogenic

Phenotype. Cell Transplant. 2014

May 2. [Epub ahead of print]. PMID

24800751.

Wang N, Zhang W, Cui J, Zhang H,

Chen X, Li R, Wu N, Chen X, Wen S,

Zhang J, Yin L, Deng F, Liao Z, Zhang

Z, Zhang Q, Yan Z, Liu W, Ye J, Deng Y,

Wang Z, Qiao M, Luu HH, Haydon RC,

Shi LL, Liang H, He TC. The piggyBac

transposon-mediated expression of

SV40 T antigen efficiently immor-

talizes mouse embryonic fibroblasts

(MEFs). PLoS One. 2014 May 20; 9(5):

e97316. PMID 24845466.

John Martell, MDZornoza, Lucas; Barr, Christopher BS;

Martell, John MD; Bragdon, Charles

PhD; Malchau, Henrik MD PhD; “Eval-

uation of New Radiographic Analysis

Software in Measuring Polyethylene

Wear in Total Knee Arthroplasty”; New

Orleans, LA March 2014.

James Mok, MDBrooks DE, Agochukwu UF, Arrington

ED, Mok JM: Psychological Distress

in the Active Duty Military Spine

Patient. Mil Med 2013 Oct; 178(10):

1059–1064.

Schoenfeld AJ, Mok JM, Cameron B,

Jackson KL, Serrano JA, Freedman BA:

Evaluation of Immediate Post-oper-

ative Complications and Outcomes

Among Military Personnel Treated

for Spinal Trauma in Afghanistan: A

Cohort-Control Study of 50 Cases. J

Spinal Disord Tech. 2014 Jul 3 [Epub

ahead of print].




Xian Chen, Sheng Wen, Yunfeng

He, Fang Deng, Junhui Zhang, Hue

H. Luu, Lewis L Shi, Zhenming Hu,

Rex C. Haydon, James Mok, and

Tong-Chuan He. Characterization of




Materials Research: Part A 2013 [in

press].

Galvin JW, Freedman BA, Schoenfeld

AJ, Cap AP, Mok JM. Morbidity of

early spine surgery in the multiply

injured patient. Arch Orthop Trauma

Surg. 2014 Jul [Epub ahead of print]

PubMed PMID: 25077784.

Publications

Orthopaedic Surgery & Rehabilitation Medicine30

Bruce Reider, MDReider, B; What’s App, Doc?; American

Journal of Sports Medicine, July 2013,

1487–1489

Reider, B; The Quest; American

Journal of Sports Medicine, August

2013, 1747–1749

Reider, B; Salvage Operation;

American Journal of Sports Medicine,

September 2013, 1995–1997

Reider, B; Apoptosis; American Jour-

nal of Sports Medicine, October 2013,

2237–2239

Reider, B; Headlines; American

Journal of Sports Medicine, December

2013, 2739–2741

Reider, B; Big D; American Journal of

Sports Medicine, January 2014, 25–26.

Reider, B; Quality of Life; American

Journal of Sports Medicine, February

2014, 275–277.

Reider, B; Moneyball; American Jour-

nal of Sports Medicine, March 2014,

533–535.

Reider, B; Round Hole, Square Peg;

American Journal of Sports Medicine,

April 2014, 789–792.

Reider, B; Recalculating…; American

Journal of Sports Medicine, May 2014,

1037–1038.

Lewis Shi, MDLiu X, Qin J, Luo Q, Bi Y, Zhu G, Jiang

W, Kim SH, Li M, Su Y, Nan G, Cui J,

Zhang W, Li R, Chen X, Kong Y, Zhang

J, Wang J, Rogers MR, Zhang H, Shui

W, Zhao C, Wang N, Liang X, Wu N, He

Y, Luu HH, Haydon RC, Shi LL, Li T, He

TC, Li M. Crosstalk between EGF and

BMP9 signaling pathways regulates

the osteogenic differentiation of

mesenchymal stem cells. Journal

of Cellular and Molecular Medicine.

J Cell Mol Med. 2013 Jul 11. doi:

10.1111/jcmm.12097.

Wang Y, Hong S, Li M, Zhang J, Bi Y,

He Y, Liu X, Nan G, Su Y, Zhu G, Li R,

Zhang W, Wang J, Zhang H, Kong Y,

Shui W, Wu N, He Y, Chen X, Luu HH,

Haydon RC, Shi LL, He TC and Qin J.

Noggin Resistance Contributes to the

Potent Osteogenic Capability of BMP9

in Mesenchymal Stem Cells. Journal

of Orthopaedic Research. 2013 Jul 16.

doi: 10.1002/jor.22427.

Sheehan SE, Gaviola GC, Sacks,

AC, Gordon RW, Shi LL, Smith SE.

Traumatic Shoulder Injuries: A Force

Mechanism Analysis - glenohumeral

dislocation and instability. American

Journal of Roentgenology. 2013

Aug; 201(2): 378–93. doi: 10.2214/

AJR.12.9986.

Sheehan SE, Gaviola GC, Sacks,

AC, Gordon RW, Shi LL, Smith SE.

Traumatic Shoulder Injuries: A Force

Mechanism Analysis of complex

injuries of the shoulder girdle and

proximal humerus. American Journal

of Roentgenology. 2013 Sep; 201(3):

W409–24. doi: 10.2214/AJR.12.9987.

Zhang J, Weng Y, Liu X, Wang J,

Zhang W, Kim SH, Zhang H, Li R,

Kong Y, Chen X, Shui W, Wang N,

Zhao C, Wu N, He Y, Nan G, Chen X,

Wen S, Zhang H, Deng F, Wan L, Luu

HH, Haydon RC, Shi LL, He TC* and

Shi Q*. Endoplasmic reticulum (ER)

stress inducible factor cysteine-rich

with EGF-like domains 2 (Creld2) is

an important mediator of BMP9-reg-

ulated osteogenic differentiation of

mesenchymal stem cells. PLOS One. 2013 8(9): e73086.

Shi LL, Boykin RE, Lin A, Warner

JJP. Association of suprascapular

neuropathy with rotator cuff tendon

tears and fatty degeneration. Journal

of Shoulder and Elbow Surgery. 2013.

2013 Sep 20. doi:pii: S1058–2746 (13)

00288–7. 10.1016/j.jse.2013.06.011.

Chai W, Lian Z, Chen C, Liu J, Shi LL,

Wang Y. JARID1A, JMY, and PTGER4

Polymorphisms Are Related to An-

kylosing Spondylitis in Chinese Han

Patients: A Case-Control Study. PLoS

One. 2013 Sep 19;8(9): e74794. doi:

10.1371/journal.pone.0074794.

Goel DP, Romanowski JR, Shi LL, Warner JJP. Scapulothoracic

Fusion: outcomes and compli-

cations. Journal of Shoulder and

Elbow Surgery. 2013 Nov 23. doi:pii:

S1058–2746(13)00436–9. 10.1016/j.

jse.2013.08.009.

Shui W, Zhang W, Yin L, Nan G, Liao Z,

Zhang H, Wang N, Wu N, Chen X, Wen

S, He Y, Deng F, Zhang J,. Luu HH, Shi LL, Hu Z, Haydon RC, Mok J, He TC.

Characterization of scaffold carriers

for BMP9-transduced osteoblastic

progenitor cells in bone regenera-

tion. Journal of Biomedical Materials

Research: Part A. 2013 Oct 16. doi:

10.1002/jbma.35006.

Gao Y, Huang E, Zhang H, Wang J, Wu

N, Chen X, Wang N, Wen S, Nan G,

Deng F, Liao Z, Wu D, Zhang B, Zhang

J, Haydon RC, Luu HH, Shi LL, He TC.

Crosstalk between Wnt/b-Catenin and

Estrogen Receptor Signaling Syner-

gistically Promotes Osteogenic Differ-

entiation of Mesenchymal Progenitor

Cells. PLoS One. 8(12): e82436.

Ek ET, Shi LL, Tompson JD, Freehill

MT, Warner JJ. Surgical treatment

of isolated type II superior labrum

anterior-posterior (SLAP) lesions:

repair versus biceps tenodesis. J.

Shoulder Elbow Surg. 2014 Jan 2. Pii:

S1058–2746(13)00514–4.

Leclere LE, Shi LL, Lin A, Yannopoulos

P, Higgins LD, Warner JJ. Complete

fatty infiltration of intact rotator cuffs

caused by suprascapular neuropathy.

Arthroscopy. 2014 Mar 13. pii: S0749-

8063(14)00074-7. doi: 10.1016/j.

arthro.2014.01.010.

Li X, Chai W, Ni M, Xu M, Lian Z, Shi LL, Bai Y, Wang Y. The effects of

gene polymorphisms in interleukin-4

and interleukin-6 on the suscep-

tibility of rheumatoid arthritis in a

Chinese population. Biomed Res Int.

2014;2014:264435.

Wen S, Zhang H, Li Y, Wang N, Zhang

W, Yang K, Wu N, Chen X, Deng F, Liao

Z, Zhang J, Zhang Q, Yan Z, Liu W,

Zhang Z, Ye J, Deng Y, Zhou G, Luu

HH, Haydon RC, Shi LL, He TC, Wei G.

Characterization of Constitutive Pro-

moters for piggyBac Transposon-me-

diated Stable Transgene Expression in

Mesenchymal Stem. PLoS ONE. 2014

Apr 8; 9(4): e94397.

Lamplot JD, Liu B, Yin L, Zhang W,

Wang Z, Luther G, Wagner, E, Li R,

Nan G, Shui W, Yan Z, Rames R, Deng

F, Zhang H, Liao Z, Liu W, Zhang J,

Zhang Z, Zhang Q, Ye J, Deng Y, Qiao

M, Haydon RC, Luu HH, Angeles J, Shi LL, He TC, Ho SH. Reversibly Immor-

talized Mouse Articular Chondrocytes

Acquire Long-Term Proliferative Ca-

pability while Retaining Chondrogenic

Phenotype. Cell Transplantation. 2014

May 2 Epub.

Jiang JJ, Toor AS, Shi LL, Koh JL. An

Analysis of Perioperative Compli-

cations in Patients following Total

Shoulder Arthroplasty and Reverse

Total Shoulder Arthroplasty. Journal of

Shoulder and Elbow. 2014. In press.

Wang N, Zhang W, Cui J, Zhang H,

Chen X, Wen S, Zhang J, Yin L, Deng

F, Liao Z, Zhang Z, Zhang Q, Yan Z, Liu

W, Ye J, Deng Y, Wang Z, Qiao M, Luu

HH, Haydon RC, Shi LL, Liang H, He

TC. The piggyBac Transposon-Me-

diated Expression of SV40 T Antigen

Efficiently Immortalizes Mouse Embry-

onic Fibroblasts (MEFs). PLoS One.

2014. In press.

Shi LL, Jiang JJ, Ek ET, Higgins LD.

Failure of the Lesser Tuberosity

Osteotomy Following Total Shoulder

Arthroplasty.” Journal of Shoulder and

Elbow Surgery. 2014. Accepted.

Lamplot JD, Angeline M, Angeles J,

Beederman M, Wagner E, Rastegar F,

Scott B, Skjong C, Mass D, Leland JM,

Haydon RC, Luu HH, He TC, Kang R,

Ho S, Shi LL. Distinct Effects of Plate-

let-Rich Plasma and BMP13 on Rotator

Cuff Tendon Injury Healing in a Rat

Model. American Journal of Sports

Medicine. 2014. Accepted.

Jiang J, Toor A, Shi LL, Koh JL.

Comparison Of Perioperative Com-

plications Following Total Elbow

Arthroplasty In Patients With And

Without Diabetes. Journal of Shoulder

and Elbow Surgery. 2014. Accepted.

Brian Toolan, MDStern PJ. Albanese S. Bostrom M. Day

CS. Frick SL. Hopkinson W. Hurwitz

S. Kenter K. Kirkpatrick JS. Marsh JL.

Murthi AM. Taitsman LA. Toolan BC.

Weber K. Wright RW. Derstine PL.

Edgar L. 2013. Orthopaedic Surgery

Milestones. Journal of Graduate Med

Educ. 5(1 Suppl 1) 36–58.

Malhotra G, Cameron J, Toolan BC.

2014 Diagnosing Chronic Diastasis of

the Syndesmosis: A Novel Measure-

ment on Computed Tomography.

Foot & Ankle Intl. 35(5) 483–8.


ABC FellowshipAfter the fellowship was firmly es-tablished in the 1950s, the principle emerged that North American fellows (from Canada and the U.S.) would travel to the UK and either South Africa or Australia/New Zealand on odd-numbered years, and fellows from the other countries would travel to North America on even-numbered years. Dr. Luu and the 2015 ABC Fellows will travel for five weeks next spring to the UK, Australia and New Zealand.

The ABC has always been, and remains today, one of the highest honors a young academic orthopaedist in North America can receive. We are very proud to have in our department three faculty who were previously honored as ABC Fellows: Michael Simon, MD (1983), Douglas R. Dirschl, MD (2001) and Rex Haydon, MD, PhD (2005)

Midway Crossings/Bauer Latoza and James Carpenter Design Associates

Congratulations to Hue H. Luu, MD awarded the American British Canadian (ABC) Traveling Fellowship from the American Orthopaedic Association

The ABC traveling fellowship was established shortly after the end of World War II as a means of enabling American and British orthopaedic surgeons to continue some of the sharing of ideas and techniques that they were able to institute during the war.


Sincerely, Douglas R. Dirschl, MDLowell T. Coggeshall Professor and ChairmanDepartment of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medicine and Biological Sciences

Alumni 2015

Graduating Residents(clockwise from top left) Kevin Hardt, MD—Kevin will be going to Northwestern

Memorial Hospital in Chicago, IL for an

Adult Reconstruction Fellowship under

Dr. David Manning, MD, program director.

Tyler Krummenacher, MD—Tyler will be

going to St. Luke’s Roosevelt Hospital in

New York, NY for a Hand Fellowship under

Dr. Steven Z. Glickel, MD, program direc-

tor. Deepak Reddy, MD—Deepak will be

going to Leatherman-Norton Healthcare in

Louisville, KY for a Spine Surgery Fellow-

ship under Dr. Mladen Djurasovic, MD,

program director. Christian Skjong, MD—

Christian will be going to Brown University

in Providence, RI for a Hand and Upper

Extremity Fellowship under Dr. Edward

Akelman, MD, program director.

Next year’s AAOS meeting is being held in Las Vegas. The University of Chicago’s Alumni Reception will be held at Bally’s Las Vegas/Las Vegas 1 on Friday, March 27, 2015 from 6:30 to 8:30 p.m. I look forward to seeing you at the Annual Meeting.


The Chicago Theological Seminary/Nagle Hartray

Jovito Angeles, MD

2014 Scaphoid Fractures and Nonunions.

Lecture, Doctors Demystify, University of

Chicago Medical Center

2014 Common Upper Extremity Fractures,

Lecture, 20th Annual Primary Care

Orthopaedics Course, Chicago, IL

Robert Bielski, MD

Changing Strategies in Pediatric Osteomy-

elitis. Visiting lecturer at Tachdjian Memorial

Lecture at Lurie Children’s Hospital, Chicago,

IL, October 24, 2013

Management of Pediatric Femur Fractures.

Grand Rounds at University of Toledo Medical

Center, Department of Orthopaedic Surgery,

February 1, 2014

Rex C. Haydon, MD, PhD

R Kulwin, T Balach, M Cote, T Peabody,

R Haydon. Factors Affecting Wound Healing In

Soft Tissue Sarcomas Of The Anterior Thigh.

Annual Meeting of the Musculoskeletal Tumor

Society. San Francisco, CA, October 4, 2013

Tong-Chuan He, MD, PhD

BMPs, Stem Cells and Regenerative

Medicine, the Grand Rounds, Department

of Orthopaedic Surgery and Rehabilitation

Medicine, The University of Chicago Medical

Center, Chicago, IL, March 5, 2014

Molecular pathogenesis of human osteosar-

coma. Invited speaker at 2014 International

Symposium on Frontiers in Life Sciences and

the 15th Anniversary of Epithelial Cell Biology

Research Center, jointly hosted by the

Chinese University of Hong Kong and

Chongqing Children’s Hospital, April 11–13,

2014

Stem Cell Biology and Tumorigenesis: Impli-

cations in Drug Development. Department of

Pharmacology & Toxicology, Indiana Univer-

sity School of Medicine, Indianapolis, IN, USA,

September 16, 2014

Ryan Hudson, MD

University of Chicago Primary Care Ortho-

paedics, Emerging Field of Ultrasound in

Orthopaedics, June 2014

University of Chicago Physical Therapy,

July 2014

Athletico Physical Therapy, May 2014

Novacare Physical Therapy-Musculoskeletal

Ultrasound Use in Sports Medicine, April 2014

Accelerated Physical Therapy, March 2014

Richard Kang, MD

Workup and Management of Femoroacetab-

ular Imingement. Physical Therapy Depart-

ment Educational Conference, University of

Chicago, Chicago, IL, November 7, 2013

Workup and Management of Femoroacetab-

ular Imingement. Orthopaedic Surgery De-

partment Educational Conference, University

of Chicago, Chicago, IL, November 27, 2013

Hip Physical Exam and Imaging. Orthopaedic

Surgery Department Educational Conference,

University of Chicago, Chicago, IL, January

17, 2014

Spectrum of Sports Medicine. Athletico Edu-

cational Conference, Matteson, IL, February

11, 2014

Articular Cartilage Repair and Regeneration.

Orthopaedic Surgery Department Grand

Rounds, University of Chicago, Chicago, IL,

February 19, 2014

Joint Preservation. Current Concepts in

Primary Care Sports Medicine, Chicago, IL,

February 27–29, 2014

Fabricant PD, Taylor SA, McCarthy MM,

Gausden E, Moran C, Kang RW, Cordasco

FA: Open and Arthroscopic Anterior Shoulder

Stabilization. American Academy of Ortho-

paedic Surgeons, New Orleans, LA, March

11–15, 2014

Ho S: Hip Arthroscopy for Non-Arthritic Hip

Problems. 20th Annual Primary Care Ortho-

paedics, Chicago, IL, June 11, 2014

J. Martin Leland, MD

Invited speaker, Arthroscopy Journal Editors

Meeting, Rome, Italy, October 2013

Invited speaker, Hip Arthroscopy Course,

Arthrocare Training Facility, Austin, TX,

November 2013

Invited speaker, Stryker Product Fair, AANA

Fall Meeting, Las Vegas, NV, November 2013



January 2014

Invited speaker, Arthrocare National Sales

Meeting, Austin, TX, February 2014

Invited speaker, Stryker Sports Medicine

Product Fair, AAOS Academy Meeting, New

Orleans, LA, March 2014



March 2014

Invited speaker, Accelerated Physical Therapy

Lecture Series, Chicago, IL, March 2014

Invited speaker, React Physical Therapy

Lecture Series, Chicago, IL, March 2014

Presentations


PresentationsJ. Martin Leland, MD (continued)

Invited speaker, Arthroscopy Journal Review-

ers Meeting, AANA Annual Meeting, Holly-

wood, FL, May 2014

Invited speaker, Frontrunners/Frontwalkers,

Chicago, IL, June 2014

Invited speaker, Arthroscopy Journal Board of

Trustees Meeting, Williamsburg, VA, July 2014

Invited speaker, American Journal of Ob-

stetrics and Gynecology Editor’s Meeting,

Chicago, IL, August 2014

Invited speaker, Arthroscopy Journal Editors

Meeting, Winston-Salem, NC, October 2014

Invited speaker, Focus Demonstration, AANA

Fall Meeting, Palm Desert, CA, Nov 2014

Hue Luu, MD

Invited speaker at an international conference

and demonstration TKA surgeries in Chongq-

ing, China in Oct 2014

John Martell, MD

Invited Moderator, Session #217 Implant

Wear, ORS Annual Meeting, San Antonio, TX,

January 2013

Daniel Mass, MD

Host & Instructor, Doctors Demystify—

The Wrist—The University of Chicago

Instructor, Management of Acute Hand Inju-

ries. 20th Annual Primary Care Orthopaedics

Course, The University of Chicago

James Mok, MD

Mok JM, Galvin J, Schoenfeld AJ, Freedman

BA: Early Spine Surgery in the Multiply Injured

Patient: Implications of Damage Control

Criteria. Podium Presentation. North Ameri-

can Spine Society 28th Annual Meeting, New

Orleans, Louisiana, October 9–12, 2013

Mok J, Kang H, Hansen E, Kandemir U, Rollins

M, Kim H: Relationship Of Intramuscular

Tissue Oxygenation And Muscle Viability In

A Compartment Syndrome Model. Poster

Presentation. 29th Annual Meeting of the

Orthopaedic Trauma Association, Phoenix,

Arizona, October 9–12, 2013

Mok JM: The MRI Says Stenosis: Does My

Patient Need Spine Surgery? Clinical Case

Conference. Section of General Medicine,

the University of Chicago, Chicago, Illinois,

October 21, 2013

Mok JM: Rheumatoid Neck and Degenerative

Back: Same Surgeries, Different Reasons.

Grand Rounds. Section of Rheumatology,

the University of Chicago, Chicago, Illinois,

October 22, 2013

Galvin J, Cap A, Schoenfeld A, Freedman B,

Mok JM: Early Spine Surgery in the Multi-

ply Injured Patient: Implications of Damage

Control Criteria. Podium Presentation. 118th

AMSUS Annual Meeting, Seattle, Washington,

November 3–8, 2013

Mok JM: The Surgeon’s Role in Management

of Spinal Cord Injury. Grand Rounds. Schwab

Rehabilitation Hospital, Chicago, Illinois,

November 22, 2013

Galvin J, Cap A, Schoenfeld A, Freedman B,

Mok JM: Early Spine Surgery in the Multiply

Injured Patient: Implications of Damage

Control Criteria. Podium Presentation.

Society of Military Orthopaedic Surgeons

55th Annual Meeting, Vail, Colorado, Decem-

ber 9–13, 2013

Liu X, Mok J, Kang H, Jin J, Boehme A,

Hansen E, Kandemir U, Rollins M, Kim HT:

Non-operative Treatment For Compartment

Syndrome With Phenylephrine and Dobuta-

mine. Poster Presentation. 60th Annual Meet-

ing of the Orthopaedic Research Society,

New Orleans, Louisiana, March 15–18, 2014

Mok JM, Hansen EN, Rollins M, Liu X, Kan-

demir U: Intramuscular Tissue Oxygenation

Correlates with Muscle Viability in Treated

and Untreated Compartment Syndrome.

Poster Presentation. 2014 American Ortho-

paedic Association/Canadian Orthopaedic

Association Combined Meeting, Montreal,

Quebec, June 18–21, 2014

Mok JM, Galvin J, Cap A, Schoenfeld A,

Freedman B: Early Spine Surgery in the Mul-

tiply Injured Patient: Implications of Damage

Control Criteria. Podium Presentation. 2014

American Orthopaedic Association/Canadian

Orthopaedic Association Combined Meeting,

Montreal, Quebec, June 18–21, 2014

Bruce Reider, MD

Patient Selection for Meniscus Repair. Indian

Arthroscopy Society International Congress,

Mumbai, India, September 20, 2013

Clinical and Radiographic Evaluation of

Patello-Femoral Instability. Indian Arthrosco-

py Society International Congress, Mumbai,

India, September 20, 2013

Microfracture: What Does the Evidence Tell

Us? Indian Arthroscopy Society International

Congress, Mumbai, India, September 21, 2013

Contentious Issues in Rotator Cuff Healing.

Indian Arthroscopy Society International

Congress, Mumbai, India, September 22, 2013

The ACL: Swings of the Pendulum. Australian

Orthopaedic Association, Darwin, NT, Austra-

lia, October 9, 2013


Getting Your Research Published. Australian

Orthopaedic Association, Darwin, NT Austra-


Is Laboratory Research Relevant to Clinical

Sports Medicine? Australian Knee Society,

Hamilton Island, Queensland, Australia,

October 12, 2013

Biologic Enhancement of Healing in Sports

Medicine: PRP and MSCs. Australian Knee

Society, Hamilton Island, Queensland, Austra-


How to Review a Scientific Paper. Australian

Knee Society, Hamilton Island, Queensland,

Australia, October 13, 2013

Reviewing a Paper: The Basics. International

Forum of Orthopaedic Sports Medicine

and Arthroscopic Surgery, Shanghai, China,

May 8, 2014

Contentious Issues in Rotator Cuff Healing.

International Forum of Orthopaedic Sports

Medicine and Arthroscopic Surgery, Shanghai,

China, May 8, 2014

PRP: The Case For and Against. International

Forum of Orthopaedic Sports Medicine and

Arthroscopic Surgery, Shanghai, China,

May 9, 2014

Reviewing a Paper: An Organized Approach.

Japanese Orthopaedic Association, Kobe,

Japan, May 24th, 2014

Tips for Performing a Systematic Review.

Argentine Arthroscopy Association, Buenos

Aires, June 5, 2014

Conservative Treatment of Rotator Cuff Tears.

Argentine Arthroscopy Association, Buenos

Aires, June 5, 2014

Getting Your Research Published. Argentine

Arthroscopy Association, Buenos Aires June

6, 2014

Lewis Shi, MD

Jiang J, Toor A, Shi LL, Koh JL. An Analysis of

Perioperative Outcomes in Patients Following

Total Shoulder Arthroplasty and Reverse Total

Shoulder Arthroplasty. ASES Closed meeting.

Las Vegas, NV, October 13, 2013

Toor A, Jiang J, Shi LL, Koh JL. A Compar-

ison Of Perioperative Outcomes Following

Total Elbow Arthroplasty In Patients With And

Without Diabetes. ASES Open meeting. AAOS

Specialty Day. New Orleans, LA, March 15,

2014

Jiang J, Toor A, Shi LL, Koh JL. A Compar-


Total Shoulder Arthroplasty In Patients With

And Without Diabetes. Podium presentation.

AAOS Annual meeting. New Orleans, LA,

March 13, 2014

Toor, AS, Lu M, Ek ET, Koh JL, Elhassan B,

Shi LL. Tendon transfer options around the

shoulder. Scientific exhibit. AAOS Annual

meeting, New Orleans, LA, March 2014

Toor A, Jiang J, Shi LL, Koh JL. A Compar-


Total Elbow Arthroplasty In Patients With And

Without Diabetes. Mid-America Orthopaedic

Association meeting. Poster. San Antonio, TX,

April 25, 2014

Jiang J, Toor A, Shi LL, Koh JL. A Comparison

Of Perioperative Outcomes Following Total

Shoulder Arthroplasty In Patients With And

Without Diabetes. Mid-America Orthopaedic

Association meeting. Podium presentation.

San Antonio, TX, April 25, 2014

Jiang J, Toor A, Shi LL, Koh JL. An Analysis of

Perioperative Outcomes in Patients Follow-

ing Total Shoulder Arthroplasty and Reverse

Total Shoulder Arthroplasty. Mid-America

Orthopaedic Association meeting. Podium

presentation. San Antonio, TX, April 25, 2014

Jiang J, Toor A, Shi LL, Koh JL. Patients un-

dergoing total elbow arthroplasty for elbow

fracture have higher perioperative compli-

cations: a nationwide analysis of 3797 cases.

ASES 2014 Closed meeting. Pinehurst, NC

Michael A. Simon, MD

Guest Speaker: “Is There Value of ACGME

Accreditation of Orthopaedic Surgery Sub-

specialties?” OREF/ORS 16th Annual Resident

Research Symposia, Northwestern University,

Chicago, IL, May 2014

Christopher Sullivan, MD

2014 Primary Care Orthopaedics Course,

Chicago, IL

Brian Toolan, MD

Stewart CM, Manning DW, Dirschl DR, Toolan

BC. Poster 6: Is it time for orthopaedic

surgery to have its own match: Results of a

multiyear, multicenter questionnaire data.

Presented at the 32nd Annual Meeting of

Mid-America Orthopaedic Association, San

Antonio, TX, April 24–27, 2014


Orthopaedic Residency Program

2014–2015

Erwin Bennett, MD Jimmy Jiang, MD Min Lu, MD Gautam Malhotra, MD Zachary Sisko, MD Aneet Toor, MDPGY5

Joseph Cohen, MD Ananth Eleswarapu, MD Oliver Schipper, MD Jason Somogyi, MD Cory Stewart, MDPGY4

Harpreet Bawa, MD Kyle Borque, MD Pranay Patel, MD Anna Cohen-Rosenblum, MD

Robert Stewart, MDPGY3

Kenneth Chakour, MD Srikanth Divi, MD Patrick Leung, MD Jonathan Twu, MD Noelle Whyte, MDPGY2

Blake Burkert, MD Ravand Khazai, MD David Landy, MD Michael Perrone, MD Paul Shultz, MDPGY1


In MemoriamDr. Enneking graduated from the University of Wisconsin medical school in 1949. He completed his internship at the University of Colorado in Denver in 1950 and began an orthopaedic residency at the University of Chicago that was soon interrupted by his service in the Korean War. He was initially stationed at the San Diego Naval hospital but then served two years in a forward MASH unit on the Korean Peninsula. Returning home from the war, Dr. Enneking returned to Chicago where he resumed his orthopaedic surgery residency. He trained under Dr. Howard Hatcher, then the leading figure in the field of orthopaedic oncology.

His first academic posting was to the University of Mississippi at the age of 29 where he was the chief of orthopaedic surgery for four years. In 1960, Dean William Harrell recruited Dr. Enneking to help establish the first medical school for the state of Florida. Along with Dr. Edward Woodward, another University of Chicago alumnus, they founded the Department of Surgery and the Division of Orthopaedic Surgery at the University of Florida (UF). Eventually the division be-came its own department and Dr. Enneking was its first chairman. He and the other founding members of the medical school faculty remained at UF for their entire careers. They gave the institution its unique blend of stature and loyalty that enabled it to prosper and evolve into the vibrant institution that it is today.

Over the course of his professional life, Dr. Enneking became a leader in the world of orthopaedic surgery and an international icon. His list of awards and honors is too numerous to list. Of note, he received the Kappa Delta award three times; this award is given to the leading researcher in U.S. orthopaedics. He was the president of multiple national and international societies including the American Orthopaedic Association and the International Society of Limb Salvage. He was the sole author of six books on the diagnosis and treatment of musculoskeletal tumors and disease. He also jointly published a voluminous number of articles and books.

A memorial service in his honor was held on July 26, 2014 at Queen of Peace Catholic Church in Gainesville, Florida.

William (Bill) Fisher Enneking, MD

William Fisher Enneking, MD, died peacefully on July 17, 2014. Bill, as he was always known, was born in Madison, Wisconsin on May 9, 1926. Bill grew up in Madison, with a life centered on sailing, competitive athletics and the outdoors. He graduated from the University of Wisconsin High School in 1943. On the advice of his father, he immediately enlisted in the armed services so he could choose his branch of service that was, of course, the Navy.


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