BT SPIRIT for at Gujarat on DBFOT Basis - Global Tenders · Table of Contents 1 ... [Design, Build,...

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Project Information Memorandum

BTSPIRIT

Biotechnology Savli Park Incubator for Research,

Innovation and Technopreneurship

at Savli, Vadodara, Gujarat

on DBFOT (Design, Build, Finance, Operate & Transfer)

Basis

Gujarat State Biotechnology Mission (GSBTM)

Department of Science & Technology, Government of Gujarat

Block No 11, 9th Floor, Udyog Bhavan, sector 11,

Gandhinagar – 382017, Gujarat, India

Email: [email protected], Website: www.btm.gujarat.gov.in

: +91-79-232 52197 FAX: +91-79-232 52195

November 2010

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Table of Contents

1. Project Background ......................................................................................................................... 3

2. Deliverables To Be Provided By The Concessionaire ....................................................... 5

3. Description Of Services To Be Provided By The Concessionaire ................................. 8

4. Specifications ..................................................................................................................................... 9

5. Broad Design Specifications ....................................................................................................... 16

6. Good Laboratory Practices & Specific Construction Consideration For

Laboratory Space .................................................................................................................................... 18

A. GOOD LABORATORY PRACTICES & SPECIFIC CONSTRUCTION CONSIDERATION FOR WET LABORATORY

SPACE: .................................................................................................................................................................... 18

B. GOOD LABORATORY PRACTICES & SPECIFIC CONSTRUCTION CONSIDERATION FOR BIO-IT

LABORATORY SPACE .............................................................................................................................................. 20

C. GOOD LABORATORY PRACTICES & SPECIFIC CONSTRUCTION CONSIDERATION FOR CLINICAL TRIAL &

HEALTHCARE RESEARCH SPACE ............................................................................................................................ 21

D. SPECIFIC DESIGN CONSIDERATION FOR LABORATORY/ RESEARCH SPACE ........................................ 22

7. Support From Government ......................................................................................................... 23

8. Quarterly Reports To Be Submitted By The Concessionaire To The Authority .... 24

9. Comprehensive List Of Equipments ........................................................................................ 25

10. Comprehensive List Of Equipmentsphase Wise Break Up (Phase 1: Required

Along With The Building) ..................................................................................................................... 33

11. Comprehensive List Of Equipmentsphase Wise Break Up (Phase 2: With 20%

Occupancy Of The Incubator) ............................................................................................................ 38

12. Comprehensive List Of Equipmentsphase Wise Break Up (Phase 3: With 50%

Occupancy Of The Incubator) ............................................................................................................ 43

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1. Project Background

1.1 Background

1.1.1 The Government of Gujarat, to give thrust to the biotechnology industry in the State,

has decide to set up a state-of-the-art biotechnology park Project (the “Project”)

through Public-Private Partnership (the “PPP”) on [Design, Build, Finance, Operate

and Transfer (the “DBFOT”)] basis at Savli near Vadodra through its nodal agency

Gujarat State Biotechnology Mission (hereinafter referred to as “GSBTM”), and has

decided to carry out the bidding process for selection of [a private entity as] the

bidder to whom the Project may be awarded. The park is spread over 700 acres

within the GIDC Industrial Estate.

1.1.2 In line with the efforts and initiatives being taken to give thrust to the Biotechnology

Industry, the State Government also proposes to set up a ‘state-of-the-art’

Biotechnology Incubator at the Biotech Park in Savli near Vadodara. The biotech

Incubator would act as a catalyst that stimulates research & development and

creation of new biotechnology ventures. The proposed incubator is being set up with

an objective to create knowledge and develop entrepreneurship in the biotechnology

space in the community. To begin with the park shall focus on the following areas in

the biotechnology space: BioPharma, Bioagri, Industrial Biotechnology, environment

biotechnology, contract research and biotechnology in general. It may , however, by

mutual consent, add more thrust areas later.

1.1.3 The incubator is intended to nurture innovative ideas into successful technology

oriented businesses. GSBTM proposes to reduce the time lag between the

technology development and commercialization and also aims at accelerating the

development and growth of biotechnology enterprises by providing a range of critical

support services.

1.1.4 The incubator is aimed to encourage and support innovation-led & knowledge based

businesses by providing world class services and facilities and other support

infrastructure at competitive prices.

1.1.5 This facility will provide Gujarat with a “First-in-class” life science incubator that

generates leading discoveries & treatments resulting in significant improvement in

human healthcare and overall improved quality of life.

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1.2 Objective of the Project

The objectives of the Incubator is to:

Provide “turn-key” laboratories meeting global standards in services, facilities,

environment/ health/ safety, & customer satisfaction;

Creating an ideal tenant mix to create perfect synergies among the tenants;

Creating symbiotic relationship amongst the various stakeholders;

Mentoring & advising the start-ups and SMEs as a guiding hand;

1.3 The incubator will serve as a magnet for the rich science conducted in Gujarat and

will feature unique, affordable and fully built out space for a wide range of

entrepreneurs and companies.

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2. Deliverables to be provided by the Concessionaire

The deliverables will include scientific infrastructure, in the form of building infrastructure,

with all its component and supportive facilities, utilities. It will also include the management

services which the company is required to extend, ensure and offer, during the project

period. The details are given below,

Building infrastructure: The company is required to develop a minimum of 1,25,000 sq ft

of lab space, with individual components, as specified below. This is inclusive of 25,000 sq

ft, or 20% of total area whichever is more, and conforming to norms of Multi-tenanted wet

lab and accommodating a maximum of 10 incubatee, which has to be developed and will be

reserved for first generation biotech entrepreneurs from Gujarat, who will be considered on

first come first basis.

Each of the components is required to have the facilities as have been explained below. The

building infrastructure will also include support infrastructure, as has been explained in

Section 3.

The six wings envisaged under the Incubation Block are:

Wing Building Area (in square meter)

Facilities

A Common Facility

Building 1,825

Includes analytical lab, validation lab, proteomic analysis

& bio-process lab, chemical labs, oligonucleotide

synthesis, etc.

Facilities that can be developed as independent business

models include common sterilization room,

biotechnology imaging facilities, antigen-antibody core

facility, radio-immuno facility, dark room, common cold-

room, common cells-bank, etc.

A business centre inclusive of conference hall, discussion

rooms as well as a small section for administration and

reception has also been envisaged.

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Facilities

B Mammalian Labs

Facility 1,540

Includes laboratories for inoculation and harvesting

incubation, chilling room, centrifugation/purification,

media preparation, filtration, media filling, etc.

Space for decontamination, sterilization, washing,

experimental animal centre, etc. has been envisaged.

Downstream processing facilities for virus separation,

protein extraction & chromatography as well as cell

characterization lab have also been envisaged.

C Microbial Labs

Facility 1,540

The facility should be designed such that probable

tenants may be able to carve out space as per their

requirements.

Includes laboratories for inoculation and harvesting

incubation, chilling room, infection,

centrifugation/purification, media preparation, filtration,

media filling, etc.

Space for decontamination, sterilization, washing,

fungal/yeast/bacterial labs, etc. has been envisaged.

Downstream processing facilities for virus separation,

protein extraction & chromatography as well as cell

characterization lab have also been envisaged.

D Multi-tenanted

Wet Labs 1,582

This wing shall primarily lodge wet labs of modular

nature that can be custom-sized to suit the

requirements of the prospective tenants.

Generally, space of about 30% of this wing, can also be

custom modified to lodge bio-computing/bioinformatics

facility.

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Facilities

E Multi-tenanted

Wet Labs 1,583

This wing shall primarily lodge labs of modular nature

that can be custom sized to suit the requirements of the

prospective tenants.

Generally, space of about 30% of this wing, can also be

custom modified to lodge bio-computing/bioinformatics

facility.

F

Pilot Plant Facility

and Plant - Tissue

Culture Facility

2,015

This wing shall lodge pilot plant facility with two

bioreactors/fermentors, each of 500 litres capacity with

adequate facilities of upstream & strain development as

well as downstream processing.

The Tissue Culture Facility shall lodge laboratories as

well as temperature controlled green house, etc.

The technical specifications of each individual facility have been provided in general in

Sections 3 - 6.

These are the key components, with area indicated and this is the minimum construction

which bidder is required to build. Full scale operation may need essentially needed

functional facilities or ancillary facilities and the built up area is likely to increase by another

15-20%, which may be kept into consideration.

Bidder is free to develop his own design; however it will need technical approval from the

committee constituted for the purpose.

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3. Description of Services to be provided by the Concessionaire

The Concessionaire shall provide the following services as a part of the Management Services:

A. Services to be provided by the Company:

Administration and upkeep of common areas

Common Utilities

Operation of Analytical Instruments

Operations of Pilot Plant Facility

B. Maintenance Services:

Surveillance and Security

Housekeeping

Utility Services Maintenance

Landscaping

Pest Control Services

Handling of Effluents, chemical solid waste and biomedical waste

Awarding Annual Maintenance Contracts for equipment

Sourcing and Warehousing

Support services to Incubatees for instruments

Help Desk

C. Third Party Resource Guide:

Customs Clearance

Legal/ Patent Counseling

Environment Clearances

Liaison with government authorities

Accounting and secretarial services

Business planning and fund raising for Tenants

Travel, housing and logistics

Human Resource Services and Payroll

Employee Relocation

Training (with external trainers)

D. Outsourced Services

Transportation to and from Biotech Incubator facilities, for the employees of the Tenants and the Company Personnel

Cafeteria Operations

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The Incubation Facilities (in Phase

I) including Technology Incubator,

Common Equipment Library, Pilot

Plant Facilities, etc

4. Specifications

Biotech Incubator

The incubator will be a part of

the innovation arcade at the

Biotech Park.

The incubation centre will

comprise of a leasable multi

tenanted labspace, common

equipment library, and training

centre.

The design of the Incubation

Block, amounts to a total of

approximately 10,000 square

meters and comprises of six wings in addition to the integrated services of utilities and

animal care centre.

The specifications of the six wings envisaged under the Incubation Block, are as described in

Section 2.

The incubation facility is designed to accommodate modules of laboratories for individual

scientist entrepreneurs, for start-up companies or for established companies that require

comparatively larger space.

The small modules of laboratories are designed as closed labs and the remaining

bigger modules are open ones.

The open labs support team-based work and the concept is based on accommodating

multiple principle investigators, in which researchers share not only the space itself but

also equipment, bench space, and support staff. Each unit may however, be provided

with modular furnishings and some minor instruments such as – laminar air flow,

microscope, shaker, balance, etc. as per the requirements. These open labs are

suitable for biotech companies that have multiple teams focusing on separate or same

research projects. The open lab format facilitates communication between scientists

and makes the lab more easily adaptable for future needs.

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All the laboratories will be equipped with workbenches, refrigerators, freezers and the

latest electrical and telecommunications connectivity options.

In addition to the laboratory space, two fully equipped conference rooms have been

proposed to be shared by all units in the incubation center.

The bigger lab modules will have a dedicated common room within the module.

Support Infrastructure

a) Wet Lab Space: Wet laboratory space is defined as a laboratory where chemicals, drugs,

or other material or biological matter are tested and analyzed requiring water, direct

ventilation, and special piped utilities.

b) Antibody and Antigen Core Facility: This facility will serve for preparation of antibody

reagents and related services required for R&D activities of the incubatees. The common

equipment in the Antigen & Antibody Core Facility include laminar flow hoods, tissue

culture incubators, a liquid nitrogen freezer, a refrigerator/freezer, centrifuges, and

other necessary general molecular/cell biology laboratory equipment. This core facility

will be supported by experimental animal house.

c) Cell/Tissue Culture Laboratory Facility: The facility is required to study and culture cells,

tissues and embryos, to perform cell cloning, preparation of irradiated feeder layers,

suspension and re-aggregate cultures, tissue explants and chimeras and to determine

the feasibility of experiments.

d) Chemical Laboratory Facility: The lab will be equipped with conductivity meters, pH

meters, spectrophotometers and gas chromatographs, etc. to perform the biochemistry

related research.

e) Micro Array Laboratory: The R&D activities to be performed in the laboratory include

RNA isolation, cDNA preparation and labelling, hybridization, washing and scanning.

f) Genome Analysis and Biotechnology Core Facility: This facility will support incubatees to

conduct research in the field of genomics. This laboratory can be divided into several

facilities namely sequencing laboratory facility, DNA & RNA, polypeptide, synthesis

laboratory facility, DNA/RNA synthesis, oligo-nucleotide synthesis, peptide synthesis,

and cDNA cloning/synthesis.

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g) Analytical Laboratory Facility: This laboratory will be equipped with a number of

analytical instruments to be used for biotech R&D.

h) Basic Research Laboratory: This facility supports R&D in cell biology, custom expression

systems, molecular biology, molecular immunology and virology.

i) Green House Facility: This is basically an environmentally controlled plant growing space

to support the R&D activities in plant biotechnology. The environmental chambers will

provide for controlled growth studies at temperatures between -5 °C & 60 °C and 0 to

90% humidity.

j) Animal House: This facility will house experimental animals such as fish, pigs, mice,

laboratory rats, rabbits, poultry, pigeons, etc. to support clinical trials in the biotech

park. It will take basic care of animals under professional supervision of veterinary

surgeons in accordance with the Animal Act. Animal rooms will be well equipped with

micro-isolators and will be provided with controlled supply of treated water and filtered

air.

k) Proteomics Analysis and Bioprocess Laboratory: The Proteomics Analysis Laboratory

aims to provide for recombinant protein expression, protein purification (HPLC, FPLC),

peptide synthesis, fermenters, and mass spectrometry.

l) Biotechnology Imaging Facility: This will be a resource facility dedicated to the

acquisition and analysis of images for biological research and clinical applications. This

facility is necessary to view the ultra-structure of cells (viruses, bacteria, molecules) and

surface topography of biological materials to analyze a cell or organelle.

m) Cold Rooms: Cold rooms are very important and form one of the core facilities required

for biotech R&D. They serve for environmentally controlled experimentation at low

temperatures, long-term storage of frozen materials and also for specialized low-

temperature material preparation for experimentation.

n) Hot Rooms: Hot rooms serve for environmentally controlled experimentation at high

temperature (above ambient) and long-term storage of materials for experimentation.

o) Biosafety Cabinets: The term "containment" is used in describing safe methods for

managing infectious materials in the laboratory environment where they are being

handled or maintained. The purpose of containment is to reduce or eliminate exposure

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of laboratory workers, other persons, and the outside environment to potentially

hazardous agents. The three elements of containment include laboratory practice &

technique, safety equipment, and facility design.

Safety equipment includes biological safety cabinets (BSCs), enclosed containers, and

other engineering controls. The biological safety cabinet (BSC) is the principal device

used to provide containment of infectious splashes or aerosols generated by many

microbiological procedures. As part of the biotech park it is proposed to develop bio

safety cabinets in the incubation facility conforming to various bio safety levels (BSL),

i.e. BSL I, BSL II and BSL III. It is proposed to develop 5 BSL I cabinets, 2 BSL II

cabinets and 1 BSL III cabinet.

p) Quality Assurance and Control: This facility is proposed to ensure the quality of research

and products as per the GLP/GMP standards. It will carry out activities like cleaning &

monitoring, compliance audits, equipment validation/calibration, facilities

design/construction, ISO, and QA development.

q) Bio-Computing/In-Silico Biology Facility: The proposed In-silico Biology Center will

include:

Data Analysis and Processing Laboratory: This facility will comprise PC

workstations with high-resolution printers. The laboratory will also provide access

to desktop-based sequence and image analysis and processing applications.

Data Center: This facility will house core infrastructure to support the computing

facility. It will comprise UNIX, LINUX and Windows based servers with disk

storage and backup systems. These servers run various sequencing applications,

databases, web services and house copies of genomic databases.

r) Molecular Modeling Laboratory: This facility will comprise Silicon Graphic Workstations

equipped with stereovision and software for molecular modeling.

Microarray Analysis Laboratory: This facility will have dual flat screen PC

workstations running the latest Microarray analysis software.

Imaging Analysis: This facility will have high end and high resolution workstations

with image acquisition and analysis software

Software Development Laboratory

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Sr. No. Description Nos /Details

I Hardware

1 Server class machines 5

2 Work stations 20

3 Desktop computers 10 with latest configuration for graphic use

4 Printer 1 high resolution laser jet

5 Large scale storage device 10 terra bites storage devise

6 Connectivity Broadband connection / dedicated ethernet connection

II Software Category

1 Protein / DNA sequence analysis Latest Genomics, Proteomics Software having

2 Modeling and structure based drug design Latest softwares for drug design, discovery and chemo-informatics

3 Micro-array analysis software

s) Safety Equipment in Laboratories: Each laboratory will comprise fume hood, bio-safety

cabinets, emergency eyewash, emergency shower, toxic gas cabinet, fire safety, and

radio activity control cells. The design shall follow the bio-safety standards laid down by

the competent authority.

Apart from the details mentioned above each wet lab / modulator wet lab / common

instrumentation lab should be equipped with the following: -

LAF benches

Island lab table

Suitable side lab table

Fuming hood/chambers

Pendent for the utilities – ½” NB 6 pipes

Suitable electrical connections/accessories

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Epoxy painted floor

Wall – Double skin PUF sandwiched, prefabricated clean room panels, minimum 80 mm thick

Ceiling – Double skin PUF sandwiched, prefabricated clean room panels, minimum 80 mm thick

Proper sanitary drainage system

Proper supply and return air ducting with suitable plenum (HEPA EU 14) / pre filters

Each room must be equipped with personal air lock, material air lock, pass boxes (static / dynamic), and door inter-locking system

Digital display and monitoring for pressure gradient, room temperature, relative humidity and other critical room parameter

Connected and controlled by Building Management System (Desigo/Scada)

HVAC system and other utilities should be provided through service floor

Each room/lab should have independent AHU

All AHU should be equipped with global suction unit and global exhaust unit

The MOC and fabrication of utility piping should be as per latest prevailing standard of USP 27 & above

Clean corridor and gray corridor

t) Other parameters

Temperature: 18C to 22C

Relative humidity: 50% to 60%

Pressure gradient: At least 20 Pa more than adjacent room and higher than adjoining corridor

Air changes per hour: 80

u) Infrastructure

“Tenant Support Infrastructure” such as front office, cafeteria, rest areas, office space etc.

Good ventilated construction

Continuous water supply

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Uninterrupted power or captive power generation

Water treatment plants (deionization plant, distilled water plant, water purification plant)

Service corridor (consisting of water supply network, sewage lines, utility/effluent pipelines, telecom bandwidth, power lines, storm water drains, etc.)

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5. Broad Design Specifications

I. Design Requirements for Research Space / Laboratories

A. General specifications

S. No. Activity Specifications

1 All built up structures All built up structure shall confirm to National Building Code of India, Construction Specifications of CPWD/PWD, and local building by laws of BDA/BMP

2 All laboratories All laboratories including incubation, wet lab space, common instrumentation (if any) shall confirm to GLP/GMP standards

3 Storage Facilities The Rules for the Manufacture, Use, Import, Export and Storage of Hazardous micro-organisms Genetically engineered organisms or cells shall be complied with :

a) The Manufacture, Storage and import of Hazardous Chemical Rules, 1989

b) The Chemical Accidents (Emergency Planning, Preparedness and Response) Rules, 1996

c) The Manufacture, Storage and Import of Hazardous Chemical (Amendment) Rules, 2000

d) Notification on Recognition of the laboratories that are allowed to use of pathogenic micro organisms or genetically engineered organisms or cells for the purposes of research

4 Pollution control measures a) The Water (Prevention and Control of Pollution) Cess Act, 1977, amended 1992

b) The Water (Prevention and Control of Pollution) Act, 1974, amended 1988

c) The Air (Prevention and Control of Pollution) Act 1981, amended 1987

d) The Environment (Protection) Act, 1986, amended 1991

e) Environment (Siting for Industrial Projects) Rules, 1999

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S. No. Activity Specifications

5 Noise control Noise Pollution (Regulation and Control) Rules, 2000

6 Solid Waste Handling a) The Hazardous Wastes (Management and Handling) Rules, 1989

b) The Bio-Medical Waste (Management and Handling) Rules, 1998

c) The Municipal Solid Wastes (Management and Handling) Rules, 2000

7 R.C.C. Work, Brick Work, Flooring, Roofing

As per relevant BIS Standards/CPWD specifications

8 Water Supply, Sewerage As per relevant BIS Standards/CPWD specifications. Develop facilities for supply of domestic water and laboratory grades of water.

9 Power As per relevant BIS Standards/CPWD specifications and National Electric Code

10 Effluent Treatment Shall be developed as per the applicable Acts/Regulations.

The treated effluent shall comply with PSPCB/CPCB disposal standards. The minimum quality of treated effluent to be either equal to or better than:

a) Suspended solid not more than 30 mg/l

b) B.O.D. - 5 days at 20oC not more than 30 mg/l

c) COD not more than 250 mg/l

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6. Good laboratory practices & specific construction consideration

for laboratory space

This Schedule sets out specific requirements in relation to wet laboratory/Bio-IT and

laboratory space for healthcare research/clinical trials

A. Good laboratory practices & specific construction consideration for wet

laboratory space:

Flooring: The floor must be non-pervious with covings to the wall. This can be achieved by

use of Vitrified flooring or any other type;

Floor Height & Ceiling: In all laboratory spaces that contain or may contain fume hoods,

the ceiling heights should be a minimum of 3 m and with a floor to floor height of 4.1 m to

4.5 m;

Walls: wall and partitions should either be insulated masonry or gypsum board;

Wall Furnishing: The walls’ and partitions’ surfaces shall be painted with glossy or semi

gloss latex based paint;

Doors: Laboratory doors shall be of standard height of 7'-0'' (2.17 m). In the laboratory

wing, doors opening from laboratory rooms should not protrude more than 6 inches (0.15

m) into corridors regardless of the corridor’s width. Laboratory rooms should have one 4'-0''

(1.22 m) opening to allow large equipment to be carried in and out of the room.

HVAC Requirements: Most of the equipment and experiments are temperature- and

humidity-sensitive. Constant conditions shall be ensured in the wet laboratory spaces such

that the equipment can perform properly and that experiments produce accurate results.

Every laboratory rooms shall be controlled individually in accordance with the following:

a) During summer, the temperature should be maintained at: 72° FDB (22.2° C (DB) + / - 2° F (1.1°C) and 40% RH + / - 5%;

b) During winter, the temperature should be maintained at: 72° FBD (22.2° C (DB) + / - 2°F (1.1°C) and 30% RH + / - 5%;

c) For laboratories that are primarily instrumental rooms, the standard shall be as follows: 70° FDB (21.1° C (DB) + / - 2°F (1.1° C);

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Specialised HVAC System: HVAC systems to be installed in every laboratory room. The

following are the two types of HVAC systems to be installed in the wet labspace area:-

System 1: A two-position, constant volume terminal reheat system providing the required

volume of air in full during daytime operation hours when the fume hoods sash is open.

When the fume hood sash is closing, the system will, by controlling the speed of the supply

and exhausts fans, reduce the airflow and thus the volume of air exhausted by the hood.

System 2: A variable air volume system (VAV) designed to utilize variable volume hoods

with variable speed exhaust fans, variable air supply terminals, and variable volume general

area exhaust.

Fire Protection & Suppression System: Considering the high risk factors to researchers

in terms of possible explosion, and exposure to chemicals, the wet lab space should be well

equipped with automatic fire hydrant system, sprinkler system with dedicated U.G sump,

Optical smoke detectors & fire alarm systems, Portable chemical emergency fire

extinguishers

Electrical Works: Power needs for the wet research laboratories far exceed those for

typical commercial buildings due to usage of high power consuming equipments such as

freezers, refrigerators, controlled temperature rooms, fume hoods, tissue culture areas, and

other research equipment. The wet labspace should have an emergency 100% power back

up through DG Sets, UPS with high capacity loads for equipments, lightning protection

system, high speed passenger & service lifts, public address system etc.

Plumbing: Chemical resistant waste and vent pipe should be used for all laboratory sinks

and equipment intended to receive acids and chemicals. The waste would be routed through

a chemical neutralizing device prior to connecting to the drainage system.

Non-flammable Gas Distribution System: The following gases shall be provided at the

stated purity - Compressed Air, Nitrogen (N2), Helium (He), Argon Ar), Argon/Methane

(Ar/CH4) (95%/5%), Liquid Nitrogen (Liq. N2), Liquid Argon (Liq. Ar) ,Carbon Dioxide (CO2)

Support Infrastructure: Effluent treatment plant, sewage treatment plant, reverse

osmosis (R.O) water plant, boilers, power substation/ feeder.

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B. Good laboratory practices & specific construction consideration for Bio-IT

laboratory space

HVAC Requirements: Constant and reliable HVAC systems in Bio-IT Laboratory spaces to

ensure proper temperature- and humidity levels in which equipment can perform properly;

Fire Protection & Suppression System: Automatic fire hydrant system, Sprinkler system

with dedicated U.G sump, Optical smoke detectors & fire alarm systems;

Electrical Works: Power needs for the Bio-IT laboratories far exceed those for typical

commercial buildings due to high usage of specialized high-performance computing

equipments in data management and data analysis centers, medical imaging centers, and

other such computing facilities. These labspace should have DG sets for 100% power back

up, UPS with high capacity loads for equipments, , Lightning Protection System, Passenger

& service lifts, Public address system etc;

Support Infrastructure: IT network, Sewage Treatment Plant, Power Substation/ feeder;

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C. Good laboratory practices & specific construction consideration for clinical trial

& healthcare research space

HVAC Requirements: Constant and reliable HVAC systems in Clinical Trial & Healthcare

Research spaces to ensure proper temperature- and humidity levels in which medical

equipment can perform properly;

Electrical Works: The clinical trial & healthcare research space should have 100% power

back up through DG sets. The research space should also have back up through UPS with

high capacity loads for medical equipments, lightning protection system; high speed bed

lifts, stretcher lifts, passenger & service lifts; public address system etc;

Gas Distribution System: The following gases shall be provided Compressed Air, Vacuum,

Oxygen, and Nitrous;

Support Infrastructure: Medical waste disposal area, sewage treatment plant, power

substation/ feeder;

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D. Specific design consideration for laboratory/ research space

All Good Laboratory Practices should be met by developer. All health and safety hazards

must be anticipated and carefully evaluated so that protective measures can be

incorporated into the design.

Laboratory support spaces (e.g. desk area for scientists/ medical practitioners, break out

areas, solvent storage room, hydrogenation room, chemical storage room and other such

areas that facilitate research) should be planned.

Materials which in combination with other substances may cause a fire or explosion, or may

liberate a flammable or poisonous gas, must be kept separate. When designing the building,

the developer should factor enough space for solvent storage outside the laboratory

building.

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7. Support from Government

A. Grant:

A grant of Rs. 20 Crores (Rupees Twenty Crores) shall be provided to the successful bidder

towards purchase of equipments and utilities to be released phase wise as mentioned in the

section 9, 10, 11 and 12 of this document.

B. Land on Lease:

The successful bidder shall be provided 10 acres of land on lease rental basis for the period

of 35 years.

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8. Quarterly Reports to be submitted by the Concessionaire to the

Authority

The quarterly report to be submitted to the GSBTM by the Company shall contain only the

following information:

a) Tenants operating in the BT-SPIRIT - utilization percentage (lab space/ pilot plant

facility);

b) Activities in the BT-SPIRIT during the quarter;

c) Any upgrade/modification done to the BT-SPIRIT and the costs expended for the

same;

d) Structural repairs and additions carried out in the BT-SPIRIT and the costs expended

for the same;

e) Report on BT-SPIRIT Assets uptime;

f) Changes in recruitment policy and operation memo;

g) Contribution to the Depreciation Fund (post 12 quarters) and

h) Changes in the Company Personnel.

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9. Comprehensive List of Equipments

2 B. Common Instrumentation and analytical facility (including Animal Testing Facility)

BIOTECHNOLOGY - TECHNOLOGY BUSINESS INCUBATOR @ SAVLI BIOTECH PARK, VADODARA

Sr. No.

Item

Total No of

Units

Cost per Unit (in INR lacs)

Total Cost (in

INR lacs)

Priority 1 Priority 2 Priority 3

Remarks / Suggested Item in lieu No of Units

Cost per Unit (L)

No. of

Units

Cost at

Stage 1 (in INR lacs)

No. of

Units

Cost at


No. of

Units

Cost at


I Bacterial Culture Section

1 20 L Cell Culture Fermentor

1 10 10 1 10 0 0 0 0

2 100 L Cell Culture Fermentor

1 60 60 0 0 1 60 0 0

II Auxiliary Facilities and analytical facilities proposed to be provided in Biotech Incubator Facility

1 Island table each 12’ x5’

15 0.5 7.5 5 2.5 5 2.5 5 2.5

2 Peripheral Flat Tables 40 0.4 16 15 6 5 2 20 8

3 Fridges 12 0.2 2.4 3 0.6 4 0.8 5 1

4 Ordinary pH Meters 6 0.3 1.8 2 0.6 2 0.6 2 0.6

This is an indicative List. Before going for purchase the technological upgrades or higher versions available must be considered. Since the technology is highly dynamic, any substitute equipments with better efficiency be considered.

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Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


5 Coarse Balance 5 0.3 1.5 2 0.6 2 0.6 1 0.3

6 Automated Fine Balance

8 1.5 12 1 1.5 3 4.5 4 6

7 Laminar flow 6 1.5 9 2 3 2 3 2 3

8 Fume-hoods 6 1 6 2 2 2 2 2 2

9 Water baths 10 0.25 2.5 2 0.5 4 1 4 1

10 Dry bath 8 0.1 0.8 2 0.2 3 0.3 3 0.3

11 Continuous De-ionisation System 10L/hr

1 5 5 1 5 0 0

12 Ultra Pure water purification system –1.0 L/hr

1 10 10 1 10 0 0 (e.g.: Milli Q)

13 Magnetic Stirrers (hot plate)

10 0.1 1 2 0.2 4 0.4 4 0.4

14 Vortex Mixer 5 0.1 0.5 2 0.2 2 0.2 1 0.1

15 Auto Titrator 2 0.2 0.4 1 0.2 1 0.2 0

27


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


16 Orbital shaker with control

2 2 4 1 2 1 2 0

17 Standard Incubator with control

10 0.5 5 2 1 5 2.5 3 1.5

18 Microbiological Incubator

2 0.5 1 1 0.5 1 0.5 0

19 Dry heat Sterilizer (100L)

3 0.25 0.75 1 0.25 2 0.5 0

20 Autoclave (10L) 3 0.5 1.5 1 0.5 2 1 0

21 Horizontal Autoclave (100L)

1 10 10 1 10 0 0

22 Bio-safety Cabinet 6 3 18 2 6 2 6 2 6

23 Deep Freezer 6 0.6 3.6 2 1.2 2 1.2 2 1.2

24 Deep Freezer ( - 86 C)

3 5 15 1 5 1 5 1 5

25 West Frost (- 20 C) 12 1 12 4 4 4 4 4 4

26 CO2 Incubator 4 5 20 1 5 2 10 1 5

28


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


III Common Instrumentation Facility

1 DNA Sequencer * 1 100 100 0 0 1 100 0 0 3130 Capillary based (e.g.: Beckman CEQ 2000 Series)

2 500 Mhz – NMR* 1 125 125 0 0 0 0 0 0 Might not be needed

3 pH meters* 8 0.3 2.4 2 0.6 3 0.9 3 0.9

4 Minifuges 8 1 8 4 4 2 2 2 2

5 Centrifuge with rotors*

1 10 10 1 10 0 0

6 UV Spectrophotometer*

6 20 120 2 40 2 40 2 40 Tecan -

7 Ultra Centrifuge with rotors*

2 15 30 1 15 1 15 0 0

8 Gel Documentation system*

3 3 9 1 3 1 3 1 3

9 Microscope (fluorescent with CCTV)*

3 5 15 1 5 1 5 1 5

29


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


10 Inverted Microscope with Camera and micro manipulator*

3 35 105 1 35 1 35 1 35 Micromanipulator be reconsidered

11 ELISA Plate Reader with Automatic Washer*

2 6 12 0 0 1 6 1 6 Not needed

12 Biochemical analyzer* 1 5 5 0 0 1 5 0 0

13 PCR* 10 2 20 2 4 4 8 4 8

14 Electrophoresis Apparatus

12 5 60 2 10 5 25 5 25 Big-Med-Small- Vertical-Horizontal Powerpacks

15 HPLC* 3 35 105 1 35 1 35 1 35 BioAnalyser

16

Support services Modifications (Media kitchen, water Distillation Unit, washing room, dark room)

1 5 5 1 5 0 0

These equipments may be replaced by equivalent or superior technology in the market.

30


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


Total 1083.65 260.15 490.7 207.8

IV Hardware

1 Server class machines 5 40 200 2 80 1 40 2 80 High Performance Computing (HPC) Cluster (Onyx)

2 Work Stations 20 10 200 4 40 6 60 10 100 Workstations (Silicon Graphic Inc)

3 Desktop computers (P4 – 3.0 GHz) 1 GB RAM

10 0.3 3 5 1.5 3 0.9 2 0.6

4 Printer (High resolution laser jet)

1 1.5 1.5 1 1.5 0 0

5 Large scale storage device (terra bites storage)

10 20 200 2 40 3 60 5 100 Storage

Connectivity Broadband connection / Dedicated Ethernet connection

1 20 20 1 20 0 0 0 0 5MBPS = Rs. 6 Lacs pa

V Software Category 0 0 0

31


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


1 Protein / DNA sequence analysis

20 0 0 0 0 PER ANNUM

GCG Suite of applications

0 0 0 PER ANNUM

DNA star – Lasergene Suite of applications

0 0 0 PER ANNUM

2 Modelling and Structure based drug design


Acelyrys - Discovery Studio


3 Micro array analysis software

0 0 0 PER ANNUM

sub-total b 624.5 183 160.9 280.6

TOTAL (a + b) 1708.15 443.15 651.6 488.4

32


Sr. No.

Item

Total No of

Units


Total Cost (in

INR lacs)



Cost per Unit (L)

No. of

Units

Cost at


No. of

Units

Cost at


No. of

Units

Cost at


Additional Equipment considering the technical requirements & financial feasibility like MALDI-TOF-TOF

1 500 500 1 500

TOTAL (a + b) 2208.15 443.15 1151.6 488.4

33

10. Comprehensive List of Equipments - Phase wise Break up (Phase 1: Required along with the Building)


Sr. No.

Item Out of total No of Units


Priority 1 Remarks / Suggested

Item in lieu No of Units

Cost per Unit (L) No. of

Units Cost at Stage 1 (in INR lacs)


1 20 L Cell Culture Fermentor 1 10 1 10


1 Island table each 12’ x5’ 15 0.5 5 2.5

2 Peripheral Flat Tables 40 0.4 15 6

3 Fridges 12 0.2 3 0.6

4 Ordinary pH Meters 6 0.3 2 0.6

5 Coarse Balance 5 0.3 2 0.6

6 Automated Fine Balance 8 1.5 1 1.5

7 Laminar flow 6 1.5 2 3

8 Fume-hoods 6 1 2 2

9 Water baths 10 0.25 2 0.5


34

Sr. No.







10 Dry bath 8 0.1 2 0.2

11 Continuous Deionisation System 10L/hr

1 5 1 5

12 Ultra Pure water purification system– 1.0 L / hr

1 10 1 10 (e.g.:Milli Q)

13 Magnetic Stirrers (hot plate) 10 0.1 2 0.2

14 Vortex Mixer 5 0.1 2 0.2

15 Auto Titrator 2 0.2 1 0.2

16 Orbital shaker with control 2 2 1 2

17 Standard Incubator with control 10 0.5 2 1

18 Microbiological Incubator 2 0.5 1 0.5

19 Dry heat Sterilizer (100L) 3 0.25 1 0.25

20 Autoclave (10L) 3 0.5 1 0.5

21 Horizontal Autoclave (100L) 1 10 1 10

22 Bio-safety Cabinet 6 3 2 6

23 Deep Freezer 6 0.6 2 1.2

24 Deep Freezer ( - 86 C) 3 5 1 5

35

Sr. No.







25 West Frost (- 20 C) 12 1 4 4

26 CO2 Incubator 4 5 1 5


1 pH meters* 8 0.3 2 0.6

2 Minifuges 8 1 4 4

3 Centrifuge with rotors* 1 10 1 10

4 UV Spectrophotometer* 6 20 2 40 Tecan -

5 Ultra Centrifuge with rotors* 2 15 1 15

6 Gel Documentation system* 3 3 1 3

7 Microscope (fluorescent with CCTV)* 3 5 1 5


3 35 1 35 Micromanipulator be reconsidered

9 PCR* 10 2 2 4

10 Electrophoresis Apparatus 12 5 2 10 Big-Med-Small-Verti-Horti-Powerpack

11 HPLC* 3 35 1 35 BioAnalyser


36

Sr. No.







12 Support services Modifications (Media kitchen, water Distillation Unit, washing room, dark room)

1 5 1 5

Total 260.15

IV Hardware

1 Server class machines 5 40 2 80 High Performance Computing (HPC) Cluster (Onyx)

2 Work Stations 20 10 4 40 Workstations(Silicon Graphic Inc)


10 0.3 5 1.5

4 Printer ( High resolution laser jet) 1 1.5 1 1.5


10 20 2 40 Storage

Connectivity Broadband connection / Dedicated Ethernet connection

1 20 1 20 5MBPS = Rs. 6 Lacs pa

V Software Category

1 Protein / DNA sequence analysis 20 0 PER ANNUM

GCG Suite of applications 0 PER ANNUM

37

Sr. No.







DNA star – Lasergene Suite of applications

0 PER ANNUM

2 Modeling and Structure based drug design

10 0 PER ANNUM

Acelyrys - Discovery Studio 50 0 PER ANNUM

3 Micro array analysis software 0 PER ANNUM

sub-total b 183

TOTAL (a + b) 443.15

38

11. Comprehensive List of Equipments - Phase wise Break up (Phase 2: with 20% Occupancy of the Incubator)

B. Common Instrumentation and analytical facility (including Animal Testing Facility)

Sr. No.

Item Out of total No of Units Cost per Unit (in INR lacs)






1 100 L Cell Culture Fermentor 1 60 1 60




3 Fridges 12 0.2 4 0.8



6 Automated Fine Balance 8 1.5 3 4.5



9 Water baths 10 0.25 4 1


39

Sr. No.






10 Dry bath 8 0.1 3 0.3



13 Auto Titrator 2 0.2 1 0.2

14 Orbital shaker with control 2 2 1 2

15 Standard Incubator with control 10 0.5 5 2.5

16 Microbiological Incubator 2 0.5 1 0.5

17 Dry heat Sterilizer (100L) 3 0.25 2 0.5

18 Autoclave (10L) 3 0.5 2 1



21 Deep Freezer ( - 86 C) 3 5 1 5

22 West Frost (- 20 C) 12 1 4 4



1 DNA Sequencer * 1 100 1 100 3130 Capillary based(e.g: Beckman CEQ 2000 Series)

40

Sr. No.






2 pH meters* 8 0.3 3 0.9

3 Minifuges 8 1 2 2


5 Ultra Centrifuge with rotors* 2 15 1 15





9 ELISA Plate Reader with Automatic Washer *

2 6 1 6 Not needed

10 Biochemical analyzer* 1 5 1 5

11 PCR* 10 2 4 8

12 Electrophoresis Apparatus 12 5 5 25 Big-Med-Small-Verti-Horti-Powerpack

13 HPLC* 3 35 1 35 BioAnalyser

14 Support services Modifications (Media kitchen, water Distillation Unit, washing room, dark room)

1 5 0


41

Sr. No.






Total 490.7

IV Hardware

1 Server class machines 5 40 1 40 High Performance Computing (HPC) Cluster(Onyx)

2 Work Stations 20 10 6 60 Workstations (Silicon Graphic Inc)


10 0.3 3 0.9


10 20 3 60 Storage

5 Connectivity Broadband connection / Dedicated Ethernet connection

1 20 0 0 5MBPS = Rs. 6 Lacs pa

V Software Category 0



DNA star – Lasergene Suite of

applications 0 PER ANNUM


10 0 PER ANNUM


42

Sr. No.







sub-total b 160.9

TOTAL (a + b) 651.6

Additional Equipment considering the technical requirements & financial feasibility like MALDI-TOF-TOF

1 500 1 500

TOTAL (a + b) 1 1151.6

43

12. Comprehensive List of Equipments - Phase wise Break up (Phase 3: with 50% Occupancy of the Incubator)


Sr. No.

Item Out of total No of Units Cost per

Unit (in INR lacs)

Priority 3 Remarks / Suggested Item

in lieu No of Units


Units Cost at Stage

3 (in INR lacs)

I Auxiliary Facilities and analytical facilities proposed to be provided in Biotech Incubator Facility



3 Fridges 12 0.2 5 1



6 Automated Fine Balance 8 1.5 4 6



9 Water baths 10 0.25 4 1

10 Dry bath 8 0.1 3 0.3


44

Sr. No.


Unit (in INR lacs)


in lieu No of Units


Units Cost at Stage

3 (in INR lacs)



13 Standard Incubator with control 10 0.5 3 1.5



16 Deep Freezer ( - 86 C) 3 5 1 5

17 West Frost (- 20 C) 12 1 4 4


II Common Instrumentation Facility

1 pH meters 8 0.3 3 0.9

2 Minifuges 8 1 2 2





45

Sr. No.


Unit (in INR lacs)


in lieu No of Units


Units Cost at Stage

3 (in INR lacs)



7 ELISA Plate Reader with Automatic Washer *

2 6 1 6 Not needed

8 PCR 10 2 4 8

9 Electrophoresis Apparatus* 12 5 5 25 Big-Med-Small-Verti-Horti-Powerpack

10 HPLC* 3 35 1 35 BioAnalyser might serve better

Total 203.8

III Hardware

1 Server class machines (Onyx) 5 40 2 80 High Performance Computing (HPC) Cluster

2 Work Stations (Silicon Graphic Inc) 20 10 10 100 Workstations


10 0.3 2 0.6


10 20 5 100 Storage


46

Sr. No.


Unit (in INR lacs)


in lieu No of Units


Units Cost at Stage

3 (in INR lacs)

5 Connectivity Broadband connection / Dedicated Ethernet connection

1 20 0 0 5MBPS = Rs. 6 Lacs pa

IV Software Category 0



DNA star – Lasergene Suite of

applications 0 PER ANNUM


10 0 PER ANNUM



sub-total b 280.6

TOTAL (a + b) 484.4

* * * * * *

Date post:	04-May-2018
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