Volume 10 , Issue 2 Editor: Weiting Ho, DDS Faculty Advisor: Lewis Claman, DDS September, 2007

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PROTECT YOUR FUTURE UPPORT YOUR SPECIALTY

elo Mariotti’s editorial entitled “Staying the plains that the OSU Periodontal program is ads. Do we as alumni choose to take the ’ and fund an endowed chair in logy or do we take the ‘Low Road’ and be t and apathetic about the future of our l program? ve each of us the opportunity to earn a /or certificate in one of the best specialties . A post-graduate degree of which we can ud and one that has enabled us to pursue of our choice. time for us to invest in our periodontal d our chosen specialty. The OSU l program needs your monetary t to continue its high level of achievements l/international recognition. clinical and research periodontal program dership of distinction. An endowed chair is ble to compete with other universities to retain quality leaders. It is imperative to temporary, progressive Department of logy to preserve the autonomy of our

ithout our specialty, where would you be? make a difference to protect our future. dge or send your donation today.

arvey, DDS Fred Sakamoto, DDS

rmo, DDS Jeffrey Stephens, DDS

ek, DDS Joseph Koberlein, DDS

Buc

The Cutting Edge 1

Staying the Course Angelo Mariotti, DDS, PhD, Chair

years ago I could not have imagined the es achieved by the Department of ntology today. Our students and faculty are ed nationally and internationally and the tal program is active, contemporary, ing and progressive – the envy of academic . All this has happened because of faculty

umni who believed in our dedication to ce. However when you get to the top of the ere is a danger of becoming complacent. Herbold argues in his book entitled “Seduced cess” that successful businesses lose their tive edge to compete as a result of destructive rs that are created and nurtured by success. e of these actions include: 1) a lack of urgency, g protective and proud and 3) having an ent mentality. The faculty are aware that our lishments can be fleeting and we have l “reality checks” to determine if what we are

eally makes a difference. Nonetheless, the ent is moving to a cross- roads that will affect,

y what we do but, who we are. More lly, within the next decade the College of

on Page 2

kM

Please Join Us

eye Reception

onday, October 29, 2007, 5:30 –7:00 pm

Venue:

Renaissance Hotel, Room 7 Washington, DC

Hope to see you there!

Inside This Issue

1 Letter from Alumni

1 Chairman’s Note

3 Voice of the Director

4 Predoctoral Director’s Report

5 Recent Awards and Diplomates

6 New Faculty Profile

7 Resident’s Review

12 OSU Periodontal Alumnus Profile

Chairman’s Note, Continued Dentistry will be selecting a new Chair for the Department of Periodontology. Since the periodontal Chair plays such a pivotal role in determining the direction of periodontal education at Ohio’s flagship university, it is important that the Ohio periodontal community begin to prepare for the next leader upon my retirement. To attract the best and brightest in a dwindling field of periodontal academicians to OSU, the College of Dentistry will be required to promise more than a management position in a successful department. We would be protective and proud to consider only an Ohioan as an appropriate replacement and we would have an entitlement mentality to believe that a periodontist of substance would want to come to OSU at any cost. To enhance the chances of recruiting a person of consequence, the College will need to establish an Endowed Chair in Periodontology. To endow a Chair at OSU presently requires 1.5 million dollars and these dollars will come primarily from friends and alumni. To be sure, this is not an inconsequential sum, yet alumni from Endodontics (which has endowed a Chair and a Professorship) and Orthodontics (which is well on the way to endowing a Chair) have made substantial commitments in a short period of time. Dental academics is extremely fluid and there are always open positions for periodontal chairs (there are 83 periodontal programs in North America alone); therefore, the ability to find a qualified periodontal leader will continue to be an urgent issue leading some institutions to either indefinitely leave the position open or worse, to fill the position with an unqualified candidate. Therefore, to find a competent and capable individual for OSU in a timely manner, I believe that we will have to have an appropriate and prestigious enticement: an Endowed Chair in Periodontology. Like you, I know that money does not grow on trees. I also know that you work hard for a better life for you and your family; however, without a concerted approach over time by alumni and friends dedicated to the periodontal future of Ohio, a fully funded endowment will never become a reality. The bottom line is that your help will be essential for a periodontal endowment if OSU is to remain a strong and viable periodontal program for the future. Our past has been bright and today we are thriving, but without your help the future viability of academic periodontology in Ohio will decline. So what can you do to make a difference? As an example, if each of the estimated 185 practicing OSU periodontal alumni donated the proceeds from three patient cases over three years time (approximately $10,000), we would easily meet our goals. At this time, just 6 alumni have seeded the endowment with over $200,000 worth of cash or pledges but more is needed to be successful. If you are interested in making this endowment a reality, send a donation or make a pledge. Information is available on the OSU Section of Periodontology web site (http://dent.osu.edu/perio/alumni_giving.php) or if you want to chat more about this feel free to call me (614-292-0371). As we move toward our 60th Anniversary in 2009 as the premier periodontal program, show the nation how firm thy friendship, O-H-I-O.

From the Editor Weiting Ho, DDS

Another academic year has gone by so fast. We just said goodbye to our new graduates and soon we welcomed our new first year residents to this buckeye family. I sincerely wish the best to our graduates and I am also excited to work with our new residents. This year we also have a new fulltime faculty, Dr. Ben Chien. Let’s welcome Dr. Chien join our big family.

In this issue of The Cutting Edge you will find useful and important information on our post doctoral clinic

and pre-doctoral clinic. These changes not only increase our work efficiency many times but improve the quality of our periodontal program.

The Cutting Edge 2

Voice of the Director Dimitris Tatakis, DDS, PhD

Dear Alumni and Friends,

The past 6 months have been full of activity. On May 4th, 2007, Ohio State, in partnership with Colgate-Palmolive, hosted the Volpe prize, an international award named in honor of Dr. Anthony Volpe. The Volpe prize aims to recognize the best clinical research in Periodontology by pre- and post-doctoral students. This friendly competition brought to town students and periodontal faculty colleagues from several U.S. and Canadian dental schools. We really enjoyed having them visit OSU.

Our 2007 senior residents have either already completed their clinical and MS requirements and have left Columbus or will do so by August. Our 2006-2007 Chief Resident, Dr. Jeffrey Wessel, whose MS thesis research was on “The revascularization of soft tissue grafts”, is now stationed in Norfolk, Virginia, as a US Navy Lieutenant. Jeff, who scored at the 99th percentile among all periodontal residents during this year’s In-Service Examination, was the winner of the 2007 Midwest Society Research Forum competition and the runner-up of the inaugural Volpe prize. He will be presenting his final results as an Orban prize finalist during the upcoming AAP meeting in Washington, DC. Dr. Renita Burrell, has returned to Wisconsin to pursue private practice; Renita’s MS thesis was on “Distribution of clarithromycin in gingiva”. Dr. Chun-Han Chou has moved back to North Carolina, where he is in private practice; Chun-Han’s MS thesis research was on “Characterization of clarithromycin accumulation by cultured human oral epithelial cells and gingival fibroblasts” and he presented his work during the recent IADR meeting in New Orleans. Dr. Samer Khoury, who also presented his MS thesis work on “Indices of early wound healing following one-stage dental implant placement – clinical parameters and proinflammatory biomarkers” during the New Orleans IADR meeting, has moved back to Texas, where he is pursuing private practice. All of us are very proud of the accomplishments of this year’s graduating class.

Speaking of accomplishments, two more alumni attained Diplomate status since our last report. Congratulations to Drs. William Cho (2006) and Randy Fitzgerald (2006)!

In July, the program welcomed four new first year residents: Drs. Irma Iskandar (University of Florida), Chad Matthews (University of Kentucky), Shaun Rotenberg (Medical College of Georgia), and Janel Yu (University of Western Ontario, London, Ontario, Canada). We are delighted to have them join our Buckeye family and we all look forward to working with them. We were also fortunate in the last few months to have been able to hire new staff. We welcomed two new staff members, Ms. Lisa Howard, who is a Dental Assistant, and Ms. Courtney Johnson, who joined our clinic as Information Associate and is working at the front desk. It is a pleasure to have them in the group. The residents and I are always appreciative of your continuing support of the program as we keep on receiving referrals for patients who cannot afford periodontal treatment in a private practice setting. Should you need to contact the clinic for a patient referral or any other reason, please call 614-292-4927. You can always reach me at tatakis.1@osu.edu or at 614-292-0371.

All of us look forward to seeing you, the alumni and friends of the Program, during the annual AAP meeting in Washington, DC. Please make a note that the OSU Section of Periodontology will host the Buckeye Reception on Monday, October 29, 2007. Best wishes,

Dimitris Tatakis

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Predoctoral Director’s Report Lewis Claman, DDS, MS

OSU SECTION OF PERIODONTOLOGY TO LAUNCH NEW INITIATIVE FOR PERIODONTAL MANAGEMENT

IN DENTAL STUDENT CLINICS

Background All full time periodontal faculty members at Ohio State enthusiastically embrace a strong effort for appropriate periodontal management for patients. We know that the model for managing patients at OSU has a great impact on referral patterns in private practice. We are aware that lack of timely and appropriate referrals to periodontists is a national issue and want to take a leadership role at Ohio State. Our overarching objectives for a new initiative are to have patients presenting with periodontal health or gingivitis managed by students under the supervision of dental hygiene and general dentistry faculty and to have patients with true periodontal needs comprehensively charted, diagnosed, treatment planned and appropriately referred under the supervision of periodontal faculty. Our effort is consistent with the 2006 AAP Guidelines for the Management of Patients with Periodontal Diseases and will help engage general dentists and dental students in the recognition of periodontal problems. Part of the initiative will be to have patients in periodontal health or gingivitis bypass comprehensive periodontal charting. This will alleviate a logjam in patient scheduling, while allowing our students and faculty to focus their efforts on patients with periodontal problems. We are spearheading our efforts with three initiatives. The first strategy will be to have the Periodontal Screening and Recording (PSR) implemented in the OSU Screening Clinic. The second strategy will be to clearly define periodontal conditions that mandate referral to the Graduate Periodontics Clinic. The third strategy will be for periodontal surgery to be specified in the initial treatment plan so patients are clearly informed on potential treatment costs. PSR in the Screening Clinic At Ohio State, third and fourth year dental students are assigned to the new screening clinic, which is mainly supervised by general dentistry faculty. Until now, there has been no clinical assessment of the periodontal status during this appointment, with only no probing and only panoramic radiograph available. The Periodontal Screening and Recording (PSR) is a time efficient system for general dentists and will provide valuable information to expedite dental care for periodontally healthy patients, while triggering the need for comprehensive periodontal examinations, periodontal diagnosis and referral to the Graduate Periodontal Clinic for patients with periodontal problems. Patients with minimal periodontal problems will not have comprehensive charting and will be supervised by general dentistry faculty. Periodontal faculty however, will verify the patient’s status before definitive treatment is initiated, to safeguard that important periodontal problems are not missed. Patients with periodontal problems will receive comprehensive periodontal charting, diagnosis and treatment plans, supervised by periodontal faculty. Those patients with advanced periodontal disease will be directly referred to the Graduate Periodontics clinic.

Referral to graduate periodontics in the predoctoral (CCC) clinic We have adopted new guidelines for referring patients to the grad perio clinic. These guidelines parallel the AAP guideline, with a few changes. We will mandate pre-treatment referral to graduate periodontics for patients with aggressive periodontitis, generalized deep pocketing, gingival recession in the esthetic zone, acute periodontal problems and drug induced gingival enlargement. We will also require referral to graduate periodontics for patients who do not respond to initial periodontal therapy. An integral part of this process will be to have all full time periodontal faculty, part time periodontal faculty and graduate periodontal students consistently follow our guidelines for referral. Specifying periodontal surgery in the treatment plan Many patients are appropriately referred to the Graduate Periodontics Clinic at periodontal re-evaluation following initial therapy. However, the likelihood of required periodontal surgery may not have been previously presented to the patient. We are making a special effort to have periodontal surgery specified in patients’ overall treatment plans, even if no pretreatment referrals are made.

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Recent Awards to Faculty and Students

Dr. Binnaz Leblebicioglu: 2007 OSU Student Government Teaching Award.

Dr. Purnima Kumar:

2007 OSU Student Government Teaching Award.

Dr. James Palermo: 2007 American Academy of Periodontology Outstanding Educator Award for Ohio State.

Dr. Palermo has been a dedicated part time teacher at Ohio State since 1973. He has had an enormous impact on postdoctoral student clinical periodontal education

and greatly deserves recognition.

Dr. Lewis J. Claman: Honored hooder at the

Class of 2007 Convocation Ceremony in June.

Dr. Messick: Outstanding Clinic Instructor Award at the

Class of 2007 Convocation Ceremony in June.

Dr. Jeffrey Wessel: First place in the Midwest Society of Periodontology 2007 Graduate Student Research Forum for his

work: ‘Revascularization of Gingival Grafts: a Laser Doppler Flowmetry Study’. Orban Competition finalist in the AAP 2007.

Runner-up in the international Volpe Prize Competition for clinical periodontal research.

Congratulations to Our New Diplomates

Dr. William Cho (class of 2006)

Dr. Randy Fitzgerald (class of 2006)

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New Fulltime Faculty

Dr. Hua-Hong (Ben) Chien

Dr. Chien was born and raised in Taiwan. He obtained his dental degree from China Medical University, Taiwan in 1986. He then attended the State University of New York at Buffalo, School of Dental Medicine from 1990 to 1997, where he received his PhD in Oral Biology and certificate in Periodontics. Dr. Chien moved back to his native country, Taiwan, in November 1997 and served as a full time faculty at the China Medical University. In 2001, he was appointed as the Dean in School of Dentistry at China Medical University. In July 2007, he joined the College of Dentistry at the Ohio State University, where he is working as a clinical associate professor for the Section of Periodontology. Dr. Chien’ scientific interests include periodontal regeneration, implant dentistry and the effects of the herbal mouthrinse on gingival angiogenesis.

The Cutting Edge 6

Resident’s Review

Burning Mouth Syndrome Huei-Ling Chang, DDS

Introduction Burning mouth syndrome (BMS) is a relatively common oral condition which presents a challenge for both diagnosticians and clinicians. In a referral-based oral pathology practice study,1 Haberland and coworkers reported 10% of referrals from physicians and dentists to be BMS, which is the second most common problems next to candidiasis. The syndrome is characterized by a burning sensation without presence of oral mucosal changes. The International Association for the Study of Pain (IASP) has described the sensation as “unremitting oral burning or similar pain”.2 BMS is most commonly observed among middle-aged, post-menopausal women with hormonal changes or personality disorders.3, 4 BMS affects seven times more women than men.5 6 Due to lack of a universal diagnostic criteria, prevalence ranges from 0.7% to 4.6%.7-9 In the United States, approximately 1.3 million adults are potentially affected by BMS. Several synonymous terminologies such as “oral dysesthesia”, “stomatodynia”, “glossodynia”, and “scalding tongue” are also used to describe the clinical presentations of BMS. Of the various oral complaints and locations, “pain” appeared to be the most common symptom, and the tongue is the primary site involved.3, 9 Method A PubMed search of the English language, or English translation literature available, published between 1980 to the present day with keywords of “burning mouth syndrome”, “prevalence”, “symptoms”, and “treatment” was performed. 114 articles were initially selected and reviewed. Of those, 77 articles were cited. Multi-center studies, randomized clinical trials, controlled clinical trials, communication letters and case reports with relevant information were reviewed and discussed. Classification BMS can be categorized by the severity of symptoms as mild, moderate or severe, according to Basker et al.10, and moderate BMS is reported most frequently. BMS can also be classified according to its nature and possible etiology. 5 In type 1 BMS, patients wake up with no symptoms; the burning begins and the intensity increases as the day goes on, while the peak is reached in the evenings. In type 2 BMS, the burning is present on waking and persists throughout the day. The symptoms in type 1 and 2 are both unremitting. Unusual site involvement, such as the floor of mouth or the throat is seen in type 3. In addition, the course of pain is intermittent with a pain-free period occurs during the day. Another classification proposed by Scala et al. 11 is based on the etiopathogenesis of BMS. The primary BMS, or the “true” BMS refers to the condition of unknown causes, while local or systemic factors are often associated with secondary BMS. However, the psychogenic role in both subgroups still needs to be clarified. Symptoms and Signs Scala et al.11 described two clinical characteristics for the diagnosis of BMS: (1) a “symptomatic triad” which includes pain, xerostomia and dysguesia (2) “no signs or other detectable changes in the oral mucosa” Pain Pain is the cardinal sign of BMS. The IASP defined BMS as unremitting pain for at least 6 months, 2 and the average duration is 2 to 5 years. Patients describe the sensation as: burning (62.5%)12, heat, stinging, itching, swelling, pain, numbness and scalded mouth. The tongue is the most commonly involved site with a reported frequency of 37.5-100%. 9, 13-15 Patients often complain of burning pain in the anterior two-thirds of tongue, although the margin of tongue, or the whole tongue can demonstrate involvement. Other common locations include the hard palate and the mucosal part of the lower lip. Other sites with reported BMS involvement are the oropharynx, maxillary gingiva, denture bearing areas, throat, buccal mucosa and floor of the mouth. The intensity of pain is often measured with visual analog scale (VAS) in which 0 means no pain and 10 refers to the most extreme pain. The average VAS score reported by patients ranged from 6.0 to 7.4. 12, 13, 16 Continuous pain (Type 1 or 2 by Lamey & Lewis, 1989) is the common pattern of frequency, while 16.7-37.5% of patients have intermittent pain. 12, 15 Xerostomia Subjective xerostomia is approximately reported in 29.6-75% of BMS patients 9, 12, 17-19 despite the absence of clinical findings indicative of salivary gland disease such as the enlargement of parotid gland. Half of the patients presented with hyposalivation and 40% with reduced flow 12, 15; defined as the resting salivary flow rate averages below 0.2 ml/min. It should be noted that xerostomia is commonly associated with psychological disorders and as a result of multiple medications used among BMS patients. Dysgeusia Dysgeusia, or altered taste sensation, is another common complain of people who suffer from BMS with a prevalence of 60-70%.15,

18 21 Bergdahl and Bergdahl 20 examined patients with perceived taste disturbance and found 20% of the cases were related to BMS. Sensations are described as bitter, metallic or both. A whole-mouth-test of gustatory function comparison between individuals with BMS and healthy controls revealed a significantly lower score in BMS (mean 11.9) than control (mean 14.3). 22,23 Additionally, a significantly higher percentage of subjects demonstrated taste disturbances of sweet, salty, sour and bitter compared to controls.24 Etiology Multiple factors are associated with BMS despite the fact that its true etiology is still unclear. Although the primary cause of BMS remains the major challenge for diagnosis, it is beneficial for clinicians to understand all possible related etiologies of both primary and secondary BMS. Continued on Page 8

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Resident’s Review, Continued Local Factors Oral infections such as candidiasis have been shown to be related with oral burning; 3, 25, 26 Vitkov and coworkers 26 found increased candidial density in sites with burning sensation in 50% of BMS patients, while symptoms subsided in all patients after successful treatment with antifungal therapy. Helicobacter pylori colonization in the oral cavity is not only associated with oral ulcers, 27 evidence also showed the presence of H. pylori in subjects with BMS. 14, 28 Laskaris et al. reported oral burning in HIV-infected patients with the prevalence of 19%, however with various other oral manifestations such as candidiasis, hairy leukoplakia, etc., more studies are needed to conclude that HIV infection is one of the causative factors of BMS. Allergic reactions to dental restorative or prosthesis materials are also related to BMS and symptoms are usually relieved after removal of allergens. Pigatto et al. 29 reported a case of severe allergy to mercury and dental amalgam, intraoral burning as well as systemic erythematous reaction were present. Other common allergens associated with dental materials include goldsodiumthiosulphate (14.0%), nickel sulfate (13.2%), palladium chloride (7.4%), cobalt chloride (5.0%), and 2-hydroxyethyl methacrylate (5.8%).30 In addition to BMS, contact allergy can manifest as intraoral ulceration, chelitis, perioral dermatitis, lichenoid reaction, and oral granulomatosis.30 Other authors found allergic reactions to food or addictives such as peanuts 31, antioxidants (octyl gallate) 32; and flavoring agents, (namely methanol or peppermint) 33 among BMS patients. A patch test can be performed if this type of reaction is suspected. Svensson and coworkers 34 compared the denture function between 30 denture-wearing patients diagnosed with BMS to 26 age-sex matched controls, and reported significantly less daily use of dentures, reduced tongue space, incorrect placement of the occlusal table and increased vertical dimension in the BMS group. Proper evaluation of denture design and habit of use is also necessary when examining denture-wearing BMS patients. Systemic Factors Vitamin B12 deficiency with or without a hematological disorder, such as pernicious or macrocytic anemia can present with an oral burning sensation and sometimes misdiagnosed as BMS.35, 36 With vitamin B12 deficiency the tongue appears smooth and shiny due to loss of filiform papillae and central fissuring. A thorough review of medical history which includes diet and laboratory tests should be considered when patients present with atrophic glossitis. Other nutritional deficiencies such as Vitamin B1, B2, B6, 37 folic acid and iron 38 are also related to oral burning sensations. Although nutritional deficiencies appear to be a factor with BMS, two studies failed to show improvement of symptoms after correction of the causes. 37, 38 Diabetic neuropathy is a progressive condition which most often involves the distal peripheral nerves leading to neuronal fiber loss, tissue atrophy, injury and pain. The complain of intraoral burning sensation among diabetic patients can be a sign of diabetic neuropathy, and glycemic control should be the first line treatment. 39 Other studies also demonstrate the relationship between BMS and diabetes. 10, 40 In addition to diabetic neuropathy, lack of glycemic control results in more fragile oral mucosa, and an increased chance of oral candidial infection; both of which could the explain burning sensation among diabetic patients. Soares and coworkers 12 reviewed the consumption of medications of 40 BMS patients. Patients took average 3.9±2.0 medicines per day, among which 95% were xerostomic agents such as hypotensives and diuretics. Several case reports described the onset of burning symptoms without evidence of mucosal changes after taking angiotension converting enzyme inhibitor (ACEI) enalapril 41, 42, eprosartan 43, captopril 42, and lisinopril 44. Other authors also reported intraoral burning after taking anxiolytics (clonazepam) 45, and selective serotonin reuptake inhibitors (SSRIs) 46 for treatment of anxiety and depression. BMS related symptoms to hormone replacement therapy were also reported.47 Since the majority of BMS occurs in the menopausal or post-menopausal females, several studies have focused on the climacteric as being a causative factor. Tarkkila et al.48 surveyed 2973 females aged 50-58 and discovered the prevalence of BMS to be 8.2-24 % of those. They report a significant correlation between the two results. Subjects also report dry mouth, burning sensation, dysguesia, and difficulty in swallowing, which were reported 23-45 % of menopausal females. 49-51 A general explanation is that hormonal alterations at menopause might lead to vasomotor, neurological, and psychological changes. Psychological Factors It is widely accepted that psychological factors play an important role in the etiology of BMS. Al Quran 16 compared the psychological profile of 32 BMS patients to the same number of age-sex matched controls using the Neo PI-R questionnaire. BMS patients showed significantly higher scores in four of the five domains: neuroticism, extraversion, openness, conscientiousness. Additionally, higher scores were recorded in all facets of neuroticism – anxiety, angry hostility, depression, self-consciousness, impulsiveness, and vulnerability. Significantly higher anxiety and depression scores in BMS patients, compared to controls, were found when a Hospital Anxiety and Depression (HAD) scale was used.52 In a group of 150 subjects presenting with burning oral symptoms, Brailo and coworkers reported 42.1% of BMS having taken anxiolytics, which was significantly higher than the 16.3% found in the control group.53 Pathology Hershkovich and Nagler24 analyzed the saliva composition and taste acuity of 180 BMS patients with or without accompanying taste aberration or xerostomia. The concentrations of sodium, total protein, albumin, IgA, IgG, IgM and lysozyme were significantly increased when compared to controls. It was noted that strikingly higher concentration of albumin, IgG and IgM were greater than normal, 3.9, 5.7, and 7.8 times respectively. A significant difference of salivary composition was also reported by other studies. 49 Spielman 54 and Matsuo 55 both reviewed the interaction of saliva and taste and pointed out that salivary components are critical in obtaining the concentration threshold for a certain taste and maintaining an ionic environment for signal transduction. This finding can help explain why there is taste alteration among BMS patients, although reduced salivary flow rate as an etiology is still controversial. One study found significant elevated levels of interleukin-2 (IL-2) and interleukin-6 (IL-6) in saliva which led to that groups’ hypothesis that BMS was an inflammatory response,56 however, Boras et al. 57 failed to prove the role of inflammation in the syndrome’s etiopathogenesis. Continued on Page 9

Resident’s Review, Continued Heckmann and coworkers23 examined the microcirculation of the tip of tongue, buccal mucosa, hard palate, lip, and oral vestibule using laser Doppler flowmetry (LDF) on 13 patients with BMS. The mucosal blood flow at the involved sites had generally a greater change upon dry-ice stimulation, especially at the hard palate which reached a level of statistical significance. Although further studies are encouraged to confirm and expand upon these results, the neurovascular microcirculatory unit might play an important role in the cause of BMS. Peripheral sensory nerve dysfunction has been studied in the pathogenesis of BMS for several decades. Biopsies taken from the tongues of patients with BMS demonstrated a 60% lower density of epithelial nerve fibers compared to healthy controls, while complete degeneration of the epithelium and diffused degenerative changes of sub-papillary nerve bundles also indicated abnormal axonal changes.58 Electrophysiological tests of another fifty-two BMS patients revealed an abnormal blink reflex in ten of the group, while most of them showed afferent abnormality of the mandibular sensory nerves.58 Furthermore, 76% of patients showed altered thresholds to one or more of the sensations: warm, cold and pre-pain which may add small fiber neuropathy as an explanation to the cause of BMS symptoms. Other studies have focused on the pathology of the central nervous system. Albuquerque, et. al.59 performed functional magnetic resonance imaging (fMRI) tests on eight BMS patients. During periods of stimulation of the trigeminal nerve with different thermal stimulants, qualitative (location) and quantitative (spatial extent and amplitude) brain activation pattern differences were demonstrated between groups. Possible causative factors of BMS from this study include hypoactivity of thalamus and activity of the pre-cuneus. Treatment Most case reports demonstrate successful elimination of oral symptoms after correcting the etiology of secondary BMS. Treatment of primary BMS is focused upon pharmaceuticals and behavioral modification. Antidepressants have been shown to be effective in reducing pain level. Demarosi et al. 60 evaluated the treatment outcome of thirty-nine patients with levosulpride (Levoren) 100mg/day over eight weeks. Seventy-two percent of subjects had partially improved while the remaining did not respond. The authors also found a more favorable response in individuals with symptoms of a shorter duration. Maina and coworkers61 compared the treatment outcome of amisulpride (Solian) 50 mg/day and selective serotonin reuptake inhibitors (SSRIs) (paroxitine (Paxil): 20 mg/day or sertraline (Zoloft): 50 mg/day ) in BMS using pain intensity, depression, and an anxiety scale assessment. Results indicated that amisulrpide and the SSRIs are both effective. Topical use of the benzodiazepine, clonazepam, also demonstrated clinical efficacy with average pain scale reduction of 2.2 compared to a reduction of 0.6 with placebo in forty-eight patients.62 Oral rinse with topical anesthetics such as benzydamine HCl,63 and dyclonine HCl 64 also seemed to be effective. Titration of capsaicin (Tabasco sauce) with warm water and rinse also showed relief of symptoms.65 Capsaicin was shown to desensitize C-nociceptors which was believed to block the pain sensation.66 Clinical efficacy of topical use of benzodiazepines and anesthetic seemed to support the view of regional small fiber neuropathy as causative factor of BMS. Systemic use clonazepam with initial dose of 0.25mg/day for one week was evaluated among 30 patients.67 Patients slowly increased the dosage to no greater than 3 mg/day based on the response to therapy and degree of side effects that occurred. Twenty-one patients demonstrated a positive response, although eight of the group reported significant side effects. Heckmann et al.68 reported no improvement of VAS score, mood scale, depression index, and chemosensory functions after the use of gabapentin (Neurontin) with a starting dose of 300 mg/day (maximum 2400 mg/day) among fifteen patients. However, a case report described significant reduction of oral burning sensation after administration of the same medication.69 Feminano and Scully70 in a double blind, controlled study used 200 mg of alpha-lipoic acid (thioctic acid) – a potent antioxidant essential to the Krebs cycle – three times a day for treatment of sixty BMS patients for a two-month period. Twenty-nine patients indicated having improvement while four had complete resolution of symptoms. A meta-analysis by Ziegler, et. al.71 demonstrated that daily use of 600 mg alpha-lipoic acid over three weeks had improved neuropathic symptoms in diabetic patients with polyneuropathy. Those same authors later reported use of tranquillizers reduced the treatment response of alpha-lipoic acid in treatment of BMS,72 which emphasizes the role of psychological evaluation in addition to medication in the treatment of BMS. Since BMS patients are reported to have higher level of anxiety, depression, etc.16, 19, 73 psychological therapy should be strongly considered as an adjunct to pharmaceutical intervention, especially with those who do not respond to medicinal therapy alone. The purpose of psychological therapy in BMS is to allow patients to recognize the course of symptoms and to explore the role of emotional stress associated with the presentation of discomfort. Cognitive behavioral therapy has been shown to be effective in management of BMS,74, 75 specifically a combination of SSRIs 76 or alph-lipoic acid77 with psychological therapy has demonstrated increased success in the treatment of BMS. Conclusion Burning mouth syndrome is a common oral pathology lesion that general dental practitioners and/or dental specialist encounter. A thorough understanding of its clinical manifestations, careful information gathering, along with proper diagnostic aids will help clinicians recognize and manage their patient’s disease and symptoms. Secondary BMS is manageable provided that the underlying condition is elucidated, then eliminated. Primary BMS remains challenging regarding its true etiology and treatment, however several possible etiologies have been investigated and certain medications alone or in combination with psychological therapy seem to be effective in assisting patients with their chief complaints. Future research direction should include larger sample sizes and long-term studies focusing on the true etiology, new therapy approaches and subsequent treatment outcomes. Continued on Page 10

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Resident’s Review, Continued References 1. Haberland CM, Allen CM, Beck FM. Referral patterns, lesion prevalence, and patient care parameters in a clinical oral pathology practice. Oral

Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:583-588. 2. Merskey H BN. Classification of chronic pain. Descriptions of chronic pain syndromes and definitions of pain terms. In: Task of taxonomy. ISAP

Press 1994:p.74. 3. Gorsky M, Silverman S, Jr., Chinn H. Clinical characteristics and management outcome in the burning mouth syndrome. An open study of 130

patients. Oral Surg Oral Med Oral Pathol 1991;72:192-195. 4. Grushka M. Clinical features of burning mouth syndrome. Oral Surg Oral Med Oral Pathol 1987;63:30-36. 5. Lamey PJ, Lewis MA. Oral medicine in practice: burning mouth syndrome. Br Dent J 1989;167:197-200. 6. Lamey PJ, Freeman R, Eddie SA, et al. Vulnerability and presenting symptoms in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral

Radiol Endod 2005;99:48-54. 7. Grushka M, Sessle BJ. Burning mouth syndrome. Dent Clin North Am 1991;35:171-184. 8. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc

1993;124:115-121. 9. Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med 1999;28:350-354. 10. Basker RM, Sturdee DW, Davenport JC. Patients with burning mouths. A clinical investigation of causative factors, including the climacteric and

diabetes. Br Dent J 1978;145:9-16. 11. Scala A, Checchi L, Montevecchi M, et al. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med

2003;14:275-291. 12. Soares MS, Chimenos-Kustner E, Subira-Pifarre C, et al. Association of burning mouth syndrome with xerostomia and medicines. Med Oral Patol

Oral Cir Bucal 2005;10:301-308. 13. Lauria G, Majorana A, Borgna M, et al. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome. Pain 2005;115:332-337. 14. Gall-Troselj K, Mravak-Stipetic M, Jurak I, et al. Helicobacter pylori colonization of tongue mucosa--increased incidence in atrophic glossitis and

burning mouth syndrome (BMS). J Oral Pathol Med 2001;30:560-563. 15. Eguia Del Valle A, Aguirre-Urizar JM, Martinez-Conde R, et al. Burning mouth syndrome in the Basque Country: a preliminary study of 30 cases.

Med Oral 2003;8:84-90. 16. Al Quran FA. Psychological profile in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:339-344. 17. Palacios-Sanchez MF, Jordana-Comin X, Garcia-Sivoli CE. Burning mouth syndrome: a retrospective study of 140 cases in a sample of Catalan

population. Med Oral Patol Oral Cir Bucal 2005;10:388-393. 18. Grushka M, Sessle BJ, Howley TP. Psychophysical assessment of tactile, pain and thermal sensory functions in burning mouth syndrome. Pain

1987;28:169-184. 19. Grushka M, Sessle BJ, Miller R. Pain and personality profiles in burning mouth syndrome. Pain 1987;28:155-167. 20. Bergdahl M, Bergdahl J. Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication. Clin

Oral Investig 2002;6:145-149. 21. Femiano F, Gombos F, Esposito V, et al. Burning mouth syndrome (BMS): evaluation of thyroid and taste. Med Oral Patol Oral Cir Bucal

2006;11:E22-25. 22. Ahne G, Erras A, Hummel T, et al. Assessment of gustatory function by means of tasting tablets. Laryngoscope 2000;110:1396-1401. 23. Heckmann SM, Heckmann JG, HiIz MJ, et al. Oral mucosal blood flow in patients with burning mouth syndrome. Pain 2001;90:281-286. 24. Hershkovich O, Nagler RM. Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or

gustatory disturbances. Arch Oral Biol 2004;49:515-522. 25. Zegarelli DJ. Burning mouth: an analysis of 57 patients. Oral Surg Oral Med Oral Pathol 1984;58:34-38. 26. Vitkov L, Weitgasser R, Hannig M, et al. Candida-induced stomatopyrosis and its relation to diabetes mellitus. J Oral Pathol Med 2003;32:46-50. 27. Mravak-Stipetic M, Gall-Troselj K, Lukac J, et al. Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction

(PCR). J Oral Pathol Med 1998;27:1-3. 28. Adler I, Denninghoff VC, Alvarez MI, et al. Helicobacter pylori associated with glossitis and halitosis. Helicobacter 2005;10:312-317. 29. Pigatto PD, Guzzi G, Persichini P, et al. Recovery from mercury-induced burning mouth syndrome due to mercury allergy. Dermatitis 2004;15:75-

77. 30. Khamaysi Z, Bergman R, Weltfriend S. Positive patch test reactions to allergens of the dental series and the relation to the clinical presentations.

Contact Dermatitis 2006;55:216-218. 31. Whitley BD, Holmes AR, Shepherd MG, et al. Peanut sensitivity as a cause of burning mouth. Oral Surg Oral Med Oral Pathol 1991;72:671-674. 32. Pemberton M, Yeoman CM, Clark A, et al. Allergy to octyl gallate causing stomatitis. Br Dent J 1993;175:106-108. 33. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis

1995;32:281-284. 34. Svensson P, Kaaber S. General health factors and denture function in patients with burning mouth syndrome and matched control subjects. J Oral

Rehabil 1995;22:887-895. 35. Lehman JS, Bruce AJ, Rogers RS. Atrophic glossitis from vitamin B12 deficiency: a case misdiagnosed as burning mouth disorder. J Periodontol

2006;77:2090-2092. 36. Field EA, Speechley JA, Rugman FR, et al. Oral signs and symptoms in patients with undiagnosed vitamin B12 deficiency. J Oral Pathol Med

1995;24:468-470. 37. Hugoson A, Thorstensson B. Vitamin B status and response to replacement therapy in patients with burning mouth syndrome. Acta Odontol Scand

1991;49:367-375. 38. Dutree-Meulenberg RO, Kozel MM, van Joost T. Burning mouth syndrome: a possible etiologic role for local contact hypersensitivity. J Am Acad

Dermatol 1992;26:935-940. 39. Carrington J, Getter L, Brown RS. Diabetic neuropathy masquerading as glossodynia. J Am Dent Assoc 2001;132:1549-1551. 40. Gibson J, Lamey PJ, Lewis M, et al. Oral manifestations of previously undiagnosed non-insulin dependent diabetes mellitus. J Oral Pathol Med

1990;19:284-287. Continued on Page 11

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Resident’s Review, Continued 41. Triantos D, Kanakis P. Stomatodynia (burning mouth) as a complication of enalapril therapy. Oral Dis 2004;10:244-245. 42. Brown RS, Krakow AM, Douglas T, et al. "Scalded mouth syndrome" caused by angiotensin converting enzyme inhibitors: two case reports. Oral

Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83:665-667. 43. Castells X, Rodoreda I, Pedros C, et al. Drug points: Dysgeusia and burning mouth syndrome by eprosartan. Bmj 2002;325:1277. 44. Savino LB, Haushalter NM. Lisinopril-induced "scalded mouth syndrome". Ann Pharmacother 1992;26:1381-1382. 45. Culhane NS, Hodle AD. Burning mouth syndrome after taking clonazepam. Ann Pharmacother 2001;35:874-876. 46. Levenson JL. Burning mouth syndrome as a side effect of SSRIs. J Clin Psychiatry 2003;64:336-337; author reply 337-338. 47. Palin SL, Kumar S, Barnett AH, et al. A burning mouth associated with the use of hormone replacement therapy. J Br Menopause Soc 2005;11:38. 48. Tarkkila L, Linna M, Tiitinen A, et al. Oral symptoms at menopause--the role of hormone replacement therapy. Oral Surg Oral Med Oral Pathol

Oral Radiol Endod 2001;92:276-280. 49. Ben Aryeh H, Gottlieb I, Ish-Shalom S, et al. Oral complaints related to menopause. Maturitas 1996;24:185-189. 50. Ferguson MM, Carter J, Boyle P, et al. Oral complaints related to climacteric symptoms in oophorectomized women. J R Soc Med 1981;74:492-

498. 51. Wardrop RW, Hailes J, Burger H, et al. Oral discomfort at menopause. Oral Surg Oral Med Oral Pathol 1989;67:535-540. 52. Sardella A, Lodi G, Demarosi F, et al. Causative or precipitating aspects of burning mouth syndrome: a case-control study. J Oral Pathol Med

2006;35:466-471. 53. Brailo V, Vueiaeeviae-Boras V, Alajbeg IZ, et al. Oral burning symptoms and burning mouth syndrome-significance of different variables in 150

patients. Med Oral Patol Oral Cir Bucal 2006;11:E252-255. 54. Spielman AI. Interaction of saliva and taste. J Dent Res 1990;69:838-843. 55. Matsuo R. Role of saliva in the maintenance of taste sensitivity. Crit Rev Oral Biol Med 2000;11:216-229. 56. Simcic D, Pezelj-Ribaric S, Grzic R, et al. Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome. Mediators

Inflamm 2006;2006:54632. 57. Boras VV, Brailo V, Lukac J, et al. Salivary interleukin-6 and tumor necrosis factor-alpha in patients with burning mouth syndrome. Oral Dis

2006;12:353-355. 58. Forssell H, Jaaskelainen S, Tenovuo O, et al. Sensory dysfunction in burning mouth syndrome. Pain 2002;99:41-47. 59. Albuquerque RJ, de Leeuw R, Carlson CR, et al. Cerebral activation during thermal stimulation of patients who have burning mouth disorder: an

fMRI study. Pain 2006;122:223-234. 60. Demarosi F, Tarozzi M, Lodi G, et al. The effect of levosulpiride in burning mouth syndrome. Minerva Stomatol 2007;56:21-26. 61. Maina G, Vitalucci A, Gandolfo S, et al. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. J Clin

Psychiatry 2002;63:38-43. 62. Gremeau-Richard C, Woda A, Navez ML, et al. Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Pain 2004;108:51-

57. 63. Sardella A, Uglietti D, Demarosi F, et al. Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial. Oral

Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:683-686. 64. Formaker BK, Mott AE, Frank ME. The effects of topical anesthesia on oral burning in burning mouth syndrome. Ann N Y Acad Sci 1998;855:776-

780. 65. Spice R, Hagen NA. Capsaicin in burning mouth syndrome: titration strategies. J Otolaryngol 2004;33:53-54. 66. Epstein JB, Marcoe JH. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral

Pathol 1994;77:135-140. 67. Grushka M, Epstein J, Mott A. An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome. Oral Surg Oral

Med Oral Pathol Oral Radiol Endod 1998;86:557-561. 68. Heckmann SM, Heckmann JG, Ungethum A, et al. Gabapentin has little or no effect in the treatment of burning mouth syndrome - results of an

open-label pilot study. Eur J Neurol 2006;13:e6-7. 69. White TL, Kent PF, Kurtz DB, et al. Effectiveness of gabapentin for treatment of burning mouth syndrome. Arch Otolaryngol Head Neck Surg

2004;130:786-788. 70. Femiano F, Scully C. Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. J Oral Pathol

Med 2002;31:267-269. 71. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.

Diabet Med 2004;21:114-121. 72. Femiano F, Gombos F, Scully C, et al. Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on

symptomatology. Oral Dis 2000;6:274-277. 73. Bergdahl J, Anneroth G, Perris H. Personality characteristics of patients with resistant burning mouth syndrome. Acta Odontol Scand 1995;53:7-11. 74. Humphris GM, Longman LP, Field EA. Cognitive-behavioural therapy for idiopathic burning mouth syndrome: a report of two cases. Br Dent J

1996;181:204-208. 75. Bergdahl J, Anneroth G, Perris H. Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral

Pathol Med 1995;24:213-215. 76. Van Houdenhove B, Joostens P. Burning mouth syndrome. Successful treatment with combined psychotherapy and psychopharmacotherapy. Gen

Hosp Psychiatry 1995;17:385-388. 77. Femiano F, Gombos F, Scully C. Burning Mouth Syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid),

and combination therapy. Med Oral 2004;9:8-13.

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OSU Periodontal Alumnus Profile

Dr. Gerald Bowers

In this issue of The Cutting Edge, we are proud to highlight the preeminent and illustrious career of Dr. Gerald Bowers. Dr. Bowers was born in Trenton, Michigan. He received his baccalaureate degree from the University of Michigan in 1950 and his DDS from the University of Michigan in 1954. He received a certificate in General Dentistry from the Navy Dental School in 1960 and completed his Masters and Certificate in Periodontology from The Ohio State University in 1962. Dr. Bowers has had a distinguished career as a periodontal educator. He was the Director of the Postdoctoral Fellowship program, Periodontal Clinic, Washington, D.C. from 1964-67. He was Chairman of the Department of Periodontics at the Naval Graduate Dental School Bethesda from 1969 to 1974. At the same time, he was a Clinical Associate Professor and Professorial Lecturer at Georgetown University. From 1974 to 1996, Dr. Bowers was a Professor and the Director of the Postdoctoral Program in Periodontics at the Baltimore College of Dental Surgery Dental School where he is currently Professor Emeritus. Dr. Bowers is recognized most by his contribution to organized dentistry. He was a consultant to the A.D.A. Council on Dental Education from 1970 to 1984. He was a representative to the A.D.A. Commission on Dental accreditation form 1969 to 1972. While in the Navy, he served in the Naval Medical Research Institute. During his career, Dr. Bowers was also a consultant to the U.S. Navy Bureau of Medicine and Dentistry, The National Institutes of Health and the Naval Dental Center. Dr. Bowers’ service career is highlighted by his enormous contributions to the American Academy of Periodontology and most especially the American Board of Periodontology. He was a member of the A.A.P. Executive Council from 1972 to 1978 and Chairman and Director of the American Board of Periodontology from 1976 to 1983. Dr. Bowers’ career is defined by his long and dedicated service as the Executive Director of the American Board of Periodontology, a position he has held since 1983. Continued on Page 13

OSU Periodontal Alumnus Profile, continued

Dr. Bowers’ contribution to the body of knowledge is universally recognized. He is especially well known for his work on periodontal regeneration through bone grafts. He is the principal author or co-author on 41 publications, one textbook, and 21 abstracts in refereed dental journals. Dr. Bowers’ expertise in periodontics has led to his being invited to participate in 20 major workshops starting in 1966. He has been an investigator on 8 funded research projects. His knowledge of periodontal surgery and specifically, periodontal regeneration, are internationally recognized. He has also been a featured presenter in more than 200 continuing education or scientific programs at dental societies. Dr. Bowers is the recipient of several distinguished honors. He was inducted at graduation from dental school into OKU. He received The Ohio State University Distinguished Alumni Award for Outstanding Achievement In Periodontal Research (1985) and the Orban Memorial Award from Loyola University in 1989. Dr. Bowers’ numerous awards from the American Academy of Periodontology include The A.A.P. Special Citation Award (1982 and 1990), the Willam J. Gies Award for achievement In Periodontology (1984 and 1987), The A.A.P. R. Earl Robinson Periodontal Regeneration Award (1990 and 2004), The A.A.P. Clinical Research award (1990), the A.A.P. Gold Medal Award (1992) and the A.A.P. Master Clinician Award (2000). Additionally, he is the 2007 recipient of the Quintessence Master Clinician Award. Dr. Bowers fondly remembers his time at Ohio State "As a wonderful time of my life!" He appreciates his interactions with fellow graduate students and faculty at the College of Dentistry and strongly feels they provided a great foundation for his successful career. Faculty, postdoctoral students and alumni at The Ohio State University Section of Periodontology take pride in recognizing Dr. Bowers’ extraordinary career accomplishments and the notoriety he has brought to our program.

If you are planning to attend the AAP meeting, please stop by to visit:

Please Join Us

Buckeye Reception

Monday, October 29, 2007, 5:30 –7:00 pm

Venue:

Renaissance Hotel, Room 7 Washington, DC

Hope to see you there!

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Photo Album

WELCOME TO OUR NEW FIRST YEAR RESIDENTS!

Program Director Dr. Dimitris Tatakis with Drs. Chad Matthews, Irma Iskandar, Janel Yu and Shaun Rotenberg.

Farewell and congratulations to our new graduates-Class of 2007!!!

Left to right: Drs. Chou, Wessel, Burrell, Tatakis and Khoury.

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MIDWEST SOCIETY OF PERIODONTOLOGY MEETING February 2007, CHICAGO

Left to right: Drs. Salas, Papapostolou, Kelsey and Lecture by Dr. P. D. Miller Ho, the second year residents.

Dr. P. D. Miller and Dr. Weiting Ho. Having a good time!!

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Dr. Jeff Wessel - winner of the 2007 Midwest Society Research Forum competition!!!

O-H-I-O !! Drs. Salas, Claman and Chang at the reception.

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Volpe Competition, May 2007

Drs. Sheridan and Kumar. Dr. Volpe, the guest of honor!!!

VOLPE competition presenters and guests.

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Dr. Binnaz Leblebicioglu. Competitors and OSU residents!

Drs. Daniels, Emecen and Ho. Dr. Wessel presenting his research.

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RESEARCH DAY, April 2006

Dr. Burrell presenting her research. Many alumni

Residents Dr. Maney presenting her research.

And in conclusion……………..

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PERIO PROM, June 2007

What a fun time! Our favorite faculty and their spouses!!

Drs. Pooja Maney, Weiting Ho and Renita Burrell 2nd year residents-Drs. Kelsey, Salas, Ho, Papapostolou

Class of 2007 with Dr. Tatakis! Our new chief resident-Dr. Jessica Stilley with Dr. Kumar.

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Drs. Terry Daniel, Lewis Claman, Chun-Han Chou Nancy Claman, Bridget Mariotti, Wei Tatakis and and Ms. Barbara Clark. Marilyn Messick.

Dr. Ling Chang, Joan, our clinic receptionist Drs. Claman and Wessel.

and Jean Spunt our Dental Hygienist.

Sisterhood : Drs. Mabel Salas and Pinar Emecen ! Fun picture!! Can you recognize our residents?

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Honor Roll of Giving

Gifts to the Section of Periodontology can be conferred to the following funds: Endowed Chair for Periodontology: To help ensure the long-term health and stability of the Section of

Periodontology at the OSU College of Dentistry, alumni and friends of the section have established a campaign to raise $1.5 million to create an Endowed Chair in Periodontology. For the Section to not only retain outstanding faculty, but to also recruit new faculty to fill the open positions today and in the future, it must distinguish itself even further from the other periodontal programs across the country. One of the best ways to do this is through the establishment of an endowed chair. For more information on what an endowed chair is and does or to talk about your interest in supporting this campaign, please contact Jim Mahony, Director of Development and Alumni Affairs, at (614) 292-1780.

The George R. App Periodontal Endowment Fund: Interest from the Endowment is used to support graduate

student education and development with special interest in providing funds for travel to meetings by The Ohio State University periodontal graduate students.

Periodontal Research and Training Fund: This fund is used to support a wide variety of periodontal activities by

the Section of Periodontology in the College of Dentistry. More specifically this fund is used for but not limited to the purchase of equipment for the graduate program, support of alumni activities (e.g. the annual AAP Buckeye Reception, CE courses, mailings, etc.), endowment of graduate research projects, purchase of food for graduate student activities, etc.

Center for Research in Periodontology: Periodontal research in the Section of Periodontology involves both

basic science and clinical science research projects.

Donors to the Periodontal Endowed Chair

Donations and Pledges ($25,000 and up): Dr. Ronald and Mrs. Marcia Garvey

Dr. Joseph and Mrs. Melanie Koberlein Dr. Winfield and Mrs. Jayne Meek

Dr. James and Mrs. Patricia Palermo Dr. Fred and Mrs. Jody Sakamoto

Dr. R. Jeffrey and Mrs. Diana Stephens

Donations and Pledges ($2,500-$4,999) Donations and Pledges ($1,000-$2,499) Project Advantage Dr. Barry and Mrs. Denise Blank Dr. Laurie McCauley

Donations and Pledges (up to $500) Dr. Charles and Mrs. Doris Solt

Total Pledges and Gifts: $206,750 Goal: $1,500,000 Balance: $1,293,250

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Upcoming Events

September 13-16, 2007 Ohio Dental Association Meeting September 27-October 2, 2007 American Dental Association Meeting, San Francisco October 27-30, 2007 American Academy of Periodontology, Washington, DC February 22-24, 2008 Midwest Society of Periodontology, Chicago February 28-March 1, 2008 Academy of Osseointegration, Boston March 29-April 2, 2008 American Dental Education Association Meeting, Dallas April 2-5, 2008 American Association for Dental Research, Dallas April 25, 2008 Periodontal Research Day, 8:30 am to 4:30 pm July 2-5, 2008 International Association for Dental Research, Toronto

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It’s Noteworthy

The Cutting Edge is available electronically! If you would like to receive it by email, please email us at osugradperio@osu.edu and let us know where you would like it delivered. It can also be accessed on the web: We encourage all alumni of our program to visit The Section of Periodontology on the OSU College of Dentistry Website. 1. The web address of the college is http://dent.osu.edu2. Click on Academic sections 3. Click on Periodontology and you will be on Periodontal Homepage You can then navigate to the Section of Periodontology’s History, Faculty, Staff, Predoctoral Program, Postdoctoral Program, Research, Service, Continuing Education, Alumni, and Patients. To access current or past The Cutting Edge issues: 1. Click on alumni 2. Click on The Cutting Edge 3. Click on any issue to open or download The direct Web address for The Cutting Edge is: http://dent.osu.edu/perio/alumni_the_cutting_edge.php

College of Dentistry Section of Periodontology Postle Hall 305 West 12th Avenue – Room #4129 Columbus, Ohio 43210 Meter: 21550-011000-61801-10000 E4A11

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