BUSINESS OPPORTUNITIES IN BIOTECHNOLOGY IN INDIA

P. K. Ghosh, Ph DManaging Director

KEE GAD Biogen Pvt. Ltd., New Delhi

(Former Adviser DBT, GOI)

pkghosh@keepharma.com

March 06, 2009

INDIAN EFFORTS TO SUSTAIN EMINENCE IN BIOTECHNOLOGY: MOSTLY A GOVERNMENT EFFORT

Government Departments DBT DST DSIR DRDO DOE & Others

Autonomous Institutions CSIR ICAR ICMR UGC/AICTE Institutions Other Institutions

P. K. Ghosh

INDIAN BIOTECH IN GLOBAL CONTEXT

Publications and Patents filings on the rise

Leadership in innovation is yet narrow

R&D Institutes & Universities low in Global ranking

Research in Industry not significant yet

Innovation and Application not strongly linked

Academia not ready to take risk for a venture

P. K. Ghosh

HEALTH & WEALTH: INDEX FOR DEVELOPMENT

A Country is highly developed if it has……

Break through remedies for major diseases like:

Cardiovascular diseases

Cancer

Viral Diseases

Killer Bacterial Diseases

Abundant availability of Clothing, Food & Drinking water

Sound Knowledge and Practice of good Hygiene

High Quality Jobs

Technologically Advanced Industries

In all the above areas Biotech can make a contribution….

P. K. Ghosh

SKILLS THAT REVOLUTIONIZED BIOTECHNOLOGY

rDNAs & MAbs

Microscopy and Imaging

Proteins & Nucleotide sequencing

PCR Technology

LC-MS & MALDI-TOP

Flow-cytometry & Cell Sorting Techniques

Chromatography & Electrophoresis

Protein & DNA Chips & Microarrays

Bio-Informatics

P. K. Ghosh

TOP CONCERNS OF INDIAN BIOTECH INDUSTRY

Scarce availability of leaders for company specific needs

Inadequate availability of skilled work force

Limited resources for research- Internal & External

Maintenance of Confidentiality

Issues of Intellectual Property

Bridging issues between R&D Institutions & Industry

Demanding statutory requirements

Biased concerns about products by opinion makers

Limited linkage between Industry need & Public research

P. K. Ghosh

BENEFITS OF TECHNOLOGY TRANSFER BY R&D INSTITUTES

To push discovery into the market

To attract Funding & Industrial Partnership

Budding skills can be placed into rewarding projects

To earn rewards through income & fame

Obliged to be transparent by disclosers – Projects, Employees, Sponsors etc.

Economic development and Societal uplift

P. K. Ghosh

BIOTECH APPLICATIONS

Health Care Agriculture

Environment Industry

GM- Planting Mats. & Hybrids

Micro-propagation

Bio-fertilizers & Bio-pesticides

Animal Improvement

r-DNA Products, Vaccines & Diagnostics Monoclonal Antibodies

Stem CellsTissue Specific delivery methods

Enzymes Fermentation based Products & Food

Biotech Instruments & Equipment Bio-energy & Bio-fuel

BioinformaticsBio-mining

Soil & Water remediationBio-safety & GMOs

P. K. Ghosh

BUSINESS OPPORTUNITIES: HEALTH CARE

rDNA Products & MAbs Cloning, Cell multiplication, Product separation & Formulations

Choice of technologies

Stem Cell Manipulation Isolation, purification & multiplication of tissue specific stem cells

Expertise in Cell re-programming to pluripotency

Over expression of certain Genes for Cell re-programming

Retro & Non-retroviral means of over expression of target genes

Tissue Specific Delivery Technologies Choice of Bio-degradable polymers & modification methods

Choice of technologies for production of precise Nano-particles

P. K. Ghosh

BUSINESS OPPORTUNITIES: AGRICULTURE

GM- Seeds: Varieties & Hybrids Choice of right materials

Cloning, Micro-propagation & Field Testing

Generation of Food & Environmental Safety Information

Extensive Public-Private Collaboration involving Opining Makers

Animal Improvement Land & Aquatic Animals Identification for Multiplication

Choice of Exotic Animal germplasm & Multiplication methods

Feed & Fodder Production technologies

P. K. Ghosh

BUSINESS OPPORTUNITIES: INDUSTRY & ENVIRONMENT

Industry r-DNA methods of producing Enzymes

Fermented Food & Beverages

Software Development for use in Biotech operations

Biotech Instruments through Electronics, Software & New Materials

Biomass Multiplication & Bio-fuel

Environment Biosafety Information generation for commercial use of GMOs

Degraded/ Polluted Soil & Water Remediation methods

P. K. Ghosh

BIOTECH PRODUCT DEVELOPMENT TREND

Drugs & Pharmaceuticals for Human

Isolating/Developing & Multiplying Totipotent Stem Cells

Genetically Modified Seeds for Agriculture

Instruments for Biotechnology

Bioinformatics

P. K. Ghosh

Biotech drugs innovation process

New Idea/ Research

Proof of Concept

Pilot Development

Production Unit setting up &

implementation into valuable form

Marketing feedback analysis

Animal Studies

Phase I, II, III Studies

Marketing Strategy

Time (Years)

Act

ors

05 10 15

R&D Institutes

Technology Development & Transfer

Strong Industry Motivation for Success

Regulatory Approval

Mon

ey S

pent

WHAT ARE THE SURVIVAL LANES?

To Intensify Basic Research

To Develop Novel Methods for Bio-generics

Mass Production of Multivalent Vaccines

Mass Production of Cheap Diagnostics

Novel Drug Delivery & Nanotechnology

GM Varieties from Public Institutions

Micro-propagation of elites

Industrial Enzymes by r-DNA technology

Mass Composting of wastes

Enzyme Enriched Food & Neutraceuticals

Bio-energy & Bio-fuels

P. K. Ghosh

THANK YOU

Turbulence ahead…

P. K. Ghosh