By: Dan Tamayo

Regenerate heart tissues that have been damaged by Myocardial Infarction

Help those with heart failure

End the need for a heart transplant list

1897-thoughts of growing cells were being discussed

1907- the first cells were grown outside of a living body

1940’s- the ability to specifically grow certain cells was discovered

1970’s- first artificial pancreas was made Mid 1990’s- starting to use direct tissue

delivery to the affected area 1998- the development of stem cells really

broadened the tissue engineering possibilities

2001-President Bush restricts the funding for stem cell research

Mid 2000’s- FDA approves most cells grafting into human bodies

2009-Obama lifts the ban on federal funding for stem cell research.

Today, scientists have been able to use the extracellular matrix from pig or rat hearts to make a new one using a technique called decellularization.

In 2011, Columbia University’s Biomedical Engineering researchers developed a new way to patch a heart.

This is the process of decellularization and recellularization.

Decellularization is when all the cells are removed except for the extracellular matrix (top)

Recellularization is when the new cells are grow in and around the new heart scaffold (bottom)

Empty Scaffold Scaffold with cultured heart cells from a rat

Small chance of immunorejection

Cost

Research

Optimal scaffold for cardiac tissue will be found

Ability to re-grow a heart from your cells to be transplanted into your body

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"Engineers Patch a Heart: Tissue-Engineering Platform Enables Heart Tissue to Repair Itself."ScienceDaily. ScienceDaily, 06 May 2011. Web. 26 Mar. 2012. <http://www.sciencedaily.com/releases/2011/05/110506171905.htm>.

Zammaretti, Prisca, and Marisa Jacon. "Cardiac Tissue Engineering: Regeneration of the Wounded Heart." Current Opinion in Biotechnology 15.430-434 (2004).Http://www.sciencedirect.com/. Web.

Columbia University. "Engineers patch a heart: Tissue-engineering platform enables heart tissue to repair itself." ScienceDaily, 7 May 2011. Web. 22 Oct. 2012.