Adenosine
Antiarrhythmic actions: Slows conduction time through the AV node,
interrupting the re-entry pathways through the AV node, restoring normal sinus
rhythm
Myocardial perfusion scintigraphy: coronary vasodilation and increases blood
flow in normal coronary arteries with little to no increase in stenotic coronary
arteries.
LRرس با 14: پایذاری هحلل رلیك شذه در سزنگ NSیا D5Wرس پایذار با 16
Pharmacologic Category:
- Antiarrhythmic Agent, Miscellaneous
-Diagnostic Agent
>10%:
Cardiovascular: Transient new arrhythmia (eg, atrial premature contractions,
atrial fibrillation) after cardioversion (55%), facial flushing (18% to 44%)
Central nervous system: Headache (2% to 18%), dizziness (2% to 12%)
Gastrointestinal: GI discomfort (13%)
Neuromuscular & skeletal: Discomfort of neck, throat, jaw (<1% to 15%)
Respiratory: Chest pressure/discomfort (7% to 40%), dyspnea (12% to
28%).......... Emphysema, bronchitis
etc…..
دی پیرادامول
کاربامازپین
Amiodarone
Inhibits adrenergic stimulation: (alpha-beta-blocking properties)
Affects sodium, potassium, and calcium channels: prolongs the action
potential and refractory period in myocardial tissue
Decreases AV conduction and sinus node function
Pharmacologic Category:
- Antiarrhythmic Agent
D5Wپایذاری در -
جذب سطحی ...... PVCساعت در ظزف 2ساعت در ظزف شیشو ای فمط 24-
PVCپیزی اس دس پیشنيادی استفاده اس تجيیشات ......
>10%:
Cardiovascular: Hypotension (I.V. 16%, refractory in rare cases)
Central nervous system (3% to 40%): dizziness, fatigue, headache, malaise,
impaired memory, involuntary movement, insomnia, poor coordination,
peripheral neuropathy, sleep disturbances, tremor
Dermatologic: Photosensitivity (10% to 75%) , pigmentation.
Endocrine & Metabolic: Hypothyroidism (1% to 22%) / hyperthyroidism
Gastrointestinal: Nausea, vomiting, anorexia, and constipation (10% to 33%)
Hepatic: AST or ALT level >2x normal (15% to 50%)
Ocular: Corneal microdeposits (>90%; causes visual disturbance in <10%)
فلکبیىید، پريکبئیه آمید ي کیىیدیهسرعت تصفی کجدی یب کلیی ثرخی داريبی ضد آریتمی کبش*
پريپبفىن، کیىیدیه، پريکبئیه آمیددر مصرف مسمبن ثب ثرخی داريبی ضد آریتمی مثل torsade depointامکبن ثريز آریتمی *
افت فشبر خن در مصرف مسمبن ثب سبیر داريبی کبىد فشبر خن تشدید*
بCCBثالکرب ي Bدر مصرف مسمبن ثب AVثیش از حد عملکرد قلت ي کبش دایت گر سرکة*
سطح سرمی دیگکسیه% 70-100 فسایشا*
خدداری از تجیس مسمبن..... ي کبش سطح سرمی ي ویم عمر ثب کلستیرامیه سبیمتیدیهغلظت سرمی آمیدارين ثب افسایش*
متتریکسبتي تئفیلیه ،دکستريمترفبن، سیکلسپریه غلظت افسایش*
فىی تئیهمتبثلیسم کبش*
تبثیر داريبی ضد اوعقبد خراکی ي امکبن ثريز خوریسی مىجر ث مرگ افسایش*
غلظت سرمی آمیدارين ثب فىی تئیه کبش*
فىتبویلثريز بیپتبوسین، ثرادی کبردی ي کبش ثرين د قلجی در مصرف مسمبن ثب *
ث عىان ثی حس کىىد مضعیلیديکبئیه در تجیس مسمبن ثب IVثريز یک مرد ثرادی کبردی سیىسی ي تشىج ثب ديز زیبد *
مهار کننده قوی آنسیم های کبدی
Verapamil
Inhibits calcium ion from entering the “slow channels” or
select voltage-sensitive areas of vascular smooth muscle and
myocardium during depolarization;
produces relaxation of coronary vascular smooth muscle
vasodilation
increases myocardial oxygen delivery in patients with angina
slows automaticity and conduction of AV node
Pharmacologic Category:
-Antianginal Agent
-Antiarrhythmic Agent
-Calcium Channel Blocker
>10%:
CNS: Headache (1% to 12%)
GI: Gingival hyperplasia (≤19%), constipation (7% to 12%)
1% to 10%:
Cardiovascular: Peripheral edema (1% to 4%), hypotension (3%),
CHF/pulmonary edema (2%), AV block (1% to 2%), bradycardia (HR <50 bpm: 1%),
CNS: Fatigue (2% to 5%), dizziness (1% to 5%), lethargy (3%), pain (2%), sleep
disturbance (1%)
Dermatologic: Rash (1% to 2%)
Lidocaine:
Pharmacologic Category :
-Antiarrhythmic Agent, Class Ib;
-Local Anesthetic
.پایذار است 24hدر دهای اتاق حذالل تا %DWSهحلل رلیك شذه با
سذین بی کزبنات........................... pH= 3-6بیشتزین پایذاری در
*increasing electrical stimulation threshold of ventricle, His-Purkinje system, and
spontaneous depolarization of the ventricles during diastole by a direct action on
the tissues.
*blocks both the initiation and conduction of nerve impulses by decreasing the
neuronal membrane's permeability to sodium ions.
Cardiovascular: Arrhythmia, bradycardia, arterial spasms, cardiovascular collapse,
edema, flushing, heart block, hypotension, sinus node supression
CNS: Agitation, anxiety, apprehension, coma, confusion, headache, hyperesthesia,
hypoesthesia, lethargy, lightheadedness, nervousness,
Gastrointestinal: Metallic taste, nausea, vomiting
Local: Thrombophlebitis
Neuromuscular & skeletal: Paresthesia, tremor, weakness
Otic: Tinnitus
Dobutamine
Stimulates beta1-adrenergic receptors; causing increased contractility and
heart rate, with little effect on beta2- or alpha-receptors
Pharmacologic Category:
-Adrenergic Agonist Agent
.ساعت هصزف شد هابمی در ریختو شد 24هحلل رلیك شذه بایستی تا -
اکسیذاسین.... تغییز رنگ **
Cardiovascular: Increased heart rate, increased blood pressure, increased
ventricular ectopic activity, hypotension, premature ventricular beats (5%, dose
related), anginal pain (1% to 3%), nonspecific chest pain (1% to 3%), palpitation
(1% to 3%)
CNS: Fever (1% to 3%), headache (1% to 3%), paresthesia
Endocrine & metabolic: Slight decrease in serum potassium
Gastrointestinal: Nausea (1% to 3%)
Hematologic: Thrombocytopenia
Local: Phlebitis, local inflammatory changes and pain from infiltration, cutaneous
necrosis (isolated cases)
Neuromuscular & skeletal: Mild leg cramps
Respiratory: Dyspnea (1% to 3%)
Dopamine
Stimulates both adrenergic and dopaminergic receptors:
-lower doses are mainly dopaminergic stimulating and produce renal and
mesenteric vasodilation
-higher doses also are both dopaminergic and beta1-adrenergic stimulating and
produce cardiac stimulation and renal vasodilation
-large doses stimulate alpha-adrenergic receptors (vasoconstriction)
Pharmacologic Category:
- Adrenergic Agonist Agent
.ساعت در دهای اتاق لابل نگيذاری است 24هحلل رلیك شذه تا -
عذم هصزف..... اکسیذاسین ( .... للیایی pH) تغییز رنگ**
*Most frequent:
Cardiovascular: Anginal pain, ectopic beats, hypotension, palpitation, tachycardia,
vasoconstriction
Central nervous system: Headache
Gastrointestinal: Nausea and vomiting
Respiratory: Dyspnea
Concurrent use with MAOIs: prolong hypertension
Use with extreme caution
Potassium chloride; KCl Pharmacologic Category: Electrolyte Supplement
Heart failure: Inhibition of the sodium/potassium ATPase pump in myocardial cells
Supraventricular arrhythmias: Direct suppression of the AV node conduction
Dermatologic: Rash
Endocrine & metabolic: Hyperkalemia
Gastrointestinal: Abdominal pain/discomfort, diarrhea, flatulence, nausea, vomiting
.ساعت هرد استفاده لزار بگیزد 24هحلل رلیك شذه فزآرده بایستی در طی
**Drug interaction:
ACE Inhibitors
Angiotensin II Receptor Blockers
Potassium-Sparing Diuretics
enhance the hyperkalemic effect
Disease/drug-related concerns:
• Acid/base disorder
• Cardiovascular disease: (eg, heart failure, cardiac arrhythmias)
life-threatening cardiac effects
• Renal impairment
• Digitalis: life-threatening cardiac effects
• Potassium-altering therapies: ACEI, potassium-sparing diuretics, potassium
containing salt substitutes
Nitroglycerin (TNG) Pharmacologic Category:
-Antianginal Agent
-Vasodilator
.رس در یخچال پایذار است 7 در دهای اتاق تا 48hدر ظزف شیشو ای تا %DWSیا N/Sهحلل رلیك شذه با *
PVC* :24 رس در یخچال 14ساعت در دهای اتاق
(سزعت انفسین، غلظت هحلل، طل ست انفسین)جذب سطحی
لزص ىای نیتزگلیسیزین*
Produces a vasodilator effect on the peripheral veins and arteries with more
prominent effects on the veins.
Cardiovascular: Flushing, hypotension, orthostatic hypotension, peripheral edema,
syncope, tachycardia
CNS: Headache (common), dizziness, lightheadedness
Gastrointestinal: Nausea, vomiting, xerostomia
Neuromuscular & skeletal: Paresthesia, weakness
Respiratory: Dyspnea, pharyngitis, rhinitis
• PDE-5 inhibitors: sildenafil, tadalafil, vardenafil
1% to 10%:
CNS: Fever (5% to 8%), confusion, pain
Dermatologic: Erythema, bruising
Gastrointestinal: Nausea (3%), diarrhea
Hematologic: Hemorrhage (major, <1% to 4%; includes cases of intracranial,
retroperitoneal, or intraocular hemorrhage
Local: Injection site hematoma (9%), local reactions
Renal: Hematuria (<2%)
Octreotide:
Pharmacologic Category:
-Antidiarrheal
-Antidote
-Somatostatin Analog
*Inhibiting serotonin release, and the secretion of gastrin, VIP, insulin, glucagon,
secretin, motilin, and pancreatic polypeptide.
*Decreases growth hormone and IGF-1 in acromegaly.
>16%: Cardiovascular: Sinus bradycardia (19% to 25%), chest pain (≤20%; non-depot
formulations)
CNS: Fatigue (1% to 32%), headache (6% to 30%), malaise (16% to 20%), fever (16% to
20%), dizziness (5% to 20%)
Dermatologic: Pruritus (≤18%)
Endocrine & metabolic: Hyperglycemia (2% to 27%)
Gastrointestinal: Abdominal pain (5% to 61%), loose stools (5% to 61%), nausea (5% to
61%), diarrhea (34% to 61%), flatulence (≤38%), cholelithiasis (13% to 38%; length of therapy
dependent)
Local: Injection site pain
Neuromuscular & skeletal: Back pain (1% to 27%), arthropathy (8% to 19%), myalgia
(≤18%)
Respiratory: Upper respiratory infection (10% to 23%), dyspnea (≤20%; non-depot
formulations)
Pantoprazole:
Pharmacologic Category:
-Proton Pump Inhibitor
-Suppresses gastric acid secretion by inhibiting the parietal cell H+/K+ ATP pump
ساعت پس اس آهساده سساسی 6هحلل آهاده ساسی شذه هی بایست حذاکثز -
.رلیك گزدد
سساعت پس اس آهساده سساسی 24هحلل رلیك شذه هسی بایسست حسذاکثز تسا -
.استفاده شد
>10%:
CNS: Headache (adults 12%; children >4%)
1% to 10%:
Cardiovascular: Facial edema (≤4%), generalized edema (≤2%)
CNS: Dizziness (≤4%), vertigo (≤4%), depression (≤2%), fever (adults ≤2%; children
>4%)
Dermatologic: Rash (adults ≤2%; children >4%), urticaria (≤4%), photosensitivity
(≤2%), pruritus (≤2%)
Endocrine & metabolic: Triglycerides increased (≤4%)
GI: Diarrhea (≤9%), abdominal pain (children >4%), vomiting (≥4%), constipation
(≤4%), flatulence (children ≤4%), nausea (children ≤4%), xerostomia (≤2%)
Hematologic: Leukopenia (≤2%), thrombocytopenia (≤2%)
Hepatic: Liver function tests abnormal (≤4%), hepatitis (≤2%)
Stereptokinase:
-Converts plasminogen to the enzyme plasmin
Pharmacologic Category:
-thrombolytic
ساعت در یخچال قابل نگهذاری 24ساعت در دمای کنترل شذه محیط و تا 8محلىل آماده سازی شذه فراورده تا - .است
Cardiovascular: Hypotension (sometimes severe)
Hematologic: Bleeding (major and minor)
Respiratory: Respiratory depression