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By: Kristin IzzoPreceptors:Elizabeth Koustis, MS, RDPamela Jessup, MS, RD
WADE PARK NUTRITION CLINIC
Askari, F., Rashidkhani, B., Hekmatdoost, A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutrition Research. 2014; 34:143-148.
CITATION
What do we know about Cinnamon?Previous research - Type 2 Diabetes
Insulin resistance, HbA1c, FBG, lipid profiles3
Supplementation daily of 1g, 1.5g, and 6g 2,3,4
NAFLDHighest cause for hepatic injuryCurrent therapies: alter insulin resistance and reduce oxidative stress
BACKGROUND
Typical therapy includes:1. Modulating insulin resistance2. Reducing oxidative stress
Goal:Determine if daily supplementation of 1.5g of cinnamon will provide therapeutic effects NAFLD characteristics?
OBJECTIVE
Randomized double blinded, placebo-controlled trial
Two parallel groupsControl and treatment
SupplementsPrepared by third party
Cinnamon v wheat flour
DESIGN
Inclusion:NAFLD diagnosis past 6 months50 patients enrolled
Ages 20-65Exclusion:
Alcohol or drug abuse, chemotherapy, other liver disease, biliary disease, autoimmune disease, cancer, pregnant/lactating, diabetic, metformin, hyperlipidemia, HTN, Vit E, or use of hepatotoxic drugs last 6 months
Tehran, Iran
PARTICIPANTS/SETTING
GroupsTreatment:
Cinnamon capsules at 750mg each x2/day Control:
Placebo x2/dayTime Period
12 weeks
INTERVENTION
Blood Sampling – at baseline and 12 weeksFBG, serum insulin, insulin resistance and sensitivity
Lipid ProfileLiver EnzymesHs-CRP
AnthropometricsDiet and physical activity survey
MEASURES
Nutritionist 4 software Dietary information
SPSS software Qualitative and quantitative data
Student’s and paired t-tests Compare variables between the groups
ANCOVA Eliminate confounding factors
Sample size Power of 80%, calculated 21 patients
P < 0.05 => statistical significance
STATISTICAL ANALYSIS
RESULTS
P <0.05
After 12 weeks of 1.5g supplementation/day… Cinnamon exhibited an effect on reducing insulin
resistance and positively modified lipid profile.
CONCLUSIONS
Go Cinnamon!
What do we tell the Veterans? Not a cure Implement gradually to avoid risk of unknown adverse
effects Affordable
Home spice v supplementFor RDs
Listen to our patients Maintain current understanding of hot topics
PRACTICAL APPLICATION
1. Askari, F., Rashidkhani, B., Hekmatdoost, A. Cinnamon may have therapeutic benefits on l ipid profile, l iver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty l iver disease patients. Nutrition Research . 2014; 34:143-148.
2. Crawford, P. Effectiveness of Cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22(5):507-12
3. Jamal, AR. Effects of cinnamon on blood glucose and lipids levels in diabetic patients (Type1). Afr J Biochem Res 2009;3(5):181-4
4. Vanschoonbeek, K. et al. Cinnamon supplementation does improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 2006;136(4):977-80
REFERENCES