TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
C Number: C50522B
Lock Date: 04/14/1994
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
TDMSE Version: 1.7.0
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder + + + + + + + + + + + M M + + + + I A + + + + + + Degeneration, Hyaline 2 Inflammation, Suppurative 1 Necrosis 1 Epithelium, Hyperplasia 2
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + A + + + + + + .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + A + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + M + + + + + + A + + + + + + .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + A + + + + + + A + + + + + + .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Basophilic Focus X X X Clear Cell Focus X Congestion
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
Degeneration, Cystic Eosinophilic Focus X X X X Hematopoietic Cell Proliferation 2 Karyomegaly 1 2 2 1 1 1 1 2 Necrosis 2 2 4 4 1 1 Regeneration 2 3 4 3 2 3 3 4 3 3 Vacuolization Cytoplasmic 1 Bile Duct, Hyperplasia 2 3 2 2 2 3 2 1 2 3 2 2 2 1
.........................................................................................................................................................................................................
Mesentery Fat, Inflammation, Chronic Fat, Necrosis
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Ulcer 2 Epithelium, Hyperplasia 4 2
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Mineralization 2 Necrosis 1 2
.........................................................................................................................................................................................................
Tooth +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
Developmental Malformation X
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 Atrium, Thrombosis
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 Hypertrophy 1 1 1 1 1 1 1 1 Capsule, Hyperplasia 2 3
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1
.........................................................................................................................................................................................................
Parathyroid Gland + + + M + + + M + M + + + + + M + I + M M + M + + Hyperplasia
.........................................................................................................................................................................................................
Pituitary Gland + + + + + + M + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia Pars Intermedia, Hyperplasia
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 2
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm 4 4
.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 3 3 Inflammation 1 3
.........................................................................................................................................................................................................
Prostate + + + + + M + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + A + + + + + + Inflammation
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 Inflammation, Granulomatous, Focal
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 3
.........................................................................................................................................................................................................
Lymph Node, Bronchial M + M M M + + M + + + + M + + + + + M + + + + M + Hyperplasia 3 2
.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M + M M + M M + + M M + + M + + + M + + I + M Hyperplasia 3 2
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + M M + + + M + M M + + + + + + M M M + Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 4 2 1 2 3 2 2 2 1 3 3 Hyperplasia, Lymphoid 2 1 2
.........................................................................................................................................................................................................
Thymus M + M M M + + M M + + + + M I + M + + I + M + + +
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M + M M M M M M M M M M M M M M M M M M
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active Prepuce, Inflammation, Chronic Active 4 4
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + Meninges, Inflammation, Chronic
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 1 Epiglottis, Metaplasia, Squamous 1
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 1 1 2 Thrombosis Alveolar Epithelium, Hyperplasia 1 1 Perivascular, Infiltration Cellular
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 3 Olfactory Epithelium, Atrophy 1 1 1 2 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 Respiratory Epithelium, Degeneration, 1 2Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + Metaplasia, Squamous
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + Inflammation 4
.........................................................................................................................................................................................................
Harderian Gland +
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst Inflammation, Chronic Active 2 4 Metaplasia, Osseous 1 Nephropathy 1 1 2 2 2 1 2 1 1 1 1 1 2 2 1 1 2 2 1 1 1 1 1 Papilla, Necrosis 3 Renal Tubule, Necrosis
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
7 3
7 2
7 3
7 3
7 3
6 0
7 3
7 3
6 3
6 2
5 3
7 3
6 6
7 3
7 3
7 3
6 2
6 6
7 3
7 3
7 3
7 3
7 3
6 3 3 9 3 3 3 3 3 4 5 8 5 4 4 4 3 4 7 6 4 3 3 4 3 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 0
males2 5 (cont...)
.........................................................................................................................................................................................................
Ureter + Transitional Epithelium, Hyperplasia 2
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 3 Transitional Epithelium, Hyperplasia 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Gallbladder + + + + + + + M + + + M + + + + A + + + + A + A + 41 Degeneration, Hyaline 2 3 2 3 5 2.4 Inflammation, Suppurative 1 1.0 Necrosis 1 1.0 Epithelium, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + A + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + A + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + A + + + 47 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + A + + + + A + M + 45 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + A + + + + A + + + 46 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + A + + + + A + + + 46 .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2 2.5 Basophilic Focus X 4 Clear Cell Focus 1 Congestion 3 1 3.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Degeneration, Cystic 4 1 4.0 Eosinophilic Focus X X X 7 Hematopoietic Cell Proliferation 1 2.0 Karyomegaly 2 1 2 3 3 1 1 1 1 1 1 19 1.5 Necrosis 4 4 1 9 2.6 Regeneration 4 2 2 2 3 3 2 4 2 2 4 2 22 2.8 Vacuolization Cytoplasmic 1 1.0 Bile Duct, Hyperplasia 3 2 2 2 2 2 3 2 2 1 2 4 1 2 2 3 1 2 1 2 34 2.1
.........................................................................................................................................................................................................
Mesentery + + 2 Fat, Inflammation, Chronic 4 1 4.0 Fat, Necrosis 3 1 3.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 1 4 1.0 Hypertrophy 1 1 1.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation 1 1 1.0
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Ulcer 2 2 2.0 Epithelium, Hyperplasia 2 4 4 3.0
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50 Mineralization 1 2.0 Necrosis 2 1.5
.........................................................................................................................................................................................................
Tooth +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
2
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Developmental Malformation X
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 43 1.1 Atrium, Thrombosis 3 1 3.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1.5 Hypertrophy 1 1 2 1 1 13 1.1 Capsule, Hyperplasia 2 2.5
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 2 3 2.3
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Parathyroid Gland + + M + M M + + + + M + I + M + + + + + + + M + + 35 Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49 Pars Distalis, Hyperplasia 1 1 1.0 Pars Intermedia, Hyperplasia 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
2
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Follicular Cell, Hyperplasia 1 1 2 1 5 1.4
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 1 3 3.0
.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 2 3.0 Inflammation 2 2.0
.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation, Suppurative 1 2 1.0
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation 2 3 2 2.5
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 2 2 1.5 Inflammation, Granulomatous, Focal 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 3 2.7
.........................................................................................................................................................................................................
Lymph Node, Bronchial + M + M + M + + M M + M + + + + M + + + + + M M M 32 Hyperplasia 2 2 4 2.3
.........................................................................................................................................................................................................
Lymph Node, Mandibular + M + + + + + + + + + M + M + + + M + + + M + + + 32 Hyperplasia 2 2.5
.........................................................................................................................................................................................................
Lymph Node, Mediastinal M + M M + + + + + + M + + M + + + + + + + M + M M 34 Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + M + + + + + + + + M + + + + + + + + + M + + + 47 Hyperplasia 2 2 3.0
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 3 3 2 3 3 3 2 2 2 4 2 3 2 3 2 26 2.5 Hyperplasia, Lymphoid 2 2 5 1.8
.........................................................................................................................................................................................................
Thymus + + + M + + M + M M + + + + + + M + + + + + + + + 34
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + M + 49 Inflammation, Chronic Active 3 1 3.0 Prepuce, Inflammation, Chronic Active 2 4 4 3.5
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 1 1.0
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Meninges, Inflammation, Chronic 1 1 1.0
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 1.0 Epiglottis, Metaplasia, Squamous 1 1.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 1 2 2 2 7 1.6 Thrombosis 1 1 1.0 Alveolar Epithelium, Hyperplasia 2 3 1.3 Perivascular, Infiltration Cellular 2 1 2.0
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 2.0 Olfactory Epithelium, Atrophy 1 1 1 7 1.1 Olfactory Epithelium, Hyperplasia, 3 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 6 1.0 Respiratory Epithelium, Degeneration, 3 1.3 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50 Metaplasia, Squamous 1 1 1.0
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye 1 Inflammation 1 4.0
.........................................................................................................................................................................................................
Harderian Gland + 2
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 1 1 1.0 Inflammation, Chronic Active 2 2 4 2.5 Metaplasia, Osseous 1 1 3 1.0 Nephropathy 1 2 1 1 2 1 1 2 1 1 1 3 1 2 1 1 2 1 1 1 1 1 1 1 47 1.3 Papilla, Necrosis 1 3.0 Renal Tubule, Necrosis 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 2
6 7
7 3
6 8
7 3
7 3
6 0
7 1
5 9
7 3
6 3
7 3
7 3
7 3
7 2
5 5
6 3
7 3
6 8
6 8
5 7
7 3
4 5
7 3
4 2 4 3 0 3 3 7 9 6 3 8 3 3 4 9 3 5 4 4 4 0 3 2 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 0
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Ureter 1 Transitional Epithelium, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 3 3 2.7 Transitional Epithelium, Hyperplasia 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder M + + + + + + M A + + + + A + + + + + + + + + + + Degeneration, Hyaline 1
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + A + + + + A + + + + + + + + + + + Necrosis 4
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + A + + + + A + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + A + + A + A + + + + + + + + + + + .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 2 Basophilic Focus X Clear Cell Focus X Degeneration, Cystic 3 Eosinophilic Focus X X X Hematopoietic Cell Proliferation
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
Karyomegaly 1 1 2 2 1 1 2 Necrosis 4 4 4 1 2 Regeneration 2 4 3 2 4 4 2 3 2 4 Bile Duct, Hyperplasia 2 3 2 2 2 3 3 2 1 2 2 2 2 1
.........................................................................................................................................................................................................
Mesentery + + + + Fat, Inflammation, Chronic 3 Fat, Necrosis 3
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + A + + + + + + + + + + + Atrophy 1 1 Cytoplasmic Alteration Hypertrophy Duct, Cyst
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + A + + + + + + + + + + + Infiltration Cellular, Mast Cell Inflammation, Suppurative Ulcer 2 2 Epithelium, Hyperplasia 2 3 2
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative Mineralization
.........................................................................................................................................................................................................
Tooth Developmental Malformation
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + Mineralization
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2 1 Hypertrophy 1 1 1 1 1 2 1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + A + + + + + + + + + + + Hyperplasia 2
.........................................................................................................................................................................................................
Parathyroid Gland + M + M + + M + + + + + M + I + + + + + + M + + + .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + I + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 12.8 PPM 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2
1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5
Thyroid Gland + + Follicular Cell, Hyperplasia 1
+ + + + + + + + + + + + + + + + + + + 1
+ + + +
males (cont...)
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Preputial Gland + + + + + + M + + + + + + + + + + + + M + + + + + Cyst 3 3 3 Inflammation 2 3
.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Inflammation, Suppurative
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation 2 2
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 2
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia Infiltration Cellular, Mast Cell
.........................................................................................................................................................................................................
Lymph Node .........................................................................................................................................................................................................
Lymph Node, Bronchial + + + M M + + M M M M M + + + + + M + M + + + + + Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node, Mandibular + M + + + M + M + + M M M + + + + + + + M M + + + Hyperplasia 4 Infiltration Cellular, Mast Cell
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + M + + M M + M + + + + + + + + + + + M I + + M Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + A + + + + + + + + + + + Angiectasis 2 Hyperplasia 3 2
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 1 1 2 3 2 2 2 2 2 2 Hyperplasia, Lymphoid 3 2
.........................................................................................................................................................................................................
Thymus M + + + + M + + + + + + + + + M + M M M M I + M I
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M .........................................................................................................................................................................................................
Skin + + + M + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 4 Prepuce, Inflammation, Chronic Active 3 3
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Spinal Cord +
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + M + + + + + + + + A + + + + + + + + + + + Hyperplasia
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage Infiltration Cellular, Histiocyte 3 3 4 3 Inflammation, Focal, Chronic 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
Alveolar Epithelium, Hyperplasia 4 2 3 1 Bronchiole, Hyperplasia 1 2 1 Mediastinum, Inflammation, Chronic 2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative 1 Nasolacrimal Duct, Inflammation,
Suppurative Olfactory Epithelium, Atrophy 2 1 1 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 2 Respiratory Epithelium, Degeneration, 1 1Hyaline Respiratory Epithelium, Polyp,
Inflammatory .........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + A + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye Inflammation
.........................................................................................................................................................................................................
Harderian Gland + + +
URINARY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
8 7 3
7 3
7 3
7 3
7 3
7 3
7 3
5 4
7 3
6 9
5 8
7 3
5 2
7 3
7 3
5 7
5 9
6 3
7 3
6 8
7 3
7 2
6 3
7 3
2 3 4 3 3 3 4 4 6 3 1 3 3 3 3 4 9 6 5 3 8 3 2 5 4 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 2
males2 5 (cont...)
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 2 Hydronephrosis 2 Inflammation, Chronic Active Metaplasia, Osseous Mineralization Nephropathy 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 Renal Tubule, Hyperplasia 1 1 2
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + A + + + + + + + + + + + Inflammation, Suppurative
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................
Gallbladder + + + M + + + A + + M + + A + + A + + A + + + + + 40 Degeneration, Hyaline 1 1.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + A + + + + + A + + A + + A + + + + + 44 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + A + + A + + + + + 46 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + A + M A + + + + + 46 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + A + + + + + A + + A + + A + + + + + 44 Necrosis 1 4.0
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + A + + A + + A + + + + + 45 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + A + + + + + A + + A + + A + + + + + 43 .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2.7 Basophilic Focus X 2 Clear Cell Focus 1 Degeneration, Cystic 1 3.0 Eosinophilic Focus X X X X 7 Hematopoietic Cell Proliferation 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Karyomegaly 2 2 2 1 2 1 13 1.5 Necrosis 4 2 7 3.0 Regeneration 2 3 3 3 4 4 4 3 4 2 4 2 4 4 2 25 3.1 Bile Duct, Hyperplasia 1 2 3 2 3 2 3 2 4 2 4 3 2 2 3 3 1 31 2.3
.........................................................................................................................................................................................................
Mesentery + + + + 8 Fat, Inflammation, Chronic 1 3.0 Fat, Necrosis 3 2 3.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + A + + + + + 48 Atrophy 1 1 4 1.0 Cytoplasmic Alteration 1 1 1.0 Hypertrophy 1 1 1.0 Duct, Cyst 3 1 3.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + A + + + + + 48 Infiltration Cellular, Mast Cell 2 1 2.0 Inflammation, Suppurative 1 1 1.0 Ulcer 1 3 1.7 Epithelium, Hyperplasia 1 1 2 6 1.8
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 2 1 2.0 Mineralization 4 1 4.0
.........................................................................................................................................................................................................
Tooth + + 2 Developmental Malformation X 4 2 4.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + 2 Mineralization 3 1 3.0
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + A + + + + + 49 Cardiomyopathy 1 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 43 1.1
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 2 4 1.8 Hypertrophy 1 2 1 1 1 1 1 1 15 1.1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 1 3 1.0
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + A + + + + + 48 Hyperplasia 1 2 1.5
.........................................................................................................................................................................................................
Parathyroid Gland + + M M + I + M + + M + + M M + + + + A M + M M M 32 .........................................................................................................................................................................................................
Pituitary Gland + + + + + M + + + + + + + + + + + + + A + + + + + 47 Pars Distalis, Hyperplasia 2 1 2 1.5
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 12.8 PPM 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5
6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS Thyroid Gland + +
Follicular Cell, Hyperplasia 1 1 + + + + + + + + + + + + + + + + + A + + + +
1 + 49
5 1.0
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + M + + + + + 47 Cyst 2 3 2 2 7 2.6 Inflammation 2 2 4 2.3
.........................................................................................................................................................................................................
Prostate + + + M + + + + + + + + + + + + + + + A + + + + + 48 Hyperplasia 1 1.0 Inflammation, Suppurative 2 1 2.0
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation 2 2.0
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + A + + + + + 49 Atrophy 1 1 3 1.3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Bone Marrow + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hyperplasia 2 1 2.0 Infiltration Cellular, Mast Cell 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node + 1 .........................................................................................................................................................................................................
Lymph Node, Bronchial + M M M M M M M + + M M M M + M M + M M M M + + M 23 Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular I + + M M M M + M + M + + + + + + M M A M M M M + 28 Hyperplasia 2 2 3.0 Infiltration Cellular, Mast Cell 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + + + M + M + M + + + A + + + + M 38 Hyperplasia 3 3 2 4 4 3.0
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + A + + + + + 48 Angiectasis 2 2 3 2.0 Hyperplasia 2 2.5
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + A + + + + + 49 Hematopoietic Cell Proliferation 3 2 2 2 3 3 2 2 2 3 2 22 2.1 Hyperplasia, Lymphoid 4 3 3.0
.........................................................................................................................................................................................................
Thymus + + M + + M M M + + + M M + + + M M + M M + + M M 28
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0 .........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Chronic Active 1 4.0 Prepuce, Inflammation, Chronic Active 3 4 3 4 6 3.3
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 1.0
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................
Spinal Cord 1
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + A + + + + + 47 Hyperplasia 2 1 2 1.5
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hemorrhage 2 1 2.0 Infiltration Cellular, Histiocyte 4 3 2 4 8 3.3 Inflammation, Focal, Chronic 2 2 2.5
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 2
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Alveolar Epithelium, Hyperplasia 1 5 2.2 Bronchiole, Hyperplasia 2 2 2 4 1 3 2 10 2.0 Mediastinum, Inflammation, Chronic 1 2.0
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 1 1.0 Nasolacrimal Duct, Inflammation, 1 2.0 2Suppurative Olfactory Epithelium, Atrophy 2 1 2 1 1 8 1.4 Olfactory Epithelium, Hyperplasia, 2 1.0 1Adenomatous Olfactory Epithelium, Metaplasia 1 2 1 1 5 1.4 Respiratory Epithelium, Degeneration, 4 1.3 2 1Hyaline Respiratory Epithelium, Polyp, 1 4.0 4Inflammatory
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + A + + + + + 48
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + 1 Inflammation 4 1 4.0
.........................................................................................................................................................................................................
Harderian Gland + + 5
URINARY SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
7 3
6 3
7 3
7 3
7 3
6 8
7 3
7 3
7 3
4 3
6 1
6 9
7 3
7 3
6 2
7 3
6 0
5 3
7 0
6 5
7 0
7 3
6 6
4 3 3 8 3 3 3 0 4 3 3 9 4 1 3 4 6 3 7 0 8 9 1 3 7 .................................................................................................................................................................
B6C3F1 MICE MALE ANIMAL ID
12.8 PPM
0 0 2 2 6
Kidney + + + + + + + + + + + + + + + + + + + A + + + + + 49 Cyst 2 2 2.0 Hydronephrosis 1 2.0 Inflammation, Chronic Active 2 4 2 3.0 Metaplasia, Osseous 1 1 1.0 Mineralization 3 1 3.0 Nephropathy 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 44 1.2 Renal Tubule, Hyperplasia 1 4 1.3
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + A + + + + + 48 Inflammation, Suppurative 4 1 4.0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder M + + + + A + M + + + + + + + A M + M + + M + A + Degeneration, Hyaline 3 Inflammation, Suppurative 1
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + M + + + + + + + + + A + + + + + + + A + .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + A + + + + + + + A + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + A M + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + A + + + + + + + + + + + + + + + + + A + .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + A + + + + + + + + + + + + + + + + + A + Peyer's Patch, Hyperplasia
.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + A + + + + + + + + + + + + + + + + + A + .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Eosinophilic Focus X X Hematopoietic Cell Proliferation Karyomegaly 2 2 2 2 2 2 2 1 2 2 Mitotic Alteration 3 Necrosis 2 4 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
Regeneration 2 2 2 3 3 3 4 4 4 3 2 Bile Duct, Hyperplasia 2 3 2 3 2 2 1 3 4 2 2 2 1 3 3 3 2 3 Centrilobular, Necrosis
.........................................................................................................................................................................................................
Mesentery + + + + + + + + + + Angiectasis 2 Fat, Necrosis 2
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + A + Atrophy Basophilic Focus Cytoplasmic Alteration 2 Hypertrophy 1
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + A + Inflammation, Suppurative 1 Ulcer 2 Epithelium, Hyperplasia 3 3 3 1
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 Necrosis 1 Pigmentation 2
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
Blood Vessel + Inflammation 3
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 Hyperplasia, Atypical 1 Inflammation 2 Mineralization Artery, Inflammation 2
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Hypertrophy 1 1 1 1 1 1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 2 2
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + A + Hyperplasia 1
.........................................................................................................................................................................................................
Parathyroid Gland M + + M + M M M + M M + M + + + M + M + M + + + + .........................................................................................................................................................................................................
Pituitary Gland M + + + + + + + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia 1 Pars Nervosa, Inflammation 2
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5
Thyroid Gland + + Follicular Cell, Hyperplasia 1
+ + + + 1
+ + + + + + + + + + + 4
+ + + + + + + +
32 PPM males (cont...)
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm Hyperplasia 2
.........................................................................................................................................................................................................
Penis + .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + M + + + + + + + Cyst 2 Inflammation 2
.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 4
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + A + Inflammation 4
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Atrophy 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2
.........................................................................................................................................................................................................
Lymph Node + Iliac, Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node, Bronchial + + M M M + + M + M + + M + + + + + + + M + M + I Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + M M + M + + M + + + + + M M M M M M M M + M M Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + M M + + + M M + + M M + + M + + + + M + Hematopoietic Cell Proliferation 2 Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + M + + + + + + + M M Angiectasis Hyperplasia
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Accessory Spleen X Hematopoietic Cell Proliferation 3 2 2 2 2 4 1 3 2 3 1 3 1 4 2 3 1 3 3
.........................................................................................................................................................................................................
Thymus + + + M M M M M + + M + + + M I + + + + M M + + I
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M + M M M M M M M M M M M M M M M .........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Edema 3 3 Inflammation, Chronic Active 2 Prepuce, Inflammation, Chronic Active 3 3 4 Subcutaneous Tissue, Cyst 3 3 Subcutaneous Tissue, Inflammation, 4Granulomatous, Focal
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + Meninges, Inflammation, Chronic
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 2 2 1 2 3 1 Alveolar Epithelium, Hyperplasia 2 2 Bronchiole, Hyperplasia 2 2 2 1 2 1 2 1
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative Olfactory Epithelium, Atrophy 1 1 2 Olfactory Epithelium, Degeneration, 1Hyaline Olfactory Epithelium, Hyperplasia,
Adenomatous Olfactory Epithelium, Metaplasia 1 1 Respiratory Epithelium, Degeneration, 1 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Harderian Gland + + + +
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Cyst 2 Hydronephrosis
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 6 4
6 0
6 3
7 1
6 0
6 2
4 9
7 3
4 9
7 0
7 3
7 3
7 3
6 2
7 1
7 3
6 8
4 3
6 0
5 6
7 1
7 3
4 7
6 6
3 9 7 5 3 7 9 5 3 1 5 4 4 4 0 5 4 8 9 2 7 7 3 0 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 4
males2 5 (cont...)
Inflammation, Chronic Active Nephropathy Pigmentation, Hemosiderin Renal Tubule, Hyperplasia
1 1 1 1 1 4
1 1 1 1 1 2 2
1
1 2 2
2
1 1 2 2 1 3 1
.........................................................................................................................................................................................................
Urinary Bladder Inflammation, Suppurative Transitional Epithelium, Hyperplasia
+ + + + + + 3
+ + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Gallbladder + + A + + + M + M + + + A + + M + + + + + + + + + 37 Degeneration, Hyaline 4 2 3.5 Inflammation, Suppurative 1 1.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + A + + + + + + + + + A + + + + + + + + + + + + 45 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Large, Rectum A M + + + + + + + + + + + + + + + + + + + + + + + 46 .........................................................................................................................................................................................................
Intestine Small, Duodenum A + A + + + + + + + + + A + + + + + + + + + + + + 45 .........................................................................................................................................................................................................
Intestine Small, Ileum A + A + + + + + + + + + + + + + + + + + + + + + + 46 Peyer's Patch, Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + A + + + + + + + + + + + + 47 .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Eosinophilic Focus X Hematopoietic Cell Proliferation 2 1 2.0 Karyomegaly 1 1 1 2 1 1 2 2 2 1 20 1.7 Mitotic Alteration 1 3.0 Necrosis 1 3 2 4 7 2.9
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
3
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
B6C3F1 MICE MALE
32 PPM ANIMAL ID
0 0 4 2 6
Regeneration Bile Duct, Hyperplasia Centrilobular, Necrosis
4 2
2 2
2 2
4 4 1
4 4
3 2
2 2
2 1
3 2
4 3
4 3 1
2
3 3
4 3
2 2
25 3.0 34 2.4 1 2.0
.........................................................................................................................................................................................................
Mesentery Angiectasis Fat, Necrosis
+ + + + + + 2
16 2 2.0 1 2.0
.........................................................................................................................................................................................................
Pancreas Atrophy Basophilic Focus Cytoplasmic Alteration Hypertrophy
+ + +
X
+ + + + + + + + + + + + + + + + + 1
+ 1
+ + + + 49 2 1.0 1 1 2.0 1 1.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Stomach, Forestomach Inflammation, Suppurative Ulcer Epithelium, Hyperplasia
+ + + + + + + + + 1
2
+ + + + +
1
+ + + + + + + 2
3
+ + + + 49 3 1.3 1 2.0 7 2.3
.........................................................................................................................................................................................................
Stomach, Glandular Inflammation, Suppurative Necrosis Pigmentation
+ + + + + + + + + + + + + + + + + + + + + + + + + 50 1 1.0 1 1.0 1 2.0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
B6C3F1 MICE MALE ANIMAL ID
32 PPM
0 0 4 2 6
Blood Vessel 1 Inflammation 1 3.0
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 40 1.1 Hyperplasia, Atypical 1 1.0 Inflammation 1 2.0 Mineralization 1 1 1.0 Artery, Inflammation 1 2.0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 3 1.0 Hypertrophy 1 1 1 1 2 1 12 1.1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 5 1.6
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49 Hyperplasia 1 2 1.0
.........................................................................................................................................................................................................
Parathyroid Gland M + + + M M + M M + M M + + + M + + + + + + + + + 31 .........................................................................................................................................................................................................
Pituitary Gland M + + + + + + + + + + M + + + + + + + + + + + + + 47 Pars Distalis, Hyperplasia 1 1.0 Pars Nervosa, Inflammation 1 2.0
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 44
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0 0B6C3F1 MICE MALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Thyroid Gland + + Follicular Cell, Hyperplasia
+ + 1
+ + + + + + + + + + 1
+ + + 1
+ + + + + + + + 50 6 1.5
32 PPM
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 3 1 3.0 Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Penis 1 .........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + M I + + + + + + + + + + 47 Cyst 3 2 2.5 Inflammation 1 2 3 1.7
.........................................................................................................................................................................................................
Prostate + + + M + + + + + + + + + + + + + + + + + + + + M 48 Inflammation, Suppurative 3 2 3.5
.........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49 Inflammation 1 4.0
.........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 1 1.0 Atrophy 1 2 2.5
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 45
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 3 2.0
.........................................................................................................................................................................................................
Lymph Node + 2 Iliac, Hyperplasia 2 2 2.0
.........................................................................................................................................................................................................
Lymph Node, Bronchial + M + M + + + M M M M + + M + + + + + + + M + + + 33 Hyperplasia 2 2 2 2.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular M + M + M + + + + M + + M + M + + + M + + + + M M 27 Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mediastinal M + + + M M + + + + + + M + M + + + + + + + + + + 37 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 2 3 2 2.5
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + I + + + + + + 46 Angiectasis 2 1 2 3 1.7 Hyperplasia 4 4 2 4.0
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Accessory Spleen Hematopoietic Cell Proliferation 3 2 2 2 4 3 3 3 2 3 2 2 2 2 4 2 35 2.5
.........................................................................................................................................................................................................
Thymus M M M + + + M M + + M M + M + M + M + M M M + M + 25
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 46
1
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 1 .........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Edema 2 3.0 Inflammation, Chronic Active 1 2.0 Prepuce, Inflammation, Chronic Active 4 4 5 3.6 Subcutaneous Tissue, Cyst 2 3.0 Subcutaneous Tissue, Inflammation, 2 3.5 3Granulomatous, Focal
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Meninges, Inflammation, Chronic 1 1 1.0
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 47
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 2 3 4 4 3 11 2.5 Alveolar Epithelium, Hyperplasia 2 2.0 Bronchiole, Hyperplasia 2 1 1 2 1 2 1 1 4 3 18 1.7
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 1 1 1 1 4 1.0 Olfactory Epithelium, Atrophy 1 1 1 1 7 1.1 Olfactory Epithelium, Degeneration, 1 1.0
Hyaline Olfactory Epithelium, Hyperplasia, 2 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 1 5 1.0 Respiratory Epithelium, Degeneration, 2 1.0
Hyaline .........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Harderian Gland + + + + + + + 11
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cyst 1 2.0 Hydronephrosis 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 48
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
8 6 9
6 6
7 3
6 7
6 6
6 7
5 5
5 9
7 3
6 0
7 3
6 0
7 3
5 6
5 4
7 3
3 8
5 0
6 2
7 3
7 3
7 0
6 8
5 7
8 3 3 4 9 6 9 1 6 4 7 4 6 4 5 5 3 2 2 3 4 4 1 0 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 4
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Inflammation, Chronic Active 3 2 3 3.0 Nephropathy 1 1 1 1 1 1 1 3 1 1 1 1 2 2 1 1 1 2 2 1 2 43 1.3 Pigmentation, Hemosiderin 2 1 2.0 Renal Tubule, Hyperplasia 1 1 1 5 1.2
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + M + + + + + + + + + I + + + + + + + 48 Inflammation, Suppurative 1 4 3 2.7 Transitional Epithelium, Hyperplasia 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 49
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + Dysplasia 1 Inflammation, Suppurative 2 Epithelium, Hyperplasia 3
.........................................................................................................................................................................................................
Gallbladder + + + M + + M + M M + + M I + + + + + + + M + + + Degeneration, Hyaline 2 2
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + M + + + M + + + + + M .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + Peyer's Patch, Hyperplasia
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 3 Basophilic Focus
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 50
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
Eosinophilic Focus X X X X X Hematopoietic Cell Proliferation 1 Karyomegaly 1 2 1 1 2 3 2 2 3 1 1 Necrosis 4 4 Regeneration 2 3 2 2 2 3 3 4 4 2 3 2 Bile Duct, Hyperplasia 3 2 3 2 2 3 2 2 3 3 3 4 4 2 2 2
.........................................................................................................................................................................................................
Mesentery + + + + + Inflammation, Granulomatous, Focal 2 Thrombosis Fat, Necrosis 3
.........................................................................................................................................................................................................
Oral Mucosa + .........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 Hyperplasia Hypertrophy
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 2 Ulcer 2 2 2 2 1 2 2 Epithelium, Hyperplasia 2 1 3 1 2 3 2 3 1 3 2 4 3
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Mineralization Necrosis 1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 51
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 Atrium, Thrombosis
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hypertrophy 1 1 Capsule, Hyperplasia
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 2
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1
.........................................................................................................................................................................................................
Parathyroid Gland + M M M M I M M + + M M + + M + M + + + + + M M + .........................................................................................................................................................................................................
Pituitary Gland + + + + + M + + + + + + + + + + + + + + M + + + + .........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 52
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
B6C3F1 MICE MALE ANIMAL ID
80 PPM
Follicular Cell, Hyperplasia
0 0 6 0 1
1 1 1 2
GENERAL BODY SYSTEM NONE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + Granuloma Sperm 1 Inflammation 1
.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Cyst 2 3 2 Fibrosis 2 Inflammation 2
.........................................................................................................................................................................................................
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 2 1
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 53
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2
.........................................................................................................................................................................................................
Lymph Node + + .........................................................................................................................................................................................................
Lymph Node, Bronchial + + M + + M M M + M M M + M + + + + M M + M M + M Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + M M + + M + + + M + M + M M M + M + + .........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + M + M I + + M + + + + + + M + + + M + + + Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + M + + + + + + + + + + + + + M + + + + Angiectasis 3
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 Hematopoietic Cell Proliferation 2 2 3 2 3 3 2 3 2 4 2 2 3 3 3 2 2 Infiltration Cellular, Histiocyte
.........................................................................................................................................................................................................
Thymus + M + I + M M + + + M + + + M + M M M + + + + M + Hyperplasia, Lymphoid
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 54
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 4 4 4 Epidermis, Hyperplasia Prepuce, Inflammation, Chronic Active 4 Subcutaneous Tissue, Inflammation,
Suppurative 2
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 2
.........................................................................................................................................................................................................
Skeletal Muscle +
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 Inflammation, Suppurative Epiglottis, Metaplasia, Squamous
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte 2 2 4 3 2 3 2 2 4 4 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 55
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
Inflammation, Focal, Chronic Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 1 2 1 2 3 2 2 2 3
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 1 Lateral Wall, Necrosis Olfactory Epithelium, Atrophy 3 3 1 3 3 3 2 3 3 2 3 3 2 2 2 3 2 2 3 2 2 3 2 3 Olfactory Epithelium, Degeneration,
Hyaline Olfactory Epithelium, Hyperplasia, 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 3 1 3 3 3 2 3 3 2 3 2 2 2 2 3 2 2 3 2 2 3 1 3 Respiratory Epithelium, Degeneration, 1 1 1 1Hyaline Respiratory Epithelium, Necrosis
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + Inflammation 4
.........................................................................................................................................................................................................
Harderian Gland + M M + + + + + .........................................................................................................................................................................................................
Zymbal's Gland M M M
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 56
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 4 2
7 3
3 9
7 3
6 2
6 8
6 0
7 3
7 3
5 2
6 0
6 4
6 3
7 3
4 5
7 0
5 7
7 0
7 3
6 8
6 5
6 4
6 5
6 5
4 2 3 2 3 4 0 3 3 4 4 8 4 5 3 4 1 9 1 3 7 9 9 7 9 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 6
males2 5 (cont...)
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Glomerulosclerosis 3 4 Hydronephrosis Metaplasia, Osseous Nephropathy 1 1 1 1 3 3 2 1 1 1 1 1 1 1 1 2 2 1 1 Pigmentation, Hemosiderin 2 Renal Tubule, Hyperplasia 1 1 2 Renal Tubule, Necrosis
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 57
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Dysplasia 1 1.0 Inflammation, Suppurative 1 2.0 Epithelium, Hyperplasia 1 3.0
.........................................................................................................................................................................................................
Gallbladder + + + + + + + + + + M + M A + + + + + + + + + + + 40 Degeneration, Hyaline 4 3 2.7
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + A A + + + + + + + + + + + 45 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + A A + + + + + + + + + + + 48 Inflammation, Suppurative 1 1 1.0
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + A + + + + + + + + + + + 49 Peyer's Patch, Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + A + + + + + + + + + + + 49 Angiectasis 1 3.0 Basophilic Focus 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 58
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Eosinophilic Focus X X X 8 Hematopoietic Cell Proliferation 3 3 2 4 2.3 Karyomegaly 3 2 3 1 1 1 2 3 2 2 1 3 1 1 2 1 2 4 29 1.9 Necrosis 1 4 4 4 6 3.5 Regeneration 4 4 4 2 2 4 3 4 4 3 2 3 2 4 4 27 3.0 Bile Duct, Hyperplasia 4 3 4 2 1 2 4 3 4 2 4 4 3 3 2 3 3 3 3 4 36 2.9
.........................................................................................................................................................................................................
Mesentery + + + + + + 11 Inflammation, Granulomatous, Focal 1 2.0 Thrombosis 3 1 3.0 Fat, Necrosis 1 3.0
.........................................................................................................................................................................................................
Oral Mucosa 1 .........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 1 2 1.0 Hyperplasia 1 1 1.0 Hypertrophy 1 1 2 1.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 2 5 1.8 Ulcer 2 2 2 2 1 12 1.8 Epithelium, Hyperplasia 2 3 3 2 1 1 3 2 2 2 1 2 3 2 4 2 29 2.2
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + A A + + + + + + + + + + + 48 Mineralization 1 1 1.0 Necrosis 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 59
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + 1 .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 2 45 1.2 Atrium, Thrombosis 4 1 4.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hypertrophy 1 1 1 1 1 1 1 9 1.0 Capsule, Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + A + + + + + + + + + + + 49 Hyperplasia 2 1.5
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1 1 4 1.3
.........................................................................................................................................................................................................
Parathyroid Gland M + + + M + + + + + + + M + M + + + + + M + M + M 30 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 60
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Follicular Cell, Hyperplasia 1 1 1 7 1.1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50 Granuloma Sperm 1 1.0 Inflammation 1 1.0
.........................................................................................................................................................................................................
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Cyst 3 2.3 Fibrosis 1 2.0 Inflammation 1 2.0
.........................................................................................................................................................................................................
Prostate + + + + + + + + + + M + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Seminal Vesicle + + + + + + + + + + + + A A + + + + + + + + + + + 48 .........................................................................................................................................................................................................
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50 Atrophy 2 1 4 1.5
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 61
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 2 2 5 2.2
.........................................................................................................................................................................................................
Lymph Node + 3 .........................................................................................................................................................................................................
Lymph Node, Bronchial + M M + M + + + + + + M + M + + + M M + + + M + M 28 Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular M + + + M + M + + + + + + + + + M + + M + M + M + 34 .........................................................................................................................................................................................................
Lymph Node, Mediastinal + I + + + + M + M + + + + + + M M + + M + + + + M 37 Hyperplasia 3 2 4 3 4 3.0
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 48 Angiectasis 4 2 3.5
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 2.0 Hematopoietic Cell Proliferation 2 1 4 3 4 2 2 4 4 3 2 2 2 2 31 2.6 Infiltration Cellular, Histiocyte 1 1 1.0
.........................................................................................................................................................................................................
Thymus + + + + I I + + + M + + + + + + + + M + + + M M + 34 Hyperplasia, Lymphoid 4 1 4.0
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland M M M M M M M M M M M M M M M M M M + M M M M M M 1 .........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 62
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Chronic Active 4 4 4.0 Epidermis, Hyperplasia 3 1 3.0 Prepuce, Inflammation, Chronic Active 1 4.0 Subcutaneous Tissue, Inflammation, 1 2.0
Suppurative
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 1 2.0
.........................................................................................................................................................................................................
Skeletal Muscle 1
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 2 1 4 1.3 Inflammation, Suppurative 1 1 2 1.0 Epiglottis, Metaplasia, Squamous 1 1 1.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 4 3 2 3 3 3 3 2 3 3 2 22 2.9
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 63
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
0B6C3F1 MICE MALE 0 ANIMAL ID 6
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Inflammation, Focal, Chronic 3 1 3.0 Alveolar Epithelium, Hyperplasia 2 3 2 2.5 Bronchiole, Hyperplasia 2 2 4 3 1 2 2 2 2 1 2 4 3 2 23 2.2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 3 1 6 1.5 Lateral Wall, Necrosis 2 1 2.0 Olfactory Epithelium, Atrophy 3 3 2 3 3 2 2 2 2 3 2 2 3 2 3 3 1 3 3 3 3 3 2 3 3 49 2.5 Olfactory Epithelium, Degeneration, 2 2.0 2 2Hyaline Olfactory Epithelium, Hyperplasia, 48 2.0 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 3 2 3 3 2 2 2 2 3 2 2 3 2 3 3 1 3 3 3 3 2 2 3 3 49 2.5 Respiratory Epithelium, Degeneration, 10 1.2 2 1 2 1 1 1Hyaline Respiratory Epithelium, Necrosis 2 1 2.0
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye 1 Inflammation 1 4.0
.........................................................................................................................................................................................................
Harderian Gland + + + + + + 12 .........................................................................................................................................................................................................
Zymbal's Gland 0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 64
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
9 7 3
5 8
6 3
7 3
6 4
7 3
6 4
6 0
6 2
6 3
6 7
6 2
6 7
7 3
6 4
5 2
7 3
6 2
6 7
7 3
6 6
5 6
5 8
6 5
5 3 7 5 3 9 3 4 0 8 7 7 0 2 3 9 3 3 4 7 3 3 7 9 6 .................................................................................................................................................................
B6C3F1 MICE MALE ANIMAL ID
80 PPM
0 0 6 2 6
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Glomerulosclerosis 2 3.5 Hydronephrosis 2 1 2.0 Metaplasia, Osseous 1 1 1.0 Nephropathy 1 1 1 1 2 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 42 1.2 Pigmentation, Hemosiderin 1 2.0 Renal Tubule, Hyperplasia 2 1 5 1.4 Renal Tubule, Necrosis 2 1 2.0
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
*** END OF MALE DATA ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 65
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder + M + + + M + + + + + + + M + + + + + + + + M + + Angiectasis Cyst 4 Inflammation, Suppurative 1 2 Necrosis 2
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + M + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + M + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium, Hyperplasia Peyer's Patch, Hyperplasia 2
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Basophilic Focus X X 4 X
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 66
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
Clear Cell Focus Degeneration, Fatty 1 Eosinophilic Focus X X X X X X X X Fibrosis 2 Hematopoietic Cell Proliferation 1 Necrosis 2 1 Bile Duct, Cyst Bile Duct, Hyperplasia 2
.........................................................................................................................................................................................................
Mesentery + + + + + + Angiectasis Fat, Necrosis 3 2 3 3
.........................................................................................................................................................................................................
Oral Mucosa + Pharyngeal, Hyperplasia 4
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + M + Atrophy 1 Hypertrophy
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 1 Mineralization 2 Epithelium, Hyperplasia 1
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 67
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + Hyperplasia 1 Inflammation
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation Hyperplasia 1 Hypertrophy 1 1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 1 1
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + M + .........................................................................................................................................................................................................
Parathyroid Gland M M + + + + + + + M + + + + + M + M M M + + + + + .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Pars Distalis, Hyperplasia 3 2 2 2 1 2 4 2
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 68
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0 0B6C3F1 MICE FEMALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CONTROL 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2
1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5
Thyroid Gland + + Follicular Cell, Hyperplasia 3
+ + 4
+ + + + + + + + + + + 1
+ 1
+ 1
+ 2
+ + + + + + + 1
females (cont...)
GENERAL BODY SYSTEM .........................................................................................................................................................................................................
Tissue NOS
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + M + + + M + M M + M + + + + + + M + + + + + + .........................................................................................................................................................................................................
Ovary + M + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 2 3 Cyst 4 2 1 2 2 2 2 3 1 3 3
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 2 Hemorrhage Hydrometra Hyperplasia, Cystic 4 2 3 2 Inflammation, Suppurative 4
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 3 Necrosis
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 69
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
.........................................................................................................................................................................................................
Lymph Node + Iliac, Hyperplasia 2 Pancreatic, Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Bronchial M + + + + M + + + M M + + + + + + M + M M M M + + Hyperplasia 3
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + + M M + + + M M M + + + M + M M M + M + M + + Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + M M + + + M + + + + + M + M + + + + + M .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + M + + + + + + + + + + + + + + + + + Angiectasis 4 Hematopoietic Cell Proliferation Hyperplasia 3 2 4 2
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hematopoietic Cell Proliferation 2 3 2 3 2 Hyperplasia, Lymphoid 2 2 3 2 2 2 2 Infiltration Cellular, Mononuclear Cell 2
.........................................................................................................................................................................................................
Thymus M + + + + + + + + + + + + + + + + + + M M + + + + Angiectasis 2 Atrophy Hyperplasia, Lymphoid 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 70
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + M + + + + + + + .........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active Subcutaneous Tissue, Inflammation,
Suppurative
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1 2 2 3 2 2 2 1 1
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + Gliosis 2 Meninges, Inflammation, Chronic 3 1
.........................................................................................................................................................................................................
Peripheral Nerve .........................................................................................................................................................................................................
Spinal Cord Degeneration
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 71
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Histiocyte Alveolar Epithelium, Hyperplasia 1 Perivascular, Infiltration Cellular
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Olfactory Epithelium, Atrophy 1 1 1 Olfactory Epithelium, Degeneration,
Hyaline Olfactory Epithelium, Hyperplasia, 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 Respiratory Epithelium, Degeneration, 1 1 1 1 1 1 1 1 1 1 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye .........................................................................................................................................................................................................
Harderian Gland +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 72
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 7 3
6 8
7 3
6 3
7 3
4 9
7 3
7 3
4 7
7 3
7 2
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
7 3
6 6
7 3
5 4 1 5 5 5 3 5 5 7 5 9 5 4 5 5 4 5 4 5 5 4 4 3 5 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 1
females2 5 (cont...)
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis Inflammation, Chronic Active Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Artery, Inflammation, Chronic 3 Renal Tubule, Mineralization
.........................................................................................................................................................................................................
Ureter .........................................................................................................................................................................................................
Urethra .........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 73
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + M + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Gallbladder + + + + + + + + + + M + + + + + + + + + + + + + + 45 Angiectasis 2 1 2.0 Cyst 1 4.0 Inflammation, Suppurative 1 3 1.3 Necrosis 1 2.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + M + + + + + 48 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50 Epithelium, Hyperplasia 2 1 2.0 Peyer's Patch, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 2 3.0 Basophilic Focus 4 4.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 74
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Clear Cell Focus 2 1 2.0 Degeneration, Fatty 1 1.0 Eosinophilic Focus X X X X 4 13 4.0 Fibrosis 1 2.0 Hematopoietic Cell Proliferation 1 1.0 Necrosis 1 1 4 1.3 Bile Duct, Cyst 2 1 2.0 Bile Duct, Hyperplasia 1 2 1.5
.........................................................................................................................................................................................................
Mesentery + + + + 10 Angiectasis 1 1 1.0 Fat, Necrosis 3 2 3 7 2.7
.........................................................................................................................................................................................................
Oral Mucosa 1 Pharyngeal, Hyperplasia 1 4.0
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 49 Atrophy 1 1 3 1.0 Hypertrophy 1 1 2 1.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 1 2 1.0 Mineralization 1 2.0 Epithelium, Hyperplasia 4 1 2 4 2.0
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 75
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Blood Vessel + 2 Hyperplasia 1 1.0 Inflammation 3 1 3.0
.........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 35 1.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 1 1.0 Hypertrophy 2 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 1.0
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Parathyroid Gland + M + + M + M + + + + + + M + + M M + + + + M + M 35 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + M + + + + + + + + + 49 Pars Distalis, Hyperplasia 2 2 2 2 1 1 1 2 2 1 18 1.9
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 76
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0 0B6C3F1 MICE FEMALE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ANIMAL ID 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 CONTROL 2 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5
6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS Thyroid Gland + +
Follicular Cell, Hyperplasia + + + +
1 + 1
+ + + + + + + + + + + + 2
+ + + + + 1
+ 2
50 12 1.7
GENERAL BODY SYSTEM .........................................................................................................................................................................................................
Tissue NOS + 1
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + + + + + M + + I + + + + + M + + + + + + + + + 41 .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + M + + + + + + + + 48 Atrophy 2 3 2 2 7 2.1 Cyst 2 1 2 2 1 2 2 2 2 20 2.1
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 3 2.0 Hemorrhage 2 1 2.0 Hydrometra 3 2 2 3 2.3 Hyperplasia, Cystic 3 5 2.8 Inflammation, Suppurative 1 4.0
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 2 3.0 Necrosis 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 77
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Lymph Node + + + 4 Iliac, Hyperplasia 1 2.0 Pancreatic, Hyperplasia 4 1 4.0
.........................................................................................................................................................................................................
Lymph Node, Bronchial + M M + + M + + + I + + M + M + + + + + + M M M + 32 Hyperplasia 3 2 3.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + I + + + + M + M + + + + + M + + M + + + M M + 32 Hyperplasia 2 2 2.0
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + M M M + M + + M + + + + + + M + 38 .........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + M + + + + 48 Angiectasis 1 4.0 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 2 2 6 2.5
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 1 1.0 Hematopoietic Cell Proliferation 3 2 4 2 2 3 2 2 13 2.5 Hyperplasia, Lymphoid 2 2 9 2.1 Infiltration Cellular, Mononuclear Cell 1 2.0
.........................................................................................................................................................................................................
Thymus + + M + + + + + + + + + M + + + + + + + + + M + + 44 Angiectasis 1 2.0 Atrophy 2 1 2.0 Hyperplasia, Lymphoid 2 2 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 78
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Skin + + + + + + + + + + + + A + + + + + + + + + + + + 49 Inflammation, Chronic Active 3 1 3.0 Subcutaneous Tissue, Inflammation, 2 2.5 3 2Suppurative
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 3 2 1 1 2 1 15 1.7
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Gliosis 1 2.0 Meninges, Inflammation, Chronic 1 3 1.7
.........................................................................................................................................................................................................
Peripheral Nerve + 1 .........................................................................................................................................................................................................
Spinal Cord + 1 Degeneration 3 1 3.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 79
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Infiltration Cellular, Histiocyte 3 1 3.0 Alveolar Epithelium, Hyperplasia 1 1.0 Perivascular, Infiltration Cellular 2 1 2.0
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Olfactory Epithelium, Atrophy 2 1 1 6 1.2 Olfactory Epithelium, Degeneration, 3 1.0 1 1 1Hyaline Olfactory Epithelium, Hyperplasia, 2 1.0
Adenomatous Olfactory Epithelium, Metaplasia 2 1.0 Respiratory Epithelium, Degeneration, 17 1.0 1 1 1 1 1 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + 1 .........................................................................................................................................................................................................
Harderian Gland + 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 80
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
1 7 0
7 3
7 3
5 2
7 3
7 0
6 7
7 3
5 4
7 3
7 3
4 8
7 3
7 3
0 3
7 3
7 3
7 3
7 3
6 3
7 3
7 3
7 3
7 3
0 5 5 4 7 4 6 7 5 1 4 5 6 5 5 5 5 5 5 4 7 4 4 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 1
CONTROL 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hydronephrosis 3 1 3.0 Inflammation, Chronic Active 1 1 1.0 Nephropathy 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 41 1.0 Artery, Inflammation, Chronic 1 3.0 Renal Tubule, Mineralization 2 1 2.0
.........................................................................................................................................................................................................
Ureter + 1 .........................................................................................................................................................................................................
Urethra + 1 .........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 81
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium, Hyperplasia 1
.........................................................................................................................................................................................................
Gallbladder + + A M + + + + + + + + A + + + + + + + + + + A + Inflammation, Suppurative 2
.........................................................................................................................................................................................................
Intestine Large, Cecum + + A + + + + + + + + + A + + + + + + + + + + A + Lymphoid Tissue, Hyperplasia
.........................................................................................................................................................................................................
Intestine Large, Colon + + A + + + + + + + + + + + + + + + + + + + + A + Inflammation, Suppurative
.........................................................................................................................................................................................................
Intestine Large, Rectum + + A + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + A + + + + + + + + + A + + + + + + + + + + A + .........................................................................................................................................................................................................
Intestine Small, Ileum + + A + + + + + + + + + A + + + + + + + + + + A + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + A + + + + + + + + + A + + + + + + + + + + + + .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Eosinophilic Focus X X X X X Hematopoietic Cell Proliferation 2 1 2 1 Inflammation, Chronic
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 82
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
Necrosis 1 2 Vacuolization Cytoplasmic Bile Duct, Hyperplasia Centrilobular, Necrosis 3
.........................................................................................................................................................................................................
Mesentery + + + + + + + Fat, Inflammation, Chronic Fat, Necrosis 3
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy 1
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation
.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Diverticulum X Ulcer Epithelium, Hyperplasia
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + A + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Atrium, Thrombosis 3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 83
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + M + + + + + + + + + + + + + + + + + + + + + + Hypertrophy 1 Capsule, Hyperplasia 2
.........................................................................................................................................................................................................
Adrenal Medulla + + M + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 2
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + + M M M + + + + + M + M + M + + + .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + M + + + Pars Distalis, Angiectasis Pars Distalis, Hyperplasia 4 3 4 2 1 Pars Intermedia, Hyperplasia
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 1 2 1 1 2 2 1 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 84
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
.........................................................................................................................................................................................................
Clitoral Gland + + M + + + M M + + + + M + + + + M + + M + M + + .........................................................................................................................................................................................................
Ovary + + + + + + + + + I + + + + + I + + + + + + + + + Angiectasis Atrophy 2 2 Cyst 1 2 1 2 4 Hemorrhage Granulosa Cell, Hyperplasia
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Hydrometra 3 4 2 4 Hyperplasia, Cystic 2 3
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node + + + Renal, Hyperplasia 3
.........................................................................................................................................................................................................
Lymph Node, Bronchial M M M M + + M + + + + + + + + M M M + + + M + + + Congestion 2 Hematopoietic Cell Proliferation 2 Hyperplasia 2 2 3
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 85
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
Lymph Node, Mandibular + + M + + + + + + + + + M M + + + + + + + + M M + Angiectasis Hyperplasia 2 Infiltration Cellular, Mast Cell 4
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + M + + + M + + + M + + M + + + + Hyperplasia 3
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + M + + + + + + + + + + + + + + + + + + + Angiectasis Hematopoietic Cell Proliferation 4 2 Hyperplasia 2
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 2 4 1 1 4 3 4 2 2 2 3 2 Hyperplasia, Lymphoid 2 2 2 2
.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + + M + M M M + + + + + + + Angiectasis 2
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 86
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 1 1 2 1
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage 2
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage Infiltration Cellular, Histiocyte 2 2 3 4 1 2 2 Thrombosis 2 Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 2 1 2 1 1 2 3 2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Infiltration Cellular, Mast Cell 2 Inflammation, Suppurative 1 Glands, Olfactory Epithelium,
Inflammation, Acute
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 87
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 7 3
5 2
6 2
7 3
7 0
7 3
6 9
7 3
6 8
4 4
7 3
6 7
6 7
5 5
5 4
7 3
2 8
6 9
7 3
4 4
7 3
6 9
6 2
6 3
7 5 3 4 4 2 5 1 4 0 0 5 3 7 1 8 5 5 1 5 7 5 0 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 3
females2 5 (cont...)
Olfactory Epithelium, Atrophy 1 Olfactory Epithelium, Hyperplasia, 1Adenomatous Olfactory Epithelium, Metaplasia 1 Respiratory Epithelium, Degeneration, 1 2 1 1 2 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye + Inflammation 4
.........................................................................................................................................................................................................
Harderian Gland + +
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis Metaplasia, Osseous 1 Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Pigmentation, Hemosiderin
.........................................................................................................................................................................................................
Urinary Bladder + + M + + + + + + + + + + + + + + + + + + + + A +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 88
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + M + + + + + + + + + + + + + + + + + + + + + + A 48 Epithelium, Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Gallbladder + + + + + + A + + + + + + + + + + + + + + + + + A 44 Inflammation, Suppurative 1 2.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + A + + + + + + + + + + + + + + + + + A 45 Lymphoid Tissue, Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + A 47 Inflammation, Suppurative 3 1 3.0
.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + M + + + + A 47 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + A + + + + + + + + + + + + + + + + + A 45 .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + A + + + + + + + + + + + + + + + + + A 45 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + A + + + + + + + + + + + + + + + + + A 46 .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + A 49 Angiectasis 4 2 3 3.3 Eosinophilic Focus X X X X X X X 12 Hematopoietic Cell Proliferation 2 5 1.6 Inflammation, Chronic 3 1 3.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 89
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
B6C3F1 MICE FEMALE
12.8 PPM ANIMAL ID
0 0 3 2 6
Necrosis Vacuolization Cytoplasmic Bile Duct, Hyperplasia Centrilobular, Necrosis
1 2 4 2
2
3 1
5 2.0 2 2.5 1 1.0 2 2.5
.........................................................................................................................................................................................................
Mesentery Fat, Inflammation, Chronic Fat, Necrosis
+ + + + +
2
+ 2
+
2
14 1 2.0 3 2.3
.........................................................................................................................................................................................................
Pancreas Atrophy Hypertrophy
+ + + +
1
+ + + 1
+ 1
+ + + + + + + 1
+ + + + + +
1
+ + + A 49 6 1.0 3 1.0
.........................................................................................................................................................................................................
Salivary Glands Inflammation
+ + + + + + + + + + 4
+ + + + + + + + + + + + + + A 49 1 4.0
.........................................................................................................................................................................................................
Stomach, Forestomach Diverticulum Ulcer Epithelium, Hyperplasia
+
3
+
2
+ + + + X
+
4
+ + + + + + + + + + + +
2 4
+ + + + + A 49 2 2 2.0 3 3.7
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + A 48
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + A 49 Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 35 1.0 Atrium, Thrombosis 1 3.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 90
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + M 48 Hypertrophy 2 2 1.5 Capsule, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + M 48 Hyperplasia 2 2.0
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + A 49 .........................................................................................................................................................................................................
Parathyroid Gland + + M M + M M + + + + M + + + M M + + + + + M + M 35 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + A 48 Pars Distalis, Angiectasis 1 1 1.0 Pars Distalis, Hyperplasia 1 1 1 8 2.1 Pars Intermedia, Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + A 49 Follicular Cell, Hyperplasia 3 1 2 2 1 1 2 15 1.5
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 91
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
B6C3F1 MICE FEMALE ANIMAL ID
12.8 PPM
0 0 3 2 6
.........................................................................................................................................................................................................
Clitoral Gland + + + + + + + + + + + M + + + + + + + M + + + + A 40 .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + A 47 Angiectasis 2 1 2.0 Atrophy 3 2 2 3 2 3 8 2.4 Cyst 4 1 1 2 4 2 1 3 1 3 2 1 3 18 2.1 Hemorrhage 3 1 3.0 Granulosa Cell, Hyperplasia 2 2 2 2.0
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hydrometra 4 4 6 3.5 Hyperplasia, Cystic 2 3 2.3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + A 49 Atrophy 4 1 4.0 Hyperplasia 2 2 2.0
.........................................................................................................................................................................................................
Lymph Node 3 Renal, Hyperplasia 1 3.0
.........................................................................................................................................................................................................
Lymph Node, Bronchial + M M + + M + + + M + M + + + M + + + M M M + + A 31 Congestion 1 2.0 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 3 2.3
.........................................................................................................................................................................................................
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 92
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Lymph Node, Mandibular + + + + + + + M + + + + + M + + M + + + + + + M A 40 Angiectasis 3 1 3.0 Hyperplasia 2 2 2.0 Infiltration Cellular, Mast Cell 1 4.0
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + + + + + + + + M + + + + + + + M 44 Hyperplasia 1 3.0
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + M + + + + + + + + + + + + M + + + M + + A 45 Angiectasis 2 1 2.0 Hematopoietic Cell Proliferation 2 3.0 Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hematopoietic Cell Proliferation 2 2 2 3 3 1 2 2 3 3 2 2 25 2.4 Hyperplasia, Lymphoid 2 5 2.0
.........................................................................................................................................................................................................
Thymus M M M M + + + + + + + M + + + M M + M M + + + M M 35 Angiectasis 1 2.0
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + A 49 Inflammation, Chronic Active 4 4 3 3.3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 93
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + A 49 Fibrous Osteodystrophy 2 1 2 1 1 2 1 11 1.4
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hemorrhage 1 2.0
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hemorrhage 4 1 4.0 Infiltration Cellular, Histiocyte 1 2 1 1 1 2 4 14 2.0 Thrombosis 1 2.0 Alveolar Epithelium, Hyperplasia 2 1 2.0 Bronchiole, Hyperplasia 3 2 2 2 2 4 1 15 2.0
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + A 49 Infiltration Cellular, Mast Cell 1 2.0 Inflammation, Suppurative 1 1.0 Glands, Olfactory Epithelium, 1 2.0 2Inflammation, Acute
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 94
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 7
3 5 3
5 5
6 7
3 1
7 1
6 9
7 3
7 0
7 3
7 3
7 3
7 3
7 3
6 9
7 1
4 8
6 3
5 4
6 9
7 0
6 2
7 3
6 3
3 2
5 1 1 4 8 9 1 4 8 4 5 5 5 5 0 9 2 6 0 8 8 3 4 1 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 3
12.8 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Olfactory Epithelium, Atrophy 1 1 2 1 5 1.2 Olfactory Epithelium, Hyperplasia, 3 1.0 1 1Adenomatous Olfactory Epithelium, Metaplasia 1 1 3 1.0 Respiratory Epithelium, Degeneration, 9 1.2 1 1 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + A 49
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Eye 1 Inflammation 1 4.0
.........................................................................................................................................................................................................
Harderian Gland + + + + 6
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + A 49 Hydronephrosis 2 1 2.0 Metaplasia, Osseous 1 1.0 Nephropathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 35 1.0 Pigmentation, Hemosiderin 2 1 2.0
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + A 47
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 95
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder + + + + + M + + A + + + + + M + + + + + A + + + + Degeneration, Hyaline 2 Inflammation, Suppurative
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + I + + + + + + A + + + + A + + + + Lymphoid Tissue, Hyperplasia 1
.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + M + + + + + + + + + + + + + + + + + + + + + + M .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + A + + A + A + + + + A + + + + A + + + + .........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + A + + + + + + + + + A + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + A + + + + + + + + + A + + + + A + + + + Peyer's Patch, Hyperplasia 2
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 2 3 Degeneration, Fatty Eosinophilic Focus X X X X X X X Hematopoietic Cell Proliferation 1 2 1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 96
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
Mineralization Necrosis 2 2 2 1 1 1 3 Bile Duct, Hyperplasia Centrilobular, Degeneration 1 Centrilobular, Necrosis 2 1
.........................................................................................................................................................................................................
Mesentery + + + + + + + + + + + + + + + Hemorrhage 2 Fat, Necrosis 3
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Atrophy 1 1 1 Hypertrophy
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Ulcer 1 1 Epithelium, Hyperplasia 2 2 3 1 2
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + Necrosis 2 2 2
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Mineralization 1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 97
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation Hypertrophy 1 Inflammation, Granulomatous, Focal 1
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia
.........................................................................................................................................................................................................
Parathyroid Gland M + + M + + + + + M + M + M + M + + + M + M + M + .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + M + + + M + + + + + + Pars Distalis, Angiectasis Pars Distalis, Hyperplasia 3 3 2
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + Follicular Cell, Hyperplasia 1 2 1
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 98
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
.........................................................................................................................................................................................................
Clitoral Gland M + + M + M + M + + + + M + + + + + I + + + + M M .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + M M Atrophy 2 1 2 3 2 Cyst 2 4 3 Granulosa Cell, Hyperplasia 2
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Hydrometra 3 Hyperplasia, Cystic 2 Inflammation, Suppurative 4 2
.........................................................................................................................................................................................................
Vagina
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node + Hyperplasia Iliac, Hyperplasia
.........................................................................................................................................................................................................
Lymph Node, Bronchial + + + + + + M + M M + + M + M M + M + M + + + + + Hematopoietic Cell Proliferation Hyperplasia 2 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 99
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + + I + + + M + M + M M M I M + M + + + + + M M .........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + M + + + + + + + + + + M + + + + + + Hematopoietic Cell Proliferation 2 Hyperplasia 3 3
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hyperplasia 2
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 4 3 4 3 3 4 2 2 2 3 3 2 2 2 3 2 3 2 4 4 2 4 2 3 Hyperplasia, Lymphoid
.........................................................................................................................................................................................................
Thymus + + + + + + + + + + + + + + + + M + + M + + M + + Atrophy 2 3
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Chronic Active 2
MUSCULOSKELETAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 100
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 3 2 1
.........................................................................................................................................................................................................
Skeletal Muscle +
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1 Inflammation, Suppurative 1
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Hemorrhage 4 Infiltration Cellular, Histiocyte 2 2 3 2 3 2 2 2 3 Alveolar Epithelium, Hyperplasia Bronchiole, Hyperplasia 2 3 1 2 1 2 2 2 Perivascular, Infiltration Cellular 2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative Nasolacrimal Duct, Inflammation,
Suppurative
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 101
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
3 4 4
5 3
5 3
2 1
5 0
6 0
6 4
6 3
4 6
5 4
4 9
6 7
7 3
6 9
6 3
6 5
5 2
5 3
5 8
4 8
5 8
5 1
5 0
6 0
1 0 7 9 6 3 8 9 5 3 3 9 4 5 1 4 6 7 1 8 7 2 5 5 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 5
females2 5 (cont...)
Olfactory Epithelium, Atrophy 1 Olfactory Epithelium, Metaplasia Respiratory Epithelium, Degeneration, 1 1 1 1Hyaline Respiratory Epithelium, Necrosis
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Harderian Gland + +
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Hydronephrosis 2 Nephropathy 1 1 2 1 1 1 1 1 1 1 1 1 Papilla, Necrosis Renal Tubule, Necrosis 2 3 3
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + A M + + + + + + + + Hemorrhage
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 102
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Gallbladder + M + A + + + + + + + + + + + + + + + M + + A + + 42 Degeneration, Hyaline 2 2 2.0 Inflammation, Suppurative 1 2 2 1.5
.........................................................................................................................................................................................................
Intestine Large, Cecum + A + + + + + + + + + + + + + + + + + + + + A + + 45 Lymphoid Tissue, Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Intestine Large, Colon + A + + + + + + + + + + + + + + + + + + + + A + + 48 .........................................................................................................................................................................................................
Intestine Large, Rectum + A + + + + + + + + + + + + + + + + + + + + A + + 46 .........................................................................................................................................................................................................
Intestine Small, Duodenum + A + A + + + + + + + + + + + + + + + + + + A + + 42 .........................................................................................................................................................................................................
Intestine Small, Ileum + A + + + + + + + + + + + + + + + + + + + + A + + 46 .........................................................................................................................................................................................................
Intestine Small, Jejunum + A + A + + + + + + + + + + + + + + + + + + A + + 44 Peyer's Patch, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 4 2.8 Degeneration, Fatty 2 2 2 2.0 Eosinophilic Focus X X X X X X X X 15 Hematopoietic Cell Proliferation 1 2 2 2 1 2 9 1.6
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 103
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
B6C3F1 MICE FEMALE
32 PPM ANIMAL ID
0 0 5 2 6
Mineralization Necrosis Bile Duct, Hyperplasia Centrilobular, Degeneration Centrilobular, Necrosis
2 2 1
2
2 3
1 1 2
1 2.0 13 1.8 1 1.0 2 1.5 2 1.5
.........................................................................................................................................................................................................
Mesentery Hemorrhage Fat, Necrosis
+ + + + +
2
+ + + + + + + 27 1 2.0 2 2.5
.........................................................................................................................................................................................................
Pancreas Atrophy Hypertrophy
+ + + + + + 1 1
+ + + 3
+ + + + + +
1
+ + + +
1
+ + M A + + 48 5 1.4 3 1.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Stomach, Forestomach Ulcer Epithelium, Hyperplasia
+ + + + + + + + +
1
+ 1
+ + +
1
+ + + + + +
1
+ + + A + + 49 3 1.0 8 1.6
.........................................................................................................................................................................................................
Stomach, Glandular Necrosis
+ + + + + + + + + + + + + + + + + + + + + + A + + 49 3 2.0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 2 1 1 2 2 1 2 1 1 1 1 1 1 2 34 1.1 Mineralization 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 104
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hematopoietic Cell Proliferation 2 2 2 2.0 Hypertrophy 1 1 3 1.0 Inflammation, Granulomatous, Focal 1 1.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + I + + + + + + + + + + + + + A + + 48 .........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + M A + + 48 Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Parathyroid Gland + + + I M I + + + + M + M + + M M + + M + + M + M 31 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48 Pars Distalis, Angiectasis 4 1 4.0 Pars Distalis, Hyperplasia 4 1 1 4 7 2.6
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + A + + 49 Follicular Cell, Hyperplasia 3 2 3 1 2 8 1.9
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 105
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Clitoral Gland M M + + M + M M + + M + + + M + + + M M + + + + M 32 .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + A + + 47 Atrophy 4 1 7 2.1 Cyst 2 1 5 2.4 Granulosa Cell, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 2 3.0 Hydrometra 4 2 3.5 Hyperplasia, Cystic 1 2 1.5 Inflammation, Suppurative 2 3.0
.........................................................................................................................................................................................................
Vagina + 1
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hyperplasia 2 2 3 2.0
.........................................................................................................................................................................................................
Lymph Node + + + + 5 Hyperplasia 3 1 3.0 Iliac, Hyperplasia 2 1 2.0
.........................................................................................................................................................................................................
Lymph Node, Bronchial + + M + M + + + + M + + + M M + + M + M + + M + + 34 Hematopoietic Cell Proliferation 3 1 3.0 Hyperplasia 2 2 4 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 106
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Lymph Node, Mandibular + M + + + + + + + + + M M M + + + + M + M + + + + 33 .........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + + + M + + + + + M + + M + + + + 45 Hematopoietic Cell Proliferation 1 2.0 Hyperplasia 3 3 2 2 2 7 2.6
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + M + + + + + + + + + + + + + + + + + A + + 48 Angiectasis 2 1 2.0 Hyperplasia 2 2 2.0
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hematopoietic Cell Proliferation 2 4 3 2 2 3 3 3 4 2 4 4 2 2 4 2 3 2 42 2.8 Hyperplasia, Lymphoid 2 1 2.0
.........................................................................................................................................................................................................
Thymus + + + + M + + + M + M M M M + + M + + + + + A + + 39 Atrophy 2 3 2.3
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Chronic Active 1 2.0
MUSCULOSKELETAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 107
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
.........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 2 2 1 6 1.8
.........................................................................................................................................................................................................
Skeletal Muscle + 2
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0 Inflammation, Suppurative 1 1.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hemorrhage 1 4.0 Infiltration Cellular, Histiocyte 3 2 4 1 3 3 1 2 2 18 2.3 Alveolar Epithelium, Hyperplasia 3 1 3.0 Bronchiole, Hyperplasia 3 4 2 2 12 2.2 Perivascular, Infiltration Cellular 1 2.0
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + A + + 49 Inflammation, Suppurative 3 1 1 3 1.7 Nasolacrimal Duct, Inflammation, 1 1.0 1Suppurative
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 108
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 6
0 6 2
5 5
4 7
4 2
5 2
3 4
5 7
6 7
3 8
5 9
6 4
6 5
6 2
3 9
6 2
6 2
7 1
6 2
3 7
5 5
5 2
4 5
6 6
6 5
7 3 1 2 5 4 6 2 1 9 6 4 6 0 4 9 9 7 4 8 1 3 4 7 2 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 5
32 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Olfactory Epithelium, Atrophy 1 1 2 4 1.3 Olfactory Epithelium, Metaplasia 2 1 2.0 Respiratory Epithelium, Degeneration, 10 1.3 2 2 1 1 2 1Hyaline Respiratory Epithelium, Necrosis 2 1 2.0
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + A + + 49
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Harderian Gland + + 4
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + A + + 49 Hydronephrosis 4 3 4 4 3.3 Nephropathy 1 1 1 1 1 2 1 1 1 1 1 1 1 25 1.1 Papilla, Necrosis 2 1 2.0 Renal Tubule, Necrosis 3 4 2.8
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + M + + + + + + A + + 46 Hemorrhage 2 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 109
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Gallbladder + + + + A + + + + + + + + + + + + M + + A + + + A Inflammation, Suppurative 1
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + A + + + + + + + + + + + + + + + + + + + + Hemorrhage 3
.........................................................................................................................................................................................................
Intestine Large, Colon + + + + A + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + M + + + + + + M + + + + + + + + + M + + .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + A + + + + + + + + + + + + + + + + + + + + Necrosis Epithelium, Hyperplasia 2
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + A + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 4 Basophilic Focus X Eosinophilic Focus X X X X X X X X X X X X X Hematopoietic Cell Proliferation 1 2 1 1 1 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 110
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
Hyperplasia, Lymphoid Mineralization Necrosis 1 2 2 2 Regeneration Vacuolization Cytoplasmic Bile Duct, Cyst Bile Duct, Hyperplasia 2 1 1 Centrilobular, Degeneration 2 Centrilobular, Necrosis 2 2
.........................................................................................................................................................................................................
Mesentery + + + + + + + + + Angiectasis Fat, Necrosis 2 2 4 3 2 3 3 2
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Atrophy 1 1 Hyperplasia Hypertrophy 1 Duct, Cyst 4
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 4 3 4 Inflammation, Suppurative 2 2 1 Ulcer 2 1 Epithelium, Hyperplasia 2 2 2 2 3 3 2 2 4 2 2 4 2
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 111
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
Degeneration, Hyaline Inflammation, Suppurative 2 Epithelium, Hyperplasia
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + Cardiomyopathy 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 Artery, Inflammation 2
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 1 Hypertrophy 2 Necrosis
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia Necrosis
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 1
.........................................................................................................................................................................................................
Parathyroid Gland + M + + M + + M M + + + + + + + + + M + M + + + + .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 112
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
Pars Distalis, Hyperplasia Pars Intermedia, Hyperplasia
1 1
.........................................................................................................................................................................................................
Thyroid Gland Follicular Cell, Hyperplasia
+ + + + + + + + + + + + + + + 2
+ + + + + 1
+ + + + +
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland + + M + + + M + + M M + + + + + + + + + + + + + + .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + M + + + + + + + + + Atrophy 2 2 2 Cyst 2 Fibrosis Hemorrhage Corpus Luteum, Hyperplasia 4
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hemorrhage 2 Hydrometra 4 3 2 4 Hyperplasia, Cystic 4 3 Endometrium, Hyperplasia 2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 113
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis 2 Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node + + Iliac, Hyperplasia 4
.........................................................................................................................................................................................................
Lymph Node, Bronchial + + + M + + + M + + + + + M + + M + + M + M + + + Hyperplasia 2
.........................................................................................................................................................................................................
Lymph Node, Mandibular + M + + + + + + + + + + M M + + + M + M + + + + + Hematopoietic Cell Proliferation Hyperplasia 2 4 4 3
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + M + I + + + + + + + + + + + + M + + + M + + + Hyperplasia 2 2 3 3 2
.........................................................................................................................................................................................................
Lymph Node, Mesenteric M + + + + + + + + + M + + + + + + + + + + + + + + Congestion Hematopoietic Cell Proliferation Hemorrhage Hyperplasia Inflammation, Chronic
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + Hematopoietic Cell Proliferation 2 2 4 4 3 4 3 3 2 4 3 4 4 3 2 4 2 3 2 4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 114
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
Hyperplasia, Lymphoid 2 .........................................................................................................................................................................................................
Thymus + M M + + + I M + + + + + + + + + + + + + + + + M Atrophy
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + Galactocele Hyperplasia 2 2
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + Sebaceous Gland, Hyperplasia 4
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + Fibrous Osteodystrophy 2 1 4 1 1 1 Fracture
.........................................................................................................................................................................................................
Skeletal Muscle +
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + Meninges, Inflammation, Chronic
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 115
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + Hyperplasia 2 1 1 Inflammation, Suppurative 1 Epiglottis, Hyperplasia 2
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + Angiectasis Hemorrhage 1 Infiltration Cellular, Histiocyte 3 2 3 2 4 2 2 2 3 Inflammation, Focal, Chronic Alveolar Epithelium, Hyperplasia 2 1 2 Bronchiole, Hyperplasia 3 2 3 3 2 2 1 2 2 3 4 2 2 2 2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + Inflammation, Suppurative 2 Inflammation, Chronic Metaplasia 1 Olfactory Epithelium, Atrophy 2 3 2 2 2 3 3 2 2 2 2 3 2 2 2 1 2 3 2 2 2 2 2 1 Olfactory Epithelium, Hyperplasia, 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 2 3 2 2 2 3 2 2 2 2 2 3 2 1 2 3 2 2 2 2 1 1 Respiratory Epithelium, Degeneration, 1 1 1 1 1 1 2 1 1 1 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 116
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 4
6 5 7
6 0
5 7
4 5
7 3
6 5
6 5
5 2
5 6
2 5
6 2
6 1
5 8
5 3
4 6
5 2
6 3
7 3
7 3
4 4
5 2
6 7
6 3
3 2
7 9 7 6 3 4 2 9 3 5 2 4 0 2 1 3 4 1 5 5 3 4 4 8 4 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 0 1
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0 0 0 0 0 0 0 0 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4
0 0 7
females2 5 (cont...)
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Ear + .........................................................................................................................................................................................................
Harderian Gland + + + + + + .........................................................................................................................................................................................................
Zymbal's Gland + +
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + Metaplasia, Osseous 1 Nephropathy 1 1 1 1 1 1 1 1 Pigmentation, Hemosiderin 2
.........................................................................................................................................................................................................
Urinary Bladder I + + + A + + + + + + + + + + + + M + + + + + + +
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 117
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
ALIMENTARY SYSTEM .........................................................................................................................................................................................................
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Gallbladder + + + M + + + + + + M + + + + + + + + A + + M + + 42 Inflammation, Suppurative 1 2 1.0
.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 49 Hemorrhage 1 3.0
.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + + + + + + + + + + M + + + + + + + + + + 46 .........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + A + + + + + 48 Necrosis 2 1 2.0 Epithelium, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + A + + + + + 49 .........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 49 .........................................................................................................................................................................................................
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 4.0 Basophilic Focus X Eosinophilic Focus X X 4 X X X X X X X X X X X X 28 4.0 Hematopoietic Cell Proliferation 1 2 3 1 1 2 12 1.5
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 118
2
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Hyperplasia, Lymphoid 2 1 2.0 Mineralization 1 1 1.0 Necrosis 1 1 1 7 1.4 Regeneration 2 1 2.0 Vacuolization Cytoplasmic 4 1 4.0 Bile Duct, Cyst 2 1 2.0 Bile Duct, Hyperplasia 3 1.3 Centrilobular, Degeneration 1 4 3 2.3 Centrilobular, Necrosis 2 3 2.0
.........................................................................................................................................................................................................
Mesentery + + + + + + + + + + + + 21 Angiectasis 2 1 2.0 Fat, Necrosis 2 3 1 4 2 3 4 2 3 4 18 2.7
.........................................................................................................................................................................................................
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Atrophy 1 3 1.0 Hyperplasia 1 1 1.0 Hypertrophy 1 1 1 4 1.0 Duct, Cyst 1 4.0
.........................................................................................................................................................................................................
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50 .........................................................................................................................................................................................................
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 3 3.7 Inflammation, Suppurative 2 3 1 2 2 8 1.9 Ulcer 2 2 2 5 1.8 Epithelium, Hyperplasia 2 4 4 4 2 2 2 2 4 4 4 1 2 4 27 2.7
.........................................................................................................................................................................................................
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 119
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Degeneration, Hyaline 1 1 1.0 Inflammation, Suppurative 1 1 2 4 1.5 Epithelium, Hyperplasia 1 1 1.0
CARDIOVASCULAR SYSTEM .........................................................................................................................................................................................................
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50 Cardiomyopathy 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 33 1.1 Artery, Inflammation 1 2.0
ENDOCRINE SYSTEM .........................................................................................................................................................................................................
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 1 1.0 Hypertrophy 1 2 1.5 Necrosis 4 1 4.0
.........................................................................................................................................................................................................
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 1.0 Necrosis 3 1 3.0
.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1.0
.........................................................................................................................................................................................................
Parathyroid Gland + + + + + + + + M M + + + + M M + + M + + M + + M 37 .........................................................................................................................................................................................................
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 120
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
Pars Distalis, Hyperplasia 4 1 1 1 3 3 2 9 1.9 Pars Intermedia, Hyperplasia 4 1 4.0
.........................................................................................................................................................................................................
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Follicular Cell, Hyperplasia 1 2 4 1.5
GENERAL BODY SYSTEM NONE
GENITAL SYSTEM .........................................................................................................................................................................................................
Clitoral Gland M + M + M + M + + M M M + + + + + M M + + + M + M 35 .........................................................................................................................................................................................................
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 49 Atrophy 2 2 2 6 2.0 Cyst 1 1 2 1 2 6 1.5 Fibrosis 2 1 2.0 Hemorrhage 2 1 2.0 Corpus Luteum, Hyperplasia 1 4.0
.........................................................................................................................................................................................................
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 4 2 3.0 Hemorrhage 4 2 3.0 Hydrometra 3 2 3 3 8 3.0 Hyperplasia, Cystic 4 3 3.7 Endometrium, Hyperplasia 1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 121
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
HEMATOPOIETIC SYSTEM .........................................................................................................................................................................................................
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 1 2.0 Hyperplasia 2 2 2 4 2.0
.........................................................................................................................................................................................................
Lymph Node 2 Iliac, Hyperplasia 1 4.0
.........................................................................................................................................................................................................
Lymph Node, Bronchial M + + + + M + + + M + + M M M + + + + + + + + + + 38 Hyperplasia 2 2 3 2.0
.........................................................................................................................................................................................................
Lymph Node, Mandibular + + + + + + + + + M + + + + M + + M M + M + + + + 40 Hematopoietic Cell Proliferation 2 1 2.0 Hyperplasia 4 3.3
.........................................................................................................................................................................................................
Lymph Node, Mediastinal + + + + + + + + + M + + M + M + + M M + M + + + + 40 Hyperplasia 2 2 7 2.3
.........................................................................................................................................................................................................
Lymph Node, Mesenteric + M + + + + + + + + + + + + + + + + M + + + + + + 46 Congestion 2 1 2.0 Hematopoietic Cell Proliferation 4 1 4.0 Hemorrhage 3 1 3.0 Hyperplasia 4 2 2 3.0 Inflammation, Chronic 2 1 2.0
.........................................................................................................................................................................................................
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hematopoietic Cell Proliferation 3 4 4 3 3 2 2 2 1 2 2 2 4 3 2 2 3 4 4 39 2.9
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 122
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
B6C3F1 MICE FEMALE ANIMAL ID
80 PPM
0 0 7 2 6
Hyperplasia, Lymphoid 2 3 3 2.3 .........................................................................................................................................................................................................
Thymus + + M + M + + + + M + + + + M + + + + + + M + + M 39 Atrophy 2 1 2.0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
INTEGUMENTARY SYSTEM .........................................................................................................................................................................................................
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50 Galactocele 4 1 4.0 Hyperplasia 2 3 2.0
.........................................................................................................................................................................................................
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50 Sebaceous Gland, Hyperplasia 2 2 3.0
MUSCULOSKELETAL SYSTEM .........................................................................................................................................................................................................
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50 Fibrous Osteodystrophy 2 1 1 9 1.6 Fracture X 1
.........................................................................................................................................................................................................
Skeletal Muscle 1
NERVOUS SYSTEM .........................................................................................................................................................................................................
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50 Meninges, Inflammation, Chronic 1 1 1.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 123
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
RESPIRATORY SYSTEM .........................................................................................................................................................................................................
Larynx + + + + + + + + + + + + + + + + + + + + + + + + + 50 Hyperplasia 1 1 5 1.2 Inflammation, Suppurative 1 1.0 Epiglottis, Hyperplasia 1 2.0
.........................................................................................................................................................................................................
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50 Angiectasis 2 1 2.0 Hemorrhage 1 1.0 Infiltration Cellular, Histiocyte 2 2 3 2 2 3 2 2 3 2 2 2 4 2 23 2.4 Inflammation, Focal, Chronic 2 1 2.0 Alveolar Epithelium, Hyperplasia 2 4 1.8 Bronchiole, Hyperplasia 2 2 1 4 2 3 3 2 2 2 2 1 4 1 1 30 2.2
.........................................................................................................................................................................................................
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50 Inflammation, Suppurative 2 1 1 4 1.5 Inflammation, Chronic 4 1 4.0 Metaplasia 1 1.0 Olfactory Epithelium, Atrophy 3 2 2 2 3 1 2 1 1 2 2 2 2 1 3 2 2 1 2 2 3 2 2 47 2.0 Olfactory Epithelium, Hyperplasia, 44 1.9 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2Adenomatous Olfactory Epithelium, Metaplasia 3 2 2 2 3 1 2 1 1 2 2 2 1 3 2 2 1 2 1 2 2 2 44 2.0 Respiratory Epithelium, Degeneration, 25 1.2 1 1 1 2 1 2 1 1 2 1 1 1 2 1Hyaline
.........................................................................................................................................................................................................
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 124
TDMS No. 05136 - 08 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Reqsted: 06/07/2007
Test Type: CHRONIC CHLOROPRENE Time Report Reqsted: 11:44:08
Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 126-99-8 First Dose M/F: 09/13/90 / 09/13/90
Species/Strain: MICE/B6C3F1 Lab: BNW
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DAY ON TEST 5
3 6 3
6 1
3 8
5 9
6 7
6 3
6 3
3 3
4 8
6 3
6 2
0 0
6 6
5 4
4 6
6 4
6 8
6 6
5 3
5 7
6 3
6 4
5 2
6 3
1 2 5 3 6 3 1 5 6 4 2 9 3 3 8 2 9 0 6 8 9 5 9 4 1 .................................................................................................................................................................
0B6C3F1 MICE FEMALE 0 ANIMAL ID 7
80 PPM 2 6
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 2 2 2 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 * TOTALS
SPECIAL SENSES SYSTEM .........................................................................................................................................................................................................
Ear 1 .........................................................................................................................................................................................................
Harderian Gland + + + 9 .........................................................................................................................................................................................................
Zymbal's Gland + 3
URINARY SYSTEM .........................................................................................................................................................................................................
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50 Metaplasia, Osseous 1 1.0 Nephropathy 1 1 1 1 2 1 1 1 1 1 1 1 20 1.1 Pigmentation, Hemosiderin 2 2 3 2.0
.........................................................................................................................................................................................................
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 47
*** END OF REPORT ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade + .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as: x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) Moderate I .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 125