Osteoporosis

Calsi-Soya By PH. Basim. Alibagli

NATURES GIFTS

Bone and its component Bone Homeostasis Bone remodeling Definition and classification of osteoporosis Prevalence Risk Factors and presentation Diagnosis Consequences Management principle Treatment goal

Osteoporosis Objectives

Bone and its component

Organic Component: protein collagen & specialized

cells called osteoclasts, osteoblasts, and osteocytes

Inorganic component: Mainly as calcium phosphate,

in the form of Hydroxyapatite

Bone Homeostasis

Bone Homeostasis: the situation when the body

requires and achieves an equal amount of bone resorption and bone formation

the amount of bone eroded by osteoclasts is equal to theamount of bone produced by osteoblasts, thereby producing a stable net mass of bone in the body

Homeostasis

Bone Remodeling The combined processes of breaking down bone and

building new bone are called Bone Remodeling.

It is the body’s way of maintaining bone homeostasis.

5 Stages: Initiation, Resorption, Reversal, Bone formation and Completion of remodeling.

Remodeling: Activation

Osteoclast precursor cells are attracted to a bone site and penetrate the bone lining cells. These osteoclast precursor cells then form activated osteoclasts that align themselves in direct contact with mineralized bone matrix.

Remodeling: Resorption

The osteoclasts erode a cavity by removing mineral and organic components from the bone. The osteoclasts eventually die. This completes the resorption phase.

Remodeling: Revarsal

Cells of unknown origin prepare the bone surface for new bone formation by smoothing the surface of the cavity and depositing a thin layer of a cement-like substance.

Remodeling: Formation

Cells of unknown origin prepare the bone surface for new bone formation by smoothing the surface of the cavity and depositing a thin layer of a cement-like substance.

Remodeling: Resting

The lining cells rest on the bone surface until the next cycle of bone remodeling begins.

Some osteoblasts become osteocytes.

Remodeling timeline

Definition of Osteoporois

National Osteoporosis Foundation: a disease characterized by low bone

mass an micro-architectural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures.”

World Health Organization : bone mineral density T-score greater

than –2.5 standard deviations from the mean peak adult bone mass (ie. a woman in her 30’s).”

Classification of Osteoporosis

Primary osteoporosis• Juvenile osteoporosis. • Idiopathic osteoporosis• Postmenopausal

osteoporosis• Age-related, or senile,

osteoporosis

• Secondary osteoporosis• Congenital• Diet• Drugs• Endocrine disorder• Other Systemic Disorder

Osteoporosis

Building & Losing bone with years

Prevalence

“Osteoporosis, the silent thief of your bone”

Prevalence…

Worldwide, over age of 50 1 in 3 women / 1 in 8 men have osteoporosis.

80 % of those suffering from osteoporosis are women. Affects 75 million persons in the US, Europe and Japan.

Over 50% of women aged 50 years or older and 20% of men will suffer an osteoporosis-related fracture within their remaining lifetime

Risk Factors Being female Older age Family history of osteoporosis or broken bones Being small and thin History of broken bones Low sex hormones• Low estrogen levels in women, including menopause • Missing periods (amenorrhea) • Low levels of testosterone and estrogen in men

Risk Factors… Diet• Low calcium intake • Low vitamin D intake • Excessive intake of protein,

sodium and caffeine Inactive lifestyle Smoking , Alcohol abuse Certain medications• steroid , anticonvulsants etc

Certain diseases• anorexia nervosa, rheumatoid

arthritis, gastrointestinal diseases and others

Presentation

People may not know that they have osteoporosis until they break a bone.

Vertebral (spinal) fractures may initially be felt or seen in the form of Persistent, unexplained back pain Loss of height Spinal deformities such as

kyphosis or stooped posture.

Diagnosis Bone mineral density (BMD) tests can measure bone

density in various sites of the body.

BMD test is done to diagnose and predict fracture risk and to monitor therapy.

For patients on pharmacotherapy, it is typically performed 2 years after initiating therapy and every 2 years thereafter; however, more frequent testing may be warranted in certain clinical situations.

Diagnosis… Dual-energy X-ray Absorptiometry (DXA) Scan

• “Gold-standard” for BMD measurement.• Measures “central” or “axial” skeletal sites: spine and

hip.• May measure other sites: total body and forearm.• Validated in many clinical trials.• Available in Bangladesh.

Diagnosis…

Dual-energy X-ray Absorptiometry (DXA) Scan

Classification T-score

Normal -1 or greater

Osteopenia Between -1 and -2.5

Osteoporosis -2.5 or less

Severe Osteoporosis -2.5 or less and fragility fracture

ComplicationsFRACTURE ,

The most serious complication of Osteoporosis that leads to

Increased morbidity Increased mortality

Decreased quality of life

Complications…

Wrist fracturemen 1 in 40 (2.5%)

women 1 in 6 (16%)

Spinal fracturemen 1 in 20 (5%)

women 1 in 6 (16%)

Hip fracturemen 1 in 17 (6%)

women 1 in 6 (17.5%)

Management principle

Decreased fracture risk

Life style modification Therapeutic Intervention

• Minimizing risk factors Slowing/stopping bone loss

• Minimizing factors that Contribute to fall

Maintaining or increasing bone density and strength

Maintaining or improving bone microarchitecture

Pharmacologic management

Supplements such as which maintain bone mass Calcium, Vitamin D

Anti-resorptive agents which inhibit bone resorption Bisphosphonates

Anabolic agents, which stimulate bone formation and, in turn, increase

bone mass.

Goal of treatment Prevent further bone loss Increase or at least stabilize bone density Prevent further fractures Relieve deformity (e.g., kyphoplasty) Relieve pain Increase level of physical functioning Increase quality of life

The Perfect Bone Supplement!

Build Healthy Bones With CALSI-SOYA

Calsi-soya is an all-natural health supplement claimed to prevent you from osteoporosis, which happens due to bone fractures and other bone related issues. Calsi-soya is also used as a supplement to maintain bone health.

What Calsi-soya Can Do?• It supports bone health by increasing

bone density.

• Recover and helps to regain bone mass which is very important for healthy bone.

• Prevent Osteoporosis.

• Provide and supply bones with sufficient vitamins and minerals.

• Boost and makes strong Bone function, so Bones will work efficiently.

Ingredients

Why Calci-Soya Balance supplement?

Vitamin K, calcium, zinc, magnesium and manganese: ossification and bone healing

Vitamin D3, boron, lysine, magnesium: reducing urinary calcium excretion Manganese and soy polysaccharides: calcium sediment in bone tissuesCopper and lysine: collagen synthesisContains calcium carbonate: most absorbable form of calciumOnly calcium + vitamin D3 supplement containing soy isoflavone: effective in improving menopause symptoms especially flushing, nocturnal perspiration and bone mass density reductionProduced under global standard certification of cGMPProduced and packed in US

Calci-soya BalanceFirst choice for standing against the silent disease

Promotes bone and joint healthReduces risk of osteoporosisImproves osteoporosis through:

Increasing bone minerals concentrationBone healing and synthesis

Reduces painImproves healing process in stress fracturesImproves menopause symptoms including flushing and nocturnal perspiration

Grow old strong

• Calci soya is not just a calcium supplement; It is everything bone needs

• Administration: one soft gel per day with a meal

• Do not deprive your bones from minerals. Using supplements is not a necessity for people suffering from osteoporosis. If you care about this disease earlier, you can easily prevent it with nutrition and sporting. It is never late for improving your bones conditions. Ossification is possible even in elderly women.

Risk factors for osteoporosis

Risk factors for osteoporosis

Risk factors for osteoporosis

Hormone deficiency

such as estrogen in women and androgen in

men

Overusing some drugs

Physical inactivity

Thyroid gland

malfunctions

Bone cancer and some inherited genetic

conditions

Insufficient calcium

and vitamin D3

intake

Soy isoflavone: effective in preventing osteoporosis and reducing menopause

• Possesses estrogenic properties and prevents osteoporosis

• Prevents decline in mineral concentration in bone mass tissue

• Improves complications caused by menopause including flushing, nocturnal perspiration and vaginal dryness

• Proper replacement for HTR (hormonal treatment replacement) with no side effects

Calcium: most essential element for ossification

• Human body needs calcium in ossification process.• Calcium prevents bone decomposition in menopause

ladies.• Calcium carbonate; a calcium form with high

absorption abilities• Calcium carbonate has 40% absorbable calcium;

whereas has 21% in calcium citrate.

Vitamin D; increasing calcium and phosphorous absorption

• Increases calcium absorption• Increases minerals concentration in bone mass tissue• Vitamin D and calcium deficiency is a main risk factor

of osteoporosis. It is because low calcium levels increase parathyroid functions. Parathyroid hormone increases bone decomposition and therefore increases number and activity of osteoclasts which absorb calcium from bone tissue.

Zinc; important element in vitamin D activities:

• Improve biochemical activities of zinc• Increases osteoblasts differentiation and

synthesis of bone tissues proteins• Prevents calcium resorption from bone

tissue• Increases mineral concentration in bone

mass tissue• Increases bone mass density• Improves fracture healing rate in

conditions such as aging, calcium and vitamin D deficiency, estrogen deficiency and diabetes

• Zinc deficiency can decrease osteoblasts’ activities and collagen synthesis. It also can delay and slow down bone mass growth.

L-lysine; effective in collagen synthesis

• Increase calcium absorption in digestive tract and reduces urinary calcium excretion

• Improves collagen synthesis (collagen is 25% of total body protein and is essential for bones and other tissues)

Magnesium:Increases calcium absorption and metabolisms

Is essential for transforming vitamin D to its active form

• Induces thyroid gland into calcitonin secretion (which in turn protects bone tissue)

• Improves parathyroid gland modification and prevents bone tissue decomposition

Copper; reducing calcium resorption from bones

• Improves protein synthesis necessary for connective and bone tissue

• Improves mechanical resistance of collagen in bone tissue

• Prevents minerals resorption to bloodstream

Manganese; increasing mineral concentration in bone tissue

• Increases bone minerals• Increases protein and cartilage

syntheses• Manganese deficiency can

reduce calcium sediment in bone tissues and increase fracture risk

• Manganese deficiency can reduce mineral concentration in bone tissue and increase bone decomposition

Boron; reducing calcium excretion

• Human body needs boron for different ossification metabolisms including calcium, magnesium, vitamin D, estrogen and possibly testosterone metabolism. Generally studies show boron improves minerals concentration and estrogen levels; especially in women intake insufficient magnesium.

• Role of boron in bone health• Prevents minerals concentration

reduction• Prevents calcium excretion in women

during menopause• Improves calcium metabolism

Vitamin K

• Improves calcium absorption in bone mass tissue

• Improving bio-activating proteins responsible in ossification metabolisms

• Improving mineral concentration in bone mass tissue

• Improving bone synthesis and healing process

http://www.sciencedirect.com/science/article/pii/S0140673607613154

http://www.emedicinehealth.com/osteoporosis/page2_em.htm

http://jn.nutrition.org/content/132/7/2048.full.pdf+html

http://www.pharmaceutical-journal.com/libres/pdf/articles/pj_20051015

_soy.pdf

http://umm.edu/health/medical/altmed/supplement/calcium

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621390

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509509

http://drtorihudson.com/articles/osteoporosis-strategies-for-prevention-

and-management/

http://link.springer.com/article/10.1007/s11010-009-0358-0#page-1

http://link.springer.com/article/10.1007/s774-002-8445-y#page-1

http://www.naturalhealthadvisory.com/daily/osteoporosis-prevention-an

d-treatment/natural-treatment-for-osteoporosis-%E2%80%93-how-bod

y-building-amino-acids-can-help-the-body-build-strong-bones

www.betterbones.com/bonenutrition/20keybonenutrients.pdf

http://ajcn.nutrition.org/content/61/2/341.full.pdf+html

References

Why Calsi-soya?•This Product works for men and women alike.•The complete list of ingredients are listed online.•All Ingredients used are backed by clinical studies.•Comparatively affordable.•There are lots of positive user reviews.

Success Stories I have been taking Calsi-soya for about two years and my osteoporosis is improved, nails are not chipping, and my level test scores are good. I highly recommend it. The price is very competitive. By Bronxirishboy, USA

I have a family history of osteoporosis, so I knew that I needed to do something to help overcome this issue. I chose Calsi-soya because of the way that it provided a complete way to fight against bone loss, and I've never regretted my choice. I've been taking Calsi-soya for several years now, and I positively love it.

By Jessie Smith, CA

Hitting menopause was definitely not an easy time for me. Between the mood swings and the physical changes, I felt frustrated with myself much of the time. However, one positive change that I made during that time was to start taking Calsi-soya to help improve my bone density. Calsi-soya has helped me to keep my bones healthy and strong. By Lisa Henry, Florida

Recommendation Generally, Both Men and Women are at a risk of Bone Loss, for them regular use of Calsi-soya recommended.

The person, who has calcium deficiency, must take Calsi-soya for Recoupment.

Dosage:Take 1 tablets daily with food

Conclusion

For Further info visit:

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These types of Bone supplement are vital for the individuals who are

suffering with osteoporosis or any bone ailments. As this is a bone

supplement, it supplies all vital an important

vitamins and minerals to bones to make them

healthy and promote efficient working.

If this product used regularly, it will

improve Bone mass Density and Prevent

future Degeneration.