Date post: | 11-May-2015 |
Category: |
Business |
Upload: | cambridgeip-ltd |
View: | 2,584 times |
Download: | 0 times |
© 2010 CambridgeIP Ltd. All rights reserved
Recent Patenting Trends in NanoParticle Manufacturing
Nanoformulation 2010
Stockholm, 11/06/2010
11th June 10
Ilian Iliev, CEO and co founder of CambridgeIPQuentin Tannock, Chairman and Co Founder of CambridgeIPKarishma Jain, Associate Consultant
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• CambridgeIP background
• Patent landscaping – a primer
• Patenting in Nanotech broadly
• Patenting in Nanoparticle Manufacturing
2
© 2010 CambridgeIP Ltd. All rights reserved.
3 © 2009 CambridgeIP. All rights reserved
• IP Landscape® informing IP and R&D strategy:
– Our global IP databases, proprietary methodologies and consulting provide unique patent landscape coverage, highlighting technology “white space” and informing your own FTO due diligence efforts
• Identify Prospective Partners or Acquisitions:
– Information on top corporate, university and governmental partner/acquisition candidates operating in your area of interest
• Technology Marketing :
– Advice on active companies and consortiums who could leverage your patents and technologies around the world
We operate www.boliven.com , industry leading patent and science literature search platform with 100 million documents (join now - its free!)
Provider of Actionable Patent-based Technology Intelligence
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• CambridgeIP background
• Patent landscaping – a primer
• Patenting in Nanotech broadly
• Patenting in Nanoparticle Manufacturing
4
© 2010 CambridgeIP Ltd. All rights reserved.5 © 2009. CambridgeIP. All rights
reserved
A reminder: why Patent Landscaping is necessary
Patents can be a highly reliable source of information about an industry
• Patents as data are structured, comparable, objective and information rich
• Information on technology, inventors, linkages to other fields…
But… there are major challenges related to
• Defining your technology space
• Identifying relevant patents
• Interpreting the results
Akin to finding multiple needles in multiple haystacks
A simple search for ‘silicon device’ returns 671,882 patents! Where do you begin?
© 2010 CambridgeIP Ltd. All rights reserved.
Multiple patents protect a single product or process
6
Canister
Actuation System
Valves and Mouthpiece
© 2010 CambridgeIP. All rights reserved
© 2010 CambridgeIP Ltd. All rights reserved.
Discovery of networks and knowledge flows
7 © 2010 CambridgeIP Ltd. All rights reserved
Case Study:Plastic Logic,Cambridge University Spin-off
Blue: InventorRed: OwnerSize: Quantity
0
50
100
150
200
250
300
350
400
0
10
20
30
40
50
60
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Pate
nts
-C
um
ula
tive
Pate
nts
-Y
earl
y
Number of Patents: Annual and Cumulative
Number of New Applications Cumulative
© 2010
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• CambridgeIP background
• Patent landscaping – a primer
• Patenting in Nanotech broadly
• Patenting in Nanoparticle Manufacturing
8
© 2010 CambridgeIP Ltd. All rights reserved.9
Nano-context: Key Conclusions from Previous Research (1)
Patent trends research indicates that nanotechnology:• Is a cross-cutting technology applicable to multiple market sectors
• Has high levels of public development and support , compared to the average in other fields
• Global development and application
– US is a leader in terms of volume of patent filings , and is highly diversified
– Nanobiotechnology dominates European patent filings
– Nanoelectronics dominates Japan activity
Source: EPO (2007)
© 2010 CambridgeIP Ltd. All rights reserved.
CambridgeIP research reveals:• Higher inter-relation between patents in nano-field
– Higher patent forward citation rates for patents relative to forward citation rates observed elsewhere
– Rising strength of China: Rise in China patenting rates (accompanied by acquisitions of companies and technologies by Chinese companies)
– Russia: Russian nanotechnology developments are often be overlooked in the English speaking world. Many clients have little or no exposure to patent and non-patent literature in Cyrillic. The role of RusNano?
• Patenting rates slow down from 2004 in some nanotechnology sub-spaces, in part driven by:
– Delays in patentn filings (perhaps due to „time to market‟ and other considerations)
– Fewer nano patents granted: Increased sophistication and rigor of the nano-patent examination process
– Lower levels of VC investment: end of the honeymoon?
• Multiple & varied technology areas with inter-dependencies and growing number of applications
10
Nano-context: Key Conclusions from Previous Research (2)
1996: A relatively small number of
IPCs is associated with the
nanotechnology field
2006: An „explosion‟ of activity across an ever-increasing array of industrial applications: no single „core area can be discerned: indicative of a „raft‟ or a „platform‟ technology entering maturity
© 2010 CambridgeIP Ltd. All rights reserved.
Industry Example: Photovoltaics patents and nano-related patents
PV and Wind are the most highly patent low-carbon energy fields
The key patent holders differ between PV overall and nano-PV
Number of patents by year
Photovoltaic Space and subspaces
0
1 00
2 00
3 00
4 00
5 00
6 00
7 00
8 00
9 00
1976
1978
1980
1982
1984
1986
1988
1990
1992
1994
1996
1998
2000
2002
2004
2006
Nanotech Related Amorphous Silicon Cd Te CIS & CIGS Dy e Sensitized
Source: Chatham House – CambridgeIP (2009) ‘Who Owns Our Low-Carbon Future?’Full report available for download from CambridgeIP’s website: www.cambridgeip.com
Report was co-authored with Bernice Lee and Felix Preston of Chatham House
Assignee Patent # Assignee Patent # Assignee Patent #
SHARP 608 UNIVERSITY CALIFORNIA 42 SANYO 57
CANON 561 NANOSOLAR INC 41 CANON 49
SANYO 483 KONARKA TECHNOLOGIES INC 40 KANEGAFUCHI KAGAKU KOGYO KK 36
MITSUBISHI 416 GENERAL ELECTRIC CO 34 FUJI ELECTRIC CO LTD 33
MATSUSHITA ELECTRIC 359 SAMSUNG ELECTRONICS CO LTD 30 ENERGY CONVERSION DEVICES INC 28
FUJI ELECTRIC CO LTD 258 WILLIAM MARSH RICE UNIVERSITY 26 HITACHI 23
HITACHI 223 CANON 24 GUARDIAN INDUSTRIES 22
MERCK PATENT GMBH 198 DUPONT 22 SHARP 22
KYOCERA CORPORATION 190 SONY CORP 21 MITSUBISHI 21
KANEGAFUCHI KAGAKU KOGYO KK 184 NANOSYS INC 19 SIEMENS 18
Nanotech RelatedOVERALL Amorphous Silicon
Assignee Patent # Assignee Patent # Assignee Patent #
SHARP 608 UNIVERSITY CALIFORNIA 42 SANYO 57
CANON 561 NANOSOLAR INC 41 CANON 49
SANYO 483 KONARKA TECHNOLOGIES INC 40 KANEGAFUCHI KAGAKU KOGYO KK 36
MITSUBISHI 416 GENERAL ELECTRIC CO 34 FUJI ELECTRIC CO LTD 33
MATSUSHITA ELECTRIC 359 SAMSUNG ELECTRONICS CO LTD 30 ENERGY CONVERSION DEVICES INC 28
FUJI ELECTRIC CO LTD 258 WILLIAM MARSH RICE UNIVERSITY 26 HITACHI 23
HITACHI 223 CANON 24 GUARDIAN INDUSTRIES 22
MERCK PATENT GMBH 198 DUPONT 22 SHARP 22
KYOCERA CORPORATION 190 SONY CORP 21 MITSUBISHI 21
KANEGAFUCHI KAGAKU KOGYO KK 184 NANOSYS INC 19 SIEMENS 18
Nanotech RelatedOVERALL Amorphous Silicon
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• CambridgeIP background
• Patent landscaping – a primer
• Patenting in Nanotech broadly
• Patenting in Nanoparticle Manufacturing
12
© 2010 CambridgeIP Ltd. All rights reserved.
Nanoparticle manufacturing background
Nanotechnology has cross-sectoral application
A number of challenges before its full commercial potential is realised:
• Lack of large scale manufacturing techniques
• Challenge on cost effective production
• Health/safety concerns
• Very long time to market for nano-products
• Unclear regulatory framework – affecting investment decisions into R&D and manufacturing capacity
13
© 2010 CambridgeIP Ltd. All rights reserved.
14
Patent Study Methodology
We undertook patent research into key nano-particle manufacturing techniques and identified patents of interest emerging over the last 5 years
• Using expert interviews and our patent data mining we built a technology matrix covering:
– 15 manufacturing methods
– 14 industry applications
• We conducted a semi-automated and expert-validated analysis of the space and identified example patents
• In the next slides we show some of our results
• Further research is available on request
© 2010 CambridgeIP Ltd. All rights reserved.
Nano-Technology Manufacturing Methods
Method Detail Type
Deposition techniques
To settle nanoparticles from a bulk material onto a pre-existing surface
Top Down
Mechanical Production of nanoparticles using physical mechanism
Top Down
Wet chemistry Nanoparticles used in chemical organic solution
Bottom Up
Gas phase synthesis Nanoparticles being produced in gas phase using various technologies
Bottom Up
Production in liquid carbon dioxide
Liquid CO2 infused with nanoparticles for coating/cleaning purposes
Bottom Up
Use of scaffolds (polymer)
Use of a mould to build nanoparticles Bottom Up
Creating nanoscale devices by using larger, externally-controlled materials, directing their formation
Using small molecular components, building them up into more complex assemblies
© 2010 CambridgeIP Ltd. All rights reserved.
Technology Matrix: Bio related Fields
16
NanoParticles Manufacturing
Techniques
drug delivery/
(re)
Formulation
Medicine –
diagnostics
scaffolds for
tissue
engineering
Cosmetics
Deposition techniques
lithography xvacuum coating
spray coating
Mechanical
ball milling xplanetary grinding x
Wet chemistry
Sol-Gel Processing x x x xHydrothermal synthesis x x xmicroemulsion processing x x x xnanoemulsion processing x x x xSonochemical processing x x x x
Gas phase synthesis
plasma vaporization
chemical vapour synthesis
laser ablation
Production in liquid CO2 x x x x
Use of scaffolds (polymer) x x x x
Bo
tto
m U
pTo
p D
ow
n
© 2010 CambridgeIP Ltd. All rights reserved.
Technology Matrix:Environment related Fields
17
Key area of concern for climate change policy
NanoParticles Manufacturing
Techniques
fuel cells Photovoltaics construction
and concrete
air purification water
purification
Deposition techniques
lithography x x x xvacuum coating x x x xspray coating x x x x
Mechanical
ball milling x xplanetary grinding x x
Wet chemistry
Sol-Gel Processing x x x xHydrothermal synthesis x x xmicroemulsion processing x x xnanoemulsion processing x x xSonochemical processing x x x
Gas phase synthesis
plasma vaporization xchemical vapour synthesis xlaser ablation x
Production in liquid CO2 x x x x
Use of scaffolds (polymer) x x
Bo
tto
m U
pTo
p D
ow
n
© 2010 CambridgeIP Ltd. All rights reserved.
Technology Matrix:Industry related Fields
18
NanoParticles Manufacturing
Techniques
automotive aerospace lubricants for
industrial
components
paints, smart
coatings
catalysis electronics
Deposition techniques
lithography x x x x x xvacuum coating x x x x x xspray coating x x x x X x
Mechanical
ball milling x x x x xplanetary grinding x x x x x
Wet chemistry
Sol-Gel Processing x x x x xHydrothermal synthesis x x x x x xmicroemulsion processing x x x x xnanoemulsion processing x x x x xSonochemical processing x x x x x
Gas phase synthesis
plasma vaporization x x x x xchemical vapour synthesis x x x x xlaser ablation x x x x x
Production in liquid CO2 x x x x x x
Use of scaffolds (polymer) x x x x x x
Bo
tto
m U
pTo
p D
ow
n
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• CambridgeIP background
• Technology Field Definition
• Patent Examples
• Appendices
19
© 2010 CambridgeIP Ltd. All rights reserved.
CN101602508
Method for preparing monodisperse nano silicon dioxide spherical particle hydrosol and application thereof
Assignee: UNIV ZHEJIANG SCIENCE & TECH [CN]
Inventor: JIANJUN CHEN [CN]; NAIYAN WANG [CN]; LINHUI GAO [CN]; ZHAO WANG [CN]
Publication Date: 2009-12-16
Abstract: The invention discloses a method for preparing monodisperse nano silicon
dioxide spherical particle hydrosol and application thereof. The method adopts a sol-gel method and comprises the following steps: using ammonia as a catalyst for the hydrolysis of ethyl orthosilicate, and using ethanol as a solvent to prepare nano SiO2 particles, namely adopting a method for preparing the SiO2 particles through a st ber method so as to obtain a suspension of the SiO2 particles dispersed in the ethanol solvent; adopting a heating and blasting process to volatize most of the ethanol in the suspension so as to obtain a nano silicon dioxide particle slurry; and adding an aqueous solution of alkamine into the slurry to finally prepare a nano SiO2 hydrosol, wherein the volatized ethanol can be reused after being collected. The hydrosol is applied to modified water-based external wall coatings, water-based fire-retardant coatings and water-based woodwork coatings. The nano silicon dioxide does not exist in the form of powder to avoid agglomeration of nano particles and improve the dispersity of the nano particles in the water-based coatings, thereby improving the performances of weatherability, washability, storage stability and the like of the coatings.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Sol-Gel
20
aerospace paints, smart
coatings
construction
and concrete
© 2010 CambridgeIP Ltd. All rights reserved.
CN101602596
Lithium tantalate nano powder and preparation method thereof
Assignee: UNIV CHINA GEOSCIENCES WUHAN [CN]
Inventor: JIANHUI HU [CN]; YANGAI LIU [CN]; MINGHAO FANG [CN]; ZHANXING SUN [CN]; CHAOHUI HUANG [CN]
Publication Date: 2009-12-16
Abstract: The invention relates to lithium tantalate nano powder
and a preparation method thereof, and belongs to the technical field of functional ceramic powder. The lithium tantalate nano powder is prepared by a sol-gel method. Ta2O5 and Li2CO3 as main raw materials and citric acid (CA) as a complexing agent react to form a stable metal-citric acid complex compound which is used as a tantalum source and a lithium source; an ethylene glycol (EG) esterifying agent is added into the metal-citric acid complex compound to form a polymer network with the citric acid; tantalum ions and lithium ions are evenly dispersed in the network to form stable polymer precursor sol; and the polymer precursor sol is dried and calcined to form LiTaO3 nano powder with good dispersion property. Because the Ta2O5 is used as an initial raw material of the tantalum, the cost is low; and the experimental device requirement is low, the process is simple, and the operation is convenient.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Sol-Gel
21
Cosmetics Medicine –
diagnostics
automotive aerospace electronics
© 2010 CambridgeIP Ltd. All rights reserved.
MX2009007013
PROCESSES FOR THE HYDROTHERMAL PRODUCTION OF TITANIUM DIOXIDE.
Assignee: DU PONT [US]
Inventor: CORBIN DAVID RICHARD [US]; HUTCHENSON KEITH W; LI SHENG; TORARDI CARMINE; MCCARRON EUGENE MICHAEL
Publication Date: 2009-07-09
Abstract: The present invention provides hydrothermal
processes for the production of titanium dioxide from titanyl hydroxide. The use of specific crystallization directors, or additives, can promote the formation of rutile, anatase, or brookite. Variation of process operating parameters can lead to either pigmentary-sized or nano-sized rutile.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Hydrothermal
drug delivery/
(re)
Formulation
Medicine –
diagnostics
catalysis automotive aerospace paints, smart
coatings
electronics
22
© 2010 CambridgeIP Ltd. All rights reserved.
KR20080096023
METHOD OF PREPARING LITHIUM TITANATE NANOPARTICLES UNDER SONOCHEMICAL CONDITION
Assignee: SAMSUNG ELECTRONICS CO LTD [KR]; UNIV CHUNG ANG IND [KR]; SEOUL NAT UNIV IND FOUNDATION [KR]
Inventor: SHIM IL WUN [KR]; KWAK HO YOUNG [KR]; LEE SEUNG SOO [KR]; BYUN KI TAEK [KR]; PARK JONG PIL [KR]; KIM SIN KYU [KR]
Publication Date: 2008-10-30
Abstract: A manufacturing method of lithium titanate nano particle is provided to
raise a composition and a purity of the lithium titanate by using the precursor manufactured by coating the lithium hydroxide which is reactant onto a surface of titanium dioxide. The lithium titanate nano particle can be mass-produced by heat-treating in the more mild condition in a short time. Furthermore, the lithium titanate nano particle manufactured from the manufacturing method is usefully used as the lithium secondary battery cathode material. A lithium titanate nano particle is manufactured by manufacturing precursor manufactured by coating the lithium hydroxide onto a surface of the titanium dioxide, and heat-treating the precursor at the low temperature less than 500deg.C for the short time in the alcohol solution by performing the sonochemical reaction under the multiplexer sound wave luminescence condition. The alcohol solution contains a titanium dioxide(TiO2) and a lithium hydroxide(LiOH).
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Sonochemical
automotive electronics
23
© 2010 CambridgeIP Ltd. All rights reserved.
US20090022995
IN-SITU NANOPARTICLE FORMATION IN POLYMER CLEARCOATS
Assignee: University of Kentucky, Institute for Sustainable Manufacturing (?)
Inventor: GRAHAM USCHI URSULA M [US]; KHATRI RAJESH [US]; DAVIS BURT H [US]
Publication Date: 2009-01-22
Abstract: Methods and compositions for forming a transparent
clear coat characterized by a desired property, such as a color effect, resistance to UV light-induced degradation and/or scratch resistance, on a substrate are detailed according to embodiments of the present invention. Particular compositions and methods for producing a transparent clear coat layer include nanoparticles formed in-situ during curing of a transparent clear coat. Curable clear coat compositions are described according to embodiments of the present invention which include one or more substantially dissolved nanoparticle precursors.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Spray Coating
24
automotive aerospace paints, smart
coatings
© 2010 CambridgeIP Ltd. All rights reserved.
WO2009011981
METHOD OF FORMING STABLE FUNCTIONALIZED NANOPARTICLES
Assignee: UNIV TULANE [US]; MITCHELL BRIAN S [US]; FINK MARK J [US]; HEINTZ
ANDREW S [US]
Inventor: MITCHELL BRIAN S [US]; FINK MARK J [US]; HEINTZ ANDREW S [US]
Publication Date: 2009-01-22
Abstract: A novel top-down procedure for synthesis of stable
passivated nanoparticles uses a one-step mechanochemical process to form and passivate the nanoparticles. High-energy ball milling (HEBM) can advantageously be used to mechanically reduce the size of material to nanoparticles. When the reduction of size occurs in a reactive medium, the passivation of the nanoparticles occurs as the nanoparticles are formed. This results in stable passivated silicon nanoparticles. This procedure can be used, for example in the synthesis of stable alkyl- or alkenyl-passivated silicon and germanium nanoparticles. The covalent bonds between the silicon or germanium and the carbon in the reactive medium create very stable nanoparticles.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Ball Milling
25
catalysis fuel cells
© 2010 CambridgeIP Ltd. All rights reserved.
KR20090074360
POROUS NANOCARBON MANUFACTURING METHOD USING BALL MILLING
Assignee: LEE IN SOON [KR]
Inventor: LEE IN SOON [KR]; PARK TAE HEE [KR]
Publication Date: 2009-07-07
Abstract: A method for manufacturing porous nano carbon
through ball milling is provided to control the maximum speed of a motor of a ball mill based on the sizes of containers. A method for manufacturing porous nano carbon through ball milling comprises the following steps of: putting 10g-10kg of natural graphite or processed artificial graphite with the size of 10mum -20cm in a ball mill's container; and settling a ball with the size of 8-150mm and the weight of 400g-450kg in the ball mill's container. The size of the ball depends on the weight of carbon inputted. The container has 98mm of height and 90mm of inner diameter. The processing speeds of the ball mill have rotation speed of 32000rpm and revolution speed of 1200rpm.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Ball Milling
fuel cells
26
© 2010 CambridgeIP Ltd. All rights reserved.
EP1867386
Method for the production of nanoparticles
Assignee: Applied Materials, Inc (?)
Inventor: WENDLING THOMAS
Publication Date: 2007-12-19
Abstract: The present invention relates to methods for the
production of nanoparticles which may be optionally coated. In particular, the present invention relates to methods for the production of nanoparticles characterized in that precursors are subjected to substantially the same amount of activation energy in the activation zone at a predetermined concentration of precursors and at a predetermined time of exposure to the activation energy. Furthermore, the present invention relates to nanoparticles produced by the methods according to the present invention. Finally, the present invention concerns a device for producing nanoparticles according to the method of the present invention. The activation energy is selected from the group of RF plasma, MW plasma, IR plasma, thermal plasma, heat, photon absorption, plasma by electric discharge or radioactive radiation or sonar energy.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Chemical Vapour Synthesis
27
aerospace paints, smart
coatings
fuel cells electronics
Large Scale Manufacturing
© 2010 CambridgeIP Ltd. All rights reserved.
US2010044646
Supercritical fluid process for producing nano graphene platelets
Assignee: Angstron Materials, Inc. (?)
Inventor: ZHAMU ARUNA [US]; JANG BOR Z [US]
Publication Date: 2010-02-25
Abstract: The present invention provides a process for producing
pristine or non-oxidized nano graphene platelets (NGPs) that are highly conductive. The process comprises: (i) subjecting a graphitic material to a supercritical fluid at a first temperature and a first pressure for a first period of time in a pressure vessel and then (ii) rapidly depressurizing the fluid at a fluid release rate sufficient for effecting exfoliation of the graphitic material to obtain the NGP material. Conductive NGPs can be used as a conductive additive in transparent electrodes for solar cells or flat panel displays (e.g., to replace expensive indium-tin oxide), battery and supercapacitor electrodes, and nanocomposite for electromagnetic wave interference (EMI) shielding and static charge dissipation, etc.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Production in Liquid CO2
Medicine –
diagnostics
automotive aerospace Photovoltaics air
purification
electronics
28
© 2010 CambridgeIP Ltd. All rights reserved.
US2010035062
MANUFACTURING METHODS OF MAGNESIUM-VANADIUM COMPOSITE OXIDE NANOPARTICLE AND MAGNESIUM-VANADIUM COMPOSITE OXIDE NANOPARTICLE MANUFACTURED BY THE SAME
Assignee: Schaefer School of Engineering & Science (?)
Inventor: LIM CHUL TACK [KR]; CHOI CHANG HWAN [KR]; CHUN BYOUNG JIN [KR]; YANG JIN HYUCK [KR]
Publication Date: 2010-02-11
Abstract: Provided are manufacturing methods of a magnesium-
vanadium composite oxide nanoparticle that make it possible to manufacture a composite oxide of several tens of nanometers in size containing two kinds of metals, and also to accurately design and manufacture a product material having a desired ratio between the metals, and a magnesium-vanadium composite oxide nanoparticle manufactured by the manufacturing methods. In the manufacturing method, a solution containing a magnesium salt and a vanadium salt is prepared. An organic polymer having nano-sized pores is dipped in the prepared solution, and is then heated until the organic polymer is calcined, thereby manufacturing a magnesium-vanadium composite oxide nanoparticle.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Use of Scaffolds
29
Photovoltaics Fuel Cells electronics
coatngs
© 2010 CambridgeIP Ltd. All rights reserved.
New EU regulation may require cosmetics manufacturers to list any nanoparticles contained in products marketed within the European Union
• Approved on November 2009 by the Council of the European Union• All ingredients present in the product in the form of nanomaterials should be clearly indicated in the list of ingredients
© 2010 CambridgeIP Ltd. All rights reserved.
Toxicology
30
The ruling defines nanomaterial as 'an insoluble or biopersistant and intentionally manufactured material with one or more external dimensions, or an internal structure, on the scale from 1 to 100 nm'.
1,160 L’Oréal patents including ‘nano’
© 2010 CambridgeIP Ltd. All rights reserved.© 2010 CambridgeIP Ltd. All rights reserved.
Nanotoxicology: A Large Network
31
Own 3 patents on Cell Nanotoxicology(See next Slide)
Pioneers in the preventionNow working with the EC
Specialized Magazine
A Network of Universities and Institutes
Database
© 2010 CambridgeIP Ltd. All rights reserved.
WO2007094870
TOXICOLOGY AND CELLULAR EFFECT OF MANUFACTURED NANOMATERIALS
Assignee: UNIV CALIFORNIA
Inventor: CHEN FANQING [US]
Publication Date: 2007-08-23
Abstract: The increasing use of nanotechnology in consumer
products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. We have performed whole genome expression array analysis and high content image analysis-based phenotypic measurements on human skin fibroblast cell populations exposed to multiwall carbon nano-onions (MWCNOs), multiwall carbon nanotubes (MWCNTs), and semiconductor nanocrystals. Here we demonstrate that exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response.; Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described MWCNOs can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Toxicology
Nanotoxicity
32
© 2010 CambridgeIP Ltd. All rights reserved.
Contents
• Project Background and Definitions
• Technology Matrix
• Patent Examples
• Conclusion
33
© 2010 CambridgeIP Ltd. All rights reserved.
Patterns noticed in initial searches:
• Most nanoparticle manufacturing patents primarily target a specific material or class of materials rather than an application
• The application patents typically tend to be for formulations involving several components, and methods for manufacturing them
• Many of the recent patents are from key emerging market locations including China and Russia
• Many of the patents are about the manufacturing method and the nanoparticles: indicative of early stage of development of process
© 2010 CambridgeIP Ltd. All rights reserved.
Volume/Quality Requirements for Nanoparticle Manufacturing
We know some of the volume/quality requirements for nanoparticle manufacturing
The key question will be which are the technologies that become adopted/accepted in each of these fields
As the technology matures, the different industry field requirements will determin industrial R&D
Volume Requirements
Quality
Requir
em
ents
HighLow
Low
High
Cement/ Construction
Cosmetics
Scaffolds for tissue engineering
Drug formulations/delivery
Aerospace
Medical Diagnostics
Catalysis
Photovoltaic
Paints/coatings
Industrial lubricants
Automotive
Fuel Cells
Air purification
Water purification
Experimental applications
© 2010 CambridgeIP Ltd. All rights reserved.
36 © 2010 Cambridge Intellectual Property Ltd. All rights reserved.
…and finally…
Please contact Ilian Iliev for a copy of the results and any other questions you may have:
[email protected]+44 77 863 73965
Thank You !Ilian Iliev
(CEO and Co Founder)
GSM: +44-077-863-73965
Tel: +44-1223-370-098
Corporate Office
Cambridge Intellectual Property LtdSheraton HouseCastle Park, CambridgeCB3 OAX United KingdomUK: +44 (0) 1223 370 098Fax: +44 (0) 1223 370 040
Internet Resources
Website: www.cambridgeip.comBlog: www.cambridgeip.com/blog
Sign-up for our Free Newsletteron our Home Page
Quentin Tannock
(Chairman and Co Founder)
GSM: +44-077-862-10305
Tel: +44-1223-370-098
© 2010 CambridgeIP Ltd. All rights reserved.
WO2007109244
NOVEL NANOPARTICLES FOR DELIVERY OF ACTIVE AGENTS
Assignee: MOREHOUSE SCHOOL OF MEDICINE [US]; LILLARD JAMES W [US]; SINGH RAJESH [US]; SINGH SHAILESH [US]
Inventor: LILLARD JAMES W [US]; SINGH RAJESH [US]; SINGH SHAILESH [US]
Publication Date: 2007-09-27
Abstract: Milled nanoparticles comprising a biolgically active
agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Planetary grinding
37
Cosmetics drug
reformulation /
reconstitution
drug delivery Medicine –
diagnostics
© 2010 CambridgeIP Ltd. All rights reserved.
CN101597035
Method for preparing nano vanadium nitride electrode material
Assignee: UNIV SICHUAN [CN]
Inventor: HENG LIU [CN]; LING LU [CN]
Publication Date: 2009-12-09
Abstract: The invention relates to a method for preparing a nano
vanadium nitride electrode material for a super capacitor. The method comprises the following steps: using analytically pure vanadium pentoxide as an initial raw material, preparing a precursor of nano vanadium nitride by a sol-gel method, filtering sol of V2O5, refrigerating the precursor for 20 to 30 hours at the temperature of between 20 DEG C below zero and 50 DEG C below zero in a refrigerator, then putting the precursor into a refrigeration dryer, and refrigerating and drying the precursor for 20 to 30 hours; and performing nitriding and reducing reaction on the precursor for 1 to 3 hours at the temperature of between 550 and 800 DEG C under the atmosphere of ammonia gas to obtain nano-scale vanadium nitride granules. The method is simple to operate, and can prepare the spherical vanadium nitride granules of about 12 nanometers; and the vanadium nitride granules used as the electrode material for the super capacitor have specific capacity of 398 to 608 F/g.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Sol-Gel
38
electronics
© 2010 CambridgeIP Ltd. All rights reserved.
US20050287308
Method for producing nanoparticles and nanostructured films
Assignee: UNIV TEXAS
Inventor: BECKER MICHAEL F [US]; KETO JOHN W [US]; KOVAR DESIDERIO [US]
Publication Date: 2005-12-29
Abstract: A method for producing composite, shelled, alloy and
compound nanoparticles as well as nanostructured films of composite, shelled, alloy and compound nanoparticles by using laser ablation of microparticles is disclosed.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Laser Ablation
39
aerospace lubricants for
industrial
components
paints, smart
coatings
© 2010 CambridgeIP Ltd. All rights reserved.
CN1915811
Method for preparing Nano carbon white from fly ash based on gas phase sol gel method
Assignee: UNIV JIANGSU [CN]
Inventor: NI LIANG JIANG [CN]
Publication Date: 2007-02-21
Abstract: This invention relates to a sol-gel method for
preparing nanoscale white carbon black from fly ashes, NaF and concentrated H2SO4. The method comprises: (1) dissolving fly ashes in HNO3, and sintering at a high temperature to obtain SiO2; (2) dropping concentrated H2SO4 onto SiO2 and SiF4 to generate SiF4 gas, introducing SiF4 gas into solution of sodium dodecyl sulfate, Sodium dodecyl sulfonate and cetyltrimethyl ammonium bromide, hydrolyzing to obtain sol and then gel, and calcining to obtain nanoscale white carbon black. The obtained nanoscale white carbon black has diameters of about 20nm, and a specific surface area of 58-631 m2/g. Besides, the nanoscale white carbon black is semi-transparent white, and has such advantages as high purity, no obvious aggregation, high dispersibility and high activity. The method has such advantages as mild reaction conditions, easy control of the techniques and simple process.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Gas Phase Solid Gel
40
aerospace paints, smart
coatings
construction
and concrete
© 2010 CambridgeIP Ltd. All rights reserved.
WO2008072239
FORMATION OF NANOMETRIC CORE-SHELL PARTICLES HAVING A METAL OXIDE SHELL
Assignee: SOL GEL TECHNOLOGIES LTD (Israel)
Inventor: TOLEDANO OFER [IL]; SERTCHOOK HANAN [IL]; ABU-REZIQ RAED [IL]; BAR-SIMANTOV HAIM [IL]; SHAPIRO LEORA [IL]
Publication Date: 2008-06-19
Abstract: A process for preparing nanocapsules having a core-
shell structure, comprising: (a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10 = 10-80 nm, d50 = 30-200 nm, and d90 = 70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.
© 2010 CambridgeIP Ltd. All rights reserved.
Example Patent: Sol-Gel
drug delivery/
(re)
Formulation
paints, smart
coatings
41