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Cancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University Orientation Session for the 2012-13 Academic Year
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Page 1: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Cancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University

Orientation Session for the 2012-13 Academic Year

Page 2: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Division or Unit?

We are:

A Division in the Department of Oncology (Division of Cancer Epidemiology)

A Unit in the Department of Epidemiology & Biostatistics

(Cancer Epidemiology Unit)

Our Official Name:

The Cancer Research Society Division of Epidemiology

Page 3: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 4: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Our Mission:

»To conduct epidemiologic research on the etiology and prognosis of cancers of global public health importance with an emphasis on proposing preventive strategies.

»To provide advanced training in cancer epidemiology and prevention to graduate students and health professionals.

»To provide epidemiologic oversight and expertise to clinical collaborators in oncology.

»To provide advice to governmental and non-governmental organizations involved in cancer control policy.

»To advise pharmaceutical and biotechnology companies in developing cost-effective agents and tools for cancer prevention and screening.

Page 5: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Present Students and Fellows

New Students and Fellows in 2012 (fall)

• Hani Al-Marzouki (MSc, 2011-, Otolaryngology) • Joseph Tota (PhD, 2008-) • Sandra Isidean (PhD, 2011-) (CIHR’s Banting and Best Graduate Scholarship) • Fabiano Santos (Postdoctoral Fellow, 2012-) (McGill MICRTP Fellowship) • Ziad El-Khatib (Postdoctoral Fellow, 2011-) (McGill MICRTP Fellowship)

• Karolina Louvanto (Post-doctoral Fellow) (Sigrid Juselius Foundation Fellowship) • Eileen Shaw (MSc)

Visiting Professors on Sabbatical

• Edson D. Moreira Jr. (Fed. Univ. Bahia, FIOCRUZ, 2011-12) • Jacinto C. Silva-Neto (Fed. Univ. Pernambuco, 2012, 2013-14)

Page 6: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Past Students and Fellows (at McGill) Graduate Students, Department of Epidemiology & Biostatistics

• Alexandra de Pokomandy (MSc, 2005-09) (Dean’s Honour List) • Amin Andalib (MSc, 2010-12) • Andrea Schaffer (MSc, 2001-04) • Andrea Spence (PhD, 2001-12) • Anita Koushik (PhD, 1999-04) (CIHR and NCIC scholarships) • Ann Burchell (PhD, 2003-09) (Tomlinson and NCIC scholarships) • Candace Sirjoosingh (MSc, 2008-10) (Max E. Binz Fellowship) • Carmen Victoria (Tory) Atwood (MSc, 2002-06) • Colin Sharpe (MSc, 1993-94) • Cara Flamer (MSc, did not complete, 2001-04) • Harriet Richardson (MSc, 1993-96; PhD, 1997-03) (MRC scholarship) • Hela Makni (MSc, 1998-99) • Javier Pintos (Diploma, 1991-92; MSc, 1993-96; PhD, 1997-02) • J. João Mansure (MSc, co-supervision, 2009-12) • Julie Bruneau (MSc, 1998-03) • Jun Chen (MSc, 1999-02)

Page 7: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Past Students and Fellows (at McGill) (cont’d) Graduate Students, Department of Epidemiology & Biostatistics

• Keira Robinson (MSc, 2002-04) • Lyndsay Richardson (MSc, 2009-11) (Faculty of Medicine Gershman Memorial Fellowship) • Maaike deVries (MSc, 2009-12) (NSERC Graduate Fellowship) • Marie-Claude Rousseau (MSc, 1995-97; PhD, 1998-03) (MRC scholarship) (2x Dean’s

Honour List) • Marie Hélène Mayrand (PhD, 2002-07) (FRSQ and NCIC scholarships) (Principal’s

Dissertation Award) • Myriam Chevarie-Davis (MSc, 2010-12) (RAMQ Clinical Investigator Fellowship) • Nader Sadeghi (MSc, did not complete, 1996-98) • Nicolas Schlecht (PhD, 1999-02) (MRC scholarship) (Dean’s Honour List) • Rhea Ferguson (MSc, 2008-10) (CIHR’s Banting and Best Graduate Scholarship) • Saleh Al-Nasser (MSc, 2010-12, Surgery) • Seungmi Yang (MSc, 1999-02) • Sophie Kulaga (MSc, 1996-97) • Steven Ades (MSc, 2002-05) • Susan Brogly (MSc, 1998-99; PhD, 1999-02) (NHRDP scholarship) (Dean’s Honour List,

MSc) • Suzie Lau (MSc, 2001-08, part-time) • Tam Dang-Tan (PhD, 2002-08) (CIHR scholarship)

Page 8: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 9: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Past Students and Fellows (at McGill)

• Abdissa Negassa (1997-98) • Belinda Nicolau (jointly with Dentistry) (2002-05) • Ghislain Lugoma (2000-01, 2003-04) • Helen Trottier (2004-08) • Paul Allison (jointly with Dentistry) (1998-99) • Salah Mahmud (2002-05) • Tam Dang-Tan (2008-09) • Ann Burchell (2009)

Post-doctoral fellows, Division of Cancer Epidemiology

Page 10: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 11: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

• Eduardo Franco (James McGill Professor and Director) • Agnihotram Ramanakumar (Assistant Professor)

• Laurent Azoulay (Assistant Professor, joint part-time appointment) • Raghu Rajan (Associate Professor, joint part-time appointment) • Celia Greenwood (Associate Professor, joint part-time appointment)

• Candida Pizzolongo (Administrative Coordinator) • Nathalie Slavtcheva (Research Nurse, to July 2011) • Natalia Morykon (Research Nurse) • Amelia Rocamora (Research Nurse, to February 2012) • Beth McCallum (Research Nurse) • Melissa Cartillone (Research Nurse) • Allita Rodrigues (Medical Research Coordinator) • Jennifer Selinger (Epidemiologic Clerk) • Mengzhu Jiang (Epidemiologic Clerk, to August 2012) • Michael Antwi (Epidemiologic Clerk, to July 2012)

Research and academic staff

Page 12: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Portfolio of Studies by the Division of Cancer Epidemiology, McGill University

Areas of Concentration in the past 17 years: • Cervical cancer and HPV-associated

malignancies • Upper aero-digestive tract cancers • Childhood malignancies (Wilms’ tumour) • Prostate cancer • Inflammation and cancer etiology and prognosis • Other Cancers: endometrial, esophageal, lung • Methods • HIV epidemiology

Page 13: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

CIHR team in HPV infection and associated diseases E. Franco (PI), F. Coutlee (co-PI), P. Brassard, Z. Rosberger, M. Roger, J.

Archambault, H. Trottier, M. Brisson

Page 14: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 15: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Glandular cells line

the endocervical canal

Transformation

zone: 2 cell

types meet

Squamous cells

line the ectocervix

Two types of cervical cancer

Courtesy of Dr. Ray Apple

• Squamous cell carcinomas: 75%-80% of all cervical cancers.

• Adenocarcinomas: 20%-25% and incidence continues to increase.

Page 16: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

How we collect our specimens:

Page 17: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Natural history of HPV infection and cervical carcinogenesis

4-24 months 2-20 years Adapted from: Wright and Schiffman, NEJM 2003; Franco and Harper, Vaccine 2005

Cofactors: Host-related (polymorphisms in HLA and other genes), behavioural (smoking), hormonal/reproductive (OC use, parity), STI-related (HSV, Chlamydia),

nutritional, immunosuppression (HIV, transplantation), HPV-related (variants)

Page 18: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 19: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

HPV and Cervical Cancer Studies

Etiology, Natural History, and Transmission:

• Ludwig-McGill cohort (NIH, CIHR, NCIC) A. Negassa, H. Makni, M.C. Rousseau, N. Schlecht, S. Yang, S. Kulaga, S. Mahmud, S. Lau, H. Trottier, A. Ramanakumar, R. Ferguson, M. Chevarie-Davis

• McGill-Concordia cohort (CIHR) H. Richardson, K. Robinson, S. Mahmud, H. Trottier, A. Ramanakumar, R. Ferguson, M. Smith

• HITCH cohort (CIHR, Merck, NIH) A. Burchell

• BCCR (CIHR) and other case-control and lab studies (CIHR, NCIC) A. Koushik, A. Schaffer, S. Ades, H. Trottier, R. Ferguson

• Inuit cohort (FRSQ, CIHR) (led by P. Brassard)

Page 20: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

HPV and Cervical Cancer Studies Screening: • Newfoundland primary screening Study (NHRF) co-led by S.

Ratnam

• Kinshasa (Congo) Screening Study (PATH) G. Lugoma, S. Mahmud, A. Ramanakumar

• CCCaST Trial (CIHR, Merck) M-H Mayrand

• PICCS study: Psychosocial impact of HPV screening results (CIHR) (led by Z. Rosberger)

• BC RCT (HPV-Focal) (CIHR) led by A. Coldman, G. Ogilvie

• PEACHS: Pap Efficacy And Cervical HPV Status Study Consortium L. Richardson, A. Ramanakumar

Page 21: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

HPV and Cervical Cancer Studies HPV vaccination: • Analysis of GSK’s phase 2b trial data and natural history

studies (GSK) H. Trottier, A. Ramanakumar, S. Mahmud

• RCT of Transmission Reduction and Prevention Using HPV Vaccine (TRAP-HPV study) (Merck) Z. El-Khatib, A. Ramanakumar, A. Burchell, T. Dang-Tan

• Epidemiologic Approach to Evaluate the Potential for HPV Type Replacement Post-Vaccination (GOC) J. Tota

Other preventive strategies: • RCT of carrageenan-containing vaginal gel to prevent

HPV infection (CATCH trial) (CIHR) J. Tota, A. Burchell, A. Ramanakumar

Page 22: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

HPV and Cervical Cancer Studies Health Services and Cost-Effectiveness: • ICCAS: Audit study of invasive cervical cancers in

Montreal (CIHR) A. Spence

• Racial and Socioeconomic Disparities in Cervical Cancer Survival in the United States C. Sirjoosingh

• Cost-effectiveness analysis of new screening technologies specific to Canada (NCIC) (led by R. Rajan) C.V. Atwood

• New approaches in modeling (NIH) (led by S. Goldie) S. Mahmud

• Role of herd immunity in modelling HPV transmission (led by M. Brisson)

(Consultation to individual scientists, governments, WHO, NGOs, and industry)

Page 23: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 24: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 25: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 26: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Period and statistic

Full papers

Other papers

Total papers Chapters Books Journal

Supplements Technical Reps, etc

1995-99 34 14 48 14 1 0 8 2000-04 64 16 80 13 1 1 4 2005-09 72 30 102 15 0 8 7 2010-present 58 3 61 5 0 1 5 Total 228 63 291 47 2 10 24 Annual Avg 12.7 3.5 16.2 2.6 0.1 0.6 1.3 Avg since 2005 18.6 4.7 23.3 2.9 0.0 1.3 1.7

Scientific Productivity (Publications)

Note: Stats for 2012 until mid-September 0

5

10

15

20

25

30

1995 2000 2005 2010

Chapters

Tech Reps, etc

Articles

Page 27: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

Research Productivity Publications in top-tier journals (impact factors > 10)

Journal Title Period

1995-99 2000-04 2005- Total

Journal of the National Cancer Institute 2 5 2 9

CA Cancer Journal for Clinicians 1 1

New England Journal of Medicine 1 1

British Medical Journal 2 2

Public Library of Science-Medicine 2 2

The Lancet (includes Lancet Oncology) 4 5 9

Page 28: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 29: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 30: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .
Page 31: Cancer Epidemiology Unit, Department of Epidemiology ... · PDF fileCancer Epidemiology Unit, Department of Epidemiology, Biostatistics, & Occupational health, McGill University .

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