REBRANDING HEMP FOR THE NUTRACEUTICAL MARKET

CANTERPENE AS A HEALTHSPAN EXTENSION SUPPLEMENT

Terry Grossman,M.D. Medical Director

Morris Johnson, CTO, Founder

Silas Kanning,

Co-founders of:

Lifespan Pharma Inc.

Morris/Greg/Leah/Erin Rod Fisher Steve Burnside

OUR SHAREHOLDERS HAIL FROM AGRICULTURE, MEDICINE AND PHARMACY

REBRANDING HEMP AS CANTERPENE MAKES SENSE FOR THE NATURAL HEALTH PRODUCT / DSHEA FOOD SUPPLEMENT MARKETS

35 YEARS AGO RAPESEED EXPERIENCED THE SAME PROBLEMS AFFECTING HEMP TODAYGrowers needed to rebrand something that was associated with a machine oil regarded as too toxic for humans to consume

Low Erucic Acid Rapeseed (LEAR)?

“CANadian source of OLeic Acid” became CANOLA

It was promoted as a safe, nutritious, multi-purpose human and animal food ingredient

Hemp is undergoing a similar identity crisisHemp is undergoing a similar identity crisis iin the minds of many todayn the minds of many today

When you Google “hemp” you get recreational you Google “hemp” you get recreational and medicinal marijuana “Hits” because “pot and medicinal marijuana “Hits” because “pot people” use “hemp” indiscriminately when people” use “hemp” indiscriminately when speaking about “marijuana”speaking about “marijuana”

SOME MARIJUANA PRODUCTS associate cannabis with health benefits

and socially “sexy” memes such as

organic or chemical free

SOME CANADIAN HEMP PRODUCTS SOME CANADIAN HEMP PRODUCTS ASSOCIATE HEMP WITH MARIJUANAASSOCIATE HEMP WITH MARIJUANA

ASSOCIATING HEMP WITH MARIJUANA IS CREATING CONSUMER CONFUSION

• Solutions:• Litigate?

• Regulate?

• Educate?

• Ignore?

AFTER MUCH CONSIDERATION WE AFTER MUCH CONSIDERATION WE CONCLUDED NONE OF THE ABOVE CONCLUDED NONE OF THE ABOVE SOLUTIONS ARE PRACTICAL OR COST SOLUTIONS ARE PRACTICAL OR COST EFFECTIVEEFFECTIVE

Some hemp manufacturers Some hemp manufacturers want to capitalize on the science want to capitalize on the science which has popularized the which has popularized the term “Medical Marijuana” term “Medical Marijuana”

The best solution: The best solution: REBRANDING REBRANDING

REBRAND CANADIAN HEMP AS REBRAND CANADIAN HEMP AS CANTERPENECANTERPENE

We link Canadian Hemp with the messages:

“Extend Health-span and Lifespan naturally with cannabis chemistry”

Canterpene expands functional chemistry beyond arginine and omega3’s to include cannabinoids and terpenes

CANADIAN HEMP IS LEGAL AND EXEMPT FROM SCHEDULE 1 REGULATION AS IT IS NEITHER HERBAL

MARIJUANA NOR SYNTHETIC THC

WE HAVE PATENTED CANTERPENE WE HAVE PATENTED CANTERPENE AS A PROPRIETARY FORMULATION AS A PROPRIETARY FORMULATION OF MILLED HEMPSEEDOF MILLED HEMPSEED

DOES CANTERPENE HAVE A MARKET?

-Healthspan and lifespan extension are new unmet needs

-Personalized /Individualized Medicine is an emerging Industry

-”Bockbuster” Pharma is migrating towards “Niche” Pharma

-Canterpene Cannabis without THC contains phyto-chemistry which scientific research indicates would make it a

useful food supplement for the purpose of

personalized management of AGING

AGING CAN BE BRUTAL

This

Becomes

This-->

All

Too

Soon

IT IS POSSIBLE TO GROW OLDER WITHOUT AGING AT ANY AGE

60 yrs old 80 yrs old

ANTIAGING IS AN ENORMOUS MARKET

76 million baby boomers in the US

6 million “boomies” in Canada

Boomers now 48 – 64 and have begun to experience the “aging process” firsthand

This generation has redefined each stage of their lives and is currently redefining aging

BOOMERS REGARD AGING IS A DISEASE …

… THAT AFFECTS EVERYONE

… AND IS 100 PERCENT FATAL

THIS IS THE NEW VIEW OF AGING

Bob Delmonteque, age 84

THE TWO PILLARS OF HEALTH

Prevention EarlyDetection

CANTERPENE CAN HELP AS A PREVENTIVE ANTIAGING STRATEGY

Science has linked numerous Cannabis Science has linked numerous Cannabis compounds found in Canterpene with compounds found in Canterpene with beneficial effects on the diseases resulting beneficial effects on the diseases resulting from “normal” agingfrom “normal” aging

Canterpene captures much that other Canterpene captures much that other conventional hemp supplements have conventional hemp supplements have ignoredignored

A toolbox for slowing aging & regenerating damage is emerging:

e.g. Plastoquinine..targeting oxidative stressPlastoquinine..targeting oxidative stress

pp

  

“TA65” targeting telomerase gene activation

STEMCELL100.COM , A NUTRACEUTICAL DEVELOPED BY GENESCIENT

CLAIMS TO PROMOTE THE STABILITY AND VITALITY OF ADULT STEM CELLS SO THEY HAVE THE CAPACITY TO DIVIDE WHEN THE BODY SIGNALS A NEED FOR MORE STEM CELLS.

CONTAINS:-THEANINE - 5-N-ETHYL-GLUTAMINE FROM CAMELLIA SINESIS -OLIGO-PROANTHOCYANIDINS FROM THE PINE BARK OF THE PINUS TREE -PTEROSTILBENE, WHICH IS A LONG HALF-LIFE RESVERATROL ANALOG FROM PTEROCARPUS MARSUPIUM- ASTRAGALOSIDES EXTRACTED FROM ASTRAGALUS MEMBRANACEUS

Food supplements claiming to support stem cell healthspan

CAN CANTERPENE WORK AS A

HEALTHSPAN AND

LIFESPAN EXTENSION TOOL?

THE MEDICAL BENEFITS

CANTERPENE

NUMEROUS BIOCHEMICAL BENEFITS OF CANNABINOIDS IN HEMP

Canterpene is a source of supplemental terpenes

Many terpenes exhibit health benefits

Chemo-profiles of some cannabis varieties

AGING IS NOT

LEGALLYCLASSIFIED

AS A DISEASEBut….

SOME DISEASES/CONDITIONS ASSOCIATED WITH AGING ARE

Oxidative stress

Arthritis

Central nervous system degeneration

Parkinson’s

Alzheimer’s

Cannabidiol (CBD) the major cannabinoid in hemp has been shown to be of benefit in each of these and many other conditions

OXIDATIVE STRESSCBD treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina. Consistent with these effects, CBD treatment also significantly inhibited p38 MAP kinase in the diabetic retina. These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals.

EL Remessey AB et al. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol. 2006 Jan;168(1):235-44.

ARTHRITIS

These potentially anti-inflammatory properties of CBD, together with the lack of psychotropic effect and low toxicity prompted us to test the potential of CBD as a therapeutic agent in collagen-induced arthritis (CIA).

RESULTS: “We report that CBD has a beneficial therapeutic action on established CIA.”

Malfait AM et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9561-6.

PARKINSON’S DISEASEEvidence suggests that cannabinoids may prove useful in Parkinson's disease by inhibiting the excitotoxic neurotransmitter glutamate and counteracting oxidative damage to dopaminergic neurons

Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs. 2003;17(3):179-202.

It seems that cannabinoids could delay or even stop progressive degeneration of brain dopaminergic systems, a process for which there is presently no prevention. In combination with currently used drugs, cannabinoids might represent, qualitatively, a new approach to the treatment of PD, making it more effective.

Sevcik J, Masek K Potential role of cannabinoids in Parkinson's disease DRUG AGING 16 (6): 391-395 JUN 2000

ALZHEIMER’S DISEASEMemory loss, the first and primary symptom of Alzheimer’s disease, can be slowed down significantly in mice by cannabidiol.

In a study at the Cajal Institute in Madrid, Spain, mice were injected with a molecule found in the brain of humans suffering from Alzheimer’s disease, and then treated for one week with cannabidiol.

Those mice injected with cannabidiol successfully performed the task within 25-30 seconds, compared to control mice, who took almost double the amount of time, 45-50 seconds, to complete the task.

See also: Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004

DSHEA COMPLIANT TARGETS -Optimize the broad spectrum of Canterpene functionalities

-Add phytochemistry to enhance each functionality

-Utilize ingredients with both ethnobotanical and modern pharmacological support in peer-reviewed , published literature

-Proprietary varietal selection and agronomic production practices allow the use of the same Canterpene ingredient for several distinctly different formulations

-Formulas can be combined into a systemic therapeutic program to attack a systemic problem, AGING

“Medicine without a market benefits no one”

DSHEA COMPLIANT TARGET 1 - Support for Cancer patients Synergistic with Conventional Meds.

- Natural sourced ingredients:

1- 200mg Orange oil a source of limonene and perillic acid

2- 800mg Canterpene Hemp Oil

DSHEA COMPLIANT TARGET 1

DSHEA COMPLIANT TARGET 2- Replacement of chemistry deficits caused by aging

- Food supplement ingredients:

-10 mg DHEA (dehydroepiandrosterone) to replace sex hormones required for sexual function, and lean muscular metabolism lost because of aging.

- 200mg Acetyl L Carnitine to replace mental energy and endurance lost because of aging.

-750mg Canterpene Hemp Oil to reduce subclinical inflammation associated with aging.

-“SEXTROPY 4 U” BRANDING targets sexual health

- Complementary to “Viagra” type of products

DSHEA COMPLIANT TARGET 2

DSHEA COMPLIANT TARGET 2

DSHEA COMPLIANT TARGET 3Canterpene “hydrogen water” beverage

-Hemp tea saturated with hydrogen gas

-hydrogen water has been used therapeutically by several spas where the water has a natural hydrogen content

-Malcolm dole detailed the anticancer properties of hydrogen in 1975

-hydrogen gas mixtures are used by deep divers

-numerous papers detail the universal antioxidant properties of water with a hydrogen content

-synergistic with the cannabinoid/terpene chemistry of hemp tea

DSHEA COMPLIANT TARGET 3

DSHEA COMPLIANT TARGET 3

DSHEA COMPLIANT TARGET 3

DSHEA COMPLIANT TARGET 4

Aging Metabolome/epigenome management

Caragana -600 mg

Soy Isoflavones -50 mg

Canterpene -200 mg

DSHEA COMPLIANT TARGET 4

DSHEA COMPLIANT TARGET 4

DSHEA COMPLIANT TARGET 4

DSHEA COMPLIANT TARGET 5TELOMERASE MODIFIER ASTROGALOSIDE IV

+ CANTERPENE

In 2009, Nobel in Medicine and Physiology was awarded to three scientistsfor their research on telomeres and telomerase. Researchers find the shorter your telomeres (the caps at the ends of your chromosomes that keep the strands of your DNA from fraying), the faster you age.So here comes an anti-aging opportunity: increase telomere length.Researchers from UCLA found the extracts from Astragalus can boost production of telomerase, an enzyme that allows for the replacement of short bits of DNA, known as telomeres, that play a key role in cell replication and human aging.By now, Cycloastragenol and Astragaloside IV are the only natural nutraceutical substances verified by a study of a lab of UCLA to activate telomerase in human cells.Cycloastragenol and Astragaloside IV are extracts from a Chinese herbal Astragalus which have been used in China for over 2000 years.

DSHEA COMPLIANT TARGET 5TELOMERASE MODIFIER ASTROGALOSIDE IV +

CANTERPENE

http://www.ncbi.nlm.nih.gov/pubmed/21928670

http://www.longwoodherbal.org/astragalus/astragalus.PDF

http://www.umm.edu/altmed/articles/astragalus-000878.htm

http://www.astragalusextract.net/astragaloside.html

http://www.cmjournal.org/content/4/1/6/

http://www.ncbi.nlm.nih.gov/pubmed/16900242

http://www.naturalnews.com/027312_astragalus_research_aging.html

FUTURE RESEARCH TARGETS

6-Metabolic syndrome-diabetic process modulation: chelated vanadium flavonoid + fenugreek + Canterpene

7-CoQ10+plastoquinone +Canterpene

8-Epigenomic primer formula … Folic acid + B12

+ Biotin+Canterpene

9-Arthritis/joint support formula- vitamin D + Canterpene + hops +MSM

10-Cardio support: 400 mg Acetyl-l-Carnitine, 500 mg Canterpene +100mg time released niacin

11-Microbiome Management: to enhance your macrocellular microflora to produce beneficial bioactives

CANTERPENE AS AN ANTIAGING STRATEGY

GOOD SCIENCE WITHOUT A METHOD TO GOOD SCIENCE WITHOUT A METHOD TO COMMERCIALIZE IT WILL NOT BENEFIT COMMERCIALIZE IT WILL NOT BENEFIT ANYONEANYONE

MSRP ~ 40.00/ BOTTLE OF 100 750 MG CAPSULES1-INGREDIENTS – COMPOSITE VALUE OF INGREDIENTS

11.00/BOTTLE = (410.00/GALLON OR 50.00/POUND) -60/GALLON -TO COST OF GROWING CROP

-160/GALLON -TO BUILD AND OPERATE AND EXPAND FACILITIES AND EQUIPMENT FLEET TO CONVERT CROP IN THE FIELD TO OIL/EXTRACT/DERIVATIVES

-90/GALLON -TO PHYTOCHEMICAL R&D/CLINICAL TRIALS -100/GALLON -TO OVERHEAD/TAXES/RETURN TO INVESTORS

2-ENCAPSULATION/PKGING./BOTTELING /LABELING -9.00/BTL3-MARKETING -15.00/BOTTLE

4-DISTRIBUTION/SHIPPING -5.00/BOTTLE AS WE SCALE UP ,

WE WILL FIND MARKETING AND DISTRIBUTION EFFICIENCIES TO PROVIDE INVESTORS WITH A PROPER RETURN ON INVESTMENT

….DETAILS IN OUR BUSINESS PLAN

THE BOTTOM LINE

AFFORABLE BUT NOT CHEAP

AGING , A SYSTEMIC DEGENERATIVE SYNDROME WITH MULTIPLE THERAPEUTIC TARGETS HTTP://WWW.YOUTUBE.COM/WATCH?V=GHVXW2EE3-A

CANTERPENE- A “MEDICAL EMANCIPATION” TOOL

NUTRACEUTICALS THAT EMPOWER INDIVIDUALS

TO PERSONALLY MANAGE THEIR HEALTHSPAN

The name of the game is to “beat this clock”

Lifespan Pharma IncSW34-01-16-W2nd meridian

Box 10 Beaubier, Sk., CANADALifespan.pharma.inc@gmail.com

701-240-9411

Original CANTERPENE concept Presented at :Canadian Hemp Trade Alliance Nov 15-17, 2010

Annual Conference Winnipeg , Manitoba , Canada