8
CCS SERIES | CONTAINED COMPACTION SYSTEM DRY GRANULATION Leading Particle Processing Technologies The Fitzpatrick Company
CCS SERIES | CONTAINED COMPACTION SYSTEM DRY GRANULATION
Leading Particle Processing Technologies The Fitzpatrick Company
The Fitzpatrick Chilsonator™ is the ideal roller compaction system for dry granulation of pharmaceutical powders.
" Improve Compact Uniformity & Density Minimize the degree of ungranulated material to improve downstream powder flow characteristics with a unique pre-compression feed system and precision real-time roll gap control
" Enhance Operator Safety & Product Containment Best-in-class containment features, including WIP (wash-in-place) capabilities and in-wall designs, helps achieve full containment with minimal investment
" Minimize Maintenance & Production Downtime Fewer parts with easy access for teardown and cleaning, leads to faster changeovers and a simplified parts inventory
" Accelerate Scale-Up & Reduce Development Costs Consistent process stability is maintained across all models to ensure reliable production scale-up with direct roll force measurement and advanced control loop integration
The CCS Roll Compaction Series from Fitzpatrick
CCS SERIES Contained Compaction System
2
| Leading Particle Processing Technologies
Innovative Compaction System " Improves compact uniformity and density
Real-time roll gap feedback control and precision parallel floating rolls ensure a more uniform compact for improved downstream particle flow
" Enhances continuous process stability and scalability Direct roll force measurement with integrated load cell and PID control loop allows for a more accurate and repeatable compact density
Improve Compact Uniformity & Density
3
Independent, Two-Screw Feed Design" Eliminates the need for vacuum dearation
Independent pre-compression screw removes air from most powders prior to the compaction process
" Reduces ungranulated bypass Separate speed control of the pre-compression screw leads to more uniform density and minimizes the degree of ungranulated material passing through the compaction zone without the need for higher roll forces
Bar rotor for slow-speed “shearing” of compact
Knife rotor for “in air” impact of harder compacts
Optimized Granulation Process" Controls particle size distribution
and minimizes fines A greater selection of rotor/screen designs allows for an optimized milling process, leading to tighter PSD ranges
" Handles a wider range of powders The selection of milling options also allows for the handling and optimization of a wide range of applications, including even the hardest compacts
Hydraulic Force
Fixed Roll
Floating
Roll
CCS SERIES Contained Compaction System
FLOOR MOUNTED
CCS 720
The CCS Series is designed to fully contain all product in the processing and receiving sections of the machine. This tightly sealed design allows for the optional Product Containment System (PCS) to be added at the discharge. The PCS draws a slight vacuum in the process environment to provide maximum containment.
4
Product Containment System (PCS)" Achieves full containment with
minimum initial investment
" Minimizes product exposure to operator and environment
" Prevents product contamination and product loss
" Combines with an N2 inerting system to reduce oxygen exposure and explosion risks
Enhance Operator Safety & Product Containment
| Leading Particle Processing Technologies
Optional WIP System (Wash-in-Place)
SPRAY
SPRAY
SPRAY & DISCHARGE
5
IN-WALL CCS 1025
CCS SERIES Contained Compaction System
6
" Fewer parts to remove during production cycles, allowing for:
• Faster Changeover
• Faster Cleaning
• Less Downtime
• Less Inventory For Maintenance Parts
"Easy roll shell removal
" Hydraulic system spreads rolls for cleaning
" Double lip seal ensures technical area remains sealed while primary seal is removed for cleaning
" Components conveniently disassemble from the machine or can be removed as a unit for remote disassembly
" Fully automated controls
• Automatic operation of all components from the operator interface
• Fully instrumented with convenient display
• Batch reporting, historical trending and event logging
• 21 CFR part 11 capable (optional)
• Multiple levels of password security
Minimize Maintenance & Production Downtime
| Leading Particle Processing Technologies
7
With our industry-leading compaction technology and application expertise, Fitzpatrick is the ideal partner at every stage, from preliminary analysis to full production.
" Our lab service assists in determining if your product is a candidate for roll compaction
" Preliminary analysis covers several variables, including moisture tests and pressure vs. density curves
" We offer CCS 220 rental units or in-house lab services to help optimize the compaction process parameters for your powders
" The CCS 220 is ideal for pilot validation and easily scales to larger production units
" All CCS units offer the same diameter rolls, allowing for a more reliable scale-up to a production model, either a CCS 720 or CCS 1025
" Fitzpatrick offers extensive validation and qualification services
" Worldwide support ensures your process will keep running to specification
7
CCS 220 up to 25 kg/hr
CCS 720 up to 250 kg/hr
CCS 1025 up to 400 kg/hr
CCS 220
CCS 720
Accelerate Scale-Up & Reduce Development Costs
MATERIAL PROCESSING
CCSGEN14
Global Presence
World Headquarters IDEX MPT Centers of Excellence
Representation In Over 80 Countries Worldwide
832 Industrial Drive Elmhurst, IL 60126TEL: 630.530.3333 | FAX: 630.530.0832 | EMAIL: �[email protected] | www.�tzmill.com
Hammer MillingRoller Compaction
Conical MillingHigh Shear Mixing
High Pressure HomogenizationCell Disruption
Lean Powder HandlingBatching, Mixing and Packing
Material Processing Technologies
