Cell Injury

Slide 11:Vacuolar Degeneration Kidney

• Renal tubules– Note tiny small vacuoles– Displaced nucleus to the side

• Glomerulus

Slide 30Intestine Caseation Necrosis

Casseation Necrosis - Tuberculosis - • Irreversible injury• Grossly = like cheese – soft, whitish, crumbly -

casseous cassation necrosis• Surrounded by epitheloid cells, giant cells,

necrotic area.• On X-ray report: Fibrocasseous density• Fibrotic center • After treatment: fibrocalcitic area/fibrotic area

Slide 96:Enzymatic Fat Necrosis (Pancreas)Acute hemorrhagic pancreatitis necrosis• Exocrine function -- CHO, Fats, Lipid enzymes• Enzymes leak out of pancreas – lipase digests • Peripancreatic tissue gets digested produced fatty

acids, and stays in the tissue.• Sapponified fat - see shadowy outlines of the fat cells,

containing this. Whitish, opaque, crumbly.• Severe abdominal pain. • Note the following:

– Normal pancreatic tissue– Necrosis of peripancreatic fats by enzymes released from

pancreas

Slide: (no number)Lung Abscess

Abscess - plenty of neutrophils/enzymes• Irreversible• Heterolysis• Liquifies tissue• Pus formation• Note

– Lung abscess – digestion of lung tissue producing a cavity filled with neutrophils and necrotic material

– Alveoli with PMNs and edema