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Cellular elements 2 categories 1. Nerve cells/neurons- concerned with information processing and...

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Page 1: Cellular elements  2 categories 1. Nerve cells/neurons- concerned with information processing and signalling 2. Glial cells- supporting role  100.
Page 2: Cellular elements  2 categories 1. Nerve cells/neurons- concerned with information processing and signalling 2. Glial cells- supporting role  100.
Page 3: Cellular elements  2 categories 1. Nerve cells/neurons- concerned with information processing and signalling 2. Glial cells- supporting role  100.
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Cellular elements

2 categories

1. Nerve cells/neurons- concerned with information processing and signalling

2. Glial cells- supporting role 100 billion neurons; maybe more glial

cells

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If we took 1 second to count one neuron, counting 100 billion neurons would take more than 3000 years

All neurons are variations on the same theme

Convey information by combined electrical and chemical signaling mechanisms

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Electrical signals- rapid transmission of information from one part of neuron to another

Chemical messengers carry information between neurons

Anatomically specialized areas for collecting, integrating, conducting and transmitting information

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Components of neuron

Cell body= soma/perikaryon [karyon=nucleus]

Supports metabolic and synthetic needs of the rest of the neuron

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Processes of neurons

Dendrites –series of branching tapering processes

Receive information from other neurons via synaptic contacts/synapses

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Axon

One long cylindrical process Conducts information away from cell

body Gives rise to a series of terminal

branches, forming synapses on other neurons

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Neurons are anatomically and functionally polarized, with electrical signals travelling in only one direction under ordinary physiologic circumstances

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Anatomical classification

Depends on number of processes Multipolar- vast majority-multiple

dendrites Bipolar- 2 dendrites Pseudounipolar -

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Unipolar neurons are actually pseudounipolar

They start out as bipolar, but during development, cell body expands asymmetrically, leaving behind a stalk from which both processes emerge

Located in dorsal root and cranial nerve ganglia

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Formation of a pseudounipolar neuron

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Motor neurons and interneurons are multipolar

Bipolar neurons are located in retina and CN VIII ganglia

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Functional classification

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Sensory neurons

Directly sensitive to various stimuli [e.g. touch or temperature] or receive direct connections from non-neuronal receptor cells

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Sensory neurons

Their processes are included in somatic and visceral afferents

Somatic afferents convey pain, temperature, touch, pressure, proprioception

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Visceral afferents convey pain and other sensations from mucous membrane, glands and blood vessels

Most sensory and motor neurons live partly in CNS and partly in PNS

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The words sensory and motor are often used in a broader sense to refer to cells and axons carrying information related to sensory stimuli and the responses generated

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Motor neurons

Convey impulses from CNS/ganglia to effector cells

Their processes are included in efferent nerve fibres

Somatic efferents → skeletal muscles Visceral efferents → smooth muscle,

heart, glands

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Interneurons

≥ 99% of all neurons Form a communicating and integrating

network between sensory and motor neurons

Local interneurons have all there processes confined to a single area od CNS

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Probably not more than 20 million sensory fibres in all of spinal cord and cranial nerves combined

No more than few million motor neurons

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Projection neurons

Have long axons connecting different areas, such as a neuron in cerebral cortex whose axon reaches spinal cord

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Strictly speaking, human nervous system is almost entirely composed of interneurons and projection neurons

More than 99% are interneurons or projection neurons

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GRAY MATTER AND WHITE MATTER

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CNS is easily divisible into gray matter and white matter

Gray matter- preponderance of cell bodies and dendrites. In life it is pinkish gray due to abundant blood supply

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White matter

preponderance of axons; many of whom have myelin sheath

Myelin sheath is mostly lipid- hence the white appearance

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Nuclei

Specific areas of gray matter in CNS whose neurons are functionally related- similar areas in PNS are called ganglia

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Cortex

An area where gray matter forms a layered surface covering some part of CNS

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Subdivisions of white matter[collections of axons] Variety of names in CNS- fasciculus,

funiculus, lemniscus, peduncle- most commonly tracts

Collections of axons in PNS are called nerves

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Fasciculus = ‘little bundle’ Funiculus = ‘string’ Lemniscus = ‘ribbon’- tracts flattened out

in cross section Peduncle= ‘little foot’- site where tracts

funnel down into a compact bundle

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Features of a neuron

Synthesizes

1. neuronal enzymes,

2. structural proteins,

3. membrane components,

4. organelles and

5. some of its chemical messengers [neurotrnsmitters]

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Nucleus; large, pale staining with dispersed chromatin

Abundant RER, free ribosomes, stacks of Golgi apparatus

Many mitochondris

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Nissl bodies/Nissl substance- ribosomes, stained intensely with basic dyes, appear as clumps- prominent in large neurons

Many mitochondria

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Cytoskeleton composed of microtubules, neurofilaments [aggregates of these are called neurofibrils] and microfilaments

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Dendrites

Tapered extensions of neuronal body Collectively provide a great increase in

surface area available for synaptic inputs

In spinal cord, dendritic surface area may be 30 or more times that of cell body

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Dendrites of many neurons are studded with small protuberances called dendritic spines

These are preferred sites of some synaptic contacts

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Dendrites and dendritic spines

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Axons

Different from dendrites Cylindrical process- arises abruptly from

an axon hillock on one side of neuronal body

Initial segment has bundles of microtubules, neurofilaments and mitochondria- no Nissl substance

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It is most electrically excitable part of a neuron

Beyond initial segment, many axons are encased in spiral wrapping of a membrane called myelin sheath- greatly increases speed of propagation of electrical impulses

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Transport of macromolecules and organelles synthesized by cell body occurs away from soma[anterograde] and towards it [retrograde]

It can be slow or fast Microtubules act as ‘railroad tracks’ for

fast transport

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Many peripheral nerves are myelinated- resemble a string of sausages

Each link of sausage corresponds to a length of axon wrapped in myelin with adjacent links separated by a gap in myelin

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At this site axon is separated from extracellular space only by fingerlike processes from Schwann cells

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Myelin sheath between 2 nodes is called internode- formed by s single Schwann cell

Most of smaller axons in peripheral nerves are unmyelinated- slow conductors of electrical signals

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Glial cells

Glia =Gr. Glue Cells are so named because they fill up

most of the spaces between neurons- appear to hold them in place

Some do provide structural support Play a wide variety of additional roles

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Neuroglial cells, collectively known as the neuroglia or simply as glia, have important ancillary functions.

The neuroglial cells of the normal CNS are astrocytes, oligodendrocytes, ependymal cells (derived from neural tube ectoderm), and microglia (derived from mesoderm)

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Astrocytes occur throughout the brain and spinal cord

Oligodendrocytes produce myelin and are also found next to the cell bodies of some neurons.

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Microglial cells become phagocytes when local injury or inflammation is present.

The neuroglial cells of the peripheral nervous system are Schwann cells in nerves and satellite cells in ganglia.

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Synapse

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Neurons, neuropil, and the common glial cells of the CNS

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Neurons, neuropil, and the common glial cells of the CNS

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Supporting cells

Glia/neuroglia in CNS Schwann cells and supporting cells in

PNS Schwann cells surround neurites,

isolating them from adjacent cells and extracellular matrix

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In PNS ganglia, supporting cells are Satellite cells- surround nerve cell bodies [nucleus containing part]- analogous to Schwann cells

In development, glial cells serve as scaffolding that directs neuronal migration to appropriate sites

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Functions

Physical support for neurites Electrical insulation for nerve cell bodies

and processes Metabolic exchange pathway between

vascular system and neuronsS

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Oligodendrocytes

Processes extend around several axons in CNS

Predominant glial cell in white matter

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Astrocytes

Form a network of cells within CNS Communicate with neurons- modulate

and support their activities Fibrous astrocytes- few, long processes-

found in white matter Protoplasmic astrocytes- many short

branched processes- found in gray matter

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Important role in proper formation of CNS in fetal and embryonic development

Control ionic environment of neurons Form scar tissue in CNS damage

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Perivascular feet contribute to blood- brain barrier Regulate vasodilatation Regulate transfer of oxygen, ions and

other substances from blood to neurons

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Ependymal cells

Low cuboidal/columnar Line ventricles of brain and central canal

of spinal cord In some places they are ciliated to

facilitate movement of CSF- in others they have long microvilli

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Microglia

5% of all glial cells Part of MPS- monocyte precursors Proliferate and become actively

phagocytic in regions of injury and disease

Remove debris of apoptotic cells during CNS development

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Synapse

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Types of synapses

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Nerve injury/regeneration Nerve cells, unlike neuroglial cells,

cannot proliferate but can regenerate their axons, located in the PNS

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