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CST SIGNALING PATHWAY DIAGRAMS FOR Printed in the USA on recycled paper (25% post-consumer waste fiber) using vegetable inks and processed chlorine free. © 2015 Cell Signaling Technology, Inc. Cell Signaling Technology ® and CST ™ are trademarks of Cell Signaling Technology, Inc. Cellular Metabolism www.cellsignal.com/cellularpws 14PSTREFMCELM0259ENG_00 Please see our website for all pathway diagram backgrounds. Direct Stimulatory Modification Direct Inhibitory Modification Multistep Stimulatory Modification Multistep Inhibitory Modification Tentative Stimulatory Modification Tentative Inhibitory Modification Separation of Subunits or Cleavage Products Joining of Subunits Translocation Transcriptional Stimulatory Modification Transcriptional Inhibitory Modification Kinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-protein Acetylase Deacetylase Ribosomal subunit Other RTKs α-Adrenergic Receptor AMPKα β γ PFKFB3 LKB1 MO25α STRAD Adiponectin Receptor Leptin PKA Ras Rheb PLCβ Gα q SirT1 GS TBC1D1 ACC CPT1 Malonyl CoA CaMKK HMG-CoA Reductase FIP200 TSC2 TSC1 PGC1α Insulin SREBP-1 Fatty Acid Synthase HSL ATGL Akt B-Raf Erk p90RSK PI3K Insulin Receptor p70 S6K 4E-BP1 Beclin mTOR GβL Raptor ULK1 PI3K Class III ATG13 Atg14 p300 HNF4α TORC2/ CRTC2 CREB FoxO HDAC7 HDAC5 HDAC4 CRY1 Glut4 vesicle Glut1 vesicle Sterol/Isoprenoid Synthesis Fatty Acid Oxidation Lipolysis Glycolysis Glycogen Synthesis [cAMP] Low Glucose, Hypoxia, Ischemia, Heat Shock AICAR Exercise Brain [Ca 2+ ] Histamine Thrombin Glut Trafficking Glut4 Glut1 Autophagy Lipogenesis AMP + ADP ATP Gluconeogenesis Glucose Glut Translocation Microtubules Actin Dynamics MBS85 MYPT1 TXNIP Myosin Light Chain2 CLIP170 Tau C ytoskeletal Signaling A c u t e R e g u l a t i o n o f M e t a b o lis m Transcriptional C ontrol of M eta b olis m P r o t e in M e ta b o lis m a n d A u t o p h a g y AMPK Signaling © 2008–2015 Cell Signaling Technology, Inc. PDHK IDH1 IDH2 PHGDH Ras Ras Ras UCP2 ACSS2 Malate Malate Citrate Citrate Acetate Epigenetic Regulation ACL ACC LDHA Pyruvate Dehydrogenase NADPH NADPH NADPH NADP NADP NADP Malic Enzyme Glutaminase Oxaloacetate Glutamine Transporters Glucose Transporters Hexokinase PFK PKM2 Acetyl-CoA Glutamine OMM Stability Inhibition Cytochrome C Release Inhibition of Apoptosis Glutaminolysis Acetyl-CoA Pyruvate Pyruvate 6-P- Gluconolactone 6-P- Gluconate Amino Acids and Lipids Ribulose-5P Nucleotide Synthesis Folate Metabolism Fructose-6-P Fructose Bisphosphate 3-Phosphoglycerate PEP Glucose-6-P Lactate Serine Glycine Krebs Cycle VDAC Hexokinase Bax VDAC ANT ANT α-Ketoglutarate β-Oxidation MEK1/2 AMPK p53 TIGAR c-Myc c-Myc AMPK c-Myc HIF-1α HIF-1α SREBP LKB1 ULK1 c-Myc Erk1/2 Akt Akt mTOR NADPH NADP NADPH NADP PI3K p53 Amino Acids Cell Proliferation Fatty Acid Oxidation Autophagy Fatty Acids Fatty Acid/ Lipid Synthesis Protein Synthesis Growth Factors Macropinocytosis and other scavenging pathways Glucose Glycolysis Pentose Phosphate Shunt Warburg Effect © 2010–2015 Cell Signaling Technology, Inc. SGK c-Raf Ras Jnk Gab1 Shc GRB2 GRB10 PI3K p110 p85 IRS IRS-1 SHIP Cbl Crkll PTEN SHP-2 MEK1/2 ROS TSC2 TSC1 eIF4E Lipin1 Lipin1 4E-BP1 PRAS40 GSK-3 PP1 Bad ATP-citrate lyase p70 S6K Erk1/2 Erk1/2 Erk1/2 Akt2 Akt Akt2 PDK1 PDK1 PKCλ/ζ PKCλ/ζ Fyn SGK PKA SIK2 Torc2 AMPK LKB1 Rheb PKCθ APS PP2A IKK Insulin Receptor TNF AS160 TBC1D1 14-3-3 14-3-3 EHD1 EHBP1 Rac1 PDE3B SOCS3 TNFR1 PTP1B iNOS HSL Nck ENaC GS C3G TC10 Cav CAP Synip CIP4/2 Flotillin FoxO4 FoxO1 USF LXRα SREBP SREBP-1 SREBP FoxO3 SOS GLUT4 SNARE Complex mTORC1 mTORC2 Crkll CBP/p300 Apoptosis, Autophagy, Glucose and Lipid Metabolism Transcription PIP 3 GLUT4 Translocation GLUT4 vesicle Apoptosis Glycogen Synthesis Fatty Acid Synthesis Fatty Acid and Cholesterol Synthesis Disruption of CBP/Torc2/CREB Complex Gluconeogenesis Growth Protein Synthesis, Growth, and Proliferation FFA Glucose Nucleus Sodium Transport NO Lipolysis Degradation [cAMP] GLUT4 Exocytosis Cytoplasm mTORC2 mTOR Rictor Sin1 PRR5 DEPTOR Raptor GβL mTOR DEPTOR mTORC1 GβL Insulin Receptor Signaling © 2003–2015 Cell Signaling Technology, Inc.
