Date post: | 18-Dec-2015 |
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Protein (short protein called peptide)
• Protein =Amino Acids stuck together
• By what kind of bond?
• What kind of reaction is this?
mRNA
Synthesis ofmRNA in thenucleus
DNA
NUCLEUS
mRNA
CYTOPLASM
Movement ofmRNA into cytoplasmvia nuclear pore
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mRNA
Synthesis ofmRNA in thenucleus
DNA
NUCLEUS
mRNA
CYTOPLASM
Movement ofmRNA into cytoplasmvia nuclear pore
Ribosome
AminoacidsPolypeptide
Synthesisof protein
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2
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Cystic Fibrosis is most often caused by mutation F508 in the CFTR gene
o The CFTR gene is 189,000 bases longThere are 27 exons/ 26 introns in it.o The mRNA (all exons) is 6129 basesHow many codons is that, max?o The protein is 1480 amino acids longNormally it’s a Cl- channel, the mutation?
What do you know of your disease’s Central Dogma?
o What is the size of your gene?How many exons/introns does it have?o What is the size of your mRNA (cDNA)?How many codons does it have?o What is the size of your protein?What is the normal vs abnormal function of it?