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Chapter 1Lecture
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Hole’s Human Anatomyand Physiology
Twelfth Edition
Shier Butler Lewis
Chapter 1Introduction to Human Anatomy & Physiology
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1.1: Introduction
• Questions and observations that have led to knowledge.
• Knowledge about structure and function of the human body.
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1.2: Anatomy & Physiology
• Anatomy – the study of the structure of the human body
• Physiology – the study of the function of the human body
“The complementarity of structure and function.”
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1.3: Levels of Organization
• Subatomic Particles – electrons, protons, and neutrons• Atom – hydrogen atom, lithium atom, etc.
• Molecule – water molecule, glucose molecule, etc.
• Macromolecule – protein molecule, DNA molecule, etc.
• Organelle – mitochondrion, Golgi apparatus, nucleus, etc.
• Cell – muscle cell, nerve cell, etc.
• Tissue – epithelia, connective, muscle and nerve• Organ – skin, femur, heart, kidney, etc. • Organ System – skeletal system, digestive system, etc.
• Organism – the human
Levels of Organization
Subatomic particles
Atom
Molecule
Macromolecule
Organelle
Cell
Tissue
Organ
Organ system
Organism
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Organ Systems
Skeletal system Muscular system
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Integumentary system
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Organ Systems
Nervous system Endocrine system
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Organ Systems
Cardiovascular system Lymphatic system
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Organ Systems
Digestive system Respiratory system Urinary system
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Organ Systems
Male reproductive system Female reproductive system
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1.1 Clinical Application
• Ultrasound (US)
• Magnetic Resonance Imaging (MRI)
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1.4: Characteristics of Life (10)
• Movement – change in position; motion
• Responsiveness – reaction to a change
• Growth – increase in body size; no change in shape
• Respiration – obtaining oxygen; removing carbon dioxide; releasing energy from foods
• Reproduction – production of new organisms and new cells
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Characteristics of Life Continued
• Absorption – passage of substances through membranes and into body fluids
• Circulation – movement of substances in body fluids
• Assimilation – changing of absorbed substances into chemically different forms
• Excretion – removal of wastes produced by metabolic reactions
• Digestion – breakdown of food substances into simpler forms
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1.5: Maintenance of Life
• Life depends on five (5) environmental factors:• Water• Food• Oxygen• Heat• Pressure
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Requirements of Organisms
• Water- most abundant substance in body- required for metabolic processes- required for transport of substances- regulates body temperature
• Food- provides necessary nutrients- supplies energy- supplies raw materials
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Requirements of Organisms
• Oxygen (gas)- one-fifth of air- used to release energy from nutrients
• Heat- form of energy - partly controls rate of metabolic reactions
• Pressure - application of force on an object - atmospheric pressure – important for breathing - hydrostatic pressure – keeps blood flowing
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Homeostasis*
* Maintaining of a stable internal environment
• Homeostatic Control Mechanisms – monitors aspects of the internal environment and corrects as needed. Variations are within limits. There are three (3) parts:
• Receptor - provides information about the stimuli
• Control Center - tells what a particular value should be (called the set point)
• Effector - elicits responses that change conditions in the internal environment
Homeostatic Control Mechanisms
Stimulus(Change occursin internalenvironment.) Response
(Change is corrected.)
Receptors Effectors(muscles or glands)
Control center(set point)
(Change is comparedto the set point.)
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Homeostatic Control Mechanisms
ReceptorsThermoreceptorssend signals to thecontrol center.
too high
too low
Normal bodytemperature37°C (98.6°F)
Control centerThe hypothalamusdetects the deviationfrom the set point andsignals effector organs.
Control centerThe hypothalamusdetects the deviationfrom the set point andsignals effector organs. If body temperature
continues to drop,control center signalsmuscles to contractInvoluntarily.
StimulusBody temperaturerises above normal.
EffectorsSkin blood vesselsdilate and sweat glandssecrete.
ResponseBody heat is lost tosurroundings, temperaturedrops toward normal.
ReceptorsThermoreceptorssend signals to thecontrol center.
EffectorsSkin bloodvessels constrictand sweat glandsremain inactive.
StimulusBody temperaturedrops below normal.
EffectorsMuscleactivitygeneratesbody heat.
ResponseBody heat is conserved,temperature rises toward normal.
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• There are two (2) types:
• Negative feedback mechanisms
• Positive feedback mechanisms
Homeostatic Control Mechanisms
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Negative feedback summary:
• Prevents sudden, severe changes in the body
• Corrects the set point
• Causes opposite of bodily disruption to occur, i.e. the ‘negative’
• Most common type of feedback loop
• Examples: body temperature, blood pressure & glucose regulation
Homeostatic Control Mechanisms
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Positive feedback summary:
• Increases (accelerates) the actions of the body
• short-lived
• do not require continuous adjustments
• Examples: blood clotting and child birth
Homeostatic Control Mechanisms
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1.6: Organization of the Human Body
Thoracic cavity
Abdominalcavity
Diaphragm
Pelvic cavity
Cranial cavity
Vertebral canal
(a)
Abdominopelviccavity
Abdominalcavity
Pelvic cavity
Right pleuralcavity Mediastinum
Left pleural cavityPericardialcavity
Diaphragm
Vertebral canal
Cranial cavity
Thoraciccavity
(b)
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Thoracic & Abdominal Serous Membranes
Thoracic Membranes• Visceral pleura• Parietal pleura• Visceral pericardium• Parietal pericardium
• Visceral layer – covers an organ• Parietal layer – lines a cavity or body wall
Abdominopelvic Membranes• Parietal peritoneum• Visceral peritoneum• Parietal perineum• Visceral perineum
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1.7: Lifespan Changes
Aging occurs from the microscopic level to the whole-body level.
Can you think of some examples?
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1.8: Anatomical Terminology
Anatomical Position – standing erect, facing forward, upper limbs at the sides, palms facing forward and thumbs out
Integumentary system
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Anatomical Terminology:Orientation and Directional Terms
• Terms of Relative Position (based on anatomical position):• Superior versus Inferior (Cranial vs. Caudal)• Anterior versus Posterior (Ventral vs. Dorsal)• Medial versus Lateral• Ipsi-lateral versus Contra-lateral• Proximal versus Distal• Superficial versus Deep• Internal versus External
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Body Sections or Planes
• Sagittal or Median – divides body into left and right portions• Mid-sagittal – divides body into equal left and right portions
• Transverse or Horizontal – divides body into superior and inferior portions
• Coronal or Frontal – divides body into anterior and posterior portions
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Body Sections
A section along a frontalplane
A section along a transverseplane
A section along themedian plane
Transverse(horizontal)plane
Frontal(coronal)plane
Parasagittalplane
Median(midsagittal)plane
Body Sections
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Other Body Sections
(a) (b) (c)
Cross-section
Oblique section
Longitudinal
section
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Abdominal Subdivisions
Righthypochondriacregion
Rightlumbarregion
Rightiliacregion
Epigastricregion
Umbilicalregion
Hypogastricregion
Lefthypochondriacregion
Leftlumbarregion
Leftiliacregion
Right upperquadrant (RUQ)
Left upperquadrant (LUQ)
Right lowerquadrant (RLQ)
Left lowerquadrant (LLQ)
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Body Regions
Otic (ear)
Cervical (neck)
Acromial(point of shoulder)
Mammary (breast)
Brachial(arm)
Antecubital(front of elbow)
Antebrachial(forearm)
Genital(reproductive organs)
Cephalic (head)
Orbital (eye cavity)
Mental (chin)
Sternal
Pectoral(chest)
Inguinal(groin)
Coxal(hip)
Umbilical(navel)
Pedal (foot)
Occipital(back of head)
Acromial(point of shoulder)
Brachial (arm)
Dorsum (back)
Cubital (elbow)
Gluteal (buttocks)
Perineal
Femoral (thigh)
Popliteal (back of knee)
Plantar (sole)(a) (b)
Patellar(front of knee)
Vertebral(spinal column)
Sacral (between hips)
Lumbar(lower back)Abdominal
(abdomen)
Carpal (wrist)
Palmar (palm)
Digital (finger)
Nasal (nose)
Oral (mouth)
Frontal (forehead)
Buccal (cheek)
Tarsal (instep)
Digital (toe)
Axillary (armpit)
Crural (leg)
Sural (calf)
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Important Points in Chapter 1:Outcomes to be Assessed
1.1: Introduction
Identify some of the early discoveries that lead to our current understanding of the human body.
1.2: Anatomy and Physiology
Define anatomy and physiology and explain how they are related.
1.3: Levels of Organization
List the levels of organization in the human body and the characteristics of each.
1.4: Characteristics of Life
List and describe the major characteristics of life.
Define and give examples of metabolism.
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Important Points in Chapter 1:Outcomes to be Assessed Continued
1.5: Maintenance of Life
List and describe the major requirements of organisms.
Define homeostasis and explain its importance to survival.
Describe the parts of a homeostatic mechanism and explain how they
function together.
1.6: Organization of the Human Body
Identify the locations of the major body cavities.
List the organs located in each major body cavity.
Name and identify the locations of the membranes associated with the
thoracic and abdominopelvic cavities.
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Important Points in Chapter 1:Outcomes to be Assessed Continued
Name the major organ systems and list the organs associated with each.
Describe the general function of each organ system.
1.7: Lifespan Changes
Define aging.
Identify the levels of organization in the body at which aging occurs.
1.8: Anatomical Terminology
Properly use the terms that describe relative positions, body sections, and
body regions.
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Quiz 1
Complete Quiz 1 now!
Read Chapter 2.