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Chapter 11 - Chapter 11 - DNa introductionDNa introduction
Forensics Uses
• DNA evidence has been used to investigate crimes, establish paternity, and identify victims of war and large-scale disasters
Science and the Law: the Implications of DNA Profiling
New York State to Exonerate Innocent Prisoners Using DNA
The Smoking Gun, 9/11 DNA Evidence Revisited
DNA Paternity Test – Worldwide Increase
Background information
• Body consists of 60 trillion cells
– Most of these cells contain a nucleus The exception = Mature red blood cells
– Each nucleus contains the genetic material, or the directions, to make us who we are• The genetic material is found in structures
called chromosomes
Background information
• Chromosomes are composed of little segments called genes
– The gene is the fundamental unit of heredityHolds instruction for the body cells to make
proteins that determine everything from hair color to our susceptibility to disease
• Each gene is composed of a specific sequence of DNA
Dna
• DNA stands for deoxyribonucleic acid– Blueprint, or directions, for all living things– Universal – found in every living thing
• In humans, DNA is in the form of a double helix, or spiral ladderShape was discovered by James Watson
and Francis Crick in 1953
Dna components
• DNA is made up of primary units called nucleotides– Each nucleotide is composed of three
piecesSugar (deoxyribose)Phosphate groupNitrogenous base
– Four different bases: Adenine, Guanine, Thymine, Cytosine
DNA shape
• The sugar and the phosphate group create the backbone of the molecule– This is the sides of the ladder
• The bases are the rungs of the ladder
Base pairing rule
• Each base matches up with one other specific base = base pairing rulesAdenine will always bind to thymine, and vice
versaCytosine will always bind to guanine, and vice
versa
• Each DNA strand contains over 1 million base pairs– It is the order of bases that dictate your traits
Types of Dna
• Nuclear• Found in the nucleus• Constitutes 23 pairs of
chromosomes inherited from both parents
• Each cell contains only one nuclei
• Mitochondrial• Found in the cytoplasm• Is inherited only from
mother• Each cell contains
hundreds of thousands of mitochondria
• Can be found in skeletal remains
Nuclear DNA is present in the head of the sperm. Mitochondrial DNA is present in the tail. At conception, the head of the sperm enters the egg and unites with the nucleus. The tail falls off, losing the father’s mitochondrial DNA
Nuclear DNA Mitochondrial DNA
Non-Coding Regions
• 3 percent of the human DNA sequences code for proteins
97 percent is non-coding and is repetitive; repeating the same sequence over and over
• 50 percent of the human genome had interspersed repetitive sequences