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Cell reproduction Mitosis
produce cells with same information identical daughter cells
exact copies (clones) same amount of DNA
same number of chromosomes asexual reproduction
What are disadvantages of asexual reproduction?What are advantages?
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Asexual reproduction Single-celled eukaryotes
reproduce asexually yeast Paramecium Amoeba
Simple multicellulareukaryotes reproduceasexually Hydra budding
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Reproduction in multicellular organisms
How is it possible to maintain such geneticcontinuity in a multicellularorganism?
Baldwin brothers
Martin & Charlie Sheen, Emilio Estevez
Michael & KirkDouglas
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Sexual reproduction
What has to happento make gametes?
But how does a complex multicellularorganism reproduce? joining of gametes
egg (or ovum) sperm
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Role of Meiosis in Sexual Life Cycles Alternating processes
fertilization &meiosis alternate
meiosis reduceschromosome number diploid → haploid 2n → n
fertilization restoreschromosome number haploid → diploid n → 2n
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Meiosis &fertilization mustalternate forsexualreproduction tocontinue
Alternation of generationthe dominantmulticellular stage(n vs. 2n) differsamongst organisms
Haploid (n) organism = gametophyteDiploid (2n) organism = sporophyte
Alternation of generations:• life history having a multicellular haploid stage which alternates
with a multicellular diploid stage
Evolutionary trends:Earlier organism have dominant gametophyte (n) individual
• the gametophyte generation is the major stage in the life ofmosses, the visible stage in fungi, and is an independent plantin ferns
However, the gametophyte is only an inconspicuous structure withinthe flower or other reproductive organs of "higher" plants
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What does karyotype reveal? Mutation in chromosome number or
gross chromosomal abnormalities
Down’s syndrome
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Homologous chromosomes Paired chromosomes
both chromosomes of a pair carry genescontrolling same inherited characters homologous = same information
- 2 copies- diploid- 2n
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Sexual reproduction: Fertilization
- 2 copies- diploid- 2n
- 1 copy- haploid- 1n
What wouldhappen ifmeiosisdidn’t occur?
from Mom from Dad
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Meiosis = reduction division Meiosis
special cell division in sexuallyreproducing organisms
reduce 2n → 1n diploid → haploid (half) makes gametes (sperm, eggs)
Warning: meiosis evolved from mitosis, so stages& “machinery” are similar but the processes areradically different. Do not confuse!
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2nd division ofmeiosis separatessister chromatids
1st division ofmeiosis separateshomologous pairs
Double divisionof meiosis
DNA replication
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Steps of meiosis Meiosis 1
interphase prophase 1 metaphase 1 anaphase 1 telophase 1
Meiosis 2 prophase 2 metaphase 2 anaphase 2 telophase 2
2nd division ofmeiosis separatessister chromatids(1n → 1n)* just like mitosis *
1st division of meiosisseparates homologouspairs(2n → 1n)
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2n double
stranded
2n single
stranded
Preparing for meiosis 1st step of meiosis
Duplication of DNA Why bother?
meiosis evolved after mitosis convenient to use
“machinery” of mitosis DNA replicated in
S phase of meiosisinterphase(just like in mitosis)
M1 prophase
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2n double
stranded
2n single
strandedPreparing for meiosis
prophase1
2n double
stranded
1st division ofmeiosis separateshomologous pairs
1n single
stranded
tetrad
synapsis
telophase1
metaphase1
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Meiosis 2 2nd division of meiosis separates sister
chromatids
1n double
stranded
1n single
stranded
What doesthis divisionlook like?
metaphase2
anaphase1
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Mitosis vs. Meiosis Mitosis
1 division daughter cells
genetically identicalto parent cell
produces 2 cells 2n → 2n produces cells for
growth & repair no crossing over
Meiosis 2 divisions daughter cells
genetically differentfrom parent
produces 4 cells 2n → 1n produces gametes
crossing over
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The value of meiosis Meiosis introduces genetic variation
gametes of offspring do not have samegenes as gametes from parents
genetic recombination random assortment in humans produces
223 (8,388,608) different combinations
from Mom from Dad new gametesmade by offspring
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Random fertilization Any 2 parents will produce a zygote
with over 70 trillion (223 x 223) diploidcombinations
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And more variation…
tetrad
During Prophase 1 homologous pairs swap
pieces of chromosome sister chromatids intertwine crossing over
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Crossing over 3 steps
cross over breakage of DNA re-fusing of DNA
New combinationsof traits
What are advantages ofsexual reproduction?What are disadvantages?
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Genetic variation Meiosis & crossing over introduce
great genetic variation to population drives evolution
Consider the greater variation with 23 pairs of chromosomes =mixing and matching
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Sources of genetic variability Genetic variability in sexual reproduction
independent assortment homologous chromosomes in M1 sister chromatids in M2
crossing over between homologous chromosomes in
prophase1 random fertilization
random ovum by a random sperm
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Spermatogenesis Continuous &
prolific processin the adult male
Each ejaculationcontains 100–650million sperm
occurs inseminiferoustubules