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The Relation of Childhood Fitness &
Adiposity to Cognitive & Brain Health
The Relation of Childhood Fitness &
Adiposity to Cognitive & Brain Health
Charles H. Hillman, Ph.D.Neurocognitive Kinesiology Laboratory
Department of Kinesiology & Community HealthUniversity of Illinois at Urbana-Champaign
Physical Inactivity Trends
• There is a pandemic of physical inactivity in today’s society.
• Recent reports forecast that inactivity will continue to rise throughout the industrialized world over the next few decades (Ng & Popkin, 2012).
• Although the effects on physical health is well known, cognitive and brain health is only beginning to emerge.
Physical Fitness & Achievement Test Performance
220
240
260
280
300
320
340
360
0 1 2 3 4 5
Fitnessgram
To
tal I
SA
T S
core
Castelli, Hillman, Buck, & Erwin (2007) JSEP.
Aerobic Fitness & Achievement Test Performance
Castelli, Hillman, Buck, & Erwin (2007) JSEP.
200
250
300
350
400
0 10 20 30 40 50 60 70 80
R2 = 0.22
PACER (# Laps)
Tot
al I
SA
T
Sco
re
Body Mass Index & Achievement Test Performance
Castelli, Hillman, Buck, & Erwin (2007) JSEP.
Tot
al I
SA
T
Sco
re
200
250
300
350
400
10 15 20 25 30 35
Body Mass Index
R2 = 0.06
*p < .05**p < .01
Scudder et al. (in review).
Inhibitionthe ability to ignore distraction & stay
focused
Cognitive Flexibilitythe ability to switch
perspectives, focus of attention, or response
mappings
Working Memorythe ability to hold
information in mind and manipulate it
Cognitive Control
Flanker TaskFlanker Task
>>>>>
>><>>
<<><<
<<<<<
1000 ms
100 ms
1000 ms
1000 ms
Fitness & Basal Ganglia Volume
0
1000
2000
3000
4000
5000
6000
Left Right Left Right Left Right Left Right
Higher FitLower Fit
Caudate Nucleus Putamen
Globus Pallidus Nucleus Accumbens
*
*
*
* *
[r = -.33] [r = -.25]
[r = -.26] [r = -.35]
Chaddock et al. (2010). Developmental Neuroscience,32, 249-256.
Relational Memory Task
Chaddock et al. (2010). Brain Research, 1358, 172-183
50
55
60
65
70
75
80
Item Accuracy Relational Accuracy
Memory Performance
Low Fit
High Fit
*
Fitness, Hippocampus, & Memory
The FITKids Randomized Trial
221 Children (Rx = 109, Control = 112)
participated in >70 minutes of
intermittent moderate to vigorous
physical activity following each school
day.
An after-school physical activity program occurring on 150 of the 170 day school year.
Modified Flanker Task
1200 ms
200 ms
1200 ms
1200 ms
Change Flanker Task Performance
Switch TaskSwitch Task
2000 ms
200 ms
2000 ms
2000 ms
Change in Heterogeneous Response Accuracy
Change in P3 Amplitude
Flanker Incongruent P3 Relationship with Attendance
Switch Heterogeneous Response AccuracyRelationship with Attendance
-3
0
3
6
0 200 400 600 800 1000Time (ms)
Ampl
itude
(uV)
Post Exercise Congruent
Baseline CongruentBaseline Incongruent
Post Exercise Incongruent
Acute Exercise in Preadolescent Children
Hillman et al. (2009). Neuroscience, 159, 1044-1054.
Acute Exercise & Academic Achievement
Pontifex et al. (in press). J. Pediatrics.
Adiposity, Cognition, & Achievement
Kamijo et al. (in press). Obesity.
Obesity & Inhibition
70
80
90
100
Go NoGo
Healthy Weight Obese
Re
spon
se A
ccur
acy
(%)
*
Go NoGo
Kamijo et al. (2012). Psychophysiology.
Obesity & ERPs(NoGo-Go P3 Amplitude)
Kamijo et al. (2012). Psychophysiology.
µV
2
-2
Healthy Weight Obese
Encoding (Day 1)
Study Only Test Study
Study: 6 sec
Taft
Clay
Clay
Test: 4 sec
Study: 2 sec
Raine et al. (2013) PLOS ONE.
Rate of Learning (Day 1)A
ccur
acy
(% C
orre
ct)
Block
Higher FitLower Fit
Raine et al. (2013) PLOS ONE.
Recall (Day 2)
Free Cued
Pell Bond Ross Taft Dane Owen Glen Cass Nash Mack
Raine et al. (2013) PLOS ONE.
*
Higher FitLower Fit
Acc
ura
cy (
% C
orr
ect
)
Fitness Affects on Recall (Day 2)
Raine et al. (2013) PLOS ONE.
*
*
Higher FitLower Fit
Acc
ura
cy (
% C
orr
ect
)
Study Only Test Study
Fitness x Learning (Day 2)
Raine et al. (2013) PLOS ONE.
Conclusions
• Fitness may benefit brain health and academic performance.
• Fitness has been linked to changes in cognition that are disproportionately larger for tasks requiring cognitive control.
• Early PA experience may shape cognition and its neural underpinnings.
• Excess adiposity is related to decrements in cognitive & brain health, and scholastic achievement.
• Single bouts of aerobic exercise benefit basic and applied aspects of cognitive performance.
• Collectively, these data suggest that time spent engaged in physically active does not detract from academic performance.
• Thus, early intervention is crucial toward lifespan health and effective function of brain and cognition.
AcknowledgementsCollaborators
Sarah Buck (Chicago State U)
Darla Castelli (U Texas)
Neal Cohen (UIUC)
Eco de Geus (Vrije U)
Joe Donnelly (U Kansas Med)
Kirk Erickson (U Pitt)
Ellen Evans (U Georgia)
Bo Fernhall (UIC)
Eric Hall (Elon College)
Keita Kamijo (Waseda U)
Art Kramer (UIUC)
Eddie McAuley (UIUC)
Rob Motl (UIUC)
Matthew Pontifex (MSU)
Jason Themanson (IL Weslyan U)
Michelle Voss (U Iowa)
Funding
NICHD HD055352
NICHD HD069381
NIDDK DK085317
CNLM/Abbott Labs
Nike Foundation
IARPA
StudentsLaura ChaddockEric DrolletteChris JohnsonNaiman KhanDavis MooreKevin O’LearyLauren RaineMark ScudderKelvin Wu
Virtual Crosswalk
• Why do we care about attention and memory performance in children?
• Motor vehicle accidents are among the leading causes of death among children under the age of 16 years in the U.S.
• Given the importance of fitness to cognition, might fitness lead to better decision making at the crosswalk?
Undistracted Music Phone40
50
60
70
80
90
Lower-FitHigher-Fit
Chaddock et al. (2012). MMSE, 44, 749-753
Mechanisms for PA & Cognition• Neurogenesis
• Angiogenesis & synaptogenesis in the cerebellum (Isaacs et al., 1992)• Increased density of capillaries in the molecular layer to support
increased metabolic demands (Black et al., 1990)• Enhanced neurogenesis in the dentate gyrus (van Praag et al., 1999)
• Increased LTP and Morris water maze performance
• Increase levels of neurochemicals that improve plasticity and neuronal survival• Brain-derived neurotrophin factor (BDNF; Cotman & Berchtold, 2002)
• e.g., 7 days of voluntary wheel running increased BDNF mRNA levels in the hippocampus, cerebellum, and cortex (Neeper et al., 1996).
• Insulin-like growth factor 1 (IGF-1; Carro et al., 2001)• Serotonin (Blomstrand et al., 1989)• Dopamine (Spirduso & Farrar, 1981)
• Brain Metabolism• Regional cerebral blood flow and oxygenization (Dustman et al., 1984)• Glucose and lactate consumption associated with ∆ in neuronal pH
• Inflammation • C-reactive protein & Interleukin-6