4. 23
. 100
130~140, , ,
, , ,
.
.
77% ,
11% , 2~3%
, 1~2% .
7~9%
. 1999 2007
55.4%,
27.5%, 5.3%

.
2)
95% ,
(acute lymphoblastic leukemia,
ALL) (acute myelogenous
leukemia, AML) .
,

.

.
.
,
,
.

,
. ,

.


.
.


.
.
,


.
,

. ,


.
.


.


.
, (3,000mL/
/) ,
(pH 7 ) ,

.
.

.
2.

. 1950

,


.
,
1
.
, 10
,


.
7
3, 2 ‘ 3,
2’ .



.
2)


,

.


( 1 ).

1~9
50,000/uL ,
( 1 ).
DNA 1.16 () 4,
10, 17 ( 2, 3)
. T

. t(9;22) t(4;11)
44
.
: 1 , 10
: 50,000/uL



0 1 2 3 4 5 6 7 8 9 10 12 14 16 18 ()
70%
.
(2 ) ,


.
3)
,
5%
.

.
4
,
95%
.
.
: 40~60mg//, 1 3 ,
28, 2

: 25mg//, (3, 4
, ),

( , , ,
)
. L-
.

.

. ()

.
,


.
, .
7
, 7
14
.
.
4)

,
.
.
,

.
5)
6-
, .

. - ,
5~6


,
. 1
2
.


.
6)
. 4
,
12
. 6-


.

3, 2 .
1
.
7)
60%
.
(Blood-Brain
Barrier;BBB)
.
.


5%
.


.
.
3.

.
, ,

.
(7&3 5&3). BH-AC(), 6-

. (FAB M3 )
(ATRA)

.
20%

.
(FAB M3 )


. HLA
60~70%
.

BH-AC
HLA
,
.
t(8;21) M2
.
(M3 )
(ATRA) .
4.

.
.
,


. ,
.
.
70%
. (2
) ,


.
HLA . HLA
. HLA
.
HLA ,

(KONOS) . HLA

.
.


.
,
.
.


,
.
.
,
500/uL 38.3
.


.


.
,
. ,
,

.
3~7

.
. (Pneumocystis jiroveci)
,

.

.


(Pentamidine) .
,

.
-
(varicella-zoster virus, VZV),
(cytomegalovirus, CMV), Epstein-Barr (EBV),
.


.
.
,
( )
, ,

. 20,000/uL
.


*
.

, ,
* : ‘ ’
** :
, , , ,
.

.
.

· .

02-766-7671
www.kclf.org