+ All Categories
Home > Documents > CIO 2017 - Abstract 15831 - 03 Feb 2017provectusbio.com/media/docs/publications/CIO 2017...!"#$%&'(...

CIO 2017 - Abstract 15831 - 03 Feb 2017provectusbio.com/media/docs/publications/CIO 2017...!"#$%&'(...

Date post: 13-Mar-2020
Category:
Upload: others
View: 2 times
Download: 0 times
Share this document with a friend
1
!"#$%&' )*+%,+% ,-. /*+'012 !"13*3,4 !','"+ 5556 ! #$ %&'& () *+ , -.*/0123/ 4567%2089 !/*1: ;<=;<>: 4381*20: -?52*+.@ 4923/ (A-B: C) %70@ 5758 ; #C %&'& (D *+: ';4: ;<=;<>: =23/? '/1/E*2701@ 4923/ (DF %70@ 5559 ! GH %&'& (A+%/?7+1 !/*85792E899I 4E*23/ J/K8*2E *+@ 4923/ ($G %70@LL 55:5 ; H) %&'& () *+: ;<=;<>: 4381*20: M?207*/E80: N8?*289 J/K8*/E*7%I@ 4923/ (O %70@ 5756 ; #C %&'& (! # *+: ;<=;<>: ;<=;M'M: P4=Q'4N: '/R7?8S2025@ -.K2?/6 (BN: ) %70@ 555; ! #G J&& (D *+ , &T/1* U899 806 46?/089 !/*1: J/KV 806 &2??T7121@ 4923/ (A-B: CH %70@ 555: ; C$ J&& () *+: =75/E*7%I: ';4@L 4923/ (W2*T B21/81/: HG %70: 971* *7 S7997WX+K@ 5558 ; C) J&& (F *+: J/K&: &2??T7121: N7?*89 JIK/?*/01270: ';4: Q4&-@ -.K2?/6 (BN: FG %70@ 555< ; ## J&& () *+: J/K&: &2??T7121: N7?*89 JIK/?*/01270: Q4&-@ -.K2?/6 (BN: $D %70@ 555= ! #C J&& ($ *+ N/0/*?8*20R B28KT?8R%@ -.K2?/6 (&8?628E &7%7?5262*I: D %70@ 5:5: ; GO J&& ($ *+ GYO E%@ -.K2?/6 (Z4-: 1+1K/E*/6 *T?7%57/%57921%@ 575> ! #O =+0R (! F *+: A237: ZA>XHFDD 806 &8?57[N8E92*8./9@ -.K2?/6 (BN: $D %70@ 5757 ! G) =+0R (! # *+: &8?57[45?8.80/@ -.K2?/6 (BN: F %70@ 575; ! G) N80E?/8*2E (D *+@ 4923/ ($D %70@ 5:57 ; H) !/9807%8 (! F *+ , =+0R !/*1: J/K8*2*21: V27ET/%7: A237 , MK2@L -.K2?/6 (BN: $G %70@ 575: ; H$ <38?280 (! )H *+: &8?57[N8E92*8./9@ -.K2?/6 (BN: $H %70@ L D 9/12701 *?/8*/6 W2*T N\X$] (?/^+2?20R ?/X/0?799%/0* +06/? 1/K8?8*/ 1+5_/E* 0+%5/?@ LL E7%%/0E/6 4381*20: HX;`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`E a)!= M E =-#>(G = )I-,Q-%-E ^` W E )%3;-#23, = B"'38&,I6E ^`E a)!= Y -#2 :,($ ) b-$9+3,E C9` [ M 5#$"%"I6 )''"$(-+3' "O =-# `(3I" -#2 =9-,1 R3-%+9 !-,3E =-# `(3I"E !) 0=)] W =+ F&D3c' !-#$3, !3#+3, -#2 K381%3 0#(G3,'(+6E d3+9%3938E C) 0=)] Y a%",(2- R"'1(+-% K-81-E K-81-E aF 0=)] -#2 [ C,"G3$+&' d("19-,8-$3&+($-%'E 7#$PE e#";G(%%3E KS 0=) a", -22(+("#-% (#O",8-+("#f (#O"g1G$+P$"8 )*'+,-$+ S"P MXUYM /C"'+3, ?WW4 !75 W?M\ R"%%6Q""2E aF 0=) [JX a3*,&-,6 W?M\ C3,$&+-#3"&' B"'3 d3#I-% -' -# 5#$"%6+($ 788&#"+93,-16 O", R31-+($ ^3+-'+-'3' +.*#)0&!)*+1 $.1$,2*+1 +((".$*0&#)!2 Q(+9 !3456 ! B3-2(%6 (8-I32 2,&I 23%(G3,6 2&3 +" ,-2("1-$(+6 "O CLJM? ! 788&#"I3#($ $3%% 23-+9 -#2 +&8",J'13$(O($ -$+(G-+("# 1"+3#+(-% ! 7#+,(I&(#I %"#IJ+3,8 '&,G(G-% 23'1(+3 I,(8 1,"I#"'(' O", 83+-'+-+($ $"%",3$+-% $-#$3, K9(' *-'D3+ '+&26 (' 23'(I#32 +" 238"#'+,-+3 '-O3+6 -#2 ,3%3G-#$3 "O CLJM? O", 23'(I# "O O&+&,3 ,-#2"8(H32 '+&2(3' *789:; ,:<=>? #7@=A !8=B78C 1D:787?E: >F &G;87H7<7;: ! b-$9+3, 3+ -%PE =C7: W??W] [@W?f M[Y /%6'"'"8-% -$$&8&%-+("# -#2 +&8", $3%% 2(',&1+("# (# +(''&3 $&%+&,34 ! F(& 3+ -%PE 5#$"+-,I3+ W?M@] \f Y\UTY /8&,(#3 -#2 9&8-# KJ$3%% -$+(G-+("# -#2 +&8", 8($,"3#G(,"#83#+4 ! h(# 3+ -%PE !3%% `3-+9 -#2 `('3-'3 W?M\] Uf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
Transcript
Page 1: CIO 2017 - Abstract 15831 - 03 Feb 2017provectusbio.com/media/docs/publications/CIO 2017...!"#$%&'( )*+%,+%(,-.(/*+'012( !"13*3,4(!','"+(5556(!"#$" %&'&"()"*+","-.*/0123/"4567%2089"!/*1:";

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

L"D"9/12701"*?/8*/6"W2*T"N\X$]"(?/^+2?20R"?/X/0?799%/0*"+06/?"1/K8?8*/"1+5_/E*"0+%5/?@"LL"E7%%/0E/6"4381*20:"HX;`"806";+129/3"*W7"%70*T1"8S*/?"N\X$]!

!"!

#"!

$"!

%"!

&"!

'()* '+)* ,,)* -./.* '(0*

12(3

!"#$%&'

()'*'*+,-.//0+0-,12*3

4++03*5632/76--$86,1%

()'*'*+,-82'&0912*3

431&,-6'2*3,-43:6/12*3

!"#$%&'(# )**+"$',-./0&1

;"/6--$<&2+235,3=$./12>,12*3

?6+*16$;0+*&?65&6''2*3

!"#$@A'!"#$%&'("#'

)*'+,-$+./012-+324

5#$"%6+($ 788&#"+93,-16

!%(#($-%.:;-81%3.< =&*>[email protected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

1$.1,"%+$.%'-C,3%(8(#-,6.'-O3+6.-#2.3OO($-$6.3#21"(#+'.O",.+,3-+83#+."O.%(G3,.+&8",'.Q3,3.83+P.K";($(+6.Q-'.I3#3,-%%6.+,-#'(3#+E.-#2.+93.(#G3'+(I-+("#-%.+,3-+83#+.9-2.-$$31+-*%3.+"%3,-*(%(+6P.K93.'+&26.('.$"#+(#&(#I.+".-$$,&3.-+.[.'+&26.$3#+3,'.(#.+93.0=).(#.+Q".3;1-#'("#.$"9",+'.+".3;+3#2.-''3''83#+."O.'-O3+6.-#2.+93,-13&+($.-$+(G(+6.(#.8&%+(1%3.931-+($.+&8",.+613'P

C-&%.^._"%2O-,*E.^`E.a)!= ME.=-#>(G =.)I-,Q-%-E.^` WE.)%3;-#23,.=.B"'38&,I6E.^`E.a)!= Y -#2.:,($.).b-$9+3,E.C9` [

M.5#$"%"I6.)''"$(-+3'."O.=-#.`(3I".-#2.=9-,1.R3-%+9.!-,3E.=-#.`(3I"E.!).0=)]..W.=+.F&D3c'.!-#$3,.!3#+3,.-#2.K381%3.0#(G3,'(+6E.d3+9%3938E.C).0=)]..Y.a%",(2-.R"'1(+-%.K-81-E.K-81-E.aF.0=)]..-#2 [.C,"G3$+&'..d("19-,8-$3&+($-%'E.7#$PE.e#";G(%%3E.KS.0=) a",.-22(+("#-%.(#O",8-+("#f.(#O"g1G$+P$"8

)*'+,-$+.S"P.MXUYM./C"'+3,.?WW4!75.W?M\R"%%6Q""2E.aF..0=).....[JX.a3*,&-,6.W?M\

C3,$&+-#3"&'.B"'3.d3#I-%.-'.-#.5#$"%6+($ 788&#"+93,-16.O",.R31-+($.^3+-'+-'3'

+.*#)0&!)*+1-$.1$,2*+1 +((".$*0&#)!2 Q(+9.!3456! B3-2(%6.(8-I32.2,&I.23%(G3,6.2&3.+".,-2("1-$(+6 "O.CLJM?! 788&#"I3#($.$3%%.23-+9.-#2.+&8",J'13$(O($.-$+(G-+("#.1"+3#+(-%! 7#+,(I&(#I.%"#IJ+3,8.'&,G(G-%.23'1(+3.I,(8.1,"I#"'('.O",.83+-'+-+($.$"%",3$+-%.$-#$3,

K9('.*-'D3+.'+&26.('.23'(I#32.+".238"#'+,-+3.'-O3+6.-#2.,3%3G-#$3."O.CLJM?.O",.23'(I#."O.O&+&,3.,-#2"8(H32.'+&2(3'

*789:;-,:<=>?

#7@=A-!8=B78C-1D:787?E:->F-&G;87H7<7;:

!b-$9+3, 3+ -%PE =C7: W??W] [@W?f M[Y /%6'"'"8-% -$$&8&%-+("# -#2 +&8", $3%% 2(',&1+("# (# +(''&3 $&%+&,34! F(& 3+ -%PE 5#$"+-,I3+ W?M@] \f Y\UTY /8&,(#3 -#2 9&8-# KJ$3%% -$+(G-+("# -#2 +&8", 8($,"3#G(,"#83#+4! h(# 3+ -%PE !3%% `3-+9 -#2 `('3-'3 W?M\] Uf 3WXU[ /(88&#"I3#($ $3%% 23-+9 (# 8&,(#3 -#2 9&8-# $"%"# $-#$3,4

/7C-6-I6J-.>H-K656L

/7C-K5M-I5N-OP?-K655L

%E8::?=?9--IKM-$E;-K656L /7C-KJ-I6Q-/:E-K656L /7C-K56-I6Q-OP?-K655L

/7C-K56-I6Q-OP?-K655L%E8::?=?9--IKM-$E;-K656L

%E8::?=?9-I6K-.>H-K656L /7C-6-I6J .>H-K656L

/7C-KR-I6M-/:E-K656L/7C-M I5S-.>H-K656L

*789:;-,:<=>?'-KTS-EBU-=?V:E;:A->?E:-W=;X-YT5-B,-!3456

ZC<;7?A:8-,:<=>?<

! 1>?<=<;:?;-8:<@>?<:->[<:8H:A-=?-BPD;=@D:-;PB>8-B>A:D<-I:T9TU-B:D7?>B7U-011U-E>D>?U-[8:7<;U-@7?E8:7;=EL

!

"

"!

"!!

"#!!!

"!#!!!

"!!#!!!

"#!!!#!!!

! "!! $!! %!! &!! '!! (!! )!! *!!

+,-./-

01203,-45-6478

9:;<

=>2?@/A403:/45B1<

CDEF/.04!!!"

CDEF/.04!!!%

CDEF/.04!!!&

CDEF/.04!!!'

CDEF/.04!!!(

CDEF/.04!!!)

CDEF/.04!!!G

CDEF/.04!$!&

/7C-KJ-I6Q-/:E-K656L

!"!

#"!

$"!

%"!

&"!

'"!

()*+ (,*+ --*+ ./0/+ ()1+

23)4

!"!

!"#

$"!

$"#

%&'( %)'( **'( +,-,( %&.(

/0&1

#:A'-B1#1\-ZD7E]'-011-

%P[V:E;-6K6Q'--55TS-B,-!3456

%P[V:E;-6K6Y'--NT6-B,-!3456

%P[V:E;-666R'--6TY-B,-!3456

%P[V:E;-666Q'--YT5-B,-!3456

*87?<=:?;-&D:H7;=>?->F-,^*<-(7C-[:-$[<:8H:A

Recommended