Cite as: T. W. Linsky et al., Science
10.1126/science.abe0075 (2020).
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http://www.sciencemag.org/http://dx.doi.org/10.1038/s41586-020-2286-9http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32353859&dopt=Abstracthttp://dx.doi.org/10.1021/acscentsci.0c00272http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32226821&dopt=Abstracthttps://doi.org/10.1007/s40475-020-00201-6https://doi.org/10.1007/s40475-020-00201-6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32219057&dopt=Abstracthttp://dx.doi.org/10.1126/science.abc0870http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32753553&dopt=Abstracthttps://doi.org/10.1101/2020.04.16.045419http://dx.doi.org/10.1126/science.abd9909http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32907861&dopt=Abstracthttp://dx.doi.org/10.1126/science.abb3405http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32198291&dopt=Abstracthttp://dx.doi.org/10.1371/journal.ppat.1003760http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24348241&dopt=Abstracthttp://dx.doi.org/10.1371/journal.pbio.3000003http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30102691&dopt=Abstracthttp://dx.doi.org/10.1186/1471-2148-4-21http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15222897&dopt=Abstracthttp://dx.doi.org/10.1371/journal.ppat.1006271http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28288189&dopt=Abstracthttp://dx.doi.org/10.1016/j.meegid.2020.104260http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32092483&dopt=Abstracthttps://doi.org/10.1101/2020.06.20.161323http://dx.doi.org/10.1126/science.abd0831http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32540904&dopt=Abstracthttps://doi.org/10.1016/j.cell.2020.08.012https://pubmed.ncbi.nlm.nih.gov/32841599/http://dx.doi.org/10.1371/journal.pmed.0030237http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16796401&dopt=Abstracthttp://dx.doi.org/10.1073/pnas.0809524106http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19321428&dopt=Abstracthttp://dx.doi.org/10.1073/pnas.2003138117http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32376634&dopt=Abstracthttp://dx.doi.org/10.1073/pnas.1407087111http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25288733&dopt=Abstracthttp://dx.doi.org/10.1038/s41467-020-15562-9http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32221306&dopt=Abstracthttp://dx.doi.org/10.3390/v11010059http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30646565&dopt=Abstracthttp://dx.doi.org/10.1126/science.abb2762http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32132184&dopt=Abstracthttp://dx.doi.org/10.1016/j.cell.2020.03.045http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32275855&dopt=Abstracthttp://dx.doi.org/10.1038/s41586-020-2180-5http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32225176&dopt=Abstracthttp://dx.doi.org/10.1038/s41586-018-0830-7http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30626941&dopt=Abstracthttp://dx.doi.org/10.1126/science.aay5051http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32409444&dopt=Abstracthttp://dx.doi.org/10.1073/pnas.1908723117http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31892539&dopt=Abstracthttp://dx.doi.org/10.1016/j.cbpa.2020.02.002http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32371023&dopt=Abstracthttp://dx.doi.org/10.1016/B978-0-12-381270-4.00019-6http://dx.doi.org/10.1016/B978-0-12-381270-4.00019-6http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21187238&dopt=Abstracthttp://dx.doi.org/10.1002/wcms.1374http://science.sciencemag.org/
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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
Bjorkman, Michael Gale Jr., Luis M. Blancas-Mejia, Hui-Ling Yen and Daniel-Adriano SilvaYu-Ru Lin, Anna Josephson-Day, Ralph S. Baric, Deborah H. Fuller, Carl D. Walkey, Ted M. Ross, Ryan Swanson, Pamela J. Uland Y. Lau, Marsha L. Mason, Jerry Chen, Alex Chen, Tania Berrocal, Hong Peng, Nicole S. Clairmont, Javier Castellanos,Tien-Ying Hsiang, Katharina Esser-Nobis, Kevin Yu, Z. Beau Reneer, Yixuan J. Hou, Tanu Priya, Masaya Mitsumoto, Avery Pong, Thomas W. Linsky, Renan Vergara, Nuria Codina, Jorgen W. Nelson, Matthew J. Walker, Wen Su, Christopher O. Barnes,
published online November 5, 2020
ARTICLE TOOLS http://science.sciencemag.org/content/early/2020/11/04/science.abe0075
MATERIALSSUPPLEMENTARY http://science.sciencemag.org/content/suppl/2020/11/04/science.abe0075.DC1
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REFERENCES
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