CLINICAL REFERENCE LIST

CAS Medical Systems, Inc.

1

VALIDATION & TESTING

Validation & Testing

1. Benkwitz C, Janssen DR, Doyle TP. Accuracy performance of the FORE-SIGHT ELITE tissue oximeter in context with simultaneous vital sign recording in pediatric patients undergoing cardiac catheterization. Presented at the Congenital Cardiac Anesthesia Society 2015. Presented at Anesthesiology (ASA) 2015 #A2139.

2. Nasr V, Bergersen L, Benni PB, Bernier R, Anderson ME, Kussman BD. Validation of the FORE-SIGHT ELITE® pediatric tissue oximeter in children. Presented at the Annual Meeting of the Society of Cardiovascular Anesthesiologists 2015 A#16.

3. Kussman BD, Benni PB, Bergersen LT, Bernier R, Anderson ME, Nasr V. Validation of the FORE-SIGHT ELITE® tissue oximeter for measurement of somatic oxygenation in children. Presented at the Annual Meeting of the Society of Cardiovascular Anesthesiologists 2015 A#97.

4. Ikeda K, MacLeod DB, Grocott HP, Moretti EW, Ames W, Vacchiano C. The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation. Anesth Analg. 2014 Dec;119(6):1381-92.

5. MacLeod D, Ikeda K, Cheng C, Shaw A. Validation of the next generation FORE-SIGHT Elite Tissue Oximeter for adult cerebral tissue oxygen saturation. Anesth Analg. 2013; 116(SCA Suppl): 1-182.

6. Thompson A, Benni P, Seyhan S, Ehrenkranz R. Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants. Adv Exp Med Biol. 2013; 765:287-92.

7. Bickler PE, Feiner JR, Eilers H, Rollins M. Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers. Anesth Analg. 2013 Oct;117(4):813-23

8. Said M, Niforatos N, Rais-Bahrami K. Validation of near infrared spectroscopy to measure abdominal somatic tissue oxygen saturation in neonates. J Neonatal Perinatal Med. 2013;6(1):23-30.

9. Said M, Niforatos N, Rais-Bahrami K. Testing a new NIRS method to measure regional mesenteric tissue oxygen saturation in preterm infants that compensates for meconium and transitional stool interference. J Neonatal Perinatal Med 2012; 5(2):119-25.

10. Said M, Niforatos N, Rais-Bahrami K. Comparison of NIRS traditional vs stool compensating somatic algorithms when measuring abdominal tissue oxygen saturation on neonates ≤ 4kg. Presented at the Pediatric Academic Societies Meeting 2012 E-PAS2012:1534.581.

11. Kussman BD, Laussen PC, Benni PB, McElhinney DB, McGowan FX. Validation of the FORE-SIGHT Tissue Oximeter for measurement of somatic oxygenation in children. Presented at American Society of Anesthesiologists Annual Meeting 2011 #A1454.

12. Said M, Niforatos N, Rais-Bahrami K. Validation of flank NIRS somatic tissue oxygen saturation measurements on neonates 4 kg or less. Presented at the American Academy of Pediatrics 2010 #14989.

13. Zaouter C, Arbeid E. Influence of ambient light on cerebral oximeters. Br J Anaesth. 2010; 105(6):873-4.

14. Ing RJ, MacLeod DB, Ikeda K, Ames WA, Schulman SR. Measurement of absolute viscerosomatic tissue oxygen saturation: preliminary results. Presented at Society for Pediatric Anesthesia 2010.

15. Kussman BD, Laussen PC, Benni PB, McElhinney DB, McGowan FX. Validation of the FORE-SIGHT pediatric NIRS cerebral oximeter. Presented at American Society of Anesthesiologists 2009.

16. MacLeod DB, Ikeda K, Vacchiano C. Absolute and trending accuracy of FORE-SIGHT and INVOS cerebral oximeters in healthy volunteers. Presented at American Society of Anesthesiologists 2009.

17. MacLeod DB, Ikeda K, Vacchiano C. Simultaneous comparison of FORE-SIGHT and INVOS cerebral oximeters to jugular bulb and arterial CO-oximetry measurements in healthy volunteers. Anesth Analg. 2009; 108(SCA Suppl);1-104.

18. MacLeod DB, Ikeda K, Keifer JC, Moretti E, and Ames W. Validation of the CAS Adult Cerebral Oximeter during hypoxia in healthy volunteers. Anesth Analg. 2006; 102:S162.

19. Rais-Bahrami K, Rivera O, and Short BL. Validation of a noninvasive neonatal optical cerebral oximeter in veno-venous ECMO patients with a cephalad catheter. J Perinatol. 2006; 26(10):628-35.

20. Benni PB, Chen B, Dykes FD, Wagoner SF, Heard M, Tanner AJ, Young TL, Rais-Bahrami K, Rivera O, Short BL. Validation of the CAS neonatal NIRS system by monitoring vv-ECMO patients: preliminary results. Adv Exp Med Biol. 2005; 566:195-201.

21. Benni PB, Chen B, Dyckman W, Morgan E. Animal model validation of the CAS neonatal NIRS System, including effects of extracerebral interference. 31st Annual Meeting of the International Society on Oxygen Transport to Tissue, Rochester, New York, USA, August 2003.

Adult Applications

1. Meng L, Hall M, Settecase F, Higashida RT, Gelb AW. Monitoring cerebral tissue oxygen saturation at frontal and parietal regions during carotid artery stenting. J Anesth. 2016 Apr;30(2):340-4.

2. Trofimov AO, Kalentiev G, Voennov O, Grigoryeva V. Comparison of cerebral oxygen saturation and cerebral perfusion computed tomography in cerebral blood flow in patients with brain injury. Oxygen Transport to Tissue XXXVII. Volume 876 of the series Advances in Experimental Medicine and Biology pp 145-149. (2016)

CAS Medical Systems, Inc. 2

ADULT APPLICATIONS

3. Deschamps A, Hall R, Grocott H, et al. Cerebral oximetry monitoring to maintain normal cerebral oxygen saturation during high-risk cardiac surgery. A randomized controlled feasibility trial. Anesthesiology. 2016 Apr;124(4):826-36.

4. Loubser P. Utilization of cerebral and tissue oximetry during transcatheter aortic valve replacement. Presented at the Annual Meeting of the Society of Cardiovascular Anesthesiologists 2016 #113.

5. Eertmans W, Genbrugge C, Meex I, Dens J, Jans F, De Deyne C. The evolution of cerebral oxygen saturation in post-cardiac arrest patients treated with therapeutic hypothermia at 33°C. Presented at the International Symposium on Intensive Care and Emergency Medicine 2016.

6. Closhen D, Engelhard K, Dette F, Werner C, Schramm P. Changes in cerebral oxygen saturation following prone positioning for orthopaedic surgery under general anaesthesia: a prospective observational study. Eur J Anaesthesiol. 2015 Jun;32(6):381-6.

7. Hoogma D, Meyns B, Van Raemdonck D, Van de Velde M, Missant C, Rex S. Anesthetic management for resection of bilateral pulmonary artery sarcoma. A A Case Rep. 2015 Aug 15;5(4):64-8.

8. Heller JA, DeMaria S Jr, Govindaraj S, Lin HM, Fischer GW, Evans A, Weiner MM. Cerebral oximetry monitoring during sinus endoscopy. Laryngoscope 2015 Apr;125(4):E127-31.

9. Ameloot K, Genbrugge C, Meex I, Jans F, Boer W, Vander Laenen M, Ferdinande B, Mullens W, Dupont M, Dens J, DeDeyne C. An observational near-infrared spectroscopy study on cerebral autoregulation in post-cardiac arrest patients: Time to drop ‘one-size-fits-all’ hemodynamic targets? Resuscitation. 2015 May;90:121-6.

10. Ameloot K, Meex I, Genbrugge C, Jans F, Boer W, Verhaert D, Mullens W, Ferdinande B, Dupont M, De Deyne C, Dens J. Hemodynamic targets during therapeutic hypothermia after cardiac arrest: A prospective observational study. Resuscitation. 2015 Jun;91:56-62.

11. Ameloot K, Genbrugge C, Meex I, Janssens S, Boer W, Mullens W, Ferdinande B, Dupont M, Dens J, De Deyne C. Low hemoglobin levels are associated with lower cerebral saturations and poor outcome after cardiac arrest. Resuscitation. 2015 Nov;96:280-6.

12. Obraztsov MY, Kuzkov VV, Lenkin PI, Klyagin AA, Ivashchenko OY, Sokolova MM, Shemyakina NY, Grushitsyn AR, Gorenkov VM, Kirov MY. Monitoring of cerebral oxygenation and cognitive function in carotid endarterectomy: the role of transient bypass of carotid artery. [Article in Russian]. Anesteziol Reanimatol. 2015 May-Jun;60(3):43-8.

13. Naftalovich R, Pantin EJ, Denny JT. Cerebral oximetry decrease after external carotid clamping with normal electroencephalography and no change after internal carotid clamping. A A Case Rep. 2015 Dec 15;5(12):216-8.

14. Poterman M, Vos JJ, Vereecke HE, Struys MM, Vanoverschelde H, Scheeren TW, Kalmar AF. Differential effects of phenylephrine and norepinephrine on peripheral tissue oxygenation during general anaesthesia: A randomised controlled trial. Eur J Anaesthesiol. 2015 Aug;32(8):571-80.

15. Ni C, Xu T, Li N, Tian Y, Han Y, Xue Q, Li M, Guo X. Cerebral oxygen saturation after multiple perioperative influential factors predicts the occurrence of postoperative cognitive dysfunction. BMC Anesthesiol. 2015 Oct 26;15:156.

16. Kato S, Yoshitani K, Ohnishi Y. Impact of posture and extra cranial contamination on cerebral oximetry by near infrared spectroscopy. Presented at Anesthesiology (ASA) 2015 #A4261. Presented at the Society for Neuroscience in Anesthesiology and Critical Care 2015.

17. Meng L, Gelb A, Siegmueller C, Xiao J, Yu Z, Lieberman J, Feiner JR, Bickler PE. Correlation between blood pressure and tissue oxygenation measured on forehead and leg during posterior spinal fusion. Presented at Anesthesiology (ASA) 2015 #A1045.

18. Meng L, Xiao J, Yu Z. Effect of intra-arterial verapamil injection on cerebral tissue oxygen saturation in patients with cerebral vasospasm. Presented at Anesthesiology (ASA) 2015 #A2154.

19. Al-Badawi T, Witts S, Howell L, Rozario C, Hartley M, TangA. Cerebral oximetry and cardiac output monitoring during OPCAB Safeguarding heart and mind. Presented at the Society for Cardiothoracic Surgery in Great Britain & Ireland 2015.

20. Deiner S, Chu I, Mahanian M, Lin HM, Hecht AC, Silverstein JH. Prone position is associated with mild cerebral oxygen desaturation in elderly surgical patients. PLoS One. 2014 Sep 12;9(9):e106387.

21. Closhen D, Treiber AH, Berres M, Sebastiani A, Werner C, Engelhard K, Schramm P. Robotic assisted prostatic surgery in the Trendelenburg position does not impair cerebral oxygenation measured using two different monitors: A clinical observational study. Eur J. Anaesthesiol. 2014;31:104-109.

22. Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Shear TD, Vender JS, Levin SD, Koh JL, Parikh KN, Patel SS. Effect of ventilation on cerebral oxygenation in patients undergoing surgery in the beach chair position: a randomized controlled trial. Br J Anaesth. 2014 Oct;113(4):618-27.

23. Davies D , Clancy M, Su Z, Denghani H , Belli A. Choosing a cerebral near-infrared spectroscopy system for use in traumatic brain injury: deriving the ideal source detector layout. Critical Care. 2014, 18(Suppl 1):P468.

24. Rajagopal R, More RS, Roberts DH. Transcatheter aortic valve implantation through a transcarotid approach under local anesthesia. Catheter Cardiovasc Interv. 2014 Nov 15;84(6):903-7.

25. Desebbe O, Faulcon C, Henaine R, Tran L, Koffel C, Delannoy B, Lehot JJ, Bastien O, Maucort-Boulch D. Tissue hemoglobin monitoring is unable to follow variations of arterial hemoglobin during transitions from pulsatile to constant flow in cardiac surgery. J Cardiothorac Vasc Anesth. 2014 Jun;28(3):668-73.

CAS Medical Systems, Inc.3

26. Feldmeier C, Pitcher H, Hirose H, Cavarocchi N. Relative vs. absolute cerebral oximetry: does a skin pigmentation effect normal values on cardiopulmonary support? Austin J Surg. 2014;1(1): 1003.

27. Bouzat P, Suys T, Sala N, Oddo M. Effect of moderate hyperventilation and induced hypertension on cerebral tissue oxygenation after cardiac arrest and therapeutic hypothermia. Resuscitation. 2013 Nov;84(11):1540-5.

28. Closhen D, Berres M, Werner C, Engelhard K, Schramm P. Influence of beach chair position on cerebral oxygen saturation: a comparison of INVOS and FORE-SIGHT cerebral oximeter. J Neurosurg Anesthesiol. 2013 Oct;25(4):414-9.

29. Closhen D, Hagen F, Gööck T, Schramm P, Engelhard K, Tzanova I. Changes in regional cerebral oxygen saturation and cardiac output during sitting position in neurosurgical patients. Presented at the Society for Neuroscience in Anesthesiology and Critical Care 2013.

30. Brooker B, Douglas Ririe P. Multimodal blood conservation reduces intraoperative transfusion in a community-based cardiac surgery practice. Presented at American Society of Anesthesiologists 2013 #A2275.

31. Brinkman R, Amadeo RJ, Funk DJ, Girling LG, Grocott HP, Mutch WA. Cerebral oxygen desaturation during one-lung ventilation: correlation with hemodynamic variables. Can J Anaesth. 2013 Jul;60(7):660-6.

32. Genbrugge C, Dens J, Meex I, Boer W, Jans F, De Deyne C. Cerebral saturation monitoring during cardiopulmonary resuscitation should be used as dynamic, rather than static, information. Resuscitation. 2013 Sep;84(9):e111-2.

33. Meex I, De Deyne C, Dens J, Scheyltjens S, Lathouwers K, Boer W, Vundelinckx G, Heylen R, Jans F. Feasibility of absolute cerebral tissue oxygen saturation during cardiopulmonary resuscitation. Crit Care. 2013 Mar 1;17(2):R36.

34. Meex I, Dens J, Jans F, Boer W, Vanhengel K, Vundelinckx G, Heylen R, De Deyne C. Cerebral tissue oxygen saturation during therapeutic hypothermia in post-cardiac arrest patients. Resuscitation. 2013 Jun;84(6):788-93.

35. De Deyne C, Meex I, Jans F, Engelen K, Gutermann H, Dens J. Non-invasive monitoring of cerebral perfusion during transcatheter aortic valve implantation procedure. Am J Cardiol. 2013; 111(2):302.

36. Lenkin AI, Zaharov VI, Lenkin PI, Smetkin AA, Bjertnaes LJ, Kirov MY. Normothermic cardiopulmonary bypass increases cerebral tissue oxygenation during combined valve surgery: single-centre, randomized trial. Interact Cardiovasc Thorac Surg. 2013; 16(5):595-601.

37. Taccone FS, Fagnoul D, Rondelet B, Vincent JL, de Backer D. Cerebral oximetry during extracorporeal cardiopulmonary resuscitation. Critical Care. 2013;17(1):409-10.

38. Taccone FS, Vincent JL, de Backer D. Cerebral oximetry to adjust cerebral and systemic circulation after cardiac arrest. Intensive Care Med. 2013; 39(5):970-1.

39. Miller MA, Dukkipati SR, Chinitz JS, Koruth JS, Mittnacht AJ, Napolitano C, d’Avila A, Reddy VY. Percutaneous hemodynamic support with Impella 2.5 during scar-related ventricular tachycardia ablation (PERMIT 1). Circ Arrhythm Electrophysiol. 2013; 6(1):151-9.

40. Mutch WA, Patel SR, Shahidi AM, Kulasekara SI, Fisher JA, Duffin J, Hudson C. Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia. PLoS One. 2013;8(2):e57881.

41. Greenberg SB, Murphy G, Alexander J, Fasanella R, Garcia A, Vender J. Cerebral desaturation events in the intensive care unit following cardiac surgery. J Crit Care. 2013; 28(3):270-6.

42. Moerman A, Vandenplas G, Bové T, Wouters PF, De Hert SG. Relation between mixed venous oxygen saturation and cerebral oxygen saturation measured by absolute and relative near-infrared spectroscopy during off-pump coronary artery bypass grafting. Br J Anaesth. 2013; 110(2):258-65.

43. Koh JL, Levin SD, Chehab EL, Murphy GS. Neer Award 2012: cerebral oxygenation in the beach chair position: a prospective study on the effect of general anesthesia compared with regional anesthesia and sedation. J Shoulder Elbow Surg. 2013 Oct;22(10):1325-31.

44. Wagner H, Madsen-Hardig B, Rundgren M, Harnek J, Gotberg M, Olivecrona GK. Cerebral oximetry during prolonged cardiac arrest and percutaneous coronary intervention: a report on five cases. ICU Director. 2012 Dec 11. [Epub ahead of print]

45. Frost EA. Cerebral oximetry: a replacement for pulse oximetry? Middle East J Anesthesiol. 2012 Oct;21(6):807-13.

46. Philipsen TE, Rodrigus IE, Claeys MJ, Bosmans JM. Alternative access in transcatheter aortic valve implantation: brachiocephalic artery access. Innovations (Phila). 2012 Sep-Oct;7(5):372-5.

47. Rifai L, Key K, Taylor W, Silver MA. Safety and prognostic value of cerebral oximetry monitoring in heart failure patients during cardiopulmonary exercise. J Card Fail. 2012; 18(12):S3.

48. Allen TK, White WD, Mishriky B, Habib AS. The effect of phenylephrine administration on maternal cerebral tissue oxygenation following spinal anesthesia for cesarean delivery. Presented at American Society of Anesthesiologists Annual Meeting 2012 #A134.

49. Deiner SG, Silverstein JH, Sano M. The geriatric surgical patient: stress, anesthetics, and functional outcomes. Presented at American Society of Anesthesiologists Annual Meeting 2012 #A146.

50. Absalom AR, van Harten A, Aarden EL, Kok LF, Scheeren TW. Intraoperative cerebral tissue oxygenation and postoperative cognitive dysfunction after on- and off-pump coronary artery bypass surgery. Presented at American Society of Anesthesiologists Annual Meeting 2012 #A265.

ADULT APPLICATIONS

CAS Medical Systems, Inc. 4

51. Kalmar AF, Poterman M, Mooyaart EA, Jan Vos J, Struys MMRF, Scheeren TWL. Effect of atropine, norepinephrine and phenylephrine on cerebral oxygenation and cardiac output during anesthesia. Presented at American Society of Anesthesiologists Annual Meeting 2012 #A840.

52. Lathouwers K. The speed of deceleration of NIRS predicts the need for shunting for CEA. J Neurosurg Anesthesiol. 2012; 24(4):482.

53. Meex I, Dens J, Jans F, De Deyne C. Is there a relation between cerebral oxygenation after cardiac arrest and outcome? Eur J Anaesthesiol. 2012; 29(Suppl 50):3AP4-10.

54. Meex I, Dens J, Jans F, De Deyne C. NIRS cerebral oxygenation monitoring during induction of therapeutic hypothermia after cardiac arrest. Eur J Anaesthesiol. 2012; 29(Suppl 50):4AP1-8.

55. Meex I, Dens J, Jans F, Gutherman H, De Deyne C. NIRS cerebral oxygenation monitoring during transcutaneous aortic valve implant. Eur J Anaesthesiol. 2012; 29(Suppl 50):4AP1-10.

56. Lenkin A, Zaharov V, Lenkin P, Smetkin A, Kirov M. Normothermic cardiopulmonary bypass increases cerebral oxygenation during combined valve surgery. Eur J Anaesthesiol. 2012; 29(Suppl 50):4AP7-1.

57. Meex I, Dens J, Jans F, De Deyne C. Decrease in cerebral oxygenation at induction of therapeutic hypothermia seems related to decreased arterial CO2 tension. Eur J Anaesthesiol. 2012; 29(Suppl 50):13AP2-6.

58. Taussky P, O’Neal B, Daugherty WP, Luke S, Thorpe D, Pooley RA, Evans C, Hanel RA, Freeman WD. Validation of frontal near-infrared spectroscopy as noninvasive bedside monitoring for regional cerebral blood flow in brain-injured patients. Neurosurg Focus. 2012;32(2):E2.

59. Grocott HP. Monitoring the brain in cardiac surgery – an evolving area for research. Anaesthesia. 2012; 67(3):216-9.

60. Bilal RH, Augustine T, Hartley M, Humphries C, Roberts S, Moore R, Sogliani F. Cerebral oximetry monitoring during transcatheter aortic valve implantation (TAVI). Presented at 2012 International Society for Minimally Invasive Cardiothoracic Surgery.

61. Tang L, Kazan R, Taddei R, Zaouter C, Cyr S, Hemmerling TM. Reduced cerebral oxygen saturation during thoracic surgery predicts early postoperative cognitive dysfunction. Br J Anaesth. 2012; 108(4):623-9.

62. Rifai L Taylor W, Key K, Silver MA. Safety and prognostic value of cerebral oximetry monitoring in heart failure patients during cardiopulmonary exercise. J Heart Lung Transplant. 2012; 31(4S):S51-2.

63. Rifai L Taylor W, Key K, Silver MA. Rest cerebral oxygenation is a biomarker in heart failure patients. J Heart Lung Transplant. 2012; 31(4S):S153-4.

64. Caetano M, Campos M, Lima F. Processed EEG data and cerebral non-invasive oximetry(CNIO) in percutaneous aortic bioprosthesis implantation(PABI). Presented at Society of Cardiovascular Anesthesiologists’s 34th Annual Meeting.

65. Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion. 2012; 52(11):2459-64.

66. Rifai L, Winters J, Friedman E, Silver MA. Initial description of cerebral oximetry measurement in heart failure patients. Congest Heart Fail. 2012; 18(2):85-90.

67. Kirov MY, Lenkin AI, Zaharov VI, Paromov KV, Smetkin AA, Slastilin VY. Relationship of cerebral oxygenation and oxygen transport in complex valve surgery. Br J Anaesth. 2012; 108 (S2): ii114-5.

68. Ianchulev S, Bogdanov E. Comparison of near-infrared spectrometers INVOS 5100 and FORE-SIGHT in cardiac surgery patients. Presented at Society of Cardiovascular Anesthesiologists’s 17th Annual Update on Cardiopulmonary Bypass.

69. Miller MA, Dukkipati SR, Koruth JS, d’Avila A, Reddy VY. How to perform ventricular tachycardia ablation with a percutaneous left ventricular assist device. Heart Rhythm. 2012; 9(7):1168-76.

70. Weiner MM, Fischer GW, Rosenblatt MA. The beach-chair position and general anesthesia. Reg Anesth Pain Med. 2012; 37(1):120.

71. Weatherall A, Skowno J, Lansdown A, Lupton T, Garner A. Feasibility of cerebral near-infrared spectroscopy monitoring in the pre-hospital environment. Acta Anaesthesiol Scand. 2012; 56(2):172-7.

72. Wagner H Rundgren M, Harnek J, Götberg M, Olivecrona GK, and Madsen Hardig B. Cerebral oximetry showed Mechanical CPR effective and may be a useful indicator for CPR quality during simultaneous percutaneous coronary intervention. Crit Care Med. 2011; 39(Suppl 12):255.

73. L. Feddy, H. Saunders and M. Hartley. Cerebral oximetry use and interventions in 100 cardiac cases. Abstract presented at the Association of Cardiothoracic Anaesthetists(UK) 2011.

74. Murphy GS, Szokol JW. Blood pressure management during beach chair position shoulder surgery: what do we know? Can J Anaesth. 2011; 58(11):977-82.

75. Miller MA, Dukkipati SR, Mittnacht AJ, Chinitz JS, Belliveau L, Koruth JS, Gomes JA, d’Avila A, Reddy VY. Activation and entrainment mapping of hemodynamically unstable ventricular tachycardia using a percutaneous left ventricular assist device. J Am Coll Cardiol. 2011; 58(13):1363-71.

ADULT APPLICATIONS

CAS Medical Systems, Inc.

5

76. Lathouwers K, De Deyne C, Jans F, Meex I, De Sloovere V, Heylen R. Non-invasive monitoring of absolute cerebral tissue oxygen saturation (FORE-SIGHT technology) in healthy volunteers. Presented at Society of Neurosurgical Anesthesia and Critical Care 2011.

77. Lathouwers K, De Deyne C, Jans F, Meex I, De Sloovere V, Heylen R. Monitoring of effect of supplemental oxygen administration during locoregional anesthesia on cerebral oxygenation as measured by NIRS (FORE-SIGHT technology). Presented at Society of Neurosurgical Anesthesia and Critical Care 2011.

78. Meex I, De Deyne C, Jans F, Dens J, Lathouwers K, Heylen R. Cerebral oxygenation measured by NIRS Fore-Sight technology reveals adequacy of cerebral perfusion during cardiopulmonary resuscitation. Presented at Society of Neurosurgical Anesthesia and Critical Care 2011.

79. Meex I, De Deyne C, Dens J, Lathouwers K, Heylen R. Shivering during induced hypothermia after cardiac arrest results in significant decrease in non-invasive cerebral oxygen saturation, as measured by near infrared spectroscopy. Presented at Society of Neurosurgical Anesthesia and Critical Care 2011.

80. Rifai L, Winters J, Friedman E, Silver MA. Initial Description of cerebral oximetry measurement in heart failure patients. Southern regional meeting abstracts. J Investig Med. 2011; 59(2):501.

81. Fischer GW, Lin H-M, Krol M, Galati MF, DiLuozzo G, Griepp RB, Reich DL. Noninvasive cerebral oxygenation may predict outcome in patients undergoing aortic arch surgery. J Thorac Cardiovasc Surg. 2011; 141(3):815-21.

82. Faulkner J, Hartley M, Tang A. Using cerebral oximetry to prevent adverse outcomes during cardiac surgery. Perfusion. 2011; 26(2):79-81.

83. Greenberg S, Garcia A, Howard L, Fasanella R, Vender J. Incidence of cerebral desaturation events in the ICU following cardiac surgery. Critical Care. 2011; 15(Suppl 1):P9.

84. Hassan MA, Rozario C, Elsayed H, Morcos K, Millner R. A novel application of cerebral oximetry in cardiac surgery. Ann Thorac Surg. 2010; 90(5):1700-1.

85. Martens PR, Dhaese HL, Van den Brande FG, Van Laecke SM. External cardiac massage improved cerebral tissue oxygenation shown by near-infrared spectroscopy during transcatheter aortic valve implantation. Resuscitation. 2010; 81(11):1590-1.

86. Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr. Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass. Stroke. 2010; 41(9):1951-6.

87. Highton D, Elwell C, Smith M. Noninvasive cerebral oximetry: is there light at the end of the tunnel? Curr Opin Anaesthesiol. 2010; 23(5):576-81.

88. Henick WP, Mathews DM, Mellor A, Reich NT, Neuman GG. Phenylephrine bolus given to treat hypotension decreases cerebral oxygen saturation. Presented at American Society of Anesthesiologists Annual Meeting 2010 #A396.

89. Cordisco M, Newberger J, Shann KG, Mellas NB. Diagnosis of inadvertent cannulation of the azygos vein during cardiopulmonary bypass. J Extra Corpor Technol. 2010 Sep;42(3):235-7.

90. De Naeyer S, De Deyne C, Lansink W, Vercauteren M, Heylen R. Non-invasive absolute cerebral oximetry (FORE-SIGHT Technology) during carotid endarterectomy. Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP6-10.

91. Hemmerling TM, Tang L, Arbeid E, Zaouter C. Decrease of cerebral oxygen saturation in prone position during spine surgery measured by absolute cerebral oximetry. Presented at American Society of Anesthesiologists Annual Meeting 2010 #LB07.

92. Weiner MM, Fischer GW, Torillo TM, Lin HM, Rosenblatt MA. The effect of anesthetic technique on cerebral oxygenation in the beach chair position. Presented at American Society of Anesthesiologists Annual Meeting 2010 #A1532.

93. Vundelinckx J, De Sloovere V, Dylst D, Heylen R, De Deyne CS. Non-invasive cerebral oxygen saturation during beach chair positioning in healthy volunteers. Presented at American Society of Anesthesiologists Annual Meeting 2010 #A1686.

94. De Burghgraeve F, De Deyne CS, De Sloovere V, Jans F, Heylen R. Beach chair positioning results in significantly lower cerebral oxygen saturations. Presented at American Society of Anesthesiologists Annual Meeting 2010 #1688.

95. Espenell AE, McIntyre IW, Gulati H, Girling LG, Wilkinson MF, Silvaggio JA, Koulack J, West M, Harding GE, Kaufmann AM, Mutch WA. Lactate flux during carotid endarterectomy under general anesthesia: correlation with various point-of-care monitors. Can J Anesth. 2010; 57(10):903-12.

96. Kalmar AF, Foubert L, Hendrickx JFA, Mottrie A, Absalom A, Mortier EP, Struys MM. Influence of steep trendelenburg position and CO2 pneumoperitoneum on cardiovascular, cerebrovascular, and respiratory homeostasis during robotic prostatectomy. Br J Anaesth. 2010; 104(4):433-9.

97. Murphy GS, Szokol JW, Vaughn JA, et al. Cerebral oxygen desaturation events assessed by near-infrared spectroscopy during shoulder arthroscopy in ‚ the beach chair and lateral decubitus positions. Anesth Analg. 2010; 111(2):496-5.

98. De Burghgraeve F, De Deyne C, Truijen J, Vandermeersch E, Heylen R. Cerebrovascular reactivity (by CO2 challenge) can be monitored by non-invasive absolute cerebral oxygen saturation (FORE-SIGHT Technology). Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP8-4.

99. De Burghgraeve F, De Deyne C, Oosterbosch J, Vandermeersch E, Heylen R. Monitoring of absolute cerebral oxygen saturation (FORE-SIGHT Technology) during endoscopic shoulder surgery: beach chair positioning or conventional side positioning. Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP8-1.

ADULT APPLICATIONS

CAS Medical Systems, Inc. 6

100. Ramakers F, De Deyne C, Jans F, Vandermeersch E, Heylen R. New technology of non-invasive cerebral oximetry (FORE-SIGHT Technology) to monitor cerebral perfusion during resuscitation from cardiac arrest (CPR). Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP6-11.

101. De Naeyer S, De Deyne CS, Lathouwers K, De Sloovere V, Heylen R. Non-invasive absolute cerebral oximetry and intraluminal shunting during carotid endarterectomy. Presented at American Society of Anesthesiologists Annual Meeting 2010 # A398.

102. Beran M, De Deyne C, Lauwers G, Jans F, Heylen R. Postoperative monitoring of non-invasive cerebral oxygen saturation after carotid endarterectomy. Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP8-3.

103. Prihadi E, De Deyne C, Truijen J, Jans F, Heylen R. Acute peripheral oxygen desaturation does not result in significant decreases in cerebral oxygen saturation. Eur J Anaesthesiol. 2010; 27(Suppl 47):7AP4-7.

104. De Naeyer S, De Deyne C, Jans F, Vercauteren M, Heylen R. Monitoring of absolute cerebral oxygen saturation during induction of general anesthesia. Eur J Anaesthesiol. 2010; 27(Suppl 47):3AP8-2.

105. Fischer GW, Benni PB, Lin H-M, Satyapriya A, Afonso A, DiLuozzo G, Griepp RB, Reich DL. Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest. Br J Anaesth. 2010; 104(1):59-66.

106. Joshi B, Brady K, Lee J, Easley B, Panigrahi R, Smielewski P, Czosnyka M, Hogue CW Jr. Impaired autoregulation of cerebral blood flow during rewarming from hypothermic cardiopulmonary bypass and its potential association with stroke. Anesth Analg. 2010; 110(2):321-8.

107. Kazan R, Bracco D, Hemmerling TM. Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications. Br J Anaesth. 2009; 103(6):811-16.

108. Lathouwers KM, De Deyne CS, Mestrum R, Lauwers G, Heylen RJ. Non-invasive absolute cerebral oximetry (FORE-SIGHT) during shunting procedure for carotid surgery. Presented at American Society of Anesthesiologists 2009.

109. Brijen L, Joshi BL, Brady K, Hogue CW. Real time monitoring of cerebral blood flow autoregulation with NIRS during cardiac surgery. Presented at American Society of Anesthesiologists 2009.

110. Lathouwers KM, De Deyne CS, Lansink W, Mestrum R, Heylen RJ. Non-invasive absolute cerebral oximetry (FORE-SIGHT) during carotid endarterectomy. Presented at American Society of Anesthesiologists 2009.

111. Lathouwers KM, De Deyne CS, Jans F, Truijen J, Heylen RJ. Absolute cerebral oximetry (FORE-SIGHT) in beach chair positioning for shoulder surgery. Presented at American Society of Anesthesiologists 2009.

112. De Deyne CS, Wuyts J, De Sloovere V, Jans F, Peuskens D, Daenekindt T, Heylen RJ. Non-invasive monitoring of brain oxygen saturation during temporary clipping applied for complex cerebral aneurysm surgery. Presented at Society of Neurosurgical Anesthesia and Critical Care 2009.

113. De Deyne CS, Mestrum R, Lansink W, Lathouwers K, Jans F, Lauwers G, Schroe H, Heylen RJ. Non-invasive absolute cerebral oximetry: a new guide during carotid endarterectomy? Presented at Society of Neurosurgical Anesthesia and Critical Care 2009.

114. De Sloovere V, De Deyne CS, Wuyts J, Peuskens D, Deckers J, Daenekindt T, Weyns F, Jans F, Heylen RJ. Minimal invasive supra-orbital incision for cerebral aneurysm clipping: implications for anesthesia management. Presented at Society of Neurosurgical Anesthesia and Critical Care 2009.

115. Sterken J, De Deyne CS, Lansink W, Lauwers G, Lathouwers K, Vander Laenen M, Jans F, Heylen RJ. Monitoring of non-invasive absolute brain oxygen saturation to detect cerebral hyperperfusion after carotid endarterectomy. ESICM 2009: A-193-0046-01706.

116. D’Haeseleer K, De Deyne CS, Wuyts J, Peukens D, Vander Laenen M, Jans F, Heylen R. Non-invasive monitoring of brain oxygenation for complex cerebral aneurysm surgery. ESICM 2009: A-193-0028-01697.

117. Vanden Boer S, De Deyne CS, Weyns F, Daenekindt T, Jans F, Vander Laenen M, Heylen R. Monitoring of absolute cerebral oxygen saturation during craniotomy for acute intracerebral bleeding. ESICM 2009: A-193-0027-01705.

118. Lathouwers KM, De Deyne CS, Jans F, Crits T, Vundelinckx G, Heylen RJ. New technology of non-invasive cerebral oximetry to assess cerebral perfusion during resuscitation from cardiac arrest (CPR). Presented at the 5th Mediterranean Emergency Medicine Conference.

119. Lamote S, De Deyne CS, Lansink W, Jans F, Heylen R. Non-invasive monitoring of absolute cerebral oxygen saturation during elective shunting procedure for carotid endarterectomy. Eur J Anaesthesiol. 2009; 26 (Suppl 45):3AP6-9.

120. Dylst D, De Deyne CS, Weyns F, Jans F, Heylen R. Monitoring of absolute cerebral oxygen saturation during craniotomy for acute intracerebral bleeding. Eur J Anaesthesiol. 2009; 26(Suppl 45):7AP5-6.

121. Somers R, De Deyne CS, Jans F, Oosterbosch J, Heylen R. Monitoring of absolute cerebral oxygen saturation during endoscopic shoulder surgery: Benchchair positioning compared to conventional positioning. Eur J Anaesthesiol. 2009; 26(Suppl 45):3AP6-11.

122. Bertrand I, De Deyne CS, Wuyts J, Jans F, Heylen R. Monitoring of brain oxygenation during complex cerebral aneurysm surgery by FORE-SIGHT. Eur J Anaesthesiol. 2009; 26(Suppl 45):7AP5-8.

ADULT APPLICATIONS

CAS Medical Systems, Inc.7

123. De Troy E, De Deyne CS, Vanderspeeten K, Jans F, Heylen R. Monitoring of brain oxygenation during hyperthermic intraperitoneal chemotherapy (HIPEC) procedures. Eur J Anaesthesiol. 2009; 26(Suppl 45):3AP6-10.

124. Alfonso A, Fischer GW. Influence of positional changes on SctO2 and CBV. Presented at Outcomes 2009: “The Key West Meeting”.

125. Weiner M, Fischer GW, Torillo T, Jeng C, Rosenblatt MA. Cerebral oximetry monitoring in patients undergoing surgery with regional anesthesia in the beach chair position. Presented at Outcomes 2009: “The Key West Meeting”.

126. Fischer GW, Lin HM, DiLuozzo G, Griepp RB, Reich DL. Decreased cerebral tissue oxygen saturation during aortic surgery increases length of stay. Presented at Outcomes 2009: “The Key West Meeting”.

127. Fischer GW, Torrillo TM, Weiner MM, Rosenblatt MA. The use of cerebral oximetry as a monitor of the adequacy of cerebral perfusion in a patient undergoing shoulder surgery in the beach chair position. Pain Pract. 2009; 9(4):304-7.

128. MacLeod DB, White W, Newman MF, Ikeda K, Mathew JP. Decreased forebrain cerebral tissue oxygen saturation is associated with cognitive decline after cardiac surgery. Anesth Analg. 2009; 108(SCA Suppl);1-104.

129. Fischer GW, Lin HM, DiLuozzo G, Griepp RB, Reich DL. Decreased cerebral tissue oxygen saturation during aortic surgery increases risk of post-op complications. Anesth Analg. 2009; 108(SCA Suppl);1-104.

130. Joshi B, Brady K, Stearns J, Hogue C. Continuous monitoring of cerebral blood flow autoregulation during cardiac surgery in adults with near infra-red Spectroscopy: preliminary results. Anesth Analg. 2009; 108(SCA Suppl);1-104.

131. Fischer GW, Stone M. Cerebral air embolism recognized by cerebral oximetry. Semin Cardiothorac Vasc Anesth. 2009; 13(1):56-9.

132. Hemmerling TM, Kazan R, Bracco D. Inter-hemispheric cerebral saturation differences during thoracic surgery with lateral head positioning. Br J Anaesth. 2009; 102(1):141-2.

133. Hemmerling TM, Bluteau MC, Kazan R, Bracco D. Significant decrease of cerebral oxygen saturation during single lung ventilation measured using absolute oximetry. Br J Anaesth. 2008 Dec;101(6):870-5.

134. Hemmerling TM, Kazan R, Bluteau M, D Bracco. Unilateral ventilation during gastroesophagectomy detected by absolute cerebral oximetry. Anesth Analg. 2008; 106;S-7.

135. Fischer GW. Recent advances in application of cerebral oximetry in adult cardiovascular surgery. Semin Cardiothorac Vasc Anesth. 2008 Mar;12(1):60-9.

136. MacLeod D, Ikeda K, White W. Relationship of cerebral oximetry measured hemoglobin per volume of tissue to arterial blood hemoglobin. Anesth Analg. 2008; 106;S-120.

137. Fischer GW, Reich DL. FORE-SIGHT Cerebral Oximeter: a possible solution to Methylene Blue interference. Anesthesiology. 2008; 109 A251.

138. MacLeod DB, Ikeda K, White W, Keifer JC, Moretti E. Pilot study of FORE-SIGHT Cerebral Oximeter in cardiac patients. Anesth Analg. 2007; 104:S-129.

139. Fischer GW, Reich D, Plestis KA, Griepp RB. Results utilizing absolute cerebral oximetry monitoring suggest the need for tailored patient management during cardiac surgery. Departments of Anesthesiology and Cardiothoracic Surgery, Mount Sinai Medical Center, New York, NY, USA. Presented at the Outcomes 2006: “The Key West Meeting”.

140. Fischer GW, Reich D, Plestis KA, Griepp RB. The application of absolute cerebral oximetry during aortic surgery. Departments of Anesthesiology and Cardiothoracic Surgery, Mount Sinai Medical Center, New York, NY, USA. Anesthesiology. 2006; 105:A430.

141. MacLeod DB, Ikeda K, Moretti E, Keifer JC, Grocott H. Using the CAS Cerebral Oximeter to estimate cerebral venous oxygen saturation. Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. Anesthesiology. 2005; 103:A16.

Pediatric / Neonatal Applications

1. Cetin M, Birbicer H, Hallioglu O, Orekeci G. Comparative study between the effects of dexmedetomidine and propofol on cerebral oxygenation during sedation at pediatric cardiac catheterization. Ann Card Anaesth. 2016 Jan-Mar;19(1):20-4.

2. El-Dib M, Aly S, Govindan R, Mohamed M, du Plessis A, Aly H. Brain maturity and variation of oxygen extraction in premature infants. Am J Perinatol. 2016 Feb 23. [Epub ahead of print].

3. Gagnon MH, Wintermark P. Effect of persistent pulmonary hypertension on brain oxygenation in asphyxiated term newborns treated with hypothermia. The Journal of Maternal-Fetal & Neonatal Medicine. 2016; 29(13):2049-55.

4. Hu Z, Xu L, Zhu Z, Seal R, McQuillan PM. Effects of hypothermic cardiopulmonary bypass on internal jugular bulb venous oxygen saturation, cerebral oxygen saturation, and bispectral index in pediatric patients undergoing cardiac surgery: a prospective study. Medicine (Baltimore). 2016 Jan;95(2):e2483.

5. Peng S, Boudes E , Tan X, Saint-Martin C, Shevell M, Wintermark P. Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment? Am J Perinatol. 2015 May;32(6):555-64.

6. Zamora IJ, Stoll B, Ethun CG, Sheikh F, Yu L, Burrin DG, Brandt ML, Olutoye OO. Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis. PLoS One. 2015 Jun 10;10(6):e0125437.

ADULT APPLICATIONS

CAS Medical Systems, Inc. 8

PEDIATRIC / NEONATAL APPLICATIONS

7. White LT, Said MM, Rais-Bahrami K. Monitoring mesenteric tissue oxygenation with near-infrared spectroscopy (NIRS) during packed red blood cell transfusion in preterm infants. J Neonatal Perinatal Med. 2015;8(2):157-63.

8. Sebastian R, Cohen A, Hodge A, McKee C, Tobias J, Galantowicz M, Naguib AN. Changes in cerebral oxygen saturation during retrograde arterial prime (RAP) and venous antegrade prime (VAP) in children undergoing cardiac surgery requiring cardio-pulmonary bypass (CPB). Presented at Anesthesiology (ASA) 2015 #A4050.

9. Delrue H, Guiza F, Vlasselaers D, Fivez T, Desmet L, Van den Berghe G, Meyfroidt G. The value of the FORE-SIGHT™ monitor in the postoperative phase after congenital cardiac surgery. A descriptive statistical interim-analysis. Presented at the European Society of Intensive Care Medicine 2015.

10. Waitz M, Schmid MB, Fuchs H, Mendler MR, Dreyhaupt J, Hummler HD. Effects of automated adjustment of the inspired oxygen on fluctuations of arterial and regional cerebral tissue oxygenation in preterm infants with frequent desaturations. J Pediatr. 2015 Feb;166(2):240-4.

11. Steve M. Liao, Henry Chen, Zachary Vesoulis, Amit M. Mathur. Bilateral cerebral tissue oxygen saturation monitoring in very preterm infants. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:4123.178.

12. Franklin A, Kimura R. Increase in splanchnic fractional extraction of oxygen (FEO) in anemic very low birthweight (VLBW) infants is decreased by transfusion (Tx): A potential indication for Tx. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:3850.75.

13. Akotia D, Durham J, Petruzzelli D, Arnell K, Katheria AC. Abdominal ultrasound and near infrared spectroscopy to evaluate intestinal function. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:4190.677.

14. Katheria AC , Sauberan JB, Akotia D, Rich W, Durham J, Finer NN. A pilot randomized controlled trial of early versus routine caffeine in extremely premature infants. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:2790.3.

15. Vesoulis ZA, Liao SM, Mathur AM. A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:4122.169.

16. Vesoulis ZA, Liao SM, Mathur AM. Transfer function analysis of cerebral autoregulation in preterm infants with intraventricular hemorrhage. Presented at the Pediatric Academic Societies Meeting 2015 E-PAS2015:4122.170.

17. Katheria AC, Sauberan JB, Akotia D, Rich W, Durham J, Finer NN. A pilot randomized controlled trial of early versus routine caffeine in extremely premature infants. Am J Perinatol. 2015 Jul;32(9):879-86.

18. Kozár M, Javorka K, Javorka M, Matasová K, Zibolen M. Changes of cardiovascular regulation during rewarming in newborns undergoing whole-body hypothermia. Neuro Endocrinol Lett. 2015;36(5):434-8.

19. Schmid MB, Hopfner RJ, Lenhof S, Hummler HD, Fuchs H. Cerebral oxygenation during intermittent hypoxemia and bradycardia in preterm infants. Neonatology. 2015;107(2):137-46.

20. Hessel, T., Hyttel‐Sorensen, S. & Greisen, G. Cerebral oxygenation after birth – a comparison of INVOS® and FORE‐SIGHT™ near‐infrared spectroscopy oximeters. Acta Paediatrica. 103, 488–493 (2014).

21. Wintermark P, Hansen A, Warfield SK, Dukhovny D, Soul JS. Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neuroimage. 2014 Jan 15;85 Pt 1:287-93.

22. Skowno JJ, Quick TJ, Carpenter EC, De Lima J, Gibbons PJ, Little DG. Near-infrared spectroscopy for detection of vascular compromise in paediatric supracondylar fractures. Physiol Meas. 2014 Mar;35(3):471-81.

23. Schneider A, Minnich B, Hofstätter E, Weisser C, Hattinger-Jürgenssen E, Wald M. Comparison of four near-infrared spectroscopy devices shows that they are only suitable for monitoring cerebral oxygenation trends in preterm infants. Acta Paediatr. 2014 Sep;103(9):934-8.

24. Kussman BD, Laussen PC, McElhinney DB, Benni PB, Lin H, McGowan FX. Cerebral oxygen extraction measured by NIRS and jugular bulb oxygen saturation demonstrates the importance of hemoglobin concentration in congenital heart disease. Anesth Analg 2014; 118; S-1 – S-319.

25. Türköz A, Balcı ŞT, Gönen H, Çınar Ö, Özker E, Türköz R. The effects of different ventilator modes on cerebral tissue oxygen satura-tion in patients with bidirectional superior cavopulmonary con-nection. Ann Card Anaesth. 2014 Jan-Mar;17(1):10-5.

26. Schmid MB, Hopfner RJ, Lenhof S, Hummler HD, Fuchs H. Cerebral desaturations in preterm infants: A crossover trial on influence of oxygen saturation target range. Arch Dis Child Fetal Neonatal Ed. 2013 Sep;98(5):F392-8.

27. Szczapa T, Karpiński Ł, Moczko J, Weindling M, Kornacka A, Wróblewska K, Adamczak A, Jopek A, Chojnacka K, Gadzinowski J. Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy devices: an absolute and a relative trending oximeter. J Biomed Opt. 2013 Aug;18(8):87006.

28. Dix LM, van Bel F, Baerts W, Lemmers PM. Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate. Pediatr Res. 2013 Nov;74(5):557-63

CAS Medical Systems, Inc.9

PEDIATRIC / NEONATAL APPLICATIONS

29. Hyttel-Sørensen S, Austin T, van Bel F, Benders M, Claris O, Dempsey EM, Fumagalli M, Gluud C, Hagmann C, Hellström-Westas L, Lemmers P, Naulaers G, van Oeveren W, Pellicer A, Pichler G, Roll C, Støy LS, Wolf M, Greisen G. Clinical use of cerebral oximetry in extremely preterm infants is feasible. Dan Med J. 2013 Jan;60(1):A4533.

30. Schmid MB, Hopfner RJ, Lenhof S, Hummler HD, Fuchs H. Cerebral desaturations in preterm infants: a crossover trial on influence of oxygen saturation target range. Arch Dis Child Fetal Neonatal Ed. 2013 Sep;98(5):F392-8.

31. Almaazmi M, Schmid MB, Havers S, Reister F, Lindner W, Mayer B, Hummler HD, Fuchs H. Cerebral Near-Infrared Spectroscopy during Transition of Healthy Term Newborns. Neonatology. 2013;103(4):246-51.

32. Peng S, Boudes E, Saint-Martin C, Wintermark P. Assessing the role of near-infrared spectroscopy to predict outcome in asphyxiated newborns treated with hypothermia. E-PAS2013:3824.359

33. Elser HE, Holditch-Davis D, Levy J, Brandon DH. The effects of environmental noise and infant position on cerebral oxygenation. Adv Neonatal Care. 2012; 12 Suppl 5:S18-27.

34. Uemura K, Shimazutsu K, McClaine RJ, McClaine DJ, Manson RJ, White WD, Benni PB, Reynolds JD. Maternal and preterm fetal sheep responses to dexmedetomidine. Int J Obstet Anesth. 2012; 21(4):339-47.

35. Bettesworth J, Bhalla T, Barry N, Tobias JD. Changes in tissue oxygenation following caudal epidural blockade in infants and children. Paediatr Anaesth. 2012 Nov;22(11):1068-71.

36. Dewhirst E, Winch P, Naguib A, Galantowicz M, Tobias JD. Cerebral oximetry monitoring during preoperative phlebotomy to limit allogeneic blood use in patients undergoing cardiac surgery. Pediatr Cardiol. 2013; 34(1):75-80.

37. Quinn CT, Dowling MM. Cerebral tissue hemoglobin saturation in children with sickle cell disease. Pediatr Blood Cancer. 2012; 59(5):881-7.

38. Türköz A, Turgut Balcı S, Gönen H, Ozker E, Esen B, Türköz R. The effects of different ventilator modes on cerebral tissue oxygen saturation in patients with bidirectional superior cavapulmonary connection. Artif Organs. 2012; 36(5):15-6.

39. Chouthai NS, Chouthai AA, Shah JH, Raman S, Madan R. Near infrared spectroscopy (NIRS) in newborns with hypoxic ischemic encephalopathy (HIE) who received whole body hypothermia (WBH). E-PAS2012:4507.75

40. Fuchs H, Almazam M, Havers S, Schmid MB, Hummler HD. Cerebral oxygenation of healthy term newborns during transition to neonatal life. E-PAS2012:1534.587

41. Schmid MB, Lenhof S, Hopfner RJ, Hummler HD, Fuchs HW. Influence of arterial oxygen saturation target range on cerebral oxygenation in infants with severe apnea of prematurity. E-PAS2012:1165.2

42. Scottoline B, Takase-Sanchez M, Song D, Jegatheesan P, Govindaswami B. Cerebral oxygen saturation using multiple platforms in term and pre-term neonates during transition. E-PAS2012:2918.280

43. Chang T, du Plessis A. Neurodiagnostic techniques in neonatal critical care. Curr Neurol Neurosci Rep. 2012; 12(2):145-52.

44. Hershenson JA, Ro PS, Miao Y, Tobias JD, Olshove V, Naguib AN. Changes in Hemodynamic Parameters and Cerebral Saturation During Supraventricular Tachycardia. Pediatr Cardiol. 2012; 33(2):286-9.

45. Fuchs H, Lindner W, Buschko A, Almazam M, Hummler HD, Schmid MB. Brain oxygenation monitoring during neonatal resuscitation of very low birth weight infants. J Perinatol. 2012; 32(5):356-62.

46. Elser HE, Holditch-Davis D, Brandon DH. Cerebral Oxygenation Monitoring: A Strategy to Detect IVH and PVL. Newborn Infant Nurs Rev. 2011; 11(3):153-159.

47. Spencer CT, Byrne BJ, Bryant RM, Margossian R, Maisenbacher M, Breitenger P, Benni PB, Redfearn S, Marcus E, Cade WT. Impaired cardiac reserve and severely diminished skeletal muscle O2 utilization mediate exercise intolerance in Barth syndrome. Am J Physiol Heart Circ Physiol. 2011; 301(5):H2122-9.

48. Fuchs H, Lindner W, Buschko A, Trischberger T, Schmid M, Hummler HD. Cerebral oxygenation in very low birth weight infants supported with sustained lung inflations after birth. Pediatr Res. 2011; 70(2):176-80.

49. Zabaneh RN, Cleary JP, Lieber CA. Mesentric oxygen saturations in premature twins with and without necrotizing enterocolitis. Pediatr Crit Care Med. 2011; 12(6):e404-6.

50. Gilmore MM, Stone BS, Shepard JA, Czosnyka M, Easley RB, Brady KM. Relationship between cerebrovascular dysautoregulation and arterial blood pressure in the premature infant. J Perinatol. 2011; 31(11):722-9.

51. Naguib AN, Winch P, Ro PS, Olshove V, Tobias JD. Changes in near-infrared spectroscopy and the bispectral index during tilt-table examination. Pediatr Cardiol. 2011; 32(2):234-6.

52. Kasman N, Brady K. Cerebral oximetry for pediatric anesthesia: why do intelligent clinicians disagree? Pediatr Anaesth. 2011; 21(5):473-8.

53. Niforatos N, Said M, Rais-Bahrami K. Cerebral oximetry of preterm infants. Presented at the American Academy of Pediatrics 2010 #14487.

54. Lathouwers K, De Deyne CS, Jans F, De Sloovere V, Heylen R. Non-invasive absolute cerebral oximetry during inhalational anesthesia in young children. Presented at American Society of Anesthesiologists Annual Meeting 2010 #A939.

55. Mittnacht AJC. Near infrared spectroscopy in children at high risk of low perfusion. Cur Opin Anaesthesiol. 2010; 23:342-7.

CAS Medical Systems, Inc. 10

PEDIATRIC / NEONATAL APPLICATIONS

56. Said M, Niforatos N, Rais-Bahrami K. Testing a new NIRS method to measure mesenteric oxygenation of preterm infants that compensates for meconium and transitional stool interference. Presented at the American Academy of Pediatrics 2010 #10103.

57. Niforatos N, Said M, Rais-Bahrami K. Cerebral Oximetry Monitoring in Preterm Infants with Respiratory Distress Syndrome. Presented at the American Academy of Pediatrics 2010 #10896.

58. Chouthai N, Gopal SP, Graham P. Cerebral Oximetry Using Near-Infrared Spectroscopy (NIRS) in Newborns with Hypoxic Ischemic Encephalopathy (HIE) Who Qualify for Clinical Whole Body Hypothermia (WBH). Presented at the American Academy of Pediatrics 2010 #11601.

59. Thompson AM, Ehrenkranz RA, Benni P. Meconium interferes with NIRS measurements of the GI tract in premature neonates.Presented at Pediatric Academic Societies 2010.

60. Said M, Niforatos N, Rais-Bahrami K. Using Near Infrared Spectroscopy (NIRS) to measure bowel motility in preterm infants. Presented at Pediatric Academic Societies 2010.

61. Niforatos N, Said M, Rais-Bahrami K. Comparison of simultaneous cerebral oximeter and pulse oximeter data in preterm infants with RDS. Presented at Pediatric Academic Societies 2010.

62. Gilmore MM, Stone B, Shepard J, Brady KM. Gestational age + 5? Monitoring autoregulation in the preterm infant. Presented at Pediatric Academic Societies 2010.

63. Kimura RE, Chen Y. NIRS technology detects a decrease in intestinal blood flow caused by hypovolemia. Presented at Pediatric Academic Societies 2010.

64. Munkeby BH, Kro GAB, Saugstad OD. Accuracy of hepatic oxygenation monitoring by NIRS in newborn pigs. Presented at Pediatric Academic Societies 2010.

65. Drinkaus R, Taenzer A, Cravero J. Near Infrared Spectroscopy values during painful procedures in newborn – correlation with behavioral markers. Presented at Society for Pediatric Anesthesia 2010.

66. Baker DK, Daves S, McCarver L, Monroe Carrell Jr. Cerebral oximetry in a newborn with hypoplastic left heart and restrictive atrial septum from birth to atrial septostomy. Presented at Society for Pediatric Anesthesia 2010.

67. Mann H. Stable intensive care nursery infants’ cerebral oxygenation in supine versus prone position. Presented at 5th International Conference of Brain Monitoring & Neuroprotection in the Newborn.

68. Niforatos N, Said, M, Rais-Bahrami K. Neonatal cerebral oximetry monitoring in preterm infants with RDS. Presented at 5th International Conference of Brain Monitoring & Neuroprotection in the Newborn.

69. Fenik JC, Rais-Bahrami K. Neonatal cerebral oximetry monitoring during ECMO cannulation. J Perinatol. 2009; 29(5):376-81.

70. Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke. 2009; 40(5):1820-6.

71. Benni P, Chen B, Fenik, J et.al. Cerebral and pulse oximetry monitoring of newborns: clinical observations. Abstract of a Poster Presented at the International Symposium on Innovations and Advancements in Monitoring Oxygenation and Ventilation (ISIAMOV 2007).

44 East Industrial Road, Branford CT 06405, USATel: (203)488-6056 • Toll Free: (800)227-4414 • Fax: (203)488-9438

www.casmed.com

21-05-0154 Rev 13 0516