Clinical Research+MARCH 30 TH, 2016

AgendaPenn Medicine: An Integrated AMC

Goals and objectives

Systems and Data Landscape, 2011

Data Transformation

Governance

Systems

The Future

Penn Medicine

Penn Medicine

Goals and ObjectivesLeverage data to advance research and enable personalized medicine

Align clinical and research domains

Centralize IT and systems

Harmonize data

Engage client sponsors

Data Transformation: Value

Data Landscape

IT GovernanceSenior IT

Governance

SOM IT Governance

Research Advisory

Education Advisory

Administrative Advisory

Clinical IT Governance

IP EMR Oversight

IP EMR Operations

Inpatient Enterprise-wide Prioritization

Committee

OP EMR Oversight

OP EMR Operations

Business IT Governance

Business IT Committee

Revenue Cycle

Committee

Analytics Governance

Data Governance

System: CTMSVelos eResearch 9.x

In-use, 2009-present, Cancer Center◦ ≈700 active studies◦ Heavily customized

Enterprise Deployment◦ EMR Integration (patient, study, demographics)◦ All human-subject research◦ ≈1,500 studies◦ Minimally customized

System: LIMSLabVantage

Net-new application, 2011

Migration, lab-by-lab

Use and adoption strategic

Migrating nearly all sample management

Data Warehouse integration in progress

Aggregate for distributed biospecimen data

System: DMSNet-new application

Veeva (cloud-based)

Clinical Research Focus

Rapid deployment

eTMF

Quality documents (SOPs)

CTMS integration

• PennOmics– Research focused– Fully de-identified (3

million patients)– 6,000 genetic

sequences, 1.7 trillion variants

– Self-service access

Research Data Warehouse

System: Clinical Data WarehousePenn Data Store

Built over the past 8 years

4+ Billion rows

730+ million rows added annually

9+ source systems (EMR, lab, Rx, etc.)

Request-based access

System: Clinical Data Warehouse

The FutureSystems Integration

◦ CTMS◦ DMS◦ PennOmics◦ Penn Data Store◦ Others

Continued Data Focus◦ Ontologies/data harmonization◦ End-user adoption and access◦ Continued focus on enterprise systems

Increased focus on unstructured data/NLP

Thank YouJ a s o n H u g h e s , M B A , M SD i r e c t o r, E n t e r p r i s e Re s e a r c h A p p l i c a t i o n s & H i g h - Pe r fo r m a n c e C o m p u t i n gPe n n M e d i c i n e A c a d e m i c C o m p u t i n g S e r v i c e sPe r e l m a n S c h o o l o f M e d i c i n e a t t h e U n i v e rs i t y o f Pe n n sy l v a n i aj a h u g h e s @ u p e n n . e d u