CNE-1 C666-1 HK1 CNE-2

pi-mTOR (ser 2448)

Actin

mTOR

Veh 50pM 10nM Veh 50pM 10nM Veh 50pM 10nM Veh 50pM 10nM

RAD001 RAD001 RAD001 RAD001

Figure 2B (supp 1): Supplementary Figure to Figure 2B

Actin

pi-p70S6 kinase (Thr/Ser)

pi-p70S6 kinase (Thr389)

p70S6 kinase

CNE-1 C666-1 HK1 CNE-2

Veh 50pM 10nM Veh 50pM 10nM Veh 50pM 10nM Veh 50pM 10nM

RAD001 RAD001 RAD001 RAD001

Figure 2B (supp 2): Supplementary Figure to Figure 2B