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LIST OF PARTICIPANTS

Aarho1t, E.

Abraham, S.

Alabaster, O.

A1berti, S.

A1gan, G.

Avrameas, S.

Ayva1i, C.

Badaracco, G.

Bar1ati, S.

Barnekow, A.

Baserga, R.

Bauer, H.

Be1mont, A.

Be1trame, F.

Bologna, M.

Bradbury, E.M.

Dept. Electrical Engineering, University of Salford Sal ford M5-4WT, UK

Temple University - H.S.C. Philadelphia, PSA, USA

The George Washington University, Medical Center - Division of Emato1ogy and Onco­logy, Hashington, DC, USA

Istituto Mario Negri, Via Eritrea, 62, 20157 Milano, Italy

Genaral Botany Department, Faculty of Science University of Ankara, Turkey

Unite d' Immunocytochimique, Departement de Bio1ogie Mo1ecu1aire, Institute Pasteur 75 Paris, France

Department of Zoology, Ankara University Ankara, Turkey

Istituto Tumori Regina E1ena, Via1e Regina E1ena, 291, Roma, Italy

Consig1io Naziona1e delle Ricerche, Labora­torio di Genetica e Evo1uzionistica 27100 Pavia, Italy

Institut fur Viro1ogie, Fachbereich Human­medizin, D-6300 Giessen, FRG

Department of Pathology, Temple University School of Medicine, Broad and Ontario Street, Philadelphia, PA 19140, USA

Department of Tumor Virology, D-6300 Giessen, FRG

Temple University - H.S.C., Philadelphia, PA 19140, USA

Istituto di E1ettrotecnica, University of Genova, Genova, Italy

Istituto di Pato1ogia Genera1e, Faco1ta di Medicina e Chirurgia, 67100 L'Aqui1a, Italy .

Department of Biological Chemistry, Medical School, University of California, Davis, CA, USA

805

806

Cooper, S.

Colombini, S.

De Boni, U.

Di Pasquale, Mo

Domingo, J.

Drewinko, B.

Elci, S.

Ellwart, J.

Enginum, M.

Gabrielli, F.

Gendel, E.

Giannoulis, N.

Grattarola, M.

Guialis, A.

Hill, B. T.

Huot, J.

Julemont, F. X.

Kendall, F.

Konig, K.

Lawrence, F.

PARTICIPANTS

Department of Microbiology, The University of Michigan, Medical School, Ann Arbor, Michigan, USA

Istituto di Clinica Medica 1, Cattedra di Ematologia-Policlinico, Via del Pozzo 71 41100 Modena, Italy

Department of Physiology, Medical Sciences Building, Toronto, Canada, M5S lA8

CNR - Lafbil, Via Buonarroti, 56100 Pisa, Italy

Catedra de Histologia y Anatomia Patologica Facultad de Medicina, Barcelona, Spain

Anderson Hospital and Tumor Inst., Dept. of Laboratory Medicine, Houston, Texas 10021, USA

Faculty of Sciences, University of Firat, Elagiz, Turkey

Institut fur Hematologie, Landwehrstrasse 61, 8000 Munchen, 2, FRG

Istanbul University, Analitik Kimya Kursusu Istanbul, Turkey

Istituto di Chimica Biologica, Via Roma, 55 56100 Pisa, Italy

Cytogenetics Laboratory, Metropolitan Hospital Center, 1901 First Avenue, New York, NY 10029, USA

Saint Savvas Cancer Hospital, 171 Alexandras Avenue, Athens 603, Gree~e

Istituto di Elettrotecnica, Viale Francesco Causa, 13, Genova, Italy

The National Hellenic Research Foundation Biological Research Center, 48 Vassileos Constantinou Avenue, Athens 501/1, Greece

Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund Laboratories, PoD. Box n. 123, London, WC2A 3PX, UK

Department of Pharmacology, Faculty of Medicine, Lavac University, Quebec GlK 7P4, Canada

Faculte des Sciences Agronomique, Place Croix du Sud, 1348 Louvain la Neuve, Belgium

Dept. Physiology-Biophysics, Temple University - H.S.C., 3223 North Broad Street Philadelphia, PA, USA

Universitat Hamburg, Institut fur Biophysik und Strahlembiologie, 2 Hamburg 20, FRG

Centre National de la Recherche Scientifique Institut de Chimie des Substances Naturelles 91190 Gif-sur-Yvette, France

PARTICIPANTS

Lessin, S.

Leung, C.

Linden, W.

Lis, M.

Lovhaug, D.

Lucke-Huhle, C.

Maraldi, N. M.

Maurer-Schultze, B.

Martegani, E.

Milla, M.

Moreno, H.L.

Nagl, W.

Nicolini, C.

Numes, M.

Olijhoek, A.J.M.

Omodeo, P.

Pardee, A.B.

Paul, J.

Principe, P.

Purrello, M.

Rao, K.N.

807

Temple University, Medical School - H.S.C. Philadelphia, PA 19140, USA

Department of Physiology, Faculty of Medicine University of Manitoba, Hinnipeg, Manitoba, Canada

Institut fur Biophisics, and Radiation Biology, Krankenhaun Eppendorf, 2 Hamburg 20, FRG

Laboratory of Compared Endocrinology Institute de Recherches Clinique, 110 Avenue des Pins Ouest, Montreal H2WIR7, Quebec, Canada

Norwegian Defence Research Establishment Division for Toxicology, P.O. Box 25 N-2007 Kjeller, Norway

P.Oo Box 3640, Nuclear Research Center D-75 Karlsruhe, FRG

Istituto di Istologia ed Embriologia Generale Universita, Ancona, Italy

Institute of Medical Radiology, University of Wurzburg, 80700 Wurzburg, FRG

Catte dra di Biochimica Comparata, Facolta di Science, via Saladini, 50, 20133 Milano, Italy

Tarlac College of Technology, Tarlac, 2101, Republic of the Philippines

C.S.I.C., Instituto de Biologia Celular Velasquez 144, Madrid 6, Spain

Department of Biology, The University of Kaiserlautern, P.O. Box 3049, Kaiserlautern, FRG

Temple University, Department of Biochemistry and Physiology, Philadelphia, PA 19140, USA

Instituto Portogues de Oncologia, Franciso Gentil, Palhave, Lisboa, Portugal

Department of Electron Microscopy, University of Amsterdam, Amsterdam, The Netherlands

Istituto di Biologia Umana, Via Loredan Padova, Italy

Sidney Farber Cancer Institute, Department of Pharmacology, Division of Cell Growth and Regulation, Boston, MA 02115, USA

The Beatson Institute for Cancer Research Wolf son Laboratory for Molecular Pathology Garscube Estate, Glasgow, C61 IBD, UK

Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy

Istituto di Biologia Generale, Via Androne, 81, 95124 Catania, Italy

Department of Pathology, School of Medicine Pittsburg, PA 15261, USA

808

Rao, P.N.

Reinhardt, R.

Reynolds, T.L.

Robert-Gero, M.

Schreil, w.

Sells, B.R.

Skagen, Dankert

Starace, G.

Statakos, D.

Stein, G.S

Stein, J.L.

Steck, P.

Stragand, J.

Suau, P.

Svetina, S.

Teodori, L.

Toker, C.

PARTICIPANTS

Section of Cellular Pharmacology, Department of Developmental Therapeutics, M.D. Ander­son and Tumor Institute, Texas Medical Center, Houston, Texas 77030, USA

Department of Biology, Universitatstrasse 10 775 Konstantz, FRG

The Ohio State University, Department of Botany, 1735 Neil Avenue, Columbus Ohio, USA

Institute de Chimie des Substences Naturelles Centre National de la Recherche Scientifi­que, 91190 Gif-sur-Yvette, France

Istituto Internazionale di Biofisica e Genetica, Via Guglielmo Marconi, 10 80125 Napoli, Italy

Faculty of Medicine - H.S.C., Memorial University of New-Foundland, St. John, A1B-3V6, Canada

School of Medicine, Medical Department A 5016 Haukaland Sykehus, Bergen, Norway

CNR, clo i.M. E/R.s.~ Via Luigi Bodio 58 00191 Roma, Italy

Department of Biology, Nuclear Research Center "Demokritos", Athens, Greece

University of Florida, Dept. Immunology and Hedical Microbiology, Gainesville, FL. 32610, USA

University of Florida, Dept. Immunology and Medical Microbiology, Gainesville, FL 32610, USA

Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA

MD Anderson Hospital and Tumor Institute Texas Medical Center, Houston, Texas 77030 USA

Departamento de Bioquimica, Faculttad de Ciencias, Universidad Autonoma Bellaterra Barcelona, Spain

Institute of Biophysics, Medical Facukty and J. Stefan Institute, University of Ljubljana Ljubljana, Yugoslavia

IMERS - CNEN, Via Luigi Bodio 58, 00191 Roma, Italy

General Botany Department, Faculty of Science Ankara, Turkey

PARTICIPANTS

Tucker, R.W.

Van Meeteren, R.

Van Wijk, R.

Vasconcelos, M.

Walder, L.

Wollmer, W.

Yen, A.

Young, I.E.

Zerbini, M.L.

Zietz, S.

Zirnrnerrnan, G.J.

809

John Hopkins Oncology Center, 600 North Wolfs Street, Baltimore, MD, USA

Rijksuniversiteit Utrecht, Vakgroep Mole­cular Cell Biologie, State University 3584 CH Utrecht, The Netherlands

Department of Molecular Cell Biologie, State University, 3584 CH Utrecht, The Netherlands

Av. Almirante Jaao, Azevedo Coutinho Murtal, S. Pedro do Estoril, Portugal

Institut fur Biologie Ill, Schanzlestrasse 1 7800 Freiburg, FRG

Institut fur Biophysik, Martinistrasse 52 2000 Hamburg, FRG

Memorial Sloan Kettering Cancer Center 1275 York Avenue, New York, NY 10021, USA

Department of Biology, York University 4700 Keele Street, Downsview, Ontario M3 J-lP3 Canada

Istituto di Microbiologia, Policlico So Orsola, Via Massarenti, 9, Bologna, Italy

Drexel University, Dept. Mathematical Science, Philadelphia, PA 19140, USA

Institute for Experimental Surgery, Technical University Munich, 800 Munich, 80, FRG

CONTRIBUTOR INDEX

Abraham, S. Avrameas, S.

Ball, T. Bradbury, E.M. Barlogie, B. Baserga, R. Bauer, H. Beall, P.T. Belmont, A. Beltrame, F. Birnie, G.D. Bostian, K.A. Boswell, R.

Capanna, E. Capitani, S. Chiabrera, A. Conkie, D. Cooper, S.

Drewinko, B.

Folkman, J.

Gabrielli, F. Grattarola, M.

Halvorson, H.O. Halzlewood, C.F. Hancock, R. Harrison, P.R. Hsie, A.W.

Jacobs, H.

Kendall, F. Koppes, L.J.H.

Lessin, S. Liskay, R.M. Linden, W.

Manzoli, A. Maraldi, N.M. Mat thews , H.R. Maurer-Schultze, B. Mazia, D. Ming, P. L.

Nagl, W. Nanninga, N. Nicolini, C.

Omodeo, P.

811

Pallini, v. Pardee, A.B. Potten, C. Paul, J. Prescott, D.M.

Raher, M. Rao, P.N.

Shott, R. Stancel, G.M. Stein, G.S. Stein, J.L. Swanton, M. Swartzendruber, D.

Tucker, R.H.

Wilkes, P. Wittelsberger, S. Woldringh, C.L.

Yarger, J.G.

Zietz, S.

SUBJECT INDEX

a-Amantin, 338 acid - phosphatase ,273 Acetylation ,421, 437 Acridine Orange ,37-144, 777 Actin, 532 Actinomycin D , 524, 537 Activation, 609-616 Adenovirus, 71, 343 Adenocarcinoma, 739 Adsorption, 6 Af-8, 76 Aging, 596-601 Algae, 28, 620 Alkylation, 428 Amino acid, 357 Ami tos is, 522 Amplification Cycles, 630 Anaphase, 628 Anchorage Independence, 587 Anchorage Dependence, 562, 604 Angiosperm, 629 Annuli, 503 Antibiotics, 246 Antibodies, 52, 61 Antigens, 51-60, 61 Antiserum, 52 Area (Nuclei), 491 Argenine, 422 ATPase, 36 Automomated Image Analysis,588 Autoradiography, 83

light microscopy, 361, 488 electron microscopy, 113

Average Optical Density, 489

B period, 265 Bacterial

cytodifferentiation, 225 chemiodifferentiation, 226

BALB/3T3, 340, 370 Banding Pattern Analysis, 204 Beads-on-a-string, 414 Bending Angle, 511-514 Binding

equilibrium, 135-142 sites, 140, 490

Blastomers, 307 Boltzmann Constant, 511 Bone Marrow, 150 BHK mutants, 343 Brain, 102, 564, 742 Bromodeoxyuridine, 362 Bl6 Melanoma Tumor, 187-204

Caffein, 676 Calcium, 515 Calf Thymus, 417 Calorimetry, 516 Cancer, 187, 673-714, 773-798 Carbohydrates, 469 Carboxyl, 423 Carcinbma, 689 Carcinogenesis, 689 CD Spectra, 490 CDNA, 611-614

library, 355-364, 617 Cell

cycle, 225, 377, 411, 487

813

814

envelope, 6, 228 fusion, 69 hybrids, 308 kinetics, 93, 735, 749, 773, mass, 225, 549 morphology, 575, 587 shape, 575, 587 sorter, 135-146 surface, 51, 158, 744

Cellular Aging, 357, 595 Centrioles, 228, 366

cycle, 369 ciliated, 370

Centrosomes, 367 Cervical Cancer, 735 Chalones, 358 Chemotherapy, 695, 773-798 Chicken Erythrocyte, 138 Chinese Hamster Ovary, 557, 597 CHO Cells

transformed, 536, 557, 596 reverse-transformed, 557, 597

Chromatin, 9, 411, 487 active, 455, 463, 501 conderised, 171, 491 disperse, 477, 496 fractionation, 455 inactive, 455,472, 501 melting, 193, 504 nuclear, 122, 171, 487 structure, 411, 487

Chromocenter, 126 Chromosomes, 521-533

banding, 204, 208 Cilia, 365-370 Ciliated Protozoa, 521-534 Clinical Oncology, 735-, 773 Clone, 69-75, 609 Clonogenicity, 761 Cloning, 377, 532 Colcichine, 567, 582 Colony, 615 Commitment Theory, 596 Confluent, 148, 594 Coniugates, 51 Conjugation, 522 Continuous labeling, 94 Counterions screening, 510 Contractile Proteins, 25 Convolution factor, 589

799

Core Particle, sizes, 412

Cot curves, 527

SUBJECT INDEX

412

Covalent Binding, 62, 137 Cross

correlation, 493 linking study, 26

Cycle chromatin, 490 ciliation, 371 cell, 305, 358 centriole, 366 growth, 225 nuclear pores, 493

Cyclic AMP, 430, 504, 557-574, 699

Cyclohexamide, 358, 434 Cymbidium, 620 Cytochalasin B, 70, 360 Cytomegalovirus, 593 Cytometry

flow, 133, 735, 773 scanning, 171, 587

Cytopathology, 734

Cytoplasm geometry, 589 induce~ 360, 361

Cytoplasts, 360 Cytosine Abrabinoside , 493 Cytoskeleton, 12, 557, 575 Cytotoxic Drugs, 96, 749, 773

DAP!, 736 Debye Constant, 510 Deciliation, 371 Decondensation of Chromosome, 171 Dedifferentiation, 71 Dehydrofolate Reductase, 521, 796 Densitometer, 501 Densitometry, 491, 589 Development, 202, 377 Dibutynl-cAMP, 557, 589 Differential Calorimeter, 516 Differential Replication, 630-650 Differentiation, 213, 611 Digestion

DNAse, 502

SUBJECT INDEX

micrococcal, 504 restriction nuclear, 526

Dimer H2A-H2A, 413 H3-H4, 420

Disk-like Structures, 413 Dispersion (Chromatin), 490 Divalent Cation, 510 Division Cycle, 225 DMSO, 348 DNA

amplification, 610, 618 clone, 609 coding, 521-532 non-coding, 521-532 CD-spectrum, 491 digestion, 500 distribution, 438 gene-sized, 525 phosphates, 511-513 polyoma, 614 reannealin§" 610 replication, 253, 347, 355, RNA hybridization, 347, 609 satellite, 209 sequences, 186 spacers, 413 synthesis, 89, 355, 365, 493

DNAse, 455, 502 Don, 307 Double Helix, 516 Double Labeling, 100 Double Staing, 138 Doubling Time

prokaryotes, 231 eukaryotes, 301

Drapery-like Chromatin, 500 Drosophilia, 181, 522 Drug Activity, 749-772 Dynein, 31, 371

Early Gl, 489 EB Binding Sites , 490 E-Coli, 62

division cycle, 225-270 Electron Microscopy

of chromatin , 174, 418, 463 general criteria, 113 resolution, 119

Electrophoresis polyacrylamid gel, 34 two dimensional , 455-461

Embryos , 307, 356 Endomitosis, 629 Endopolyploidy', 633-636 Endoreduplication, 619-630 Endothelial Cells, 576-583 Enthalpy, 509, 516 En trophy , 509-513 Enzyme, 26, 271 Enucleation, 70

815

Epidermal Growth Factor, 95, 695 Ep~thelia Cells, 95, 558, 689 Erythrocyte

chick, 70 mouse, 150

Equilibrium binding studies , 136

Erythroid , 347 Ethidium Bromide

chromatin complex, 135, 490 609 Euchromatin, 172, 439

eukaryotes , 3 evolution , 171

Euglena Cells , 683 Expression, Gene, 377-410

Fl vs FlO image analysis ,596 flow minofluorimetry, 162

Feret diameter, 588" Ferritin, 63 Fertilization, 674 Feulgen, 175, 490

optimal hydrolysis, 172,589 Fibre

300A, 100A , 414 1,500A, 500

Fibroblast, 147, 558, 594 Fibrosarcoma, 340 Fibronectin, 466 Flagella, 32 Flow

cell sorting, 145 cytometry, 140, 344, 735, 776

Fluorescence RNA vs DNA, 146 membrane, 159 protein, 739

816

Fluorescent Probes, 54, 137 Fluorochromes, 137 Fluorescein, 54 Form Factor, 497, 590 Fourier Transform, 510 Fractional Charge, 511-515 Free Energy, 511-515 Freeze-Fracture, 6, 46, 118 Friend Cells, 348 Fungi, 27, 620 Fusion, 73, 360, 677

S with G2 ,360 S with GI, 360 GI+ with M, 361 GI+ with GI , 361

GO Phase, 140, 315, 337, 682 GO-GI Transition, 137, 337, 593 GI -Phase, 305, 525, 537

GI less cells, 307, 361 GI arrest, 315, 359

GI-S transition, 487-497 GI variability , 682 G2 Phase, 207, 308, 538 Gel Electrophoresis

DNA, 413 proteins, 34, 426

Gene abundance, 614 activation, 347 cloning, 80 mapping, 71, 377-386 expression, 613 histone, 360, 377-386 ribosomal, 609 oval btmlin, 522 organization, 521-532

Genome . expressed, 500, 532 non-expressed

Genetic apparatus, 3, 487, 521

Germs, 635 Glactokinase, 271 Geometric-densitometric Image

Analysis, 589 Globin

cDNA hybridization, 348, 618

SUBJECT INDEX

gene, 348, 609 mRNA, 349, 609

Globular Protiens, 416 Glycolipids, 474 Glycolitic Pathway, 674 Gray Level , 501 Growth

associated kinase, 673 cycle, 311, 356 factors, 370, 673 fraction, 139, 771 normal vs. abnormal, 557, 587

Grunstein-Hgnen colony screening, 615

HI, 455 DNA binding, 411, 428 binding enthalpy, 509-511 phosphorylation, 429, 512 removal, 512

H2A-H2B, H3 during cell cycle, 411

H3 variants, 420 H4 acetylation, 435 H5, 411-420 Haploid Genome, 619 Heat Capacity, 516 HeLa, 360

cells, 488, 535 chromatin, 489 nuclei, 492, 535

Helix coil transition,488

Hemoglobin , 352 Hepatectomized Rat Liver, 609 Heterochromatin, 383, 439, 635

constitutive, 208 facultative, 172, 208

Hepatocytes , 609 Hepatomas , 614 Higher Order Chromatin Structure, 516 Histone , 377

of active chromatin, 456 of inactive chromatin, 455 cell cycle modification, 425, 502 core, 412 depleted chromatin, 416 dissociated , 518

SUBJECT INDEX

DNA interactions, 429 genes, 377-410 kinase, 432 phosphatase, 425

Histones chemistry, 411-430 HI, 416, 505 H2A , 418, 455 H2B , 418 H3 , 417, 455 H4, 412 H5, 413, 455 self-assembly, 411

HMBA, 349 HMG Proteins, 437 Hoechst, 782 Hybrids Cells, 70 Hybridization, 616 Hydration, 536 Hydraphobic Bond, 505 Hydrogen Bond, 422

water, 539 Hydrolysis, 174 Hydroxy-Urea, 311 Hyperchromicity, 193 Hypotrichous, 522

Initiation DNA Synthesis, 126, 356-364, 488

Image analysis, 147, 172, 487 analyzer, 589

Immunoaudioradiography, 56 Immunocytological, 51 Immunoenzyme, 61 Immunoenzymatic, 63 Immunofluorescence, 55, 62 Immunoferritin, 56 In Situ, 133, 487 Informational molecule, 609 Initiation, 355 Insect, 39, 176 Insulin, 676 Integrated Optical, 488 Integument, 615 Intercalating Agents, 137 Interference

microscopy, 535

Interphase, 304 phosphorylation, 435, 505

Introns, 521

817

Ionic Strength Effect, 510-514 Isoleucine, 357 Isothiocyanate, 744

Kinase, 433, 569, 697 Knobs, 564

Labeling Patterns, 362, 488 Laser,

flow microfluorimetry, 135 Leuc ine, 359 Leukemia, 348 Light Scattering Artifacts, 135 Linker DNA, 509 Lipids, 466 Lipoprotein, 479 Liposomes, 69 Lung, 312, 357 Lymphocytes, 139

M Phase, 365, 436, 535 Macronuclei, 522 Magnesium, 411 Malignancy, 587, 653, 673 Mass Action Law

cell studies, 138 Maturation, 347 Meiosis, 522 Meiotic, 374 Megakaryocytes, 149 Melting, 176, 491 Membrane, 6, 158, 232, 678 Metaphase , 628 Metastatic Variants , 158, 594 Metazoa, 26 Methanol, 137 Methotrexate, 756

resistant, 644 Methylation, 353 Micrococcal Nuclease, 413, 500 Micronuclei, 522 Microfilaments, 3, 368, 563 Microfluorimetry

cell, 135

818

chromatin, 136 membrane, 138 laser flow, 135 static, 489

Microinjection, 73 Microtubules, 563-570 Mid

GI, 495-499 S, 355, 490

Mitosis, 372, 427 Mitotic Detachment, 412, 488, 535 Mitotic Spindle, 373 MNNG, 75 Models of Cell Cycle, 315, 356, 508 Models of Chromatin Structure

tertiary, 434, 490 quaternary, 416, 490 quinternary, 499

Molar Ellipticity, 490 Molecular Wto of Core Protein, 415 Morphometry

cell, 575, 587 chromatin, 496 nuclei, 587

Mouse bone marrow, 150 brain, 101 embryo fibroblasts, 74 liver, 610

mRNA, 377-409, 609-614 Multiprobe Cytophotometry, 135 Muscle, 86 Mutagens, 715-722 Mutants, 69, 305, 715 Mutation frequency, 715-722 Murine, 642 Myeloma, 474 Myosin, 39

NaCI effect on chromatin, 509 water, 539 nuclei, 539

Neoplastic Transformation, 673 Neurons, 101 Neutron Scattering, 415 Nitrocellulose, 615 Non-competitive procedures

65-67

SUBJECT INDEX

Non-coding DNA, 644 Non-histone

gene regulation, 499, 686 proteins, 417, 455

Non-proliferating Cells GO, 140-151 Q , 140-151

Nu-body (See Nucleosome) 412-417

Nuclear chromatin, 488 envelope, 6, 73, 126 images, 501 lOD, 488 matrix, 3, 45 morphometry, 491 pores, 493 stains, 135

Nuclear Magnetic Resonance cells y 535-541 chroma tin, 422 histones, 418 water, 535-541

Nuclease, 455 and chromatin fractionation and nuclear morphometry, 501

Nuclei image analysis, 487 electron microscopy, 463 microfluorimetry, 133

Nucleofilaments, 413, 563 Nucleolar R.~A, 127 Nucleolus, 338, 361 Nucleosome, 412

Oocytes, 187, 611 Optical

activity, 490 Ovalbumin, 612

gene, 521 Oxytricha, 521

Packing Ratio chromosomes, 201 chromatin, 414

Papanicolau, 737 Partial Hepatectomy, 610 PDP Computer, 135, 590

SUBJECT INDEX

Periodicity (higher order), 411 Permissive vs. Non-Permissive

temperature mutants, 69, 78 Peroxidase, 62 PH Effects, 555 PHA Stimulated, 139 Phase Microscopy, 63 ~hase I, 11, III WI-38, 600 Pheromone, 358 Phosphatase, 64, 431 Phospholipids, 466 Phosphorylation, 430, 568 Physarum, 25, 424 Platelet, 676 PLM, 88 Plant, 176 Plasminogen, 690 Ploidy State, 619 Plumbicon Scanner, 501 Poly-(ADP-Ribose), 561 Polyacrylamide

gels, 455 Polyamines, 470 Polyelectrolyte Theory,500-516 Polyenergid, 620 Polyhema, 575-580, 592 Polymerase

DNA, 472 RNA, 338

Polyoma Virus, 339 Polypeptides, 465 Polyploidy, 185 Polysaccharides, 54 Polysomal RNA, 614 Polytena

chromosome, 523 nuclei, 633

PPP (Platelet Poor Plasma), 370 PDGF, 370 PRR

-117 genes, 617 5B genes , 617

Prereplicative Phase, 305 Prokaryotes , 25, 225 Progression (of S Phase), 362 Proliferating Cells , 557-574 Prophase, 171 Protamine Sulfate , 627 Proteins, 465, 487

evolution, 25

819

kinase, 430, 568 metabolism , 337 modifications, 411, 502 synthesis, 84, 310 turnover , 85

Protista, 25 Protozoa , 522 Puffing , 635 Pulse-Cytophotometry

(See Flow Cytometry and/or Laser Flow Microfluorimetry)

Q Cells bone marrow, 149 fibroblasts,.148

lymphocytes, 146 Melanoma B16, 153 Melanoma Fl, 154 ·Melanoma FlO, 154

Quantum Yield, 138 Quaternary Structure, 413 Quiescent

cell , 148 Quinternary Structure , 500-503

Radioactive Tracer, 83 Radius of Gyration, 417 Random Coil , 518 Rat Liver, 609 Recombinant , 615

DNA, 377, 609 Regulatory Molecules, 685 Relaxation, 535-540 Repeating Unit, 413, 610 Resting Tissue, 148 Restriction Enzymes, 532 Restriction Points, 506, 678 Retrodifferentiation,653 Reverse Transfortation, 557-574 Rhodamine, 54 Ribosomal

gene amplification, 636 RNA synthesis, 337, 531

Ribosomes, 279 Ribosylation, 467 RNA

cRNA, 349, 465 hmRNA, 578

820

mRNA , 437, 611 shRNA, 465 synthesis, 88, 276, 337 metabolism, 590 polymerase, 76, 338 transcription, 337, 347, 463

RNAse, 778

S Phase, 305, 355, 489, 538 SI Nuclease, 205 Salivary Gland, 635 Salt Wash, 509 Saturation Density, 600 Satellite DNA, 630 Scanning

electron microscope, 119 lines, 587 cytophotometry, 588

Scatter Signal, 135 Sea Urchin, 31, 555 Sendai Virus, 64 Senescence, 600 Separation of Active and

Inactive Genome , 455 Serum , 676 Shading, 589 Size

cell, 549, 587 gene, 526 nuclei, 587

Sodium, 512-515 Solid tumor, 737 Solenoid, 417 Somatic, 642 Spacer

DNA(See also linker DNA) , 521 Spectropolarimetry, 490 Spermine, 538 Staining, 135 Staphylococcal, 505 Stationary, 593 Stem Cells, 150 Stiff Chain Polymer, 509 Stimulation

fibroblasts, 149 lymphocytes, 139

Subphases, 488 Subunit, 411 Survivals assays, 756

SUBJECT INDEX

Super helix , 489 Supernucleosomes, 411 Superpacking, 487 Superstructures, 418, 500 Supercoiled Chromatin ,412 SV-40, 337

antigen, 73 A gene, 340 DNA sequences, 342 transformed, 587

Sulforodanim, 736 Synchronized

E Coli, 242 HeLa , 488

Temperature-Sensitive Mutants 74, 323, 359

Template active vs. inactive, 455 activity, 463

Teratocarcinoma, 307 Tertiary Structure, 411,489 Telophase, 628 Tetrahyuena, 428 Texture, Chromatin, 488 Theophylline, 505-507 Thermal

denaturation, 192, 518 transitions , 504

Thermodynamics, 509-520 Time-Lapse Cinemetography, 152, 564 Transcription, 463 Transcriptional

control, 386 Transection, 523 Transfection, 72 Transformation

frequency, 557, 575, 692 Transferrin, 676 Transposons, 531 Tritiated Thymidine Incorporation

83 t-RNA, 75 Tubolin, 31, 51, 568 Tumors , 773-789

water content, 546 Tumorigencity, 575, 690 Two-order Superhelical Model, 489

SUBJECT INDEX

U Period, 258 Underreplication DNA, 629

Vertabrates, 313 Vesicle, 474 Vincristine, 106 Virus

Polyoma ,78 RNA-Sarcoma, 564, 653-672 SV40, 337, 593 transformation, 678

Water Content, 535-546 WI-38

cells ,149 Chromatin, 604 Gl vs 0 GO, 146, 594 nuclei, 600

Wright Stain, 151

Yeast, 39, 271-303

"z" Phase, 629

821