Na+/Glucose Symport
Vibrio cholerae
ProkaryoteWater-bourne pathogenProduces Cholera Toxin
Chloride Ion Channel (CFTR) involved in Cystic Fibrosis
CFTR = Cystic Fibrosis Transmembrane conductance Regulator
K = LysineR = Arginine
CFTR Channel Protein
Healthy Lung
Lung epithelial cells Lung epithelial cells
Lung epithelial cells Lung epithelial cells
Cystic Fibrosis Lung
MisfoldedCFTR proteinDegraded in ER
CF Gene Therapy
Flu virus withNormal CFTR gene
Na+/K+ ATP-dependent Active Transporter (Pump)
Pg. 396
(see also Fig. 12-12)
K+ “Leak” Channel