Prof. Marianne Boes, Ph.D.Associate Professor in Immunology,

University of Utrecht, Center for TranslationalImmunology,

Utrecht, the Netherlands

n “Antigen processing and presentation mechanisms in human diseases”

CENTER FOR PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGYMEDICAL UNIVERSITY OF VIENNAINTERNET: WWW.MEDUNIWIEN.AC.AT/CePII

Venue: Hygiene Institute, Lecture Hall 1,Kinderspitalgasse 15, Vienna IX

Time: Friday, January 24, 2020, 2.30 pm

Host: Hannes Stockinger

COLLOQUIUM IN PATHOPHYSIOLOGY, INFECTIOLOGY AND IMMUNOLOGY

BiosketchMarianne Boes

n The research of the lab of Marianne Boes explores mechanisms that drive immune recognition indisease, including cancer. It is becoming increasingly clear that many diseases have an inflammatorycomponent to them that may be treatable by immune response modification. Cancer is one suchdisease that moreover touches on many aspects of immune recognition. In the models that shestudies, she uses a reductionist approach. As far as translational research is concerned, Mariannefocuses not only on diseases of limited complexity (primary immunodeficiencies presenting withautoinflammation), but also on conditions of increasing complexity (rheumatoid disorders) andcancer.

n From 2003-2008, her laboratory was located at Harvard Medical School/Brigham and Women’sHospital in Boston, USA. Since 2008, her lab is located at the department of Paediatrics andLaboratory of Translational Immunology (LTI) at the UMC-Utrecht and Wilhelmina Children'sHospital. Research is supported financially by grants from the Science Fund of the Netherlands(NOW), the European Research Council (ERC) and industry partners. The Boes lab has long-standing collaborations with both basic and clinically oriented investigators at the UMC-Utrecht andVeterinary Medicine-UU. Several collaborative projects exist with labs elsewhere in Europe and inthe USA. Marianne is faculty member of Educational Committee Life Sciences (EC-LS) for theFaculty of Medicine - Biomedical Sciences, and member of the Infection/Immunity EducationalCommittee, and coordinator of the Advanced Course in Immunology at UMC-Utrecht.

n Selected Publications:

n Bystander T-Cells Support Clonal T-Cell Activation by Controlling the Release of Dendritic Cell-Derived Immune-Stimulatory Extracellular Vesicles. Lindenbergh MFS, Koerhuis DGJ, Borg EGF, van 't Veld EM, Driedonks TAP, Wubbolts R, Stoorvogel W, Boes M. Front Immunol. 2019 Mar 12;10:448.

n Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma. Spel L, Nieuwenhuis J, Haarsma R, Stickel E, Bleijerveld OB, Altelaar M, Boelens JJ, Brummelkamp TR, Nierkens S, Boes M. Cancer Res. 2018 Dec 1;78(23):6621-6631.

n Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells. Janssen WJM, Grobarova V, Leleux J, Jongeneel L, van Gijn M, van Montfrans JM, Boes M. J Allergy Clin Immunol. 2018 Dec;142(6):1947-1955.

n Perception of self: distinguishing autoimmunity from autoinflammation. van Kempen TS, Wenink MH, LeijtenEF, Radstake TR, Boes M. Nat Rev Rheumatol. 2015 Aug;11(8):483-92.

n Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. van der Burgh R, Nijhuis L, Pervolaraki K, Compeer EB, Jongeneel LH, van Gijn M, Coffer PJ, Murphy MP, Mastroberardino PG, Frenkel J, Boes M. J Biol Chem. 2014 Feb 21;289(8):5000-12.

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