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Colorless Carotenoids Combinations
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection and Stability
SynergismBoosting activity
TiO2 & ZnO
CoQ10
DHADiHydroxyAcetone
Retinol
IBR-Dormin®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Carotenoids
www.ibrweb.com
©
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
CoQ10
DHADiHydroxyAcetone
Retinol
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Carotenoids
Colorless Carotenoids Combinations
www.ibrweb.com
Phytoene and phytofluene •Beauty from the inside* and outside• Anti aging and photo-aging• Skin brightening/whitening – evening of skin tone• Protection against UV and its damage• Anti oxidant• Prevention of DNA damage• Anti inflammatory• Protection and enhancement of other active ingredients and their activity
©
Colorless Carotenoids Combinations
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
CoQ10
DHADiHydroxyAcetone
Retinol
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oils
DHA & EPA
Carotenoids
Phytoene and phytofluene – TiO2 & ZnO•Stabilization•Boost of SPF*•Reduce generation of free radicals and damage derived from irradiation of TiO2 & ZnO
UV filterSPF in vitro
Predicted SPF
Increase
Phytoene 5%15.2
TiO2 5%1.3
Phytoene 2.5% +TiO2 2.5%
16.08.394%
*SPF in vitro : the average of five measurement
TiO2 & ZnO
www.ibrweb.com
©
Colorless Carotenoids Combinations
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
CoQ10
DHADiHydroxyAcetone
Retinol
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oils
DHA & EPA
Carotenoids
Phytoene and phytofluene – TiO2 & ZnO•Stabilization•Boost of SPF•Reduce generation of free radicals and damage derived from irradiation of TiO2 & ZnO*
* UVA irradiated phenol stability
TiO2 & ZnO
www.ibrweb.com
©
0
5
10
15
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45
0.25% TiO2TiO2+0.01 mg/ml P&PTiO2+0.05 mg/ml P&P
% P
he
no
l aft
er
UV
A ir
rad
iati
on
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
Retinol
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Carotenoids
Phytoene & phytofluene – CoQ10•Stabilization and protection against degradation•Synergism:
1. Anti aging - reduced MMP-1 expression*2. Reduced inflammation – PGE-2*
•Anti oxidants – reduce fatigue & stress
*Fuller B.B., et al. J. Cos. Der.. 2006 March. 5(1):30
www.ibrweb.com
1. 2.
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Carotenoids
Phytoene & phytofluene – Retinol
•Stabilization and protection against degradation
A. 5% Retinol + 0.5% Phytoene &
Phytofluene
B. 0.1% Retinol+0.05% Phytoene &
phytofluene
Retinol
Retinol left in cream after 4 weeks with0.5% Phytoene & Phytofluene or 0.05% BHT
93% 68%
www.ibrweb.com
B
A
B
A
Time: 0 Time: 10 min
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Retinol
Phytoene and phytofluene – -carotene
•Stabilization and protection against degradation•IBR-AAC® Anti Aging Carotenoids – phytoene, phytofluene and β-carotene: anti oxidation, anti inflammation, UV protection and pro-retinol addition
Carotenoids
www.ibrweb.com
After 35 minutes sun and air exposureStarting point
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
Vitamin C
Retinol
Carotenoids
Squalene
IBR-Dormin ®
Phytoene and phytofluene – Omega 3 oils
• Stabilization and protection against degradation
Reduce peroxide number• Combined activities:
1. Prevention of LDL oxidation2. Anti aging- anti oxidants, anti
inflammatory and protection from UV damage
3. Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis (mostly due to phytoene and phytofluene benefits)
4. Skin protection
Omega 3 oilsDHA & EPA
www.ibrweb.com
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
IBR-Dormin ®Vitamin C
Omega 3 oilsDHA & EPA
Retinol
Carotenoids
Squalene
www.ibrweb.com
Phytoene and phytofluene – squalene
• Stabilization and protection against degradation
Reduction in peroxide number• Activities:
1. Squalene boosts the phytoene and phytofluene protection against UVA and UVB and UV damage in general
2. Anti aging- via anti oxidation and protection from UV damage
Effect of phytoene & phytofluene and squalene on % peroxides formed in EPA exposed to air
0
20
40
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80
100
120
EP
A
5%
SQ
ULE
NE
0.0
05
%
alg
al
PH
an
d P
F
0.0
1%
alg
al
PH
an
d P
F
0.0
03
7%
tom
ato
PH
and
PF
0.0
07
5%
tom
ato
PH
and
PF
Sq
uale
ne
5%
Sq
uale
ne
5%
+
0.0
02
5%
alg
al
PH
Sq
uale
ne
5%
+
0.0
05
%
alg
al
PH
Sq
uale
ne
5%
+
0.0
1%
alg
al
PH
% P
ero
xid
e c
rea
ted
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
Vitamin C
Omega 3 oilsDHA & EPA
Retinol
Carotenoids
Squalene
IBR-Dormin ®
Phytoene and phytofluene – IBR-Dormin®
• Complementary short and long term anti aging action
Colorless carotenoids- anti oxidants, UV and UV damage protectors, collagen balancing (old and new), prevention of damage to DNA.
IBR-Dormin® - slowing down aging via dormancy and slowdown of cell proliferation.
• Combined skin whitening/ brightening activity.Inhibition of melanocytes proliferation
and melanin synthesis
www.ibrweb.com
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
DHADiHydroxyAcetone
Retinol
Carotenoids
Squalene
IBR-Dormin ®
Omega 3 oilsDHA & EPA
Phytoene and phytofluene – vitamin C
• Mutual stabilization in emulsions• Activities:
1. Combined skin whitening/ brightening activity.
2. Oil soluble and water soluble anti oxidants combination
3. Reduced stretch marks and wrinkles via combined activity of induction of old collagen degradation and enhancement of new collagen synthesis
Vitamin C
www.ibrweb.com
©
Colorless Carotenoids Combinations
CoQ10
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
Retinol
Carotenoids
Squalene
IBR-Dormin ®
Omega 3 oilsDHA & EPA
Vitamin C
DHADiHydroxyAcetone
Phytoene and phytofluene – DHA (di hydroxy acetone)
•Stabilization and protection against degradation•Anti oxidants – extending artificial sun tan
www.ibrweb.com
©
Colorless Carotenoids Combinations
Contact
www.ibrweb.com
Business Development and Marketing:
Liki von Oppen-Bezalel, Ph.D.
Hartmannsweilerweg 1, 14163 Berlin, Germany
Tel: +49-30-80589698; Fax: +49-30-80589704
email: [email protected]
Office:
Inon Perry, CEO
7 Jabotinsky st., Ramat-Gan 52520, Israel
Tel:+972-3-5165432; Fax:+972-3-5165654
email: [email protected]
Colorless Carotenoids:Phytoene & Phytofluene
Efficacy Protection andStability Synergism
Boosting activity
TiO2 & ZnO
CoQ10
DHADiHydroxyAcetone
Retinol
IBR-Dormin ®Vitamin C
Squalene
Omega 3 oilsDHA & EPA
Carotenoids
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease
©