Date post: | 16-Dec-2015 |
Category: |
Documents |
Upload: | jade-gloria-kelly |
View: | 214 times |
Download: | 0 times |
The Problem – an Ulcer!
Definition : ulcer n. an open sore on an external or internal surface
Slide 1
Using an endoscope to view an ulcer and a tissue sample then taken to be analysed
View of an ulcer in the stomach
Slide 3
Dr Robin Warren - pathologist
Team work
The curious observation made by Dr Robin Warren in the samples given to him to analyse.These observations were investigated by Dr Marshall.
Slide 4
Culture of Helicobacter pylori
A sample was taken and viewed under theElectron Microscope
After months of trials and failures,an unplanned long weekend in the incubatorproduced a result!
Slide 7
How the ulcer is formed
H. pylori causes excess production of HCl by cells of the stomach lining. The stomach is trying tokill the bacterium.
The excess acid removesthe mucus layer and thestomach cells are then attacked,resulting in an ulcer.
Acid inhibitors such as Tagamet now usually prescribed for relief but they have to be taken continually.
Slide 10
How the test works.Ammonia identified in exhaled air.This is due to H. pylori conversion ofUrea into ammonia.
Slide 14
Results that provide further proof of the connection between H pylori and ulcers.
H pylori removed within 2 weeks after taking antibiotics!
Slide 15
Communicating their findings
Slide16
Book: The Ease & Difficulty of a New Discovery.
Author: Robin Warren
Nobel prize announced - 2005
From initial discovery in1981 until acknowledgmentby the scientific communityin 2005!
Slide 19