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Considering Honours in the Neuroendocrinology Research Group?
Contact us
The Clarke Lab.Regulation of Reproduction (click here)
The Nichols’ Lab.Endocrine Control of Adult Neurogenesis (click here)
The Tilbrook Lab.Impact of Stress on Physiological Systems (click here)
The Neuroendocrinology Research Group provides a diverse range of projects embracing three main areas of research
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IMPACT OF STRESS ON PHYSIOLOGICAL SYSTEMS
Sex Visceral FatReproduction
How does stress impact on fertility?
How does reproductive experience affect learning and
memory in the face of a stressor?
Why do males and females have
different incidences of stress-related
diseases?
Does being lean make you less responsive to stress?
Does being obese from an early age make you more susceptible to disease?
Endocrine Control of Adult Neurogenesis
• The Nichols’ lab is interested in regulation of adult neural stem cells by hormones and growth factors or cytokines
• We use both in vivo (upper panel – brown cluster of proliferating nuclei) and in vitro approaches (lower panel – blue nuclei, red neurons, green glia) to study how neural stem cells develop into functional neurons
• We are particularly interested in effects of stress and stress hormones (glucocorticoids) on neurogenesis during brain repair
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Regulation of Reproduction
• Processing of POMC peptides in the arcuate nucleus in different physiological states and the effects of leptin.
• Role of Kisspeptin in the regulation of the GnRH system.
• Effect of environmental pollutants and endocrine disruptors on the neuroendocrine systems.
• Activation of the GnRH system by melanocortin agonists.
Immunohistochemisrty of Kisspeptin neurons (green cells) co-expressing Progesterone Receptor (red cells)in the Arcuate Nucleus.
Expression of KiSS-1 mRNA in the Arcuate Nucleus of the ewe. Detected by in situ hybridisation.
Professor Iain Clarke has built an internationally recognized group that has remained consistently competitive in the field of neuroendocrinology and brain mechanisms relevant to the control of reproduction.
Most recently, his laboratory has made a major impact in the field of kisspeptin and their imperative role in regulating the GnRH system.
Projects Available
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Contact Us
Department of Physiology Building 13F Room F228, Clayton Campus Email: [email protected]
Professor Iain ClarkeDr Nancy Nichols
Department of Physiology Building 13F Room F243, Clayton Campus Email: [email protected]
Ass. Professor Alan Tilbrook
Department of Physiology Building 13F Room F248, Clayton Campus Email: [email protected]
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Back to Iain’s lab.Back to Nancy’s lab.Back to Alan’s lab.
ExitSheep Brain Image: http://www.msu.edu/user/brains/sheepatlas/index.html Supported by the U. S. National Science Foundation
