INSIGHTS
LETTERS
26 Nextgen voices: News from a postpandemic world
PERSPECTIVES
30 Tracing cell trajectories in a biofilmSingle bacterial cells are programmed to form multicellular structures By A. Dal Co and M. P. Brenner
RESEARCH ARTICLE p. 71
31 Shutting down RNA-targeting CRISPRThe discovery of an anti-CRISPR reveals viral escape from CRISPR immunity By R. Barrangou and E. J. Sontheimer
RESEARCH ARTICLE p. 54
NEWS
IN BRIEF
12 News at a glance
IN DEPTH
14 Officials gird for a war on vaccine misinformationFears of a rushed COVID-19 vaccine and rise of social media demand new messaging strategy By W. Cornwall
15 The line starts to formg for a coronavirus vaccineU.S. and others debate who should get priority if vaccine doses are scarceBy J. Cohen
17 Rock seen inside Venus’s orbit could solve puzzleMineral in first object so close to the Sun may be a clue to missing “mantle” asteroids By N. Redd
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3 JULY 2020 • VOL 369 ISSUE 6499 5SCIENCE sciencemag.org
CONTENTS3 JULY 2020 • VOLUME 369 • ISSUE 6499
20
17
18 A colorful chemotherapy agent could be made less toxicSafer forms of doxorubicin, which kill tumor cells without damaging DNA, could spare hearts of cancer patients By J. Kaiser
19 Greenland rock cores to trace ice’s past meltingU.S. drilling campaign could also date controversial Hiawatha impact crater By P. Voosen
FEATURES
20 Improbable oasisPools in the Mexican desert are a hot spot of microbial diversity—and a window into early life By R. P. Ortega
PODCAST; VIDEO
33 The secret life of histonesHistone H3 leads a double life as a copper reductase By J. Rudolph and K. Luger
RESEARCH ARTICLE p. 59
34 Stronger bonds bring bigger challengesA polyoxometalate photocatalyst enables selective bond activation of light alkanes By G. Oksdath-Mansilla
REPORT p. 92
35 When do fish succumb to heat?Greater sensitivity in fish reproductive stages reveals vulnerability to climate change By J. Sunday
RESEARCH ARTICLE p. 65
37 Rewilding immunologyIntegrating comparative immunology can improve human, animal, and ecosystem health By A. S. Flies and Wild Comparative
Immunology Consortium
POLICY FORUM
39 Improve alignment of researchpolicy and societal valuesThe EU promotes Responsible Research and Innovation in principle, but implementation leaves much to be desired By P. Novitzky et al.
BOOKS ET AL.
42 Better homes and safer spacesEvidence-based indoor design is more important than ever By B. Brown
43 Physics meets America’s defense agendaWar transformed 20th-century physics in sometimes subtle ways By M. Frappier
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RESEARCH
IN BRIEF
45 From Science and other journals
REVIEW
48 MicrobiologySharing vitamins: Cobamides unveil microbial interactions O. M. Sokolovskaya et al.REVIEW SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.ABA0165
RESEARCH ARTICLES
49 CancerFeasibility of blood testing combined with PET-CT to screen for cancer and guide intervention A. M. Lennon et al.RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DX.DOI.ORG/10.1126/SCIENCE.ABB9601
50 CoronavirusSARS-CoV-2 productively infects human gut enterocytes M. M. Lamers et al.
54 CRISPR biologyA phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity A. J. Meeske et al.PERSPECTIVE p. 31
59 Histone functionThe histone H3-H4 tetramer is a copper reductase enzyme N. Attar et al.PERSPECTIVE p. 33
65 Climate responsesThermal bottlenecks in the life cycle define climate vulnerability of fish F. T. Dahlke et al.PERSPECTIVE p. 35
71 BiofilmsCell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy B. Qin et al.PERSPECTIVE p. 30
REPORTS
77 CoronavirusDevelopment of an inactivated vaccine candidate for SARS-CoV-2 Q. Gao et al.
81 DielectricsUltrahigh capacitive energy density in ion-bombarded relaxor ferroelectric films J. Kim et al.
Quantum gases
84 Strongly correlated superfluid order
parameters from dc Josephson
supercurrents W. J. Kwon et al.
89 An ideal Josephson junction in an
ultracold two-dimensional Fermi gas
N. Luick et al.
92 Organic chemistryC(sp3)–H functionalizations of light
hydrocarbons using decatungstate
photocatalysis in flow G. Laudadio et al.
PERSPECTIVE p. 34
96 Solar cellsA piperidinium salt stabilizes
efficient metal-halide perovskite
solar cells Y.-H. Lin et al.
103 HIVNumber of HIV-1 founder variants
is determined by the recency
of the source partner infection
Ch. J. Villabona-Arenas et al.
ON THE COVER
Tinged blue with minerals, La Poza Azul II is one of hundreds of spring-fed pools in Cuatro Ciénegas, an oasis in the desert of northern Mexico that preserves a vast diversity of microbes resembling those in
ancient oceans. Drainage for agriculture threatens the unique ecosystems of this oasis. See page 20. Photo: Miguel Angel de la Cueva
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CONTENTS
DEPARTMENTS
11 Editorial Surviving the trauma of COVID-19 By Roxane Cohen Silver
110 Working LifeA child of the slums By Shalini Arya
Science Staff ..................................................8
Science Careers .........................................109
35 & 65
Fish embryos, like these cod, are especially sensitive to warming.
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