Copyright 2004 © Mattioli Engineering All rights reserved

Transdermal Delivery Transdermal Delivery TechnologyTechnology

Limits of existing Technology

Traditional Ionthophoresis Ineffective for high weight molecules Changes the pH of ionic drug solutions Electrolytic effect at the electrodes Electrolysis of the ionic solution

Microdermabrasion Low delivery rate Effects limited to the skin surface

Electroporation High peak currents High risk of skin damage Adverse effects

Limits of existing Technology

Ultrasounds Ineffective for high weight molecules

Microcurrents Very Low delivery rate Not validated for medical application

Topical Application (Patches) Low delivery rate Adverse effects

Mattioli Engineering’s Solution

Mattioli Engineering removes the limits…

combines the advantages of the existing technologies

to create the Transderm® Ionto system

Mattioli Engineering’s Solution

How does Transderm Ionto System works:How does Transderm Ionto System works:

1st Step: Ultrapeel® Microdermabrasion

2nd Step: Transderm® Ionto systemUsing Dermoelectroporation® Technology

DERMOELECTROPORATION®

DERMOELECTROPORATION® means:

Dermo = From preventive MicroDERMDERMaabrasion.

Electroporation = From the shape of the electrical pulses of -low current - max 5mA- delivered on the dermis after microdermabrasion.

DERMOELECTROPORATION®

DERMOELECTROPORATION® features:

“Electroporation-like” pulsed IONTOPHORESISIONTOPHORESIS with safe, current-limited, pulsed waveforms (low current - max 5mA)

RETURN ELECTRODE around the ionic drug solution delivery electrode and not separated as in traditional Ionthophoresis systems.

DERMOELECTROPORATION®

Results of DERMOELECTROPORATION®

Ionic solution of low-weight moleculesEquivalent to classic Iontophoresis, but without direct currentEquivalent to classic Iontophoresis, but without direct current

Transdermal delivery of:

Ionic solution of high-weight molecules““Electroporation-like” Transdermal delivery prior Microdermabrasion requiredElectroporation-like” Transdermal delivery prior Microdermabrasion required

Advantages of Transdermal Deliveryof Low-Weight Molecules

Positive and negative ions of the drug are transdermally delivered at the same time

No electrolytic reactions at the electrodes No change of ionic drug solution pH No electrolysis of ionic drug solution Less skin irritation Possibility for prior microdermabrasion to enhance

transdermal delivery

European Clinical tests demonstrate advantages of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of radioactive Lidocaine

Advantages of Transdermal Deliveryof High-Weight Molecules

No skin damage due to low limited-current pulses

No change in pH due to symmetrical pulse administration

No adverse effects reported

European Clinical tests demonstrate enhanced delivery of collagen

and a five-fold increase in transdermal delivery of Eparine

using Dermoelectroporation® Vs. application on the skin

Advantages of Dermoelectroporation®

TRANSDERM® IONTOTRANSDERM® IONTO

Copyright 2004 © Mattioli Engineering All rights reserved

TRANSDERMTRANSDERM®® IONTOIONTO

New FDA 510K New FDA 510K approval approval on on Vibration FeaturesVibration Features

EUROPEAN EXPERIENCES

Biostimulation & Biorestoration

Clinical Test from Dr. Bacci – Plastic cosmetic surgery specialist-Arezzo

FOR EDUCTIONAL PURPOSES ONLY

Mattioli Engineering © All rights reserved – Do not distribute – For internal use only Biorestoration

Carnitine

Collagen

Lidocaine

Rehabilitation

Dermoelectroporation and Cellulite

Clinical Test from Dr. Cavallini –Plastic surgery specialist-MILAN

FOR EDUCTIONAL PURPOSES ONLY

Mattioli Engineering © All rights reserved – Do not distribute – For internal use only

The European ExperienceCollagen

FOR EDUCTIONAL PURPOSES ONLY

Mattioli Engineering © All rights reserved – Do not distribute – For internal use only

The European Experience -Lidocaine

FOR EDUCTIONAL PURPOSES ONLY

Mattioli Engineering © All rights reserved – Do not distribute – For internal use only

FOR EDUCTIONAL PURPOSES ONLY

Mattioli Engineering © All rights reserved – Do not distribute – For internal use only

“Efficacy of Dermoelecroporation treatment on Inflammatory – degenerative pathologies of human locomotive apparatus”

Observation Study carried out at:S.C. Riabilitazione OrtopedicaOspedale “Eugenio Morelli” di SondaloAzienda Ospedaliera della Valtellina e della Valchiavenna

Project Responsible : Dr. Paolo BuselliPhysical and rehabilitative therapy specialist

S.C.-Struttura Complessa RIABILITAZIONE ORTOPEDICA

Transderm® Ionto

Distributed by:

Saratoga Aesthetics

1-800-998-1555

Email: cfkusa@aol.com