Courses Specifications€¦ · Basic Concepts of Organic Chemistry 2 2. Alkanes 2 3. Alkenes 2 4....

Courses Specifications

Pharmaceutical Chemistry Courses

2016-2017

Faculty of Pharmacy


Delta University

for Science and Technology

Faculty of Pharmacy, Delta University for Science and Technology

1

Dept. of Pharmaceutical Chemistry

Physical Chemistry .................................................................................................. 2

Pharmaceutical Organic Chemistry-1 ................................................................... 6

Pharmaceutical Analytical Chemistry-1 .............................................................. 11

Pharmaceutical Organic Chemistry-2 ................................................................. 16

Pharmaceutical Analytical Chemistry-2 .............................................................. 21

Medicinal Chemistry-1 .......................................................................................... 27



Drug Design and Development ............................................................................. 41

Quality Control ...................................................................................................... 46

Courses under supervision of Chemistry Departments ..................................... 51

Mathematics ........................................................................................................... 51

General Physics ...................................................................................................... 55

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2

Physical Chemistry

1. Basic Information:

Course title: Physical chemistry

Course code: PC 102

Department: Pharmaceutical chemistry

Program on which the course is given: B. Pharm.

Faculty: Pharmacy

University: Delta University for Sciences and Technology

Academic level: level one Fall Semester 2016-2017

Specialization: Basic Sciences

Prerequisite: None

Credit hours: Lecture :2 Practical: 1 Total: 3

Approval date: 12/3/2017

2. Course Aims:

Giving the basic concepts of some topics such as: atomic and molecular structure,

types of bonds, periodic table, chemical calculations, and types of chemical reactions

and understanding the basic principles of thermochemistry and thermodynamics of

chemical reactions and solution chemistry

3. Intended Learning Outcomes (ILOs):

a. Knowledge and understanding:

At the end of this course, student should be able to:

A1 a1. Identify the principles of basic and pharmaceutical sciences

A2 a2. Recognize the physicochemical properties of drugs

b. Intellectual Skills:


B13 b1. Interpret experimental data based on relevant chemical principles

c. Professional and Practical Skills:


C2 c1. Handle and dispose chemicals safely

d. General and Transferable Skills:


D3 d1. Work effectively as a part of a team to perform the required tasks

D9 d2. Acquire effective time management skills

D10 d3. Implement writing and presentation skills

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4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Periodic table 2

2. Electronic configuration 2

3. Properties of periodic table elements 2

4. Chemical bonding 2

5. Types of chemical reactions 2

6. Introduction to quantitative analysis 2

7. Mid-Term exam

8. Thermochemistry and Thermochemical equations 2

9. Water calorimeter, application of Hess law 2

10. Thermodynamics 2

11. Properties of electromagnetic radiations 2

12. Laws of photochemistry 2

13. General revision 2

14. Final Exam 24

15.

4.2.Practical/Tutorial:

Week

No. Topics

No. of

hours

1. Handling of chemicals and safety in laboratories 1

2. Determination of carbonate group 1

3. Determination of sulphur group 1

4. Determination of phosphate and nitrate 1

5. Revision on anions 1

6. Practical quiz -1 1

7. Mid-Term exam ---

8. Practical exam-1 1

9. Determination of group 1 & 2 1

10. Determination of group 3 & 4 1

11. Determination of group 5 1

12. Revision on cations 1

13. Practical Exam 1

14. Final Exam

15. 12

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5. Teaching and Learning Methods:

5.1. Lectures using whiteboard and data show

5.2. homework

5.3. Laboratory classes

6. Student Assessment Methods:

6.1.Assessment methods:

1. Written exam to assess knowledge, understanding, intellectual and professional skills

2. Practical exam to assess professional and practical skills

3. Class work to assess knowledge, understanding, intellectual skills, general skills and

confidence

4. Quizzes to assess knowledge, understanding and intellectual skills

6.2.Assessment schedule:

Assessment 1 Mid-term 7th week

Assessment 2 Quiz 11th week

Assessment 3 Practical 13th week

Assessment 4 Written 14th &15th weeks

6.3.Weighing of Assessments:

Mid-Term Exam & course work 25%

Final-Term Exam 50%

Practical Exam 25%

Total 100%

7. List of References:

No. Reference type

1. Analytical Chemistry, Gary D. Christian, 7th ed. John Wiely and

Sons, New York (2013). textbook

2. Dean’s Analytical Chemistry Handbook, Pradyot Patanik,

Second Edition, McGraw Hill, New York (2004). textbook

3.

Fundamentals of Analytical Chemistry, 9th ed. Douglas,A.

Skoog and Donald M. West.Sounder’s College Publishing,

Japan (2014).

textbook

Faculty of Pharmacy


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5

8. Matrix of course contents versus ILOs:

Week

No. Course contents

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1. Periodic table a1 b1 c1 d1

2. Electronic configuration a1,a2 b1 c1 d2

3. Properties of periodic table

elements a2 b1 c1 d2

4. Chemical bonding a2 b1 c1 d1

5. Types of chemical reactions a1 b1 c1 d3

6. Introduction to quantitative

analysis a1,a2 b1 c1 d3

8. Thermochemistry a1,a2 b1 c1 d1

9. Thermochemical equations a1,a2 b1 c1 d1

10. Thermodynamics a1,a2 b1 c1 d1,d2

11. Properties of electromagnetic

radiations a1,a2 b1 c1 d1,d2

12. Laws of photochemistry a1 b1 c1 d1

13. General revision a1,a2 b1 c1 d1,d2

Name Signature

Course Coordinator: Dr. Mary Wahba

Head of Department: Prof. Dr. Fatma El-Nabawia Goda

Approval Date 12/3/2017

Faculty of Pharmacy


Delta University



6

Pharmaceutical Organic Chemistry-1

1. Basic Information:

Course title: Pharmaceutical Organic Chemistry-1

Course code: PC111

Department: Pharmaceutical Chemistry


Faculty: Pharmacy


Academic level: First level Spring semester 2016/2017

Specialization: Pharmaceutical Science

Prerequisite: Physical Chemistry (PC102)

Credit hours: Lecture: 2 h Practical:1h Total:3h


2. Course Aims:

The aim of the course is to provide students with proper understanding of the basic principles of

organic reactions. In addition, providing a good idea about the stereochemistry of the chiral organic

compounds. The students will be capable to identify certain aliphatic organic compounds and

recognize their chemical properties, synthesis and reactions.




A1

a1. Represent various structural and molecular formulas of different aliphatic organic

compounds.

a2. Name the majority of aliphatic chemical structure and draw the structure of any

chemical name

A4

a3. Identify different organic functionalities, their properties, introduction and

transformation to each other, concerning aliphatic organic compounds.

a4. Recognize the stereochemistry of the chiral organic molecules through studying the

asymmetric aspects



B5 b1. Predict the IUPAC name, structure, identification qualitative tests and broad-line

synthesis of aliphatic organic compounds

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B16

b2.

Think critically about the chemistry of aliphatic organic molecules and relate their

specific structural features to possible synthesis, identification and physicochemical

properties

b3. Analyze the organic chemistry data and principles essential for comprehension of other

applied chemistry sciences



C4 c1. Identify different functional groups of organic compounds

c2. Perform identification chemical tests effectively and safely

C11 c3. Record data and write practical chemical reports



D3 d1. Work effectively in a team

D6 d2. Practice self-learning and long-life learning

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Basic Concepts of Organic Chemistry 2

2. Alkanes 2

3. Alkenes 2

4. Alkynes 2

5. Alkyl halides and Nucleophilic Substitution Reactions 2

6. Alcohols and Ethers 2

7. Mid-Term exam -

8. Aliphatic Amines 2

9. Aliphatic Aldehydes and Ketones 2

10. Aliphatic carboxylic acids & their derivatives 2

11. Stereochemistry 2



14. Final Written and Oral exam 24

15.

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Week

No. Topics

No. of

hours

1. Lab safety 1

2. Physical Characters and Solubility 1

3. Physical Characters and Solubility 1

4. General Reactions

Dry heat, Sodalime, 30%NaOH, Na2CO3, FeCl3, H2SO4, Element Test 1

5. General Reactions

Dry heat, Sodalime, 30%NaOH, Na2CO3, FeCl3, H2SO4, Element Test 1

6. Alcohols 1

7. Mid-Term exam -

8. Aldehydes and Ketones 1

9. Phenols 1

10. Aliphatic Carboxylic Acids and Salts 1

11. Aromatic Carboxylic Acids and Salts 1

12. Esters and Amides 1


14. Final Exam 12

15.


5.1. Lectures using white board and data show


5.3. video and animation


6.1. Assessment methods:




confidence

3. Oral exam to assess knowledge, understanding, intellectual skills, general skills and

confidence


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6.2. Assessment schedule:





Assessment 5 Oral 14th &15th weeks



Final-Term Exam 40%

Oral Exam 10%

Practical Exam 25%

Total 100%


No. Reference type

1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and Scott A.

Snyder11th Ed., 2014. textbook

2. A Microscale Approach to Organic Laboratory Techniques, Donald L.

Pavia, Gary M. Lampman, George S. Kriz, Randall G. Engel, 4th Ed., 2016 textbook

3. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney, J. D.

Barnes, M.J.K. Thomas, 6th Ed., 2006 textbook

4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website

5. http://www.organic-chemistry.org/ website

6. www.orgsyn.org website


No. Course contents Study

week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Basic Concepts of Organic

Chemistry 1 a1-a3 - - -

2. Alkanes 2 a1-a4 b1-b3 c1-c3 d1,d2

3. Alkenes 3 a1-a4 b1-b3 c1-c3 d1,d2

4. Alkynes 4 a1-a3 b1-b3 c1-c3 d1,d2

http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm

http://www.organic-chemistry.org/

http://www.orgsyn.org/

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5.

Alkyl halides and

Nucleophilic Substitution

Reactions

5 a1-a4 b1-b3 c1-c3 d1,d2

6. Alcohols and Ethers 6 a1-a3 b1-b3 c1-c3 d1,d2

7. Aliphatic Amines 8 a1-a4 b1-b3 c1-c3 d1,d2

8. Aliphatic Aldehydes and

Ketones 9 a1-a3 b1-b3 c1-c3 d1,d2

9. Aliphatic carboxylic acids

& their derivatives 10 a1-a4 b1-b3 c1-c3 d1,d2

10. Stereochemistry 11-13 a1-a4 b1-b3 - d1,d2

Name Signature

Course Coordinator: Prof. Fatma E. Goda

Head of Department: Prof. Fatma E. Goda


Faculty of Pharmacy


Delta University



11

Pharmaceutical Analytical Chemistry-1 1. Basic Information:

Course title: Analytical chemistry-1

Course code: PC 121



Faculty: Pharmacy


Academic level: level one Spring semester 2016/2017


Prerequisite: Physical chemistry

Credit hours: Lecture : 2 Practical: 1 Total: 3


2. Course Aims:

Giving the basic principles of the quantitative chemical analysis including acid base,

precipitimetric and complexometric analysis and cover the applications of these

methods to pharmaceutical compounds





A3 a2. Manage the different analytical techniques

A4 a3. Enumerate the theories of evaluation and standardization of chemicals and

pharmaceuticals



B3 b1. Determine suitable methods of analysis of drugs as raw materials.

B5 b2. Design appropriate methods for evaluation and standardization of various chemical

and pharmaceutical compounds




C4 c2. Select appropriate methods for identification and standardization of active substances

from different origins

C14 c3. Employ different quantitative chemical methods for assay of raw materials

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12






4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Introduction to Analytical Chemistry, introduction to

Volumetric Analysis 2

2. Acid-base theories 2

3. Calculations 2

4. Buffers 2

5. Acid-base indicators 2

6. Titration Curves 2

7. Mid-Term exam

8. Applications 2

9. Precipitimetric Titration, Solubility product principle

Factors affecting solubility of precipitates 2

10.

Titration Curves, Fractional precipitation, Mohr´s method

Volhard method, Fajan method, Liebeg’s method,

Application

2

11. Complexmetric Titration, Introduction, Types of bonds, Stability of

Complexes, Co-ordinating groups, Chelating and Sequestering agents 2

12. Metalochromic indicators,Titration with EDTA, Application 2

13. General Revision 2

14. Final Exam 24

15.


Week

No. Topics

No. of

hours

1. Introduction to volumetric analysis 1

2. Handling of accurate measures 1

3. Determination of HCl #NaOH 1

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4. Determination of HCl/acetic acid mixture 1

5. Determination of NaOH/Na2CO3 mixture 1

6. Determination of ammonium chloride by back titration 1

7. Mid-Term exam

8. Determination of aspirin by back titration 1

9. Introduction to complexometry 1

10. Determination of MgSO4 #EDTA 1

11. Determination of Ca/Mg mixture #EDTA 1

12. Determination of NaCl by Mohr method 1


14. Final Exam 12

15.



5.2. homework







confidence


confidence


5. Case study to assess the skills of problem-solving and data presentation







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Final-Term Exam 40%

Oral Exam 10%

Practical Exam 25%

Total 100%


No. Reference type

1. Analytical Chemistry, Gary D. Christian, 7th ed. John

Wiely and Sons, New York (2013). textbook

2. Dean’s Analytical Chemistry Handbook, Pradyot Patanik,

Second Edition, McGraw Hill, New York (2004). textbook

3.

Fundamentals of Analytical Chemistry, 9th ed. Douglas,A.

Skoog and Donald M. West. Sounder’s College Publishing,

Japan (2014).

textbook



week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1.

Introduction to

Analytical Chemistry,

introduction to

Volumetric Analysis

1 a1 b1 c1 d1

2. Acid-base theories 2 a1,a2 b1,b2 c1,c2 d2

3. Calculations 3 a3 b2 c3 d2,d3

4. Buffers 4 a2 b1 c3 d1

5. Acid-base indicators 5 a1 b1 c2 d3

6. Titration Curves 6 a1,a2 b1 c3 d2

7. Applications 8 a1,a2 b1 c1, c3 d1

8.

Precipitimetric Titration,

Solubility product

principle

Factors affecting

solubility of precipitates

9 a1,a2 b1 c2, c3 d1,d2

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9.

Titration Curves,

Fractional precipitation,

Mohr´s method

Volhard method, Fajan

method, Liebeg’s

method, Application

10 a1,a2 b1 c2, c3 d1,d2

10.

Complexmetric Titration,

Introduction, Types of

bonds, Stability of

Complexes, Co-ordinating

groups, Chelating and

Sequestering agents

11 a1,a3 b1,b2 c2, c3 d1

11.

Metalochromic

indicators,Titration with

EDTA,

12 a1,a3 b1,b2 c2, c3 d1

12. Application 13 a1,a3 b1,b2 c2, c3 d1

Name Signature




Faculty of Pharmacy


Delta University



16

Pharmaceutical Organic Chemistry-2 1. Basic Information:

Course title: Pharmaceutical Organic Chemistry-2

Course code: PC 211



Faculty: Pharmacy


Academic level: Second level Fall Semester 2016-2017


Prerequisite: Pharmaceutical Organic Chemistry-1 (PC111)

Credit hours: Lecture:2 Practical:1 Total:3


2. Course Aims:

The aim of the courses is to provide students with proper understanding of the basic

principles of aromaticity and heterocyclic chemistry. In addition, providing students with reactions

and mechanisms of aromatic compounds. The students will also be capable to synthesize certain

organic compounds and recognize their physicochemical properties




A1

a1. Represent various structural and molecular formulas of different aromatic and

heterocyclic organic compounds

a2. Name the majority of aromatic and heterocyclic structures and draw the structure of

any chemical name

A4

a3. Enumerate the theories of identification, synthesis, and purification of different

aromatic and heterocyclic compounds.

a4. Identify different organic functionalities, their properties, introduction and

transformation to each other, concerning aromatic and heterocyclic compounds



B5 b1. Design appropriate methods for synthesis and purification of selected aromatic and

heterocyclic compounds

B16

b2.

Think critically about the chemistry of aromatic and heterocyclic organic compounds

and relate their specific structural features to possible synthesis, identification and

physicochemical properties

b3. Analyze the organic chemistry data and principles essential for comprehension of other

applied chemistry sciences

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C4

c1. Perform chemical synthesis of selected organic compounds effectively and safely

c2. Determine the physicochemical characteristics of different aromatic and heterocyclic

compounds

C11 c3. Record data and write practical chemical reports



D3 d1. Work effectively in a team

D6 d2. Practice self-learning and long-life learning

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1.

Aromatic Compounds: Structure of benzene, The concept of

Aromaticity, Nomenclature, Electrophilic Aromatic Substitution,

Reactivity and Orientation.

2

2. Nucleophlic Aromatic Substitution, Benzene and its Homologues:

synthesis and reactions, Polynuclear Hydrocarbons. 2

3.

Aryl Halides: Nomenclature of Aryl Halides, Structure of Aryl

Halides, Physical Properties of Aryl Halides, Preparation of Aryl

Halides, Nucleophilic Aromatic Substitution.

2

4.

Aromatic Nitro Compounds: Physical properties of nitro compounds,

Preparation of nitro compounds, Reactions of nitro compounds,

Importance of nitro compounds in synthetic pathways.

2

5.

Aromatic Amines: Nomenclature of amines, Structure of amines and

the basicity concept, Physical properties of amines. Preparation of

amines. Reactions of amino compounds.

2

6.

Aromatic diazonium salts: stability relative to aliphatic salts,

mechanism of diazotization, nomenclature, reactions with retaining of

nitrogen [coupling with phenols and amines, reduction], reactions with

replacement of nitrogen [by hydrogen, OH, Cl or Br (Sandmeyer

reaction, gattermann reaction), Schiemann reaction, CN, NO2.

2

7. Mid-Term exam -

8.

Phenols: Structure of phenols. Classification and Physical Properties

of phenols. Preparation of phenols. Chemical Properties: acidity, ring

substitution. Pharmaceutical importance of phenols.

2

9.

Aromatic sulfonic acids: preparation, properties, reactions [formation

of acid chlorides, esterification, desulfonation, conversion to phenols,

ring substitution], important derivatives [Chloramines T,

Dichloramine T, Saccharine and Sulfonamides].

2

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10.

Aromatic Aldehydes and Ketones: Structure of aldehydes and ketones.

Nomenclature aldehydes and ketones. Physical Properties of

aldehydes and ketones. Preparation of aldehydes and ketones.

Nucleophilic addition Reactions. Reaction at the α-carbon. Oxidation

and reduction reactions.

2

11.

Aromatic Carboxylic Acids and Their Derivatives: Structure of

Aromatic Carboxylic Acids and Acidity Concept Nomenclature

Aromatic Carboxylic Acids. Physical Properties of Aromatic

Carboxylic Acids. Preparation of Aromatic Carboxylic Acids.

Chemical Properties of Aromatic Acids. Carboxylic Acids derivatives:

acid chlorides, acid anhydrides, acid esters, acid amides, nitriles.

Preparation of Carboxylic Acids Derivatives. Reactions of Carboxylic

Acids Derivatives. Saturated and Unsaturated Dicarboxylic Acid.

2

12.

Heterocyclic Chemistry Nomenclature, Classification of heterocycles

and Reactivity of heterocycles. Five-membered Heterocycles Typical

reactivity of five membered heterocycles, Synthesis and Reactions of

Pyrrole, Thiophen, Furan, Synthesis and Reactions of indole and

benzothiophene, benzofuran.

2

13.

Six-membered Heterocycles, Typical reactivity of pyridine, quinolines

and lsoquinolines, Synthesis and Reactions pyridine, quinoline and

isoquinoline, Typical reactivity of pyridazine, pyrimidine and

pyrazine, Synthesis and Reactions of pyridazine, pyrimidine and

pyrazine.

2

14. Final Exam 24

15.


Week

No. Topics

No. of

hours

1. Lab safety and lab equipment 1

2. Synthesis of ethyl acetate 1

3. Synthesis of methyl salicylate 1

4. Synthesis of acetanilide 1

5. Synthesis of iodoform 1

6. Synthesis of nitrotoluene 1

7. Mid-Term exam -

8. Synthesis of nitronaphthalene 1

9. Synthesis of azodye 1

10. Synthesis of diazoaminobenzene 1

11. Synthesis of ozazone 1

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12. Revision 1


14. Final Exam 12

15.


5.1. Lectures using boards and data show

5.2. Laboratory classes, tutorial discussion

5.3. video and animation






confidence


confidence







Assessment 5 Oral 14th & 15th weeks



Final-Term Exam 40%

Oral Exam 10%

Practical Exam 25%

Total 100%


No. Reference type

1. Organic Chemistry, T. W. Graham Solomons, Craig B. Fryhle, and

Scott A. Snyder11th Ed., 2014. textbook

2. Vogel's Quantitative Chemical Analysis, J. Mendham, R.C. Denney, J.

D. Barnes, M.J.K. Thomas, 6th Ed., 2006 textbook

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3. Heterocyclic Chemistry, J. A. Joule, K. Mills, 5th Ed., 2010 textbook

4. http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm website

5. http://www.organic-chemistry.org/ website

6. www.orgsyn.org website



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Aromatic Compounds 1,2 a1-a4 b1-b3 c1-c3 d1,d2

2. Aryl Halides 3 a1-a4 b1-b3 c1-c3 d1,d2

3. Aromatic Nitro

Compounds 4 a1-a4 b1-b3 c1-c3 d1,d2

4. Aromatic Amines 5 a1-a4 b1-b3 c1-c3 d1,d2

5. Aromatic diazonium Salts 6 a1-a4 b1-b3 c1-c3 d1,d2

6. Phenols 8 a1-a4 b1-b3 c1-c3 d1,d2

7. Aromatic sulfonic acids 9 a1-a4 b1-b3 c1-c3 d1,d2

8. Aromatic Aldehydes and

Ketones 10 a1-a4 b1-b3 c1-c3 d1,d2

9.

Aromatic Carboxylic

Acids and their

Derivatives

11 a1-a4 b1-b3 c1-c3 d1,d2

10. Heterocyclic Chemistry 12,13 a1-a4 b1-b3 c1-c3 d1,d2

Name Signature

Course Coordinator: Prof. Fatma E. Goda



http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/intro1.htm

http://www.organic-chemistry.org/

http://www.orgsyn.org/

Faculty of Pharmacy


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21

Pharmaceutical Analytical Chemistry-2 1. Basic Information:

Course title: Analytical chemistry-2

Course code: PC 222



Faculty: Pharmacy


Academic level: level two Spring Semester 2016-2017

Specialization: Pharmaceutical Sciences

Prerequisite: Analytical chemistry-1

Credit hours: Lecture :2 Practical: 1 Total: 3


2. Course Aims:

Giving the principle of quantitative chemical methods of analysis, Demonstrate basic

principles of redox reactions, Covers electro-analytical methods of analysis, Provides

basic concepts of spectroscopy




A3 a1. Manage the different analytical techniques

A4 a2. Enumerate the theories of evaluation and standardization of chemicals and

pharmaceuticals



B3 b1. Determine suitable methods of analysis of drugs as raw materials

B5 b2. Design appropriate methods for evaluation of various chemical and pharmaceutical

compounds




C4 c2. Select appropriate methods for evaluation and standardization of active substances

from different origins

C8 c3. Employ different quantitative chemical methods for assay of raw materials.

C14 c4. Manipulate pharmaceutical instruments and equipments safely and efficiently and

solve commonly encountered problems in pharmaceutical analysis

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22






4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1.

Redox reactions:

Introduction:

Factors affecting redox potential:

Methods for detection of end point:

2

2.

REDOX STANDARDS & APPLICATIONS:

(A) OXIDIZING AGENTS

KMnO4:

Advantages and disadvantages.

Applications

2

3.

Ce(SO4)2:


Applications:

K2Cr2O7:


Applications

2

4.

KBrO3:

Preparation of standard Br2.

Applications:

I2:

Properties.

Iodimetry & Iodometry.

Applications:

2

5.

REDUCING AGENTS

(1) FeSO4.

(2) Na2S2O3.

Pharmaceutical Applications

2

6. Electro chemistry

Introduction to electrochemistry 2

7. Mid-Term exam --

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8.

Potentiometry

Reference electrodes: Standard hydrogen electrode ,Saturated calomel

electrode

Indicator electrodes (glass electrode)

Applications

2

9. Conductometry: theory and application 2

10. Spectrophotometry

Introduction Components of spectrophotometer 2

11. Types of spectrophotometers:

Beer-Lambert law 2

12. Factors affecting absorption spectrum: Applications 2


14. Final Exam

15. 24


Week

No. Topics

No. of

hours

1. Introduction to redox titration 1

2. Determination of KMnO4 # oxalic acid 1

3. Determination of K2CrO4 by iodometry 1

4. Determination of CuSO4 by iodometry 1

5. Andrews method 1

6. revision 1


8. Determination of ascorbic acid 1

9. Introduction to spectrophotometry 1

10. Drawing of absorption spectrum and calibration curve 1

11. Drawing of absorption spectrum of KMnO4 by spectrophotometry 1

12. Drawing of calibration curve of KMnO4 by spectrophotometry 1


14. Final Exam

15. 12


5.1. Lectures

5.2. Laboratory equipment

5.3. Tutorial discussion

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confidence


confidence











Final-Term Exam 40%

Oral Exam 10%

Practical Exam 25%

Total 100%


No. Reference type

1. Analytical Chemistry, Gary D. Christian, 7th ed. John Wiely and Sons, New

York (2013). textbook

2. Dean’s Analytical Chemistry Handbook, Pradyot Patanik, 2nd ed., McGraw

Hill, New York (2004). textbook

3. Fundamentals of Analytical Chemistry, 9th ed. Douglas,A. Skoog and

Donald M. West.Sounder’s College Publishing, Japan (2014). textbook

4. http://www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Ph

otomultiplier.mp4 website

http://www.mediafire.com/download/tfw77m3ewhbte0s/Animation_Spectro_Photomultiplier.mp4



Faculty of Pharmacy


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25



week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1.

Redox reactions:

Introduction:

Factors affecting redox

potential:

Methods for detection of

end point:

1 a1,a2 b1,b2 c1,c2,c3 d1,d2

2.

REDOX STANDARDS &

APPLICATIONS:

(A) OXIDIZING AGENTS

KMnO4:

Advantages and

disadvantages.

Applications

2 a1,a2 b1,b2 c1,c2,c3 d1,d2

3.

Ce(SO4)2:

Advantages and

disadvantages.

Applications:

K2Cr2O7:

Advantages and

disadvantages.

Applications

3 a1,a2 b1,b2 c1,c2,c3 d1,d2

4.

KBrO3:

Preparation of standard Br2.

Applications:

I2:

Properties.

Iodimetry & Iodometry.

Applications:

4 a1,a2 b1,b2 c1,c2,c3 d1,d2

5.

REDUCING AGENTS

(1) FeSO4.

(2) Na2S2O3.

Pharmaceutical Applications

5 a1,a2 b1,b2 c1,c2,c3 d1,d2

6. Electrochemistry

Introduction 6 a1 b1 c3,c4 d2,d3

7. Potentiometry 8 a1 b1 c3,c4 d2,d3

Faculty of Pharmacy


Delta University



26

Reference electrodes:

Standard hydrogen electrode

,Saturated calomel electrode

Indicator electrodes (glass

electrode)

Applications

8. Conductometry: theory

and application 9 a1 b1 c3,c4 d2,d3

9.

Spectrophotometry

Introduction Components of

spectrophotometer

10 a1 b1 c2, c4 d1,d2,d3

10. Types of spectrophotometers:

Beer-Lambert law 11 a1 b1 c2, c4 d1,d2,d3

11. Factors affecting absorption

spectrum: 12 a1 b1 c2, c4 d1,d2,d3

12. Applications 13 a1 b1 c2, c4 d1,d2,d3

Name Signature

Course Coordinator: Dr. Essam Khamis

Head of Department: Prof. Fatma Goda


Faculty of Pharmacy


Delta University



27

Medicinal Chemistry-1 1. Basic Information:

Course title: Medicinal Chemistry-1

Course code: PC 331



Faculty: Pharmacy


Academic level: Third level Fall Semester 2016- 2017


Prerequisite: Pharmaceutical Organic Chemistry-2 (PC211)

Credit hours: Lecture:2 Practical: - Total:2


2. Course Aims:

To enable the student to gain an understanding of the physicochemical properties of drugs and

their biotransformation, the structures and uses of different chemotherapeutic agents, their

modes of action; the correlation between chemical structures and biological activities.




A2. a1. Recognize the physico-chemical properties of drugs and how chemical properties of

these drugs will influence in vivo and in vitro behavior.

A5. a2. Realizing how drug-receptor interactions occur and relate chemical structure to

biological activity.

A13.

a3 Illustrate the different metabolic biotransformation pathways of drugs

a4. Classify different chemotherapeutic agents; identify their chemistry, nomenclature,

molecular mode of action and their spectrum of activity.



B9. b1. Select the proper drugs for various disease conditions based on understanding

structural activity relationship and drug chemistry.

B16.

b2. Predict the pharmacological class of a given chemical structure, discuss potential

pharmacological, metabolic and therapeutic activities based on that classification.

b3. Think critically about the chemistry of drug molecules and relate the specific

structural features to target receptor affinity.

Faculty of Pharmacy


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28



C9. c1. Raise the public awareness on rationale use of chemotherapeutic agents based on an

understanding of drug chemistry.

C13. c2.

Deduce relative receptor affinity, metabolic vulnerability, distribution potential,

potential drug-drug and drug-food interactions, and potential side effects or

toxicities based on drug chemistry.

C21. c3. Manage side effects and toxicity of chemotherapeutic agents and apply oncology

supportive case.



D3. d1. Work effectively as a part of a team to perform the required tasks.

D6. d2. Develop the skills required for continued self-professional development and self-

learning.

4. Contents:

4.1.Lectures:

No. Topics No. of

hours

1,2.

Introduction

1. Physicochemical Properties and Drug Action

Major processes involved in drug action

Physicochemical parameters

Drug-Receptor interactions

4

3. Drug Metabolism : phase I , phase II 2

4.

Chemotherapeutic Agents

Antibacterial Agents

Mechanisms of antibacterial action

Antibiotics:

Antibiotics which inhibit cell wall synthesis

Penicillins

Cephalosporins

Non classical -lactams

2

5.

Antibiotics which impair protein synthesis

Aminoglycosides

Tetracyclines

Macrolides

Chloramphenicol

2

6. Agents which act on nucleic acid transcription and replication

Quinolones and fluoroquinolones 2


8. Antifungal agents

Azoles.

Antifungal Antibiotics.

2

Faculty of Pharmacy


Delta University



29

9-10.

Antiviral Agents

Nucleoside Antagonists

Non-Nucleoside inhibitors of reverse

transcriptase

Protease Inhibitors

Neuroaminidase inhibitors

4

11. Cancer chemotherapy:Antineoplastic drugs:

Tumor Cell Properties

Alkylating Agents

2

12. Antimetabolites 2

13. Miscellaneous Agents 2

14. Final Exam

15. 24


No Practical for this course


5.1. Lectures and Tutorials

5.2. Researches and Homework



1. Quizzes to assess knowledge, understanding

2. Research to assess Ability to gather and evaluate information

3. Written exam to assess Overall performance of the students

3. Oral exam to assess Confidence and understanding


Assessment 1 Quiz 1 4th week

Assessment 2 Mid-Term 7th week





Mid-Term Examination 10

Final-Term Examination 65

Oral Examination 10

Practical Examination 0

Semester work 15

Total 100%

Faculty of Pharmacy


Delta University



30


No. Reference type

1.

"Wilson and Gisvold’s Textbook of Organic Medicinal and

Pharmaceutical Chemistry" Twelfth Edition, (J. H. Block and

J. M. Beale Jr; Editors), Lippincott Williams & Wilkins,

Philadelphia, PA, 2010.

textbook

2.

"Foye’s Principles of Medicinal Chemistry", 5th edition, (David

A. Williams, Thomas L Lemke, & William O. Foye Editors),

Lippincott Williams & Wilkins, 2012. ISBN 0683307317

textbook

3. http://www.phc.vcu.edu/othercoolsites.html

ttp://pharmacy.creighton.edu/

periodical

website

4. Course Handout Prepared by staff

members



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Physicochemical Properties

and Drug Action 1-2 a1, a2, a3, a4 b3 c1, c2 d1,d2

2. Drug Metabolism 3 a1, a2, a3, a4 b2 c1, c2 d1,d2

3. Chemotherapeutic Agents

Antibacterial Agents 4 a1, a2, a3, a4 b1, b2, b3 c1, c2 d1,d2

4. Antibiotics which impair protein

synthesis 5 a1, a2, a3, a4 b1, b2, b3 c1, c2 d1,d2

5.

Agents which act on nucleic acid

transcription and replication

Quinolones and fluoroquinolones

6 a1, a2, a3, a4 b1, b2, b3 c1, c2 d1,d2

6. Mid-term 7

8. Antifungal agents 8 a1, a2, a3, a4 b1, b2, b3 c1, c2 d1,d2

9. Antiviral Agents 9-10 a1, a2, a3, a4 b1, b2, b3 c1, c2 d1,d2

10.

Cancer

chemotherapy:Antineoplastic

drugs

11 a1, a2, a3, a4 b1, b2, b3 c1, c2, c3 d1,d2

11. Antimetabolites 12-13 a1, a2, a3, a4 b1, b2, b3 c1, c2, c3 d1,d2

Name Signature

Course Coordinator: Prof. Dr. Dina El-Sherbiny

Head of Department: Prof. Fatma Elnabawya Elsayed Goda


http://www.phc.vcu.edu/othercoolsites.html

Faculty of Pharmacy


Delta University



31



Course code: PC 332



Faculty: Pharmacy


Academic level: 3rd level Spring Semester 2016- 2017

Specialization: Pharmaceutical sciences

Prerequisite: Medicinal Chemistry-1



2. Course Aims:

This course aims to enable the student to gain an understanding of the following areas of study:

drugs affecting the autonomic system, cardiovascular (CVS) systems, diuretics, antihistamines,

antiulcers and local anesthetics, their mode of action, the correlation between chemical structures

and biological activities, different synthetic pathways of representative examples, the metabolic

biotransformation and evaluation of the contents of pharmaceutical preparations.




A5

a1. Identify drug receptor interaction and molecular effect of different drug classes.

a2. Recognize the structure activity relationships (SAR) of different pharmacologically

active compounds to optimize drug action.

a3. Outline general synthetic pathways for preparation of drugs in different classes

A13

a4. Recall nomenclature, mechanism of action, therapeutic uses of drugs used in each

pharmacological class.

a5. Distinguish biotransformation pathways of drugs according to their chemical

structure



B3 b1. Determine suitable methods of drug analysis based on their chemical structure.

B9 b2. Select proper drugs for various disease conditions based on their pharmacological

activity

B16 b3. Predict Chemical properties of drugs in different classes based on molecular structure

Faculty of Pharmacy


Delta University



32



C2 c1. Handle and dispose chemicals

C9 c2. Raise public awareness of rational use of drugs

C13 c3. Examine risks concerning drug interactions, adverse reaction and incompatibilities

C14 c4. Use different quantitative chemical methods for assay of pharmaceutical preparations



D3 d1. Support a team work in the application of the analytical methods for determination of

different dosage forms.

D6 d2. Develop the skills required for self-learning

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Adrenergic drugs 2

2. Cholinergic drugs 2

3. CVS:

Antihypertensives 2

4. H1–antagonists 2

5. Antiarrhythmics 2

6. Diuretics 2

7. Mid-Term exam

8. Antianginal 2

9. Antihyperlipidimics 2

10. Anticoagulants 2

11. Antiulcer drugs 2

12. Local anesthetics 2


14. Final Exam

15. 24


Week

No. Topics

No. of

hours

1. Colorimetric assay of epinephrine 1

2. Spectroscopic assay of ranitidine 1

Faculty of Pharmacy


Delta University



33

3. Spectroscopic assay of furosemide 1

4. Colorimetric assay of benzocaine + spectro quiz 1

5. Colorimetry and spectroscopy practical EXAM 1

6. Chemdraw 2D 1

7. Mid-Term exam --

8. Chemdraw 2D 1

9. Chemdraw 2D 1

10. Chemdraw 3D 1

11. Chemdraw 3D 1

12. Chemdraw 3D 1


14. Final Exam

15. 12


5.1. Lecture using data Show and white board

5.2. Homework and assignments

5.3. Laboratory equipment.

5.4. Computers and computer lab






confidence


confidence








Assessment 5 Written 14th & 15th weeks

Faculty of Pharmacy


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34


Course work 25

Final-Term Exam 40

Oral Exam 10

Practical Exam 25

Total 100%


No. Reference type

1.





textbook

2.

Foye’s Principles of Medicinal Chemistry", 7th edition, (David

A.Williams, Thomas L Lemke & ,William O .Foye Editors),

Lippincott Williams & Wilkins, 2012.

textbook

3. http://pharmacy.creighton.edu

http://www.phc.vcu.edu/othercoolsites.html website

4. Related videos on YouTube … etc



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Adrenergic drugs 1 a1, a2, a3, a4, a5 b1, b2,b3 c1, c3 d1 d2

2. Cholinergic drugs 2 a1, a2, a3, a4, a5 b1, b2,b3 c2, c3 d1 d2

3. CVS:

Antihypertensives 3 a1, a2, a3, a4, a5 b1, b2 ,b3 c1, c3 d1 d2

4. H1-antagonists 4 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

5. Antiarrhythmics 5 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

6. Diuretics 6 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

7. Mid-term

8. Antianginal 8 a1, a2, a3, a4, a5 b1, b2 ,b3 c1, c3 d1 d2

9. Antihyperlipidemics 9 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

10. Anticoagulants 10 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

11. Antiulcer drugs 11 a1, a2, a3, a4, a5 b1, b2 ,b3 c2, c3 d1 d2

12. Local anesthetics 12 a1, a2, a3, a4, a5 b1, b2 ,b3 c1, c3 d1 d2

http://pharmacy.creighton.edu/

Faculty of Pharmacy


Delta University



35

13.

Practical part:

Quantitative analysis of selected

pharmaceutical compounds

related to studied topics

13 b1 c1, c4 d1

Chem 2 D & Chem 3 D d2

Name Signature

Course Coordinator: Prof. Dalia Rashad El-Wasseef



Faculty of Pharmacy


Delta University



36



Course code: PC 433



Faculty: Pharmacy


Academic level: 4th level Fall semester 2016/2017


Prerequisite: Medicinal Chemistry-2 (PC 332)

Credit hours: Lecture:2 Practical: - Total:2


2. Course Aims:

This course aims to enable the student to gain an understanding of the following area of

study: analgesic CNS depressant and CNS stimulant drugs, Anti-aging drugs, Anticancer

Drugs; SAR and their modes of action; the correlation between chemical structures and

biological activities drugs and their biotransformation.




A5

a1. Identify pharmacodynamics and drug receptor interactions of CNS, analgesics and

anticancer drugs.

a2. Distinguish nomenclature and structure activity relationship (SAR) of different

pharmacologically active classes.

a3 State different synthetic pathways for preparation of different drug classes

A13 a4.

Recall nomenclature, mechanism of action, therapeutic uses of drugs used in each

pharmacological class.

a5 Recognize different biotransformation pathways of drugs.



B9 b1. Predict proper drugs for various diseases based on their pharmacological activity.

B15 b2. Estimate health hazards concerning CNS drugs and narcotics use and misuse

B16 b3. Evaluate chemical properties of drugs in different classes based on molecular

structure.

Faculty of Pharmacy


Delta University



37



C9 c1. Raise public awareness on drug abuse and misuse.

C13 c2. Examine risks concerning drug interactions, adverse reactions and incompatibility in

different drug classes.



D3 d1. Work effectively as a part of a team

D6 d2. Develop the skills required for self-learning

D9 d3. Acquire effective time management

4. Contents:

4.1.Lectures:

No. Topics No. of

hours

1.

Opioid Analgesics

1. Morphine analogs

2. Morphinans

3. Benzomorphans

4. 4-Phenylpiperdines

5. Opioid Antagonists

2

2.

Nonsteroidal Anti-inflammatory Drugs

1. Salicylates

2. Paracetamol and related drugs

3. Aryl and heteroarylacetic acid

4. N-Aryl anthranilic acid

5. Oxicams

6. Selective COX-2 inhibitors

7. Drugs used in the management of Gout and hyperuricemia

2

3.

Anticancer

1. Alkylating Agents

2. Anticancer Antibiotics

2

4. Central Dopaminergic Signaling agents

1. Anti-Parkinsonian Drugs 2

5. CNS stimulants 2

6. Tricyclic antidepressants 2

7. Mid-Term exam

Faculty of Pharmacy


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38

8.

Central Nervous System Depressants

1. Anxiolytic, Sedatives and Hypnotic agents

2. Benzodiazepines

3. Barbiturates

4. General anaesthetics

2

9.

Antipsychotics

1. Phenothiazines

2. Thioxanthenes

2

10.

Aging theories

Antiaging drugs

1. Antioxidants

2. Caloric restriction mimetics

3. Anti-Wrinkles agents

2

11. Central muscle relaxants 2

12. Anti-Alzheimer Drugs 2

13. Revision 2

14. Final Exam

15. 24


No Practical for this course


5.1. Lectures using data show and whiteboard

5.2. Assignments

5.3. Researches



1. Quizzes to assess knowledge, understanding

2. Research to assess Ability to gather and evaluate information

3. Written exam to assess Overall performance of the students

3. Oral exam to assess Confidence and understanding



Assessment 2 Mid-Term 7th week




Faculty of Pharmacy


Delta University



39




Oral Examination 10

Practical Examination -

Semester work 15

Total 100%


No. Reference type

1.





textbook

2.




textbook


http://pharmacy.creighton.edu/

periodical

website



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. CNS stimulants &

antidepressant 1 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

2. Sedative & hypnotics 2 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

3.

Anticancer:

Alkylating Agents

Anticancer Antibiotics

3 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

4. Opioids analgesics 4 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

5. Nonsteroidal Anti-inflammatory

Drugs 5 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

6. Antipsychotic 6 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

7. Mid-term

8.

Central Dopaminergic

Signaling agents Parkinson

disease

8 a1, a2, a3, a4, a5 b1, b2, b3 c1, c2 d1, d2, d3

Faculty of Pharmacy


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40

9. Aging theories , Antiaging

drugs 9 a1, a2, a3, a4, a5 b1, b3 c2 d1, d2, d3

10. Anti-Alzheimer Drugs 10 a1, a2, a3, a4, a5 b1, b3 c2 d1, d2, d3

11. Central muscle relaxants 11 a1, a2, a3, a4, a5 b1, b3 c1, c2 d1, d2, d3

12. General anesthetics 12 a1, a2, a3, a4, a5 b1, b3 c1, c2 d1, d2, d3

Name Signature

Course Coordinator: Prof. Dalia Rashad El-Wasseef



Faculty of Pharmacy


Delta University



41

Drug Design and Development 1. Basic Information:

Course title: Drug Design and Development

Course code: PC 434



Faculty: Pharmacy


Academic level: Fourth level Spring Semester 2016-2017


Prerequisite: Medicinal Chemistry-2 ( PC 332)

Credit hours: Lecture: 2 Practical: NA Total: 2


2. Course Aims:

Dominating the different strategies of drug design and development including molecular

modification and the quantitative structure-activity relationships, understanding the drug-

receptor interactions and the mechanism of drug action and providing a broad and thorough

background in drug design based on drug metabolism.




A5.

a1. Identify different drug sources, drug discovery, drug receptors, and QSAR.

a2. Outline different phases involved in the development of new drugs.

a3. State the role of molecular modification of prototype in the design of new drugs.

a4. Recognize the effect of bioisosterism and stereochemistry on drug action.

a5. Describe the pharmacokinetic issue in drug design and the concept of drug

latentiation.



B6. b1. Integrate the principles of bioinformatics, computer and other tools to design new

drugs.

B16.

b2. Predict the physical, chemical properties and biological activity of organic

compounds based on molecular structure and drug-design theories.

b3. Relate the specific structural features of drug to target receptor affinity (QSAR).

b4. Modify the pharmacokinetic characters of drugs to control relative onset and duration

of action based on drug chemistry.

Faculty of Pharmacy


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42



C15.

c1. Prescribe a case history of the discovery and development of modern drugs.

c2. Modify the chemical structure of a given drug to give optimum receptor binding

affinity.

c3. Manipulate the basic concepts of drug design, development and targeting.

c4. Examine a drug structure and deduce relative receptor affinity, metabolic

vulnerability, distribution potential, possible and optimal delivery systems



D3. d1. Work effectively as a part of a team to perform the required tasks.

D6. d2. Develop the skills required for continued self-professional development and self-

learning.

D11. d3. Generate effective and reasonable solutions for rising problems based on the available

information.

D12. d4. Develop and enhance rational thinking and prudent judgment.

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1.

Introduction to Drug Discovery and Drug Development

Phases involved in Development of New Drugs

Drug withdrawal

Sources of Drugs

2

2.

Drug receptors

QSAR

Methodology in Drug Design

Classical Drug Design (Molecular modification).

Molecular simplification (Bond disconnection and design of

fragments of the lead).

2

3. Molecular association and design of rigid analogs.

Skeletal variation (Changing size and shape).

2

4. Molecular modification to make drug resistant to hydrolysis and drug

metabolism. 2

5. Molecular modification based on drug metabolism. 2

6. Drug Latentiation (Prodrugs). 2

7. Mid-Term exam --

Faculty of Pharmacy


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43

8. Prodrugs for increased drug absorption and distribution. 2

9. Prodrugs for increased drug water solubility. 2

10. Prodrugs for site specification and targeting. 2

11. Prodrugs for controlled and slow drug release. 2

12. Prodrugs for reducing toxicity and side effects. 2

13. Bioprecursor Produgs+ Mutual Prodrugs. 2

14. Final Exam

15. 24


5.1. Lectures

5.2. Tutorials

5.3. Researches and Homework





confidence


confidence



Assessment 1 Quiz week th4





Mid-Term Exam& course work 25

Final-Term Exam 65

Oral Exam 10

Total 100%


No. Reference type

1.

“An Introduction to Medicinal Chemistry”, 5th edition, Graham

L. Patrick editor, Oxford university press INC., New York,

USA, 2013. ISBN: 9780199697397

textbook

Faculty of Pharmacy


Delta University



44

2.




textbook

3. “The Organic Chemistry of Drug Design and Drug action" 2nd

Edition, Richard. B. Silverman, Editor, Academic Press, 2004. textbook


http://pharmacy.creighton.edu/ periodical



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1.

Introduction to Drug

Discovery and Drug

Development

Phases involved in

Development of New

Drugs

Sources of Drugs

1 a1, a2 b1 c1, c3 ---

2.

Drug receptors

QSAR

Methodology in Drug

Design

Classical Drug Design

(Molecular modification).

Molecular simplification

(Bond disconnection and

design of fragments of the

lead).

Molecular association and

design of rigid analogs.

2 a3 b1, b2, b3 c2,c3, c4 d1, d2, d3,

d4

3. Skeletal variation

(Changing size and shape). 3 a3, a4 b2, b3 c2, c3,c4

d1, d2, d3,

d4

4.

Molecular modification to

make drug resistant to

hydrolysis anddrug

metabolism.

4 a4, a5 b2, b3 c2, c3,c4 d1, d2, d3,

d4

Faculty of Pharmacy


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45

5. Molecular modification

based on drug metabolism 5 a4, a5 b2, b3 c2, c3,c4

d1, d2, d3,

d4

6. Drug Latentiation

(Prodrugs) 6 a5 b3 c2, c3,c4

d1, d2, d3,

d4

7. Mid-term 7

8. Prodrugs for increased drug

absorption and distribution 8 a5 b3,b4 c2, c3,c4

d1, d2, d3,

d4

9. Prodrugs for increased

drug water solubility. 9 a5 b3,b4 c2, c3,c4

d1, d2, d3,

d4

10. Prodrugs for site

specification and targeting. 10 a5, b3,b4 c2, c3,c4

d1, d2, d3,

d4

11. Prodrugs for controlled and

slow drug release 11 a5 b3,b4 c2, c3,c4

d1, d2, d3,

d4

12. Prodrugs for reducing

toxicity and side effects. 12 a5 b3,b4 c2, c3,c4

d1, d2, d3,

d4

13. BioprecursorProdugs+

Mutual Prodrugs. 13 a5 b3,b4 c2, c3,c4

d1, d2, d3,

d4

Name Signature

Course Coordinator: Prof. Dr. Dina El-Sherbiny

Head of Department: Prof. Dr. Fatma Gouda


Faculty of Pharmacy


Delta University



46

Quality Control 1. Basic Information:

Course title: Quality control

Course code: PC 522



Faculty: Pharmacy


Academic level: Level 5 Fall semester 2016/2017

Specialization: Pharmaceutical Sciences

Prerequisite: Analytical chemistry 2 (PC 211)

Credit hours: Lecture: 2 Practical: 1 Total: 3


2. Course Aims:

Giving the principles of pharmaceutical quality control and quality assurance of pharmaceutical

products and the relation between them as well as teaching students how to apply the principles of

good sampling before applying different analytical techniques. Explanation to students how to

develop an analytical control laboratory and how to select the suitable method for analysis of drug

substances in different matrices. Applying, measuring, evaluating, interpreting and performing the

validation parameters and performance criteria for an analytical method.

Application of the pharmacopeial methods of stability and stability testing of the drugs.





A7 a2. Recall the principles of various instruments and techniques in pharmaceutical industry

A20 a3. Summarize the approval process of newly introduced pharmaceutical products

A23 a4. Identify the principles of quality assurance of pharmaceutical processes

A24 a5. Distinguish appropriate quality control criteria to different aspects of pharmaceutical

industry



B2 b1. Recommend good laboratory practice guidelines in pharmaceutical research

B3 b2. Determine suitable methods of analysis and quality control of drugs as raw material

and in dosage forms

Faculty of Pharmacy


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47

B5 b3. Design appropriate methods for evaluation and standardization of various

pharmaceutical compounds

B13 b4. Interpret experimental data based on relevant pharmaceutical principles



C3 c1. Employ proper and safe storing of medicines and pharmaceutical preparation

C4 c2. Select appropriate methods for evaluation and standardization of active substances

C8 c3. Manipulate pharmaceutical instruments and equipments safely and efficiently and

solve commonly encountered problems in pharmaceutical manufacturing processes

C14 c4. Employ different quantitative chemical methods for quality control and assay of raw

materials and pharmaceutical preparations




D4 d2. Collect, evaluate and present data in accordance with standard statistical methods



4. Contents:

4.1.Lectures:

Week No. Topics No. of hours

1. Quality management concepts of quality assurance 2

2. Basic principles of chromatography, Interpretation of

chromatograms 2

3. Analytical validation procedures 2

4. Bioavailability testing 2

5. Overview of quality assurance and quality control of pharmaceutical

products and the relation between them. 2

6. International bodies and regulations and quality systems 2

7. Mid-Term exam --

8. Development of an analytical control laboratory 2

9. Measurement of uncertainty 2

10. System suitability testing 2

11. Bases of good sampling and storage

Pharmaceutical product stability 2

12. Documentation 2


14 &15 Final Exam 24

Faculty of Pharmacy


Delta University



48


Week

No. Topics No. of hours

1. Introduction to quality control and standard operating procedure. 1

2. Validation parameters: Accuracy and Precision 1

3. Validation parameters: Linearity and Range 1

4. Spectrophotometric determination of aspirin tablets 1

5. Spectrophotometric determination of furosemide injection 1

6. Validation parameters: Specificity and Robustness 1

7. Mid-Term Exam --

8. Evaluation of impurities in pharmaceutical compounds 1

9. Limit test for salicylic acid in aspirin tablet 1

10. Limit test for chloride 1

11. Limit test for sulfate 1

12. Limit test for iron in water 1


14. Final Exam

15. 12


5.1. Lectures using whiteboard

5.2. Lectures using Data show and power point presentation

5.3. Laboratory equipment



1. Written exam To assess understanding, intellectual, professional skills



confidence


confidence


Faculty of Pharmacy


Delta University



49








Mid-Term Exam & course work 25 %

Final-Term Exam 40 %

Oral Exam 10 %

Practical Exam 25 %

Total 100%


No. Reference Type

1.

1- ICH guidelines Q10 (Pharmaceutical Quality System).

2- WHO Guidelines for Sampling of Pharmaceutical Products and Related

Materials.

3- BP 2013.

textbook

2. www.who.int/medicines/areas/quality_safety/.../QualityAssurancePharmVol2.pdf

http://whqlibdoc.who.int/trs/WHO_TRS_929_eng.pdf website



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1.

Quality management

concepts of quality

assurance

1 a4,a5 b1 c4 d1

2.

Basic principles of

chromatography,

Interpretation of

chromatograms

2 a1,a2 b2,b4 c3 d2

3. Analytical validation

procedures 3 ,a2 b2,b4 c3 d2

http://www.who.int/medicines/areas/quality_safety/.../QualityAssurancePharmVol2.pdf

http://whqlibdoc.who.int/trs/WHO_TRS_929_eng.pdf

Faculty of Pharmacy


Delta University



50

4. Bioavailability testing 4 a5 b3 , b4 c1 d4

5.

Overview of quality

assurance and quality

control of pharmaceutical

products and the relation

between them.

5 a5 b3 , b4 c1 d4

6.

International bodies and

regulations and quality

systems

6 a3 b3 c2 , c4 d3

7. Mid-term 7

8.

Development of an

analytical control

laboratory

8 a2 , a3,a5 b2,b4 c1,c3 d2 , d4

9. Measurement of

uncertainty 9 a2 , a3,a5 b2,b4 c1,c3 d2 , d4

10. System suitability testing 10 a2 , a3,a5 b2,b4 c1,c3 d2 , d4

11.

Bases of good sampling

and storage

Pharmaceutical product

stability

11 a2 , a3,a5 b2,b4 c1,c3 d2 , d4

12. documentation 12 a3 b4 c2 d4

Name Signature


Head of Department: Prof. Dr Fatma Nabawya


Faculty of Pharmacy


Delta University



51

Courses under supervision of Chemistry Departments

Mathematics 1. Basic Information:

Course title: Mathematics

Course code: PC 101

Department: General


Faculty: Pharmacy


Academic level: level 1 Fall Semester 2016-2017

Specialization: Basic Science

Prerequisite: None

Credit hours: Lecture: 2 Practical: Total: 2


2. Course Aims:

This course aims at providing the students with the mathematical principles of functions and

graphs, exponential, logarithmic, and trigonometric functions as well as differential and

integral calculus.




A1 a1 Identify the principles of mathematics and its pharmaceutical applications.

A17

a2 Distinguish between the sets, sets operations, function types.

a3 Identify the concept of differentiation and integration and their pharmaceutical

applications.



B6

b1 Differentiate between the numbers’ sets and their operations to be used in

pharmaceutical calculations.

b2 Solve different mathematical problems by applying types of functions.

b3 Apply mathematical approaches for different pharmaceutical problems.

Faculty of Pharmacy


Delta University



52



C11 c1 Conduct experimental and research studies, including: presentation, analysis and

interpretation of the results

C14 c2 Employ different qualitative and quantitative mathematical operations for chemical

and biological methods



D4 d1 Able to Collect, evaluate and present data in accordance with standard

mathematical and statistical methods.

D9 d2 Acquire effective time-management skills

4. Contents:

4.1.Lectures:

Week

No. Topics

No. of

hours

1. Sets and Sets Operations (1) 2

2. Sets and Sets Operations (2) 2

3. Advanced Operation on Sets 2

4. Exponentiation and Functions 2

5. Functions Definition 2

6. Function Types (1) 2

7. Mid Term Exam -

8. Function Types (2) 2

9. Exponential & Logarithmic Functions (1) 2

10. Exponential & Logarithmic Functions (2) 2

11. Trigonometric Functions (1) 2

12. Trigonometric Functions (2) 2

13. Differentiation and integration 2

14. Final Exam

15. 24



5.2. Solving sheets

Faculty of Pharmacy


Delta University



53





confidence


5. sheets and

Reports to assess the skills of problem-solving and data presentation


Assessment 1 Quize 4th week


Assessment 5 Written 15th weeks



Final-Term Exam 75%

Oral Exam -

Practical Exam -

Total 100%


No. Reference type

1. Schaum's Mathematical Handbook of Formulas and Tables,

2000 textbook

2. Mathematics and Statistics for Use in Pharmacy, Biology, and

Chemistry, latest edition. textbook



week

ILOs

knowledge

and

understanding

intellectual

skills

professional

and

practical

skills

general and

transferable

skills

1. Sets and Sets Operations

(1) 1

a1

a2 b1 - -

2. Sets and Sets Operations

(2) 2 a2 b1 c2 -

3. Advanced Operation on

Sets 3 a2 b1 c1 d1

Faculty of Pharmacy


Delta University



54

4. Exponentiation and

Functions 4 a2 b1 c1 d1

5. Functions Definition 5 a2 b1 - d1

6. Function Types (1) 6 a2 b1 c1 d1

7. Mid Term Exam 7

8. Function Types (2) 8 a2 b2 c1 d1

9.

Exponential &

Logarithmic Functions

(1)

9 a3 b2 c1 d1

10.

Exponential &

Logarithmic Functions

(2)

10 a3 b3 c1 d1

11. Trigonometric Functions

(1) 11 a3 b2 - d1

12. Trigonometric Functions

(2) 12 a3 b2 - d1

13 Differentiation and

integration 13 a3 b3 c1 d1

Name Signature

Course Coordinator: Dr. Noha El- Attar

Head of Department: Prof. Fatma Goda


Faculty of Pharmacy


Delta University



55

General Physics 1. Basic Information:

Course title: General physics

Course code: PC103



Faculty: Pharmacy


Academic level: Level 1 Spring semester 2017

Specialization: Basic Science

Prerequisite: None


Approval date: 12-3-2017

2. Course Aims:

2.1 To understand the general physics concepts which are related to the pharmaceutical field?

2.2 Cover the basic branches in solid and liquid mechanics, hydrostatics, hydrodynamics as

well as thermodynamics, electricity, magnetism, sound waves and application of these

concepts in pharmacy.




A1

a1 Describe the concepts of solid mechanics, electricity, and optics, and give examples to

their applications in pharmacy

a2 Develop a clear understanding of basic concepts of radioactivity and nuclear medicine

and Outline the different types of magnetism and nuclear magnetic resonance

A7

a3 Identify different types of waves and outline the properties of sound waves

a4 Discuss the meaning of thermodynamics laws, heat, temperature and its effect on drug

stability.



B2 b1

Compare between the electric force, the electric field and the electric potential and

their calculations, and Identify the standing waves and the production of high and low

sound waves

b2 Determine the photo effect on drug, and investigate the different properties of matter.

B16 b3 Differentiate between the meaning of the temperature and the quantity of heat.

b4 Investigate the spectroscopic analysis and the atomic structure.

Faculty of Pharmacy


Delta University



56



C8 c1

Apply the bio-magnetic field theory in the magnetic resonance imaging, and sound

waves in medicine.

c2 Handle the radiotherapy techniques.

C11

c3 Analyze the physical parameters graphically and experimentally, and Utilize the

physics concepts , techniques ,and tools in solving problems

c4

Illustrate the electric field intensity and the electric potential and its applications in

pharmaceutical industry, and measure the power and focal length of the mirror and

lenses.



D3 d1 Work effectively both in a team and independently.

D6 d2 Create new methods to manage tasks, use resources effectively and deal with

obstacles.

D11 d3 Use modern technology in retrieving information and solving problem.

4. Contents:

4.1.Lectures:


No. Topic No. of hours

1, 2 Solid mechanics 2

3, 4 Heat and temperature 2

5 Sound and ultrasound 1

6 Nuclear and radiation 1

7 Mid term -

No. Topic No. of hours

1, 2 Solid mechanics 4

3, 4 Heat and temperature 4

5 Sound and ultrasound 2

6 Nuclear and radiation 2

7 Mid term -

8, 9 Optics and laser 4

10, 11 Electricity 4

12 Magnetism and MRI 2

13 Applications 2

14, 15 Final exam 24

Faculty of Pharmacy


Delta University



57

8, 9 Optics and laser 2

10, 11 Electricity 2

12 Magnetism and MRI 1

13 Practical exam 1

14, 15 Final exam 12


5.1 Lecture using Data show projector.

5.2 Video and animation

5.4 Laboratory sessions



1. Written exam To assess knowledge, understanding, intellectual and professional skills

2. Practical exam To assess professional and practical skills.

3. Class work To assess knowledge, understanding, intellectual skills, general skills and

confidence.

3. Oral exam To assess knowledge, understanding, intellectual skills, general skills and

confidence.

4. Quizzes To assess knowledge, understanding and intellectual skills.

5. Case study To assess the skills of problem-solving and data presentation.









Quiz 10

Practical Examination 25

Total 100%


No. Reference type

1 Physics in Biology and Medicine, 4th Edition

Paul Davidovits (2012) Textbook

Faculty of Pharmacy


Delta University



58

2 Physics for scientist and engineers 9th R.A Serway, 2015. Textbook

3 https://www.explorelearning.com/ Website



week

ILOs

knowledge and

understanding

intellectual

skills

professional

and practical

skills

general and

transferable

skills

1 Solid mechanics 1,2 a1 b3 c1

2 Heat and

temperature 3,4 a4 b3

c1

3 Sound and

ultrasound 5 a3 b1 c3 d1

4 Nuclear and

radiation 6 a2 b4 c4 d2

5 Mid term 7 - - - -

6 Optics and laser 8,9 a1 b2 c2 d3

7 Electricity 10,11 a1 b3 c2 d2

8 Magnetism and

MRI 12 a2

b3, b4 c3 d3

9 Applications 13 a1 b4 c4 d1, d3

Name Signature

Course Coordinator: Dr. Ehab Hegazy


Approval Date 12-3-2017

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