�
�1 Laboratory Services: Agrochemicals 2015
CLICK www.criticalpathservices.com
LEARN Read our awesome blog:
www.criticalpathservices.com/en/news
INTERACT tel. +1 610 558 3001
email: [email protected] Follow us on
�
Laboratory Services: Agrochemicals 2015 �2
Contents About us 3Environmental Fate at CPS 4Product Chemistry at CPS 5Specialty Services 6Instruments 7Expertise 8Appendix: Protocols 9
�
�3 Laboratory Services: Agrochemicals 2015
Who we are We’re more than a group of scientists. Specializing in environmental fate, structure elucidation, and product chemistry in the agrochemical industry, our team is engaged in the science of your business and the future of the field.
What we do Our team brings timeliness and structure to your studies. We stay at the bleeding edge of the industry through our publications, and by developing new methods like analyzing proteins via LC-MS/MS.
Why we do it Our laboratory was launched with the goal of helping our clients win in the market. No matter the stage of your pipeline, we’re interested in practicing the best science possible while moving your products forward.
Bring us on board. You’ll be glad you did.
�
Laboratory Services: Agrochemicals 2015 �4
On-target science We’ve kept our laboratory focused during our steady growth, and our carbon-14 and e-fate services are a direct product of this relentless focus on quality science.
The right expertise Our Study Directors and scientists, with over 30 years worth of experience in environmental fate and metabolism, look at your studies as their own. They know the importance of your timelines, and of open and prompt communication.
The right gear Our laboratory is outfitted with the latest instrumentation to ensure that your work—from adsorb/desorb and metabolism to mineralization and structure elucidation—receives the best treatment possible.
14C & Environmental Fate
Study Type Matrix OECD Guidelines
EPA Guidelines
Adsorption/Desorption
Soil/Sediment
106 835.1230
Hydrolysis Water 111 835.2120; 835.2130 (UV/VIS absorption
Photolysis Soil 316 835.2410
Water 834.2210; 835.2240; 830.7050 (UV/VIS absorption
Aerobic/Anaerobic transformation
Soil 307 835.4100; 835.4200
Aquatic sediment
308 835.4300; 835.4400
Aerobic mineralization
Surface water
309 835.3190
Analytical services at a glance
Study Type Tests performed
Base Price/Rate
Modifyers & Additional Costs
Adsorption/Desorption 3 Soils $
Hydrolysis 1 pH at 3 Temperatures
$
Photolysis Soil/Water $
Aerobic/Anaerobic soil metabolism 3 Soils $
Aerobic/Anaerobic water/sediment metabolism
3 Soils $
Base rates
�
�5 Laboratory Services: Agrochemicals 2015
People power Our scientists have you covered. Whether developing a method from scratch, identifying metabolites, or performing high-throughput analyses for your residue and product trials, we have the expertise, and the background, that your studies need.
High-tech New tools are always fun, and our lab has them. The newest piece in our facility—an AB Sciex Triple Quad 6500—allows us increased sensitivity for your newest methods and compounds.
Our standard We structured our laboratory according to one simple standard: Focus. We’re focused on providing high quality science while being accessible, even for your large programs. If anything, we shoot for over-communication, and that’s not a bad thing.
Residue and Product Chemistry
To talk about your studies, our rates, and more, contact us today.
tel. +1 610 558 3001 [email protected]
Study Type Guidelines Supported
Residues in rotational crops OECD 504
Multiresidue analysis OPPTS 860.1360
Stability in stored commodities
OECD 506
Field dissipation OPPTS 835.6100
Nature of residues in processed commodities
OECD 507 OPPTS 860.1300
Dislodgeabe foliar residue OPPTS 875.2100
Magnitude of residue (MOR) OPPTS 860.1500
MOR in processed commodities
OECD 508 OPPTS 860.1520
Residue decline OPPTS 860.1500
Crop field trials OECD 509 OPPTS 860.1500
Metabolism in crops OECD 501
Metabolism in rotational crops OECD 502
Metabolism in livestock OECD 503
Residues in livestock OECD 505
Total toxic residue OPPTS 860.1300
Analytical services at a glance
�
Laboratory Services: Agrochemicals 2015 �6
At the core When it comes to ILVs, full or partial method development, even radiovalidations, we’ve got your back. Our analytical and method development chemists are at the ready.
At the forefront New methods to old problems can help shape an industry. With our multiplexed analysis of proteins by LC-MS/MS, we hope to do just that by making your large molecule analyses easier, faster, and cost effective.
Specialty Analytical Services
Development & validation
Independent laboratory validation (ILV)
Method development
Method validation14C Radiovalidation
Biotechnology
Multiplexed protein analysis via LC-MS/MS
ELISA
Analytical services at a glance
Study Type Base Price/Rate (plus modifiers)
Modifiers & Additional Costs
Independent Laboratory Validation $
Method Development $
Method Validation $14C Radiovalidation $
Multiplexed protein analysis via LC-MS/MS
$
ELISA $
Base rates
�
�7 Laboratory Services: Agrochemicals 2015
Instrument
Beta-Ram 5B detector with Waters prep HPLC/UV/Fraction collector
Perkin Elmer Tri-Carb 2910 TR Liquid Scintillation Analyzer
Radiodetection
Instrument
Atlas SunTest CPS+ with Suncool
Harvey Oxidizer
UV-Vis Spectrophotometer
ELISA Tecan Iinfinite F200 microplate reader
Experimental
Instrument
Dionex ASE 350 accelerated solvent extractor
Miilestone Ethos EX microwave extractor
Waters 96-well positive pressure manifold for SPE & SLE extractions
(2) SPEX 2000 Geno-grinder extractors
Sample preparation
Tools of the trade some cool stuff we like to talk about
Instrument Front End
Waters Xevo G2-XS QTOF Acquity I-Class UPLC
AB Sciex 6500 Triple Quad LC-MS/MS
Shimadzu UPLC and CTC PAL autosampler
(2) Sciex API 4000 LC-MS/MS Agilent 1200 HPLC
(2) Agilent 6410B LC-MS/MS (1) Agilent 1290 UPLC(1) Agilent 1200 HPLC
Thermo DSQ-II GC-MS / GC-FID
Agilent 1100 LC-DAD
Chromatography
�
Laboratory Services: Agrochemicals 2015 �8
Fenn Li, Ph.D.
Our Laboratory Group Leader, Fenn has over 20 years' experience in method development and trace level analysis, and over 8 years’ experience conducting and overseeing environmental fate studies.
More about Fenn Fenn has expertise spanning HPLC, GC, LC-MS/MS, GC/MS, and instruments for detecting radiolabeled compounds (LSC, radioactivity detector, oxidizer, etc).
As a study director and principal investigator for residue and environmental fate studies, Fenn keeps our studies on track and within guideline.
One of our study director superstars, Bridgett is an analytical chemist with experience in small and large molecule separations, environmental fate and metabolism, and protein chemistry.
More about Bridgett Bridgett has worked with LC-MS/MS instruments including accurate mass, and blends this with her knowledge of biotechnology to quantify protiens via LC-MS/MS.
Bridgett also acts as study director and principle investigator for soil and aquatic transformation and other environmental fate studies.
The people just some of the expertise that makes our lab awesome
Bridgett Steele, Ph.D.
To talk about your studies, our expertise, and more, contact us today.
tel. +1 610 558 3001 [email protected]