CRCHD: Cancer Health Disparities Research and Diversity Training Opportunities

Mary Ann S. Van Duyn, PhDCenter to Reduce Cancer Health Disparities

NCI Division of Cancer Biology New Grantee WorkshopMarch 12, 2014

URMs Truly Are Underrepresented in the Cancer Research Workforce

Drew, ASBMB Today, Jan 2010.

Majority Minorities…Changing Face of the U.S.

Why is Diversity Important?

• Broadens the research “lens” to include new viewpoints from those from diverse backgrounds

• Enhances innovation and creativity in cancer research

• Contributes to reducing cancer disparities by more effectively addressing existing disparities within the population

• Promotes fairness in the use of public funds for cancer research

• Consistent with NIH’s Commitment to Excellence: providing support for talented individuals to explore ideas at the highest level of inquiry

Probability of NIH R01 awards by Race and Ethnicity (FY 2000-FY 2006 ) (N =

83,188)

• Coordinates and strengthens the NCI cancer research portfolio in basic, clinical, translational and population-based research to reduce cancer health disparities

• Leads NCI’s efforts in the training of students and investigators from diverse populations in cancer and cancer health disparities (CHD) research

Within CRCHD and Across the NCI Divisions, Offices and

Centers

NCI CRCHD Mission

Center to Reduce Cancer Health Disparities

ResearchCNP Centers

Basic Research in Cancer Health Disparities

Diversity TrainingCURE

Promoting Workforce Diversity in Cancer Research

PACHE

Integration of Research, Training, and Community

National Outreach NetworkG/BMaP

NCCCP/NCORP Liaison

Basic Research – CRCHD/DCB Collaboration

CRCHD

R21/U01

• Understanding Biological Variations• Determining Mechanisms and Pathways• Creating Tailored Diagnostics/Therapies

• All Eligible• Preliminary data is not required• $275K Direct Cost Limit for 2 year project period

http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html

To support pilot and feasibility studies and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities

Exploratory/Developmental Grant for Basic Cancer Research in Cancer

Health Disparities (R21) PAR-12-094

Basic Cancer Research in Cancer Health Disparities (U01) PAR-12-095

• All Eligible• Preliminary Data Required• $250K Direct Cost Limit per year and not to exceed 5 years

http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html

To conduct basic, mechanistic research into the biological/genetic causes of cancer health disparities.

R21/U01 Basic Research in Cancer Health Disparities (PAR-12-094/095)

Topics of U01 grants funded in FY 2013• Role of Chemokine Receptors in Prostate Cancer Progression Disparities• Investigations on HPV Variants and Ethnic Disparities in Cervical Cancer• Metabolic Profiles and Racial/Ethnic Disparities in Breast Cancer

Topics of R21 grants funded in FY 2012• Significance of Cancer Stem/Stem-like Cells in African-Americans with Colorectal

Cancer • Viral and Immune Host Response Factors as Biological Bases of Disparity in Liver

Cancer Survival among Asian Americans • Role Of MicroRNAs in Prostate Cancer among African-Americans• Glycation as a Mechanism Promoting Cancer Health Disparity• Significance of Mitochondrial DNA in African-American Prostate Cancer Patients

* 1 Lymphoma, 1 Liver Cancer, 1 Wilms‘ Tumor , 3 Multiple Cancers

Prostate Breast Colorectal Leukemia Cervical Other012345678

Research by Cancer Type (2010-13)

Fund

ed

Provocative Questions RFA

R01 and R21 mechanisms are available for each PQ

PQC – 3: How do variations in tumor-associated immune responses among patients from distinct well-defined populations, such as various racial/ethnic or age groups, contribute to differences in cancer outcomes?

 For more information: http://provocativequestions.nci.nih.gov/

Group A

Cancer Prevention and Risk

Group B

Mechanisms of Tumor Develop-ment or

Recurrence

Group C

Tumor Detection, Diagnosis,

and Prognosis

Group D

Cancer Therapy and Outcomes

Group D

Clinical Effectiveness

Diversity Training

Training

CURE

Promoting Workforce Diversity in Cancer Research (R21)

Continuing Umbrella of Research Experiences (CURE)

T R A I N E E S

High School Undergradu

ate

Pre -doctoral

Early Stage

InvestigatorsPostdoctor

al

Increase the size of the talent pool

Emphasize scientific areas of

greatest need

Expand and extend the period of training

HS Undergrad. Predoctoral Postdoctoral Early Stage Investigator

Diversity Supplements

R25TS: Cancer Prevention and

Control Clinical Oncology

Training Grants: K12S

TransitionCareer: K22

NRSA Fellowships: F31

Career Awards:K01 K08 K23

P30 Supplementsfor HS and UG students

NRSA Training Grants:T32S

R

0

1

Continuing Umbrella Research Experiences

R21

Re-Entry Supplements

Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplements

http://grants.nih.gov/grants/guide/pa-files/PA-12-149.html

• Improve the diversity of the research workforce• Students, post doctorates, and eligible investigators

Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement)

http://grants.nih.gov/grants/guide/pa-files/PA-12-150.html

• Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances

• Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH.

Research Supplements to Promote Diversity and Re-Entry

Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplement)

http://grants.nih.gov/grants/guide/pa-files/PA-12-149.html

• Improve the diversity of the research workforce• Students, post doctorates, and eligible investigators

Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement)

http://grants.nih.gov/grants/guide/pa-files/PA-12-150.html

• Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances

• Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH.

Research Supplements to Promote Diversity and Re-Entry

CRCHD DCB DCCPS DCP DCTD CSSI0

50

100

150

200

250

300

350

400

450

500

Supplement Awards by Division/Center (2001-2012)

Series1

Divisions/Centers

Num

ber o

f Aw

ards

CURE – NRSA Fellowships (F31)Ruth L. Kirschstein National Research Service Awards for Individual Pre-doctoral Fellowships • Pre-doctoral (up to 5 years) support for candidates in biomedical, behavioral, or clinical sciences

• Fellowship Requirements – Experienced mentor, enrollment in a

graduate school

• Allowable Costs – Annual stipend for Fellow’s living expenses, tuition & fees, and health insurance

• Submission dates – 4/13, 8/13, 12/13 (Electronic Submission)

http://grants.nih.gov/grants/guide/pa-files/PA-10-109.html

NCI Mentored Research Scientist Development Award to Promote Diversity (K01)

PAR-12-050

BASIC & POPULATION SCIENCE

• Individuals with research or health professional doctorate degree

• 100K Salary/30K R&D; 3-5 years support

• Submission Dates: 2/12, 6/12, 10/12

Mentored Career Development Award (K01)

• Eligibility: Investigators from Diverse Backgrounds• Preliminary Data is not required• $275K Direct Cost limit for 2 year project period

http://grants.nih.gov/grants/guide/pa-files/PAR-12-096.html

To improve the diversity of the research workforce by supporting and recruiting eligible investigators from groups that have been shown to be underrepresented.

Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer

Research (R21) PAR-12-096

Geographical Management Program (GMaP)

• Foster team science• Promote cross-training in

emergent areas of science and in basic, clinical, and population-based science• Enhance personalized

career mentoring• Share successful training

and research models • Link ESI from CURE to

available academic job opportunities to build critical mass

Basic Cancer Health Disparities Research (R21 and U01)Dr. Rina Das dasr2@mail.nih.gov

Community Networks Program CentersDr. Rina Das dasr2@mail.nih.govDr. Liz Perruccio perruccioem@mail.nih.govDr. Precilla Belin belinpl@mail.nih.gov

Diversity Supplements and U54Dr. Alison Lin alison.lin@mail.nih.gov

NRSA (F31 and T32S)Dr. Anil Wali walia@mail.nih.gov

Supplements to the CURE (P30S, R25TS, K12S) Dr. Alison Lin alision.Lin@mail.nih.gov

Career Development Awards (K)Dr. John Ojeifo (K01, K08, K23) Ojeifojo@mail.nih.gov

Exploratory Grant (Diversity R21)Dr. Anil Wali walia@mail.nih.gov

PACHE Program (P20, U54) Dr. Carmen Moten cmoten@mail.nih.gov

CRCHD General Contact Number: 240-276-6170

Promoting the Mission

http://crchd.cancer.gov

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