Cross Your Own Ocean: The story of a new tech start up

@elinhafdavieswww.elinhafdavies.co.uk

@aparitohealthwww.aparito.com

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Childhood Dream

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The Atlantic Ocean

www.nurseelin.co.uk

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www.nurseelin.co.uk

Dream big and dare to fail.

Norman Vaughan

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We’re off …!

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www.nurseelin.co.uk

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Imprinted forever …

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www.nurseelin.co.uk

ouch!

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The Mad Hatter:“Have I gone mad?”Alice: “I’m afraid so. You’re entirely bonkers.But I’ll tell you a secret. All the best people are.”

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www.nurseelin.co.uk

Nadolig Llawen.

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Second helpings are what happiness is all about. Winnie the Pooh.

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www.nurseelin.co.uk

Exploration is the physical expression of the intellectual passion.

Apsley Cherry Garrad

www.nurseelin.co.uk

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www.nurseelin.co.uk

www.nurseelin.co.uk

Duct tape is like the force.

It has a dark side and a light side…

and it holds the Universe together.

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Land Ahoy!

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www.nurseelin.co.uk

Finally …!

Dad, Mam & Gles

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The Atlantic Ocean

www.nurseelin.co.uk

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77 days

7 hours

37 minutes!

2,560 nm

rowed!

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“Nautical Nurses”

£190,000 raised for

metabolic research at

Great Ormond Street

Children’s Hospital

£190,000 towards a PhD programme

Dr Emma Footitt

graduated August 2014

Pyridoxamine 5’-phoshate oxidase (PNPO) deficiency

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Orphan Designation by European Medicine Agency

Honoured to support:Prof Peter Clayton, Dr Emma Footitt, Dr Phillipa Mills, Dr Catherine Tuleu and Dr Abeer Ahmed (SoPh).

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“Ocean Angels”

3,600 miles

78 days

15 hours

54 minutes.

World First &

Fastest Record!£26,000

raised for

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www.nurseelin.co.uk

A well-read woman is a dangerous creature. Lisa Kleypas

The many faces of Dr Elin!

Photo credit: Dr Kevin Mills

My Research Background

• Phase II, open-label, randomized, multi-centre trial to evaluate the safety and efficacy of “DRUG X” in neuronopathic Gaucher disease.

• Inclusion Criteria:

• Child is able to swallow a tablet

• Child is able to comply with study assessments

No Mum!Please don’t

make me visit Elin again!!

Saccadic Eye Movement Assessment

Using a video, infrared or scleral search coil technique

Patients face a screen and follow a target that jump on the screenaccording to a pseudo-random sequence. The subjects sit with head in chin cup andforehead against a head rest and faced a screen 1 meter away on which a red laser spot is back projected.

GAITRite™ Gait Analysis •Commercially available.

•Portable.

•Mat embedded with 16,128 sensors set 1.27 cm apart.

•Activated by mechanical pressure.

Reimbursement applications fail

Clinical trials fail

(inconclusive)

Capturing clinically meaningful

patient-data is challenging.

Clinical Trial challenges

Patient A

Patient B

Test 1 Test 2

6 months later

What the Doctor sees…

Patient A

Patient B

What the Patient experiences…

Test 1 Test 2

6 months later

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The Aparito solution

Vastly improved understanding of diseases Better, cheaper & faster drug development More participants & engagementIncreased chance of regulatory approval Higher patient empowerment & quality of life Lives Saved & Improved

Database

Pat

ien

tW

ear

able

Ap

p

Spo

nso

r

Clin

icia

n

Patient Generated Outcome

Data

Remote Disease

Monitoring

Passive Data

Capture

Continuous Data

Real Time Data

Paperless Data

Capture

DigitalisedMonitoring

Process

Real Time Flags

Medication Prompts

Designed to overcome clinical & regulatory roadblocks

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Current & Completed Trials

NIEMANNPICK C

JUVENILEIDIOPATHICARTHRITIS

DUCHENNEMUSCULARDYSTROPHY

GAUCHERDISEASE

LATEONSET TAY

SACHS

CHILDOOD EPILEPSY

www.aparito.com

@aparitohealth

~ £300K raised for charities

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My inspiration!

Henry Mia

Thank youwww.elinhafdavies.co.uk

@elinhafdavies

www.aparito.com

@aparitohealth

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