CTRF Leadership Meeting

May 6, 2002

Institutional Partners

Develop Infrastructure and Intellectual Property that

Enhances the Competitiveness of the Partners for Clinical and

Extramural Funds

Principle Objective

Evaluate gene expression (and genetic changes) in human brain, ovarian, breast and hematopoetic cancers

Link gene expression (and genetic changes) to clinical findings and clinical laboratory findings (including histopathological diagnoses) in a common database

Evaluate linked data using bioinformatics

Research Objective

ChandhokeGrant

ChristensenFryxell

Jamison

Torr (Central Admin)GinderGarrettBuck

Guiseppe-ElieAbraham

Cooper

Year 1 Year 1 Year 1

$325,000 $582,000 $93,000

Total (3 yrs) Total (3 yrs) Total (3 yrs)

$975,000 $1,734,603 $290,397

Funding From CTRF

Reminder - Cost Share Form (VCU)

Cost share expenditures not paid from cost share linked ledger 4 account must be documented using ‘In Kind/3rd Party Cost Share form’ obtained from Margie Booker’s office.

Cost Share Expenses

FY 02 Rollover

• Process exists for rollover instructions in mid May• VCU reports non general fund cash balances to

state agency together with plan for expenditures• “…once these plans have been approved agencies

will be instructed to prepare FATS transactions to create the appropriations and spread the amounts to the right programs and subprograms

• New accounts have been created for new award for FY2003-04

FY 03 Allocation

• May need to submit record of expenditures

• Will need to submit progress indicating milestones achieved

FY03, 02 Update CTRF Budget Reductions

• Request efforts to the DPB regarding the effects of budget cuts to the CTRF were successful

• April 17, 2002, the general assembly approved governor Warner’s amendment to restore funding for the Commonwealth Technology Research Fund

• Thanks to all who contributed information discussing the impacts of such a cut

Website Update

Web Site is Up and Running

URL - www.ctrf- cagenomics.vcu.edu

New Pages have been added;

content still needed

SPIN Research

Jo Ann Breaux receiving daily notices of grant opportunities

Compiling weekly document of relevant findings Will be distributed over the CTRF LISTSERV

SMART documents currently on the CTRF website

• Training is available: http://www.InfoEd.org/default.stm

1. Breast Cancer Research Program--Exploration Awards2. Breast Cancer Research Program--Physician-Scientist Training Awards3. Breast Cancer Research Program--Biotechnology Clinical Partnership Awards4. Breast Cancer Center of Excellence Awards5. Breast Cancer Research Program--HBCU/MI Partnership Training Awards6. Breast Cancer Research Program--Collaborative-Clinical Translational

Research Awards7. Ovarian Cancer Research Program--Institutional Training Grants8. Ovarian Cancer Research Program--Idea Development Awards9. RFP--Department of Defense Prostate Cancer Research Program (PCRP) for

Fiscal Year 200210. NCI--Specialized Programs of Research Excellence (SPOREs) in Pancreatic

Cancer for the Year 200211. NCI--Institutional Clinical Oncology Research Career Development Program12. NCI--Cancer Education and Career Development Program13. NHGRI--Technologies for Genomic Mapping, Sequencing & Analysis Program14. NHGRI--Pilot Projects or Feasibility Studies for Genomic Analysis15. RFA-HG-02-002--Developing Robust Components for Model Organism

Databases16. RFA-LM-02-001--NLM Internet Access to Digital Libraries Grants17. AHRQ--AHRQ Health Services Research18. Partnerships for Innovation (PFI)

SPIN Research

Tissue Bank Clinical and Pathology Laboratory Data Database Design Data Analysis Quality Assurance in Microarray

Analysis (Chip Fabrication - proposed)

Focus Group

Focus Group Leaders

GMU

G e rald in e G ran t ( G M U )S u ha il N as im ( V C U )B a rr ie C o o k ( I n o va)

Tissue Bank

L yn ne P en b e rth y (V C U )S u ha il N as im ( V C U )

J a m e s C o op e r ( I n o va)J a m e s B u rge s s ( I no va)

B a rr ie C o o k ( I n o va)

C linP ath

C u rtis J am is on ( G M U )L yn ne P en b e rth y (V C U )

G re g M ille r (V C U )M ike S he ride n ( I no va)

D B D esign

V ika s C h an d h oke ( G M U )G re g B u ck ( V C U )

D ataA nalysis

A la n C h r is ten s en ( G M U )A n d re a F e rre ira - G o n z ale z (V C U )

Q A / LQ C

VCU I nova

Focus Group Leaders

• IRB to review at INOVA

• Tissue Acquisition person to be hired and managed by Marianne Smith

– Inova to work out process for obtaining necessary informed consent

• Tissue Bank person to go to OR area with pathologist responding to request for frozen section and take tissue at that time

• Ideal procedure is unclear at this time for tissue acquisition unclear:

– Cut and freeze a piece of tissue at the OR (most rapid)

– Perform a frozen section on a block and then drop the latter into liquid nitrogen (delay 5-10min)

• Protocol handling for Bone Marrow Aspirates not yet specified

• Tissue is not to leave Inova until surg path written report is completed

INOVA -CTRF - Tissue Bank

CTRF - Tissue Bank Update

VCU - Tissue Bank

• TAS approved by IRB 4/15/02

• First Tissue Specimens have been collected; 3 Bone Marrow and 2 Breast

• Tissue Bank Staff Activities (Cynthia Losco)

– Procedures Established in Main OR and Ambulatory Surgery

– Cynthia to be notified 30 minutes before specimen to be ready on cases identified for CTRF eligibility

– In-service given to OR staff to address new procedure

– Bone Marrow Biopsy patients will be consented directly after procedure

Tissue Bank Information

Tissue Acquisition

Histopathologic Parameters

CTRF – Tissue Dispersion (DRAFT)

• Issues to be Considered– 1st Priority CTRF PIs of Participating Labs– QA Program

• Chip/chip• Labeling• RNA quality• Day to Day Run Variation

– Pre-Analytical Tissue Handling• Storage Conditions (Freezer Monitoring)• Tissue Sections Supplied• First & Last Section used for Frozen Section

Overseen by the Tissue Utilization Committee

• Data Sources– Clinical - MCCIS, Pathology, INOVA

• Desirable Info - Contains financial treatment and outcomes

• If clinical identifiers present, must be behind firewall

• Histopathology currently text format only

– Microarray Data

Database Design/Clinical InfoDatabase Design Meeting at GMU

(3/6/02)

VCU – Database Design/Clinical Info

Clinical Data Elements CTRF Leadership needs to

define minimal set of common clinical data elements; Initial choice to be the elements required to be sent to state cancer registry

Data elements will have to be built into CTRF Database – no resolution as to where data will be held

Data elements should include MIAME (Minimum Information about a Microarray Experiment) for holding Expression Array Data

Tissue Acquisition Status Access Database to is

being created to hold data elements; elements need to be defined

CTRF needs a common protocol for how to handle tissue between the consortium

Quality measures need to be defined for microarray analysis

GeneX Database (Update)

“Terabyte” Database – Questions

GMU – Database Design/Data Analysis

GeneX Database (Update)

Other (?)

VCU – Data Analysis

Schema (Preliminary) 16 Chips

Test for Variation Chip-Chip Labeling Buffers Modules (4)

QA/QC

QA Program

Establish Standing Weekly or Biweekly Meeting Dates and Times

Complete the Milestone Updates

Document Discussions and Progress Using Listservs

REMINDER

CG-TISBK: Tissue Bank CG-CLNDT: Clinical and Pathology Data CG-DBDSN: Database Design CG-ANLDT: Analyze Data (Data Analysis) CG-QAQC: QAQC CG-LDRPI: Focus Group Leaders and PIs CG-MEMBS: All Members

Communication Amongst Members and

Focus Groups

Address messages to: listname@VENUS.VCU.EDU

Unsubscribe to the listserv by submitting a message with the words SIGNOFF listname to: LISTSERV@VENUS.VCU.EDU

Subscribe to the listserv by asking the PI with whom you work to submit your name and E-mail address to the Program Director (C.Garrett)

USE the listserv(s) to inform members of your activity or to seek advice from the members.

LISTSERVS

Old Business

New Business

Intellectual property reporting - licenses, patents, etc

Publications

New applications identified - CTRF Administrative office

will search for new funding opportunities (SPIN)

will collect CVs, other support, facilities, interest documents

goal - 4 - 8 million in d.c. from CTRF CG Project

Any other discoveries

Federal money leveraged

Private research money leveraged

Advancement of technology and economic development in VA

CTRF - Specific Reportables

- - Reminder - -

Monday

June 3, 2002

9:30 am